Novel approaches in cancer study最新文献_第3页

Ovarian Cystadenocarcinoma with an Osteosarcoma Component 卵巢囊性腺癌伴骨肉瘤成分

Novel approaches in cancer study Pub Date : 2021-08-16 DOI: 10.31031/nacs.2021.06.000633

S. Sakhri

引用次数: 0

Review Article: Breast Calcifications on Mammography 综述文章:乳腺钙化的乳房x光检查

Novel approaches in cancer study Pub Date : 2021-07-26 DOI: 10.31031/nacs.2021.06.000632

Kameswari P

{"title":"Review Article: Breast Calcifications on Mammography","authors":"Kameswari P","doi":"10.31031/nacs.2021.06.000632","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000632","url":null,"abstract":"mucin accumulating in the duct, lobular acini or cavities associated with the lesion. These calcifications can appear in low to intermediate grade DCIS or benign conditions such as sclerosing adenosis and ductal hyperplasia. They take a round or hazy/amorphous shape with size of the calcification depending on the size of the duct. Calcifications within the ducts and lobules can also be formed by the calcium deposition within cell debris and Abstract Breast calcifications are the most common finding on mammograms and can show significant morphological variability. With the help of the BIRADS (Breast Imaging Reporting and Data System) lexicon they can be divided into benign and malignant types but there remains overlap between these two categories. Micro calcifications which fall in the ‘suspicious’ category can occur without the presence of an associated mass or architectural distortion. Micro- calcifications are also one of the first features to be seen on mammograms in DCIS (Ductal Carcinoma In Situ ), leading to early diagnosis and prompt treatment. With the advent of newer technologies in imaging, more information regarding the radiological extent of disease and cancer type associated with the calcification can be determined. This review aims to cover the BIRADS fifth edition descriptors and lexicons of breast calcifications on mammography. Calcifications are a common entity on mammograms, with most being benign. With the evolution in mammogram technology and screening programmes, microcalcifications have become easier to detect with reporting of DCIS increasing, thereby reducing patient mortality. With this review paper, we aim to review the imaging descriptors of benign and malignant calcifications seen on mammograms with a pictorial representation and brief literature review.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43527524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of the Potential Preventive Effects of Adiponectin in Major Cancers 脂联素对主要癌症潜在预防作用的综述

Novel approaches in cancer study Pub Date : 2021-07-09 DOI: 10.31031/nacs.2021.06.000631

Daniel Borsch

{"title":"A Review of the Potential Preventive Effects of Adiponectin in Major Cancers","authors":"Daniel Borsch","doi":"10.31031/nacs.2021.06.000631","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000631","url":null,"abstract":"A of the Potential Effects of Adiponectin in Major Abstract Adiponectin is a hormone-like cytokine (or adipokine) predominantly secreted from fat cells. Adiponectin has anti-inflammatory properties and inversely correlates with body fat mass, including visceral adiposity. This cytokine is present in different isoforms and may mediate its biological functions mainly through AdipoR1 and AdipoR2 receptors. It is thought that adiponectin has been associated with the pathological processes of diabetes, heart disease, and cancer. In our review of PubMed literature, we found interesting data regarding the effect of adiponectin levels on many types of cancer. Several studies have observed a protective role of adiponectin in some types of cancer. In endometrial, colon, kidney, postmenopausal breast cancer, and leukemia, there appears to be an inverse relationship between adiponectin levels and cancer. Understanding adiponectin’s biological connection with other hormones (e.g., insulin, insulin-like growth factors, leptin), as well as its modulation in pre-neoplastic states and malignancy to exploit its beneficial effects, could reveal potential new strategies for the management of certain types of cancer.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":"32 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41303253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-Agnostic Indications: Which Direction are We Going? 肿瘤不可知指征:我们该往哪个方向走?

Novel approaches in cancer study Pub Date : 2021-07-07 DOI: 10.31031/nacs.2021.06.000630

Kessel Boris

引用次数: 0

Circulating DNA in Serum as a Tumor Marker in Precancerous Lesions of the Cervix in Mexican Women 血清循环DNA作为墨西哥妇女宫颈癌前病变的肿瘤标志物

Novel approaches in cancer study Pub Date : 2021-07-06 DOI: 10.31031/nacs.2021.06.000629

Alcántara-Quintana Luz Eugenia

{"title":"Circulating DNA in Serum as a Tumor Marker in Precancerous Lesions of the Cervix in Mexican Women","authors":"Alcántara-Quintana Luz Eugenia","doi":"10.31031/nacs.2021.06.000629","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000629","url":null,"abstract":"Introduction: Cervical cancer is the fourth leading cause of death in the world. This poor prognosis is due to the fact that in two out of three cases the disease is diagnosed in advanced stages. Consequently, advances in detection methods can lead to early diagnosis of the disease and consequently to an improved prognosis. Methods based on serum-based tumor markers are a promising tool for early diagnosis and in general for biochemical screening of cancer patients. They also offer the added value of being non-invasive methods. Evidence has been found for the release of cellular DNA into the blood, so its quantification has the potential to serve as a tumor marker. If this DNA is detected in serum, it can reflect tumor size, viral load and response to treatment. Objective: To determine the amount of circulating DNA in serum of patients with precancerous lesions. Methods: The study was carried out with 40 healthy women and 120 women with precancerous lesions, who attended gynecological-obstetric care. Of the 120, 60 had low-grade lesions and 60 had high-grade lesions. All participants had a blood sample taken for determination of circulating DNA in serum. Specific oligonucleotides were used to determine not only the amount of circulating DNA in the patient, but also the amount of viral DNA. Papillomavirus detection/genotyping was performed by qPCR. One third of the patients showed at least one high-risk genotype. Conclusion: In this study, differential quantification of both patient and viral circulating DNA was observed.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47152769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal Approach in Histiocytic and Dendritic Cell Neoplasms 组织细胞和树突状细胞肿瘤的多模式治疗

Novel approaches in cancer study Pub Date : 2021-06-29 DOI: 10.31031/nacs.2021.06.000628

Wehrmann S

引用次数: 0

Psycho-Education Intervantion Program Among Women with Breast Cancer 癌症妇女的心理教育间隔计划

Novel approaches in cancer study Pub Date : 2021-06-24 DOI: 10.31031/nacs.2021.06.000627

Murad Abdul Raheem Younis

引用次数: 0

Comparison Between VMAT and IMRT in Remaining Volume at Risk for Large Volume Head and Neck Cancer Patients 大容量头颈部癌症患者VMAT和IMRT的剩余风险容量比较

Novel approaches in cancer study Pub Date : 2021-06-18 DOI: 10.31031/nacs.2021.06.000626

D. Ali

{"title":"Comparison Between VMAT and IMRT in Remaining Volume at Risk for Large Volume Head and Neck Cancer Patients","authors":"D. Ali","doi":"10.31031/nacs.2021.06.000626","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000626","url":null,"abstract":"Radiation therapy for advanced head and neck cancer has developed from the Three-Dimensional Conformal Radiotherapy 3DCRT to intensity modulated radiation therapy IMRT and Volumetric Modulated Arc Therapy VMAT. Remaining Volume at Risk RVR is clinically important in plan evaluating process. RVR is useful for assisting and estimating the risk of late effects. Aim: The aim of the present work is to compare dosimetric evaluation factors and dosimetric data remaining volume at risk for both IMRT and VMAT in the treatment of large volume head and neck cancer patients. methods: Eleven retrospective patients with advanced head and neck tumors were selected for the planning study. The patients’ treatments are planned by using the two different techniques (IMRT and VMAT) and optimized to evaluate highly conformal target coverage and sparing organs at risk OAR. Standard fractionation is 33 fractions with 5 fractions weekly, the prescribed doses 70Gy, 59.4Gy and 54Gy for the high, intermediate, and low risk targets by simultaneous integrated boost. Results: The study showed that VMAT and IMRT are comparable in target volumes homogeneity index HI, while VMAT is more superior (0.76, 44.4and 589) and (0.68, 55.6 and 1989) in conformity number CN, gradient index GI and Monitor Units (MU), respectively. Furthermore, VMAT has an advantage over IMRT in RVR volumes that received 15Gy, 10Gy and 5Gy, which are (4327, 5281 and 6703cc) and a 1019cGy mean dose in the VMAT technique, while in IMRT are (4435, 5311 and 6543cc) and a 1051cGy mean dose. Conclusion: The results of comparing dosimetric evaluation factors of both techniques showed that VMAT had a priority over IMRT in 3 factors of RVR evaluation parameters. Additionally, to other comparison points, especially the time on the machine, makes VMAT a first choice in the treatment plan selection.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43129091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is an Ancient Genome Repair Mechanism the Trojan Horse of Cancer? 古老的基因组修复机制是癌症的特洛伊木马吗？

Novel approaches in cancer study Pub Date : 2021-06-14 DOI: 10.31031/nacs.2021.05.000625

V. Niculescu

引用次数: 2

Many Roles of Transcriptional Factor Brachyury 转录因子Brachyury的多种作用

Novel approaches in cancer study Pub Date : 2021-05-25 DOI: 10.31031/nacs.2021.05.000624

Jun Shen

引用次数: 0