Novel approaches in cancer study最新文献_第2页

The Calamitous Contagion-Malignant Otitis Externa 灾难性的传染性恶性外耳炎

Novel approaches in cancer study Pub Date : 2022-01-24 DOI: 10.31031/nacs.2022.06.000647

Anu Bajaj

引用次数: 0

Curing Incurable Cancer 治愈不可战胜的癌症

Novel approaches in cancer study Pub Date : 2021-12-20 DOI: 10.31031/nacs.2021.06.000645

D. Dix

引用次数: 0

Implications of Network Biology in the Understanding and Therapy of Cancer 网络生物学在癌症认识和治疗中的意义

Novel approaches in cancer study Pub Date : 2021-12-16 DOI: 10.31031/nacs.2021.06.000644

Ovidiu Farc

引用次数: 0

Mini Review: Hyperthermia Treatment for Bone Cancers 小型综述:骨癌的热疗治疗

Novel approaches in cancer study Pub Date : 2021-12-08 DOI: 10.31031/nacs.2021.06.000643

O. Bretcanu

引用次数: 0

Psycho Neuroendocrino Immune (PNEI) Therapy of Cancer Beyond Melatonin 除褪黑激素外癌症的心理-神经内分泌免疫（PNEI）治疗

Novel approaches in cancer study Pub Date : 2021-11-30 DOI: 10.31031/nacs.2021.06.000641

P. Lissoni

{"title":"Psycho Neuroendocrino Immune (PNEI) Therapy of Cancer Beyond Melatonin","authors":"P. Lissoni","doi":"10.31031/nacs.2021.06.000641","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000641","url":null,"abstract":"Between the two opposite conditions of curative and palliative therapy of cancer, it has been recently demonstrated the possibility of a third way of treatment, consisting of the administration of natural nontoxic anticancer molecules drawn from the vegetal world or human body itself. At present, the main investigated anticancer natural molecule consists of Melatonin (MLT), which is present in both plants and the human body, where it is mainly released from the pineal gland according to a circadian rhythm, with a high production during night and low levels during the day [1]. In fact, it has been known for more than 50 years that the pineal gland MLT plays an anticancer action. Experimental conditions have shown that pinealectomy enhances the frequency of both spontaneous and carcinogen-induced tumor development. MLT exerts an anticancer action through at least three fundamental mechanisms, consisting of direct antiproliferative cytotoxic action, antiangiogenic activity and stimulation of the anticancer immunity [2], which is mainly mediated by IL-2 [3] and IL-12 [4], and suppressed by TGF-beta [5], IL-17 [6] and other inflammatory cytokines [7]. Studies have demonstrated that MLT is not the only anticancer principle of the pineal gland, since MLT alone has appeared to reduce, but not completely abolish the pro-tumoral effect of pinealectomy [8]. In fact, at least another indole hormone, the 5-Metoxytryptamine (5MTT) [9] and several beta-carbolines, such as 6-methoxy-1,2,3,4-tetra-hydro-beta-carboline, the so-called pinealine [10], have appeared to exert important antitumor activities. However, Abstract","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46054884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Palliative Care: The Current Situation in Saudi Arabia 姑息治疗的发展：沙特阿拉伯的现状

Novel approaches in cancer study Pub Date : 2021-11-10 DOI: 10.31031/nacs.2021.06.000640

S. Alshammary

{"title":"Development of Palliative Care: The Current Situation in Saudi Arabia","authors":"S. Alshammary","doi":"10.31031/nacs.2021.06.000640","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000640","url":null,"abstract":"Palliative care is a specialty of its own consisting of comprehensive multidisciplinary healthcare delivery to patients with a wide range of life-threatening and life-shortening diseases, including cancer. Its primary goal is to relieve symptoms of suffering such as physical pain, psychosocial and spiritual problems that affect the quality-of-life for patients as well as their families. Palliative care has a vital role in providing comfort to patient and family during active interventions like chemotherapy and radiation therapies [1]. The palliative care service in Saudi Arabia started over three decades ago at the King Faisal Specialist Hospital and Research Centre (KFSH&RC) in Riyadh by Dr. Isbister [2]. Since then, the specialty has slowly expanded. Real changes came about in 2016 when the Ministry of Health (MOH) launched the Palliative Care/Last Phase Initiative as part of the Transformation of Healthcare Vision 2030 [3]. By 2030, the Cancer care in Saudi Arabia is expected to grow by five to 10-fold. This prediction is defined by the changing demographics, with the age group most affected by cancer being the middle-aged and elderly [1]. The palliative care community in Saudi Arabia saw this as a great opportunity to develop the specialty on a national scale. The process of the development of Palliative Care/ last phase interventions was a long and meticulous one and has been very successful.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48722829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Dendrimer-Based Nanomedicine (Paramagnetic Nanoparticle, Nanocombretastatin, Nanocurcumin) for Glioblastoma Multiforme Imaging and Therapy 树突基纳米药物(顺磁性纳米粒子、纳米合成素、纳米姜黄素)用于多形性胶质母细胞瘤的成像和治疗

Novel approaches in cancer study Pub Date : 2021-10-20 DOI: 10.31031/nacs.2021.06.000639

Stephen Brown, J. Snyder, Meser M. Ali

引用次数: 3

Prognostic Value of PRISMA-7 Score for Frail Elderly Patients with Advanced Pancreatic Adenocarcinoma PRISMA-7评分对老年体弱晚期胰腺癌患者的预后价值

Novel approaches in cancer study Pub Date : 2021-10-11 DOI: 10.31031/nacs.2021.06.000638

Salah Mabrouk Khallaf

引用次数: 0

CXC Chemokine Ligand 16 Promotes the Proliferation and Migration of Hodgkin and Reed-Sternberg Cells Via the PI3K/Akt/NF-κB Signaling Pathway CXC趋化因子配体16通过PI3K/Akt/NF-κB信号通路促进霍奇金和Reed-Sternberg细胞增殖和迁移

Novel approaches in cancer study Pub Date : 2021-09-08 DOI: 10.31031/nacs.2021.06.000635

Yang Xun, Hongping Tang, Y. Pan, D. Shen, Hua Yang, Yijun Liang, Rui-xue Wang, Lixia Fan, Hui Liu, Yilong Ai, Dahai Liu, Fang Liu

{"title":"CXC Chemokine Ligand 16 Promotes the Proliferation and Migration of Hodgkin and Reed-Sternberg Cells Via the PI3K/Akt/NF-κB Signaling Pathway","authors":"Yang Xun, Hongping Tang, Y. Pan, D. Shen, Hua Yang, Yijun Liang, Rui-xue Wang, Lixia Fan, Hui Liu, Yilong Ai, Dahai Liu, Fang Liu","doi":"10.31031/nacs.2021.06.000635","DOIUrl":"https://doi.org/10.31031/nacs.2021.06.000635","url":null,"abstract":"Hodgkin’s Lymphoma (HL) is a main type of lymphoma characterized by Hodgkin’s Reed-Sternberg(H/RS) cells, which involves in many cytokines and chemokines. CXC Chemokine Ligand 16 (CXCL16) was reported to be expressed in various cancer types and was previously observed by our group to highly express in H/RS cells, yet the function and mechanism of CXCL16, as well as soluble CXCL16 (sCXCL16) on the phenotypes of HRS cells needs to be fully elucidated. To investigate the effects of CXCL16 on cell proliferation, migration, cell cycle, apoptosis, and immune-phenotypes of H/RS cells, an H/RS cell line (L428) transfected with CXCL16-overexpressed lentivirus vector was established and identified; besides, recombinant sCXCL16 was also applied on L428 cell lines in the present study. Results showed that both endogenously overexpressed CXCL16 and exogenously applied recombinant sCXCL16 protein were able to promote the proliferation and migration of L428 cells, and diminished cell apoptosis, while the immune phenotypes of L428 cells showed no significant changes. Blocking the interaction between the ligand CXCL16 and its unique receptor CXCR6 with antibody suppressed the above effects. As the pathways involved were concerned, results showed that CXCL16 upregulated the expression of several phosphorylated proteins of the PI3K/Akt and NF-κB signaling pathways, which were markedly inhibited by PI3K inhibitor LY294002 or CXCR6 antibody. The present study suggests that CXCL16 promotes the proliferation and migration of H/RS cell through its receptor CXCR6. The mechanism may involve activation of the PI3K/Akt/NF-κB signaling pathways.","PeriodicalId":93131,"journal":{"name":"Novel approaches in cancer study","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46477937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic Medicine: Using Genetic Make-up of the Human Genome, AZQ was Designed to Treat Glioblastoma, the Brain Tumor 基因组医学:利用人类基因组的基因组成，AZQ被设计用于治疗胶质母细胞瘤，即脑肿瘤

Novel approaches in cancer study Pub Date : 2021-08-18 DOI: 10.31031/nacs.2021.06.000634

Hameed Khan

引用次数: 1