Multimodal Approach in Histiocytic and Dendritic Cell Neoplasms

Histiocytic and dendritic cell neoplasms are rare but extremely aggressive tumors that represent less than 1% of all neoplasms arising in lymph nodes or soft tissues. Often the tumor is detected lately, and diagnosis is challenging both for pathologists and for clinicians. Based on the multiplicity of resembling tumors a final diagnosis is often difficult to find. Furthermore, structured therapy algorithms do not exist. Here we show our experience in diagnostics and treatment of these tumors.