Journal of clinical research and reports最新文献

{"title":"Conception and Clinical Efficacy of an Osmotic, Polymeric, Stable Nasal Filmogen Barrier for Preventive Treatment of Allergen and Pollution Induced Rhinitis and Respiratory Symptoms","authors":"R. Shrivastava, R. Shrivastava, Nathalie Maneby, G. Giroir, Marjorie Georges, A. Bhatt","doi":"10.31579/2690-1919/219","DOIUrl":"https://doi.org/10.31579/2690-1919/219","url":null,"abstract":"Background: Pollution induced allergic rhinitis and respiratory symptoms is becoming a major health problem in the world for which still there is no safe and preventive treatment. Objectives: Conceive and evaluate the allergen preventive properties and clinical efficacy of an osmotic, polymeric, stable filmogen spray, called PCNS. Materials and Methods: Amb A 1 (ragweed), Der P 1 and 2 (dust mite), Bet v 1 (birch), Alt a 1 (Alternaria, fungus), and Fel d 1 (cat dander) allergens were exposed at a concentration of 5µg/ml (20 µl per tube) on the polymeric test product film (120 and 240µl layer) and the allergens crossing the barrier were quantified in the agar gel beneath the film. 0.40% HPMC and PBS solutions, tested identically, served as controls. Clinical efficacy of PCNS nasal spray was evaluated in patients suffering from allergic rhinitis and/or respiratory symptoms (29 in test product v/s 15 in saline controls) for 22 days. Nasal, ocular, respiratory symptoms and Rhino conjunctivitis Quality of Life Questionnaire (RQLQ) were measured. Statistical analyses: The normality of the populations was determined by the Shapiro-Wilk test, then statistical analysis was performed by two-tailed Student’s test for comparisons between two groups and the two-way ANOVA followed by the post hoc Bonferroni’s test for comparisons of multiple groups. p<0.05 was considered statistically significant. The analyses were performed with the software GraphPad Prism (version 8.4.2, La Jolla, USA). NS indicates not significant. Results: PCNS polymeric spray blocked the diffusion of all the allergens while 0.40% HPMC was able to prevent diffusion of only Alt a 1 and Fel d 1 allergens. Mean reflective total nasal symptom scores (rTNSS), reflective total ocular symptom score (rTOSS), and respiratory symptoms including effect on wheezing, cough, dyspnea, and chest tightness were moderately improved in the control saline group, but the improvements were nearly twice better in the PCNS group. RQLQ was improved by 23% in saline spray v/s 46% PCNS group. 4/15 patients in saline group v/s 1/29 in PCNS group required rescue medication during the study. PCNS was highly effective in reducing allergen and pollution induced respiratory symptoms. Conclusion: a polymeric, osmotic, and stable nasal barrier against pollutants and allergens represents an innovative approach against pollution induced respiratory symptoms.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46280927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overvıew of Lower Gastroıntestınal Bleedıng ın Infants and Toddlers: A Revıew Artıcle","authors":"Volkan Sarper Erikci","doi":"10.31579/2690-1919/212","DOIUrl":"https://doi.org/10.31579/2690-1919/212","url":null,"abstract":"Lower gastrointestinal bleeding (LGIB) in infants and toddlers is commonly encountered in clinical practice. There are several factors producing LGIB in these children and are usually managed with regard to the underlying pathology that produces LGIB. Although majority of these bleeding episodes is self limited, certain infants and toddlers with LGIB may necessitate prompt management including urgent surgical intervention. In this review article it is aimed to review the etiology, epidemiology, clinical manifestations and principles of treatment of LGIB in infants and toddlers under the light of relevant literature.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45353407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effective Management and Outcome of Hand Burns","authors":"Subin Joseph","doi":"10.31579/2690-1919/213","DOIUrl":"https://doi.org/10.31579/2690-1919/213","url":null,"abstract":"Burns is a common public health problem and these injuries can be accidental, suicidal or even homicidal in nature. Hands being the most active part of the body, are often involved in burns. Hand burns represent three percent of body surface area, and are involved in more than 80% of all severe burns. Hand burns predominantly affect young adults and therefore have serious social and financial implications. The hand is one of the most frequent sites of burns scar contracture deformity. The deformities and contractures result in lifelong physical problems and affects the normal functioning of the person.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46592186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Simulation, Implementation and Measurement of Respiration Rate by Strain Gauge Sensor and Induction Method","authors":"H. Shirzadfar, Sadaf Anbarzadeh, Samaneh Dohani","doi":"10.31579/2690-1919/215","DOIUrl":"https://doi.org/10.31579/2690-1919/215","url":null,"abstract":"The human body has vital parameters such as respiration, heart rate, and body temperature. Respiratory rate (RR) is a parameter that expresses the rate of respiration per minute. Respiratory activities play an essential role in human life. The rate of respiration has a particular range, which is 14-18 cycles per minute for a healthy and normal person at rest. The oxygen in the blood enters the body during respiration and is expelled as carbon dioxide in return. Any problems with breathing may pose a serious health risk. An abnormal breathing pattern indicates serious illnesses such as cardiac arrest and hospitalization in the intensive care unit (ICU) and when it falls below a certain limit, it indicates a loss of consciousness. This is why it is so imperative to develop devices and methods measuring respiration rates.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45365703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid Profile an Important Risk Factor in Patients with Ovarian Tumors: A-Meta-Analysis","authors":"A. Clim, Lonel Nati, Flaviu Ionut Faur, A. Dobrescu","doi":"10.31579/2690-1919/220","DOIUrl":"https://doi.org/10.31579/2690-1919/220","url":null,"abstract":"Introduction In the literature ovarian tumors are know to be one of the deadliest gynecological malignancies [1-4]. In US this type of malignancy represents 2.3 % of all cancer-related death and about 4 % of all new cancer cases among women. There are several studies that have reported the role of lipid profiles and it’s role in ovarian tumorigenesis. Fatty acids are essential for cancer cells progression[4-8]. In our study we investigated the true differance in circulating lipid profiles (total cholesterol TC, triglyceride TG, high-density lipoprotein cholesterol HDL, low density lipoprotein cholesterol LDL) among patients with and without ovarian tumors (OT) using a meta-analytical approach. Methods The meta-analysis was conducted using the MOOSE guidelines. PubMed, EMBASE and Cochrane Library were extensively searched (with a period of publication restriction between 2007 and 2019) to indentify published studies using the following keywords: “ total cholesterol ”, “high-density lipoprotein”, “ triglycerides ”, “ low-density lipoprotein ”, “ ovarian cancer”, “ ovarian tumor ”, “ lipid profile ”. The search methodology is shown in Fig. 1 and all references of retrieved articles were searched manually. Results Seven studies, involving 1542 OT cases and 2195 non-cases of OT were included in this meta-analysis and I² statistics ranged between 97 and 99%. Mean circulating TC and HDL were significantly lower among OT cases compared to non-OT cases (P<0.04 and P<0.005). Conclusion There is a modest significant association between circulating HDL and risk of ovarian tumor but it is crucial to elucidate the implications of HDL in tumor manifestations and growth.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45450647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stasis Ulcers – The Unifying Concept","authors":"Jochanan E. Naschitz","doi":"10.31579/2690-1919/211","DOIUrl":"https://doi.org/10.31579/2690-1919/211","url":null,"abstract":"Chronic stasis dermatitis, usually confined to the lower legs, is a complication of longstanding interstitial edema and inflammation, due either to venous hypertension or disorders having in common excessive lymph overload. Heart failure, renal failure, liver cirrhosis, secondary and primary diseases of lymph vessels may complicate with stasis dermatitis. The same mechanisms causing stasis dermatitis can also generate skin ulcers superimposed on stasis dermatitis. In the appropriate context such skin ulcers are called \"venous ulcers\" or, in different situations, “stasis ulcers”. The distinction between venous and other stasis ulcers is usually possible at the bedside. Also, some general measures of therapy are similar for venous and other stasis ulcers: such are elastic compression, topical skin care and ulcer care. In having in common the pathophysiological mechanisms, in bearing clinical resemblance, and responding to similar therapies, a unifying concept may be opportune to comprise the spectrum of stasis dermatitis, venous and other stasis ulcers. The present work is an appeal to this aim.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43116125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etıology and Management of Lower Gastroıntestınal Bleedıng ın Neonates: A Revıew Artıcle","authors":"V. Erikçi","doi":"10.31579/2690-1919/210","DOIUrl":"https://doi.org/10.31579/2690-1919/210","url":null,"abstract":"Lower gastrointestinal bleeding (LGIB) in neonates is occasionally encountered in clinical practice. There are various causative factors prodicing LGIB in neonates and the babies are usually managed with regard to the underlying pathology that produces LGIB. Although majority of these bleeding episodes is self limited, certain neonates with LGIB may necessitate prompt management including urgent surgical intervention. In this review article it is aimed to review the etiology, epidemiology, clinical manifestations and principles of treatment of LGIB in neonates under the light of relevant literature.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47395382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Predictive Factors of Induced Abortion among Women in Ghana: Data Analysis of Maternal Health Survey, 2017.","authors":"A. Alhassan, J. Anyinzaam-Adolipore","doi":"10.31579/2690-1919/204","DOIUrl":"https://doi.org/10.31579/2690-1919/204","url":null,"abstract":"Induced abortion is a common practice for women worldwide; nevertheless, the practice of unsafe abortion rate in Ghana is in height and is a constant issue of public health concern. Objective: The main aim of the study was to identify predictive factors associated with induced abortion among women in Ghana. Methods: Ghana Maternal Health Survey data was used for this study to do an analytic cross-section study. Data analysis was done using SPSS version 20. The association between dependent and independent variables was explored using chi-square and logistic regression. Statistical significance was set at p < 0.05. Results: In this study, the prevalence of induced among the respondents was 14.8%, the prevalence was higher (25.5%) in Greater Accra Region and lower (3.2%) in Northern Region. All under-studied independent variables through chi-square analysis were associated with induced abortion with significance. However, in advance analysis through binary logistics regression model predictor factors of induced abortion in Ghana identified were; the age of the respondents’, region of orientation, religious affiliation, marital status, ethnicity, exposure to mobile phone and newspaper, and age at first sex. The logistic regression model appropriately explained the outcome variable (induced abortion) since the Hosmer-Lemeshow goodness-of-fit test p-value was more than 0.05 (X2 (8) = 4.428, P = .817). Conclusion: The prevalence of abortion in Ghana is still high, hence the need for increase public education on contraceptive use and the adverse effects of abortion through the use of modern media can go a long way to reduce the incidence of induced abortion in Ghana.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42325976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanostructures of Phospholipids on Articular Cartilage Surface and their Functions","authors":"Pawlak Pawlak, M. Sójka","doi":"10.31579/2690-1919/205","DOIUrl":"https://doi.org/10.31579/2690-1919/205","url":null,"abstract":"Phospholipids bilayers fulfill an important role in natural joint lamellar-repulsive lubrication mechanism. Low friction between surfaces coated with negatively charged the phospholipid headgroup (–PO4-) as being due to a hydration layer. Wettability of the cartilage surface depends on the number of PLs that act as a lubricant. The cartilage can be classified as a group of intelligent material, which in the wet state has a contact angle of ~0º, and the air-dry state has a contact angle of ~104º.","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":"49 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41314655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Sclerosis, Chlamydia and Gut Disbiosis","authors":"J. Medina","doi":"10.31579/2690-1919/208","DOIUrl":"https://doi.org/10.31579/2690-1919/208","url":null,"abstract":"I believe that multiple sclerosis progression could be stopped through antibiotics, dewormers, beta glucans and garlic extract and, by far the most difficult, changing the quality of the water ingested, or used for washing salads, in addition to increasing the consumption of probiotics. I believe that MS sclerosis is due to the unfortunate encounter of 3 diseases: intestinal dysbiosis, chlamydia infections and orthopedic problems. However, how would these three diseases cause demyelination of nerve fibers?","PeriodicalId":93114,"journal":{"name":"Journal of clinical research and reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46660430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}