Bioscientifica proceedings最新文献_第8页

Novel concepts about normal sexual differentiation of reproductive neuroendocrine function and the developmental origins of female reproductive dysfunction: the sheep model 关于生殖神经内分泌功能正常性分化和女性生殖功能障碍发育起源的新概念：绵羊模型

Bioscientifica proceedings Pub Date : 2019-04-05 DOI: 10.1530/BIOSCIPROCS.6.006

D. Foster, L. Jackson, V. Padmanabhan

引用次数: 0

Steroidogenesis and the initiation of parturition 甾体形成和分娩的开始

Bioscientifica proceedings Pub Date : 2019-04-05 DOI: 10.1530/BIOSCIPROCS.8.028

A. Conley, L. Reynolds

{"title":"Steroidogenesis and the initiation of parturition","authors":"A. Conley, L. Reynolds","doi":"10.1530/BIOSCIPROCS.8.028","DOIUrl":"https://doi.org/10.1530/BIOSCIPROCS.8.028","url":null,"abstract":"One of the most fundamental axioms of mammalian reproduction is that pregnancy requires the support of progesterone without which it cannot be established or maintained. Though this basic physiological tenet was accepted long ago, major gaps in our understanding of the physiology of both pregnancy and parturition remain which hamper our ability to solve clinically and agriculturally significant problems such as low fertility, fetal growth restriction, preterm birth and poor neonatal outcomes. The historical reliance of our understanding of both pregnancy and parturition on this single hormone, and how it has been measured in the vast majority of studies, may represent a tangible weakness and impediment to progress. Other weaknesses include a desire to fit all species into a unified paradigm, and a reluctance to accept that physiological processes regulated by progesterone or other progestins in different tissues might vary in reliance on classic (nuclear receptor) versus other, non-classical mechanisms of action. The relative importance of these distinct response pathways in certain cells or tissues also may differ across species, as does so much of basic reproductive physiology. It is well known that certain species are reliant on luteal function throughout gestation, whereas the placenta subsumes endocrine support in others (Geisert & Conley 1998), yet progesterone alone is still believed to be the single common element. As radical as it might seem, however, progesterone may not be the single common hormone of pregnancy in mammals.","PeriodicalId":93083,"journal":{"name":"Bioscientifica proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41582090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Control of ovarian follicular development to the gonadotrophin-dependent phase: a 2006 perspective 控制卵泡发育到促性腺激素依赖阶段:2006年的观点

Bioscientifica proceedings Pub Date : 2019-04-05 DOI: 10.1530/BIOSCIPROCS.6.004

K. McNatty, P. Smith, D. Heath, Il Juengel

引用次数: 2

Inhibin and secretion of FSH in oestrous cycles of cows and pigs 奶牛和猪发情周期中卵泡刺激素的抑制素和分泌

Bioscientifica proceedings Pub Date : 2019-04-05 DOI: 10.1530/BIOSCIPROCS.2.012

K. Taya, H. Kaneko, Gen Watanabe, S. Sasamoto

引用次数: 27

Cryopreservation of female germplasm in pigs 猪母系种质的低温保存

Bioscientifica proceedings Pub Date : 2019-04-05 DOI: 10.1530/biosciprocs.19.0004

S. Tamas, K. Kikuchi, H. Kaneko, J. Noguchi, K. Yoshioka, T. Nagai

引用次数: 3

Pigs as model systems for biomedical research 猪作为生物医学研究的模型系统

Bioscientifica proceedings Pub Date : 2019-04-05 DOI: 10.1530/biosciprocs.19.0029

H. Niemann

{"title":"Pigs as model systems for biomedical research","authors":"H. Niemann","doi":"10.1530/biosciprocs.19.0029","DOIUrl":"https://doi.org/10.1530/biosciprocs.19.0029","url":null,"abstract":"Pigs have a long standing and very successful history as biomedical model for studying human diseases and developing novel therapies mainly attributed to the many genetic, anatomical and physiological similarities with humans. Non-transgenic pig models have long been used for a wide range of human organ systems and diseases, and even complex metabolic disorders and have served as model for developing novel surgical techniques and endoscopic approaches, such as NOTES (natural orifice transluminal endoscopic surgery). The availability of the porcine genome and novel tools to add or delete specific genes significantly expands the potential for transgenic pig production. Somatic cell nuclear transfer has emerged as the preferred method for transgenesis. Well characterized transgenic pig models have been reported for Cystic fibrosis, the eye disease Retinitis Pigmentosa, atherosclerosis and diabetes. Transgenic pigs have been produced for modeling neurological diseases, including Alzheimer and Huntington disease, specific forms of cancer, and skin diseases. Transgenic pigs play an important role in developing functional porcine xenografts to combat the growing shortage of appropriate human organs for transplantation. Other important transgenic pig models include immunodeficient pigs and Oct4/GFP transgenic pigs for studies of reprogramming. Pig models will not replace the already existing mouse models but can provide significant novel insight into a variety of diseases, as mouse models frequently do not mimic the human situation. Transgenic pigs will also soon play an increasing role in the development of novel therapies based on stem cell technology. The biomedical use of pigs will also facilitate transgenic pig production for agricultural production.","PeriodicalId":93083,"journal":{"name":"Bioscientifica proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48164358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of selected nutrients in development of the porcine conceptus during pregnancy 所选营养素在猪妊娠期妊娠发育中的作用

Bioscientifica proceedings Pub Date : 2019-04-05 DOI: 10.1530/biosciprocs.19.0016

W. B. Fuller, K. Jinyoung, Song Gwonhwa, Ka Hakhyun, W. Guoyao, G. A. Johnson, J. Vallet

引用次数: 3

Assisted reproduction in Mediterranean wild ruminants: lessons from the Spanish ibex (Capra pyrenaica) 地中海野生反刍动物的辅助繁殖:来自西班牙野山羊(Capra pyrenaica)的经验

Bioscientifica proceedings Pub Date : 2019-04-05 DOI: 10.1530/BIOSCIPROCS.7.031

J. Santiago-Moreno, M. A. Coloma, A. Toledano-Díaz, C. Castaño, A. Gómez-Brunet, A. López-Sebastián

引用次数: 0

Use of the Immunocrit to monitor a split-suckle program in commercial production 在商业化生产中使用免疫批判技术来监测裂吸程序

Bioscientifica proceedings Pub Date : 2019-04-05 DOI: 10.1530/biosciprocs.19.0024

JL Vallet

引用次数: 1

Corpus luteum regression or maintenance: a duel between prostaglandins and interferon tau 黄体退化或维持：前列腺素和干扰素τ之间的决斗

Bioscientifica proceedings Pub Date : 2019-04-05 DOI: 10.1530/BIOSCIPROCS.8.024

R. Meidan

{"title":"Corpus luteum regression or maintenance: a duel between prostaglandins and interferon tau","authors":"R. Meidan","doi":"10.1530/BIOSCIPROCS.8.024","DOIUrl":"https://doi.org/10.1530/BIOSCIPROCS.8.024","url":null,"abstract":"The corpus luteum (CL), via progesterone production, plays a central role in the regulation of cyclicity and in the establishment and maintenance of pregnancy in ruminant species. In the absence of an embryonic signal, the CL will regress functionally and then structurally. Pulses of prostaglandin F2α (PGF2α) from the uterus reach the ovary via the vascular utero-ovarian plexus causing the demise of the CL. Although it is well established that PGF2α is the principal luteolytic hormone in ruminants, many aspects of its function are still being debated. The successful establishment of pregnancy requires inhibition of uterine PGF2α actions, prolongation, or maintenance of luteal function and the continuous secretion of progesterone. The conceptus signals its presence by releasing interferon tau (IFNT). IFNT acting directly on the endometrium by various mechanisms and possibly also on the CL activates antiluteolytic responses that protect the function of the CL. PGE2, synthesized by the endometrium and the CL, could also induce processes that are important for maintenance of luteal function in pregnancy. The mechanisms controlling luteal regression or its maintenance by the coordinated actions of PGF2α, IFNT, and PGE2 are discussed.","PeriodicalId":93083,"journal":{"name":"Bioscientifica proceedings","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49386463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0