British journal of rheumatology最新文献_第10页

Shape of wear particles found in human knee joints and their relationship to osteoarthritis. 在人类膝关节中发现的磨损颗粒形状及其与骨关节炎的关系。

British journal of rheumatology Pub Date : 1998-09-01 DOI: 10.1093/rheumatology/37.9.978

M S Kuster, P Podsiadlo, G W Stachowiak

{"title":"Shape of wear particles found in human knee joints and their relationship to osteoarthritis.","authors":"M S Kuster, P Podsiadlo, G W Stachowiak","doi":"10.1093/rheumatology/37.9.978","DOIUrl":"https://doi.org/10.1093/rheumatology/37.9.978","url":null,"abstract":"Objective: To analyse and compare the shape of wear particles found in healthy and osteoarthritic human knee joints for monitoring the progress of osteoarthritis, the long-term prognosis and to evaluate therapeutic regimens.Method: Joint particles from seven patients with normal cartilage in all compartments of the knee joint, 12 patients with fibrillation of less than half the cartilage thickness (grade 1), seven patients with fibrillation of more than half the cartilage thickness (grade 2) and four patients with erosions down to bone (grade 3) were analysed. A total of 565 particles were extracted from synovial fluid samples by ferrography and analysed in a scanning electron microscope. A number of numerical descriptors, i.e. boundary fractal dimension, shape factor, convexity and elongation, were calculated for each particle image and correlated to the degree of osteoarthritis using non-parametric tests.Results: Experiments demonstrated that there were significant differences between the numerical descriptors calculated for wear particles from healthy and osteoarthritic knee joints (P < 0.01), suggesting that the particle shape can be used as an indicator of the joint condition. In particular, the fractal dimension of the particle boundary was shown to correlate directly with the degree of osteoarthritis.Conclusion: Numerical analysis of the shape of wear particles found in human knee joints may provide a reliable means for the assessment of cartilage repair after surgical or conservative treatment of osteoarthritis.","PeriodicalId":9307,"journal":{"name":"British journal of rheumatology","volume":"37 9","pages":"978-84"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/rheumatology/37.9.978","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20695884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Re: Prolactin and systemic lupus erythematosus. 回复:催乳素与系统性红斑狼疮。

British journal of rheumatology Pub Date : 1998-09-01 DOI: 10.1093/rheumatology/37.9.1029

A Leaños-Miranda, D Pascoe-Lira, F Blanco-Favela

引用次数: 9

Prospective study of serum and urinary nitrate levels in patients with systemic lupus erythematosus. 系统性红斑狼疮患者血清和尿硝酸盐水平的前瞻性研究。

British journal of rheumatology Pub Date : 1998-09-01 DOI: 10.1093/rheumatology/37.9.972

M R Gonzalez-Crespo, J A Navarro, J Arenas, E Martin-Mola, J De La Cruz, J J Gomez-Reino

{"title":"Prospective study of serum and urinary nitrate levels in patients with systemic lupus erythematosus.","authors":"M R Gonzalez-Crespo, J A Navarro, J Arenas, E Martin-Mola, J De La Cruz, J J Gomez-Reino","doi":"10.1093/rheumatology/37.9.972","DOIUrl":"https://doi.org/10.1093/rheumatology/37.9.972","url":null,"abstract":"Objective: To study prospectively whether serum and urinary nitrate levels are related to lupus activity.Methods: Fifty patients with systemic lupus erythematosus (SLE) were studied prospectively for 2 yr. Every 4 months, the SLE Disease Activity Index (SLEDAI) was administered to the patients, and blood and 24 h urine samples were obtained; 88 healthy controls were also studied. Nitrate levels were measured by the Greiss method. Statistical analyses were performed using standard parametric and non-parametric tests, and analysis of serial measurements.Results: Twelve patients suffered infections, 12 active nephritis and 17 episodes of non-renal activity. By analysis of serial measurements, serum and urinary nitrate levels did not correlate with SLEDAI. C-Reactive protein (CRP) levels, presence of infection and creatinine clearance weakly influenced nitrate levels.Conclusions: In SLE, serum and urinary nitrate levels do not parallel lupus activity. Other variables, related or not to SLE, seem to affect these levels.","PeriodicalId":9307,"journal":{"name":"British journal of rheumatology","volume":"37 9","pages":"972-7"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/rheumatology/37.9.972","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20695883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Quantitative measurement of joint space narrowing progression in hip osteoarthritis: a longitudinal retrospective study of patients treated by total hip arthroplasty. 髋关节骨关节炎关节间隙狭窄进展的定量测量:全髋关节置换术患者的纵向回顾性研究。

British journal of rheumatology Pub Date : 1998-09-01 DOI: 10.1093/rheumatology/37.9.961

T Conrozier, C A Jousseaume, P Mathieu, A M Tron, J Caton, J Bejui, E Vignon

{"title":"Quantitative measurement of joint space narrowing progression in hip osteoarthritis: a longitudinal retrospective study of patients treated by total hip arthroplasty.","authors":"T Conrozier, C A Jousseaume, P Mathieu, A M Tron, J Caton, J Bejui, E Vignon","doi":"10.1093/rheumatology/37.9.961","DOIUrl":"https://doi.org/10.1093/rheumatology/37.9.961","url":null,"abstract":"Objectives: To evaluate the rate of progression of radiological joint space narrowing (JSN) in patients operated on for hip osteoarthritis (OA) and to determine its predictive factors.Methods: Study design: retrospective longitudinal trial of 61 patients who underwent total hip arthroplasty (THA) for hip OA (69 operated hips). Mean follow-up 81.2 +/- 9.9 months. Collected data: (1) standing frontal radiographs of the pelvis from diagnosis to surgery (246 films) for morphological evaluation and quantitative measurement of joint space width (JSW) (computerized reading of digitized X-rays); (2) demographic data (sex, age, body mass index, smoking status, professional and sporting activities, family history of OA); (3) clinical data (age at onset-diagnosis and THA, drug consumption, time from diagnosis to permanent disability, OA at other joints, previous THA of the contralateral hip).Statistics: multivariate analysis.Results: The yearly mean narrowing (YMN) of MeanJSW was 0.43 +/- 0.43 mm/yr (median 0.29, range 0.03-2.55). YMN correlated inversely with joint space width at operation and follow-up duration, and was increased in atrophic OA (r = 0.71). The time between diagnosis and THA correlated with JSW at diagnosis, and was inversely correlated with age at onset and YMN. It was longer in patients with hypertrophic OA (r = 0.69).Conclusion: Rapid progression of JSN, older age and absence of osteophytes appear to be the main factors leading to THA.","PeriodicalId":9307,"journal":{"name":"British journal of rheumatology","volume":"37 9","pages":"961-8"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/rheumatology/37.9.961","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20697119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 67

Microscopic measurement of cellular infiltration in the rheumatoid arthritis synovial membrane: a comparison of semiquantitative and quantitative analysis. 类风湿性关节炎滑膜细胞浸润的显微测量:半定量和定量分析的比较。

British journal of rheumatology Pub Date : 1998-09-01 DOI: 10.1093/rheumatology/37.9.1003

P P Youssef, T J Smeets, B Bresnihan, G Cunnane, O Fitzgerald, F Breedveld, P P Tak

{"title":"Microscopic measurement of cellular infiltration in the rheumatoid arthritis synovial membrane: a comparison of semiquantitative and quantitative analysis.","authors":"P P Youssef, T J Smeets, B Bresnihan, G Cunnane, O Fitzgerald, F Breedveld, P P Tak","doi":"10.1093/rheumatology/37.9.1003","DOIUrl":"https://doi.org/10.1093/rheumatology/37.9.1003","url":null,"abstract":"Microscopic measurement of inflammation in synovial tissue may be important in studies of clinical status, prognosis and response to treatment. The aim of this study was to compare quantitative microscopic analysis of inflammation with a semiquantitative grading system in rheumatoid arthritis (RA) synovial membrane. Knee synovial membrane samples from 16 patients with RA, including paired samples taken before and after treatment in nine patients, were immunostained with anti-CD68 and anti-CD3 monoclonal antibodies using standard techniques. The intensity of macrophage and T-lymphocyte infiltration was measured both by quantitative and semiquantitative techniques, and the results were compared. In a cross-sectional comparison, both methods correlated significantly for lining layer macrophage infiltration, as well as sublining layer macrophage and T-cell infiltration. However, in some patients demonstrating a clinical response to treatment, semiquantitative analysis lacked sensitivity to biologically relevant changes in mononuclear cell infiltration. These observations have important implications for future studies of therapeutic modalities.","PeriodicalId":9307,"journal":{"name":"British journal of rheumatology","volume":"37 9","pages":"1003-7"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/rheumatology/37.9.1003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20695888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 80

Air oesophagogram: a frequent, but not a specific sign of oesophageal involvement in connective tissue diseases. 空气食道造影:结缔组织疾病中食道累及的常见但非特异性征象。

British journal of rheumatology Pub Date : 1998-09-01 DOI: 10.1093/rheumatology/37.9.1011

G Lock, M Strotzer, R H Straub, J Schölmerich, S Feuerbach, A Holstege, B Lang

{"title":"Air oesophagogram: a frequent, but not a specific sign of oesophageal involvement in connective tissue diseases.","authors":"G Lock, M Strotzer, R H Straub, J Schölmerich, S Feuerbach, A Holstege, B Lang","doi":"10.1093/rheumatology/37.9.1011","DOIUrl":"https://doi.org/10.1093/rheumatology/37.9.1011","url":null,"abstract":"Objective: This study investigates the role of the air oesophagogram in conventional chest X-rays for the diagnosis of oesophageal dysmotility in patients with connective tissue diseases.Methods: Fifty-one patients with connective tissue diseases were studied by oesophageal manometry and lateral and posterior-anterior chest X-rays. The presence or absence of oesophageal air on chest X-rays were evaluated separately in the upper, middle and distal segment of the oesophagus. Forty-seven chest X-rays of patients without connective tissue diseases, who had undergone manometry for the evaluation of oesophagus-related symptoms and who had normal oesophageal function, were analysed as a control.Results: A total of 23/51 patients with connective tissue diseases showed oesophageal dysfunction in manometry; 16/51 patients (31%) had air in two or more oesophageal segments on the lateral chest X-ray. There was a significant association of manometrically proven oesophageal dysmotility and air in two or three oesophageal segments (P < 0.05; sensitivity 48%, specificity 82%). However, the prevalence of an air oesophagogram showed no significant difference between patients with connective tissue diseases and the control group (10/47; 21%).Conclusion: The radiological sign of an air oesophagogram is neither sensitive nor specific enough to omit oesophageal motility studies in patients with connective tissue diseases.","PeriodicalId":9307,"journal":{"name":"British journal of rheumatology","volume":"37 9","pages":"1011-4"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/rheumatology/37.9.1011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20695890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement in gastrointestinal tolerability of the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: results of the Safety and Efficacy Large-scale Evaluation of COX-inhibiting Therapies (SELECT) trial in osteoarthritis. 选择性环氧化酶(COX)-2抑制剂美洛昔康与吡罗西康相比改善胃肠道耐受性:骨关节炎COX抑制疗法(SELECT)安全性和有效性大规模评估试验的结果。

British journal of rheumatology Pub Date : 1998-09-01 DOI: 10.1093/rheumatology/37.9.946

J Dequeker, C Hawkey, A Kahan, K Steinbrück, C Alegre, E Baumelou, B Bégaud, H Isomäki, G Littlejohn, J Mau, S Papazoglou

{"title":"Improvement in gastrointestinal tolerability of the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: results of the Safety and Efficacy Large-scale Evaluation of COX-inhibiting Therapies (SELECT) trial in osteoarthritis.","authors":"J Dequeker, C Hawkey, A Kahan, K Steinbrück, C Alegre, E Baumelou, B Bégaud, H Isomäki, G Littlejohn, J Mau, S Papazoglou","doi":"10.1093/rheumatology/37.9.946","DOIUrl":"https://doi.org/10.1093/rheumatology/37.9.946","url":null,"abstract":"SELECT is a large-scale, prospective, international, multicentre, double-blind, double-dummy, randomized, parallel-group trial. Patients with exacerbation of osteoarthritis were treated with the recommended dose of meloxicam (7.5 mg) or piroxicam (20 mg) once daily for 28 days; 4320 patients were administered meloxicam and 4336 piroxicam. The incidence of adverse events was significantly lower in the meloxicam group (22.5%) compared with the piroxicam group (27.9%; P < 0.001), mainly due to the significantly lower incidence of gastrointestinal (GI) adverse events in the meloxicam than in the piroxicam group (10.3% vs 15.4%,; P < 0.001), while the efficacy of both drugs was equivalent. Individual GI events occurred significantly less often with meloxicam than piroxicam: dyspepsia (3.4% vs 5.8%; P < 0.001), nausea/vomiting (2.5% vs 3.4%; P < 0.05) and abdominal pain (2.1% vs 3.6%; P < 0.001). There were 16 patients with perforations, ulcerations or bleeding (PUBs) of the upper GI tract in the piroxicam group compared with seven in the meloxicam group (relative risk piroxicam:meloxicam = 1.4). Four PUBs were complicated (perforations or bleedings); none of these occurred in the meloxicam group (relative risk piroxicam:meloxicam = 1.9). The outcome of SELECT is consistent with that of the large-scale clinical trial of similar design and size which compared 7.5 mg meloxicam with 100 mg diclofenac in patients with osteoarthritis, and with a previous global analysis of the safety of meloxicam. It adds further data to the proposed relationship between selective inhibition of cyclooxygenase-2 and improved GI tolerability of non-steroidal anti-inflammatory drugs.","PeriodicalId":9307,"journal":{"name":"British journal of rheumatology","volume":"37 9","pages":"946-51"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/rheumatology/37.9.946","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20697117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 219

An open study of oxpentifylline in early rheumatoid arthritis. 奥喷替茶碱治疗早期类风湿关节炎的公开研究。

British journal of rheumatology Pub Date : 1998-09-01 DOI: 10.1093/rheumatology/37.9.1033

P D Kiely, D Johnson, B E Bourke

引用次数: 7

A long-term five-year randomized controlled trial of hydroxychloroquine, sodium aurothiomalate, auranofin and penicillamine in the treatment of patients with rheumatoid arthritis. 羟氯喹、金硫硫酸钠、金磺芬和青霉胺治疗类风湿关节炎的长期5年随机对照试验

British journal of rheumatology Pub Date : 1998-09-01 DOI: 10.1093/rheumatology/37.9.992

J D Jessop, M M O'Sullivan, P A Lewis, L A Williams, J P Camilleri, M J Plant, E C Coles

{"title":"A long-term five-year randomized controlled trial of hydroxychloroquine, sodium aurothiomalate, auranofin and penicillamine in the treatment of patients with rheumatoid arthritis.","authors":"J D Jessop, M M O'Sullivan, P A Lewis, L A Williams, J P Camilleri, M J Plant, E C Coles","doi":"10.1093/rheumatology/37.9.992","DOIUrl":"https://doi.org/10.1093/rheumatology/37.9.992","url":null,"abstract":"Objective: To compare the efficacy of hydroxychloroquine, penicillamine, sodium aurothiomalate and auranofin in the treatment of active rheumatoid arthritis over a period of 5 yr.Method: Five hundred and forty-one patients with definite or classical rheumatoid arthritis were entered into an open randomized controlled trial with a flexible dose regimen designed to reflect clinical practice. Decisions to stop treatment with any one of the disease-modifying anti-rheumatic drugs (DMARDs) were based on an agreed trial protocol which defined criteria for adverse reactions and therapeutic failure. The managing physicians' decisions were confirmed in a separate monitor clinic.Results: The proportion of patients who remained on their first DMARD or who were in remission at 5 yr was 53% for penicillamine, 34% for sodium aurothiomalate, 31%, for auranofin and 30% for hydroxychloroquine (P < 0.001). In patients who stayed on their first DMARD, all groups showed a 30-50% improvement in C-reactive protein, erythrocyte sedimentation rate, Ritchie Index and joint stiffness, and a deterioration in their Larsen score. There was no evidence of physician bias to explain the larger proportion of patients remaining on penicillamine for 5 yr.Conclusion: Despite the increased popularity of sulphasalazine and inmmunosuppressives, the drugs in this study continue to be used worldwide. The natural history of rheumatoid arthritis requires long-term follow up to establish drug efficacy. Evidence is needed as to whether the newer regimens will prove to be more effective and safer in the longer term than the commonly prescribed DMARDs. The data from this trial will provide a reference for comparison with future studies.","PeriodicalId":9307,"journal":{"name":"British journal of rheumatology","volume":"37 9","pages":"992-1002"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/rheumatology/37.9.992","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20695887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Spontaneous ambulatory activity as a quantifiable outcome measure for osteoarthritis of the knee. 自发活动作为膝骨关节炎可量化的结果测量。

British journal of rheumatology Pub Date : 1998-09-01 DOI: 10.1093/rheumatology/37.9.969

D J Walker, P S Heslop, L J Kay, C Chandler

{"title":"Spontaneous ambulatory activity as a quantifiable outcome measure for osteoarthritis of the knee.","authors":"D J Walker, P S Heslop, L J Kay, C Chandler","doi":"10.1093/rheumatology/37.9.969","DOIUrl":"https://doi.org/10.1093/rheumatology/37.9.969","url":null,"abstract":"Objective: Quantifiable outcome measures for disabling diseases such as osteoarthritis (OA) of the knee are necessary in order to compare the impact of different interventions competing for financial resources. Current subjective and questionnaire data are not satisfactory for such study. In this study, we examine the potential of the direct measurement of ambulatory activity as such a measure.Population: Patients with X-ray evidence of OA of the knee recruited to studies of anti-inflammatory agents (n = 29). Patients with OA of the knee awaiting knee replacement surgery (n = 28).Methods: Comparison of various standard measures with total energy output data from an activity monitor.Results: Spearman rho correlations of ambulatory energy output (number of steps x average amplitude of steps) correlated with other measures. Correlation with physician's opinion was greater than with patient's opinion (r = 0.4 and 0.2, respectively). There was no correlation with visual analogue pain scale or OA severity index. Correlation with scales of the Nottingham Health Profile questionnaire were not significant either for mobility (r = - 0.15) or for pain (r = - 0.13). There was, however, a significant correlation between poor sleep and increased activity (r = 0.34, P < 0.05). Correlation with Kellgren X-ray grade was significant (r = - 0.45, P = 0.01). Patients recruited to anti-inflammatory studies were 69% more active than those awaiting replacement surgery.Conclusion: The monitoring of ambulatory activity shows some construct and discriminant validity, and is worthy of further study.","PeriodicalId":9307,"journal":{"name":"British journal of rheumatology","volume":"37 9","pages":"969-71"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/rheumatology/37.9.969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20697120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11