Prospective study of serum and urinary nitrate levels in patients with systemic lupus erythematosus.

British journal of rheumatology Pub Date : 1998-09-01 DOI:10.1093/rheumatology/37.9.972

M R Gonzalez-Crespo, J A Navarro, J Arenas, E Martin-Mola, J De La Cruz, J J Gomez-Reino

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引用次数: 19

Abstract

Objective: To study prospectively whether serum and urinary nitrate levels are related to lupus activity.

Methods: Fifty patients with systemic lupus erythematosus (SLE) were studied prospectively for 2 yr. Every 4 months, the SLE Disease Activity Index (SLEDAI) was administered to the patients, and blood and 24 h urine samples were obtained; 88 healthy controls were also studied. Nitrate levels were measured by the Greiss method. Statistical analyses were performed using standard parametric and non-parametric tests, and analysis of serial measurements.

Results: Twelve patients suffered infections, 12 active nephritis and 17 episodes of non-renal activity. By analysis of serial measurements, serum and urinary nitrate levels did not correlate with SLEDAI. C-Reactive protein (CRP) levels, presence of infection and creatinine clearance weakly influenced nitrate levels.

Conclusions: In SLE, serum and urinary nitrate levels do not parallel lupus activity. Other variables, related or not to SLE, seem to affect these levels.

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系统性红斑狼疮患者血清和尿硝酸盐水平的前瞻性研究。

目的:前瞻性研究血清和尿硝酸盐水平是否与狼疮活动有关。方法:对50例系统性红斑狼疮(SLE)患者进行前瞻性研究，为期2年。每4个月对患者进行系统性红斑狼疮疾病活动指数(SLEDAI)测定，采集血液和24 h尿液样本;88名健康对照者也进行了研究。用Greiss法测定硝酸盐水平。统计分析采用标准参数检验和非参数检验，以及序列测量分析。结果:12例患者感染，12例活动性肾炎，17例非肾活动。通过一系列测量分析，血清和尿硝酸盐水平与SLEDAI无关。c反应蛋白(CRP)水平、感染和肌酐清除率对硝酸盐水平影响微弱。结论:在SLE中，血清和尿硝酸盐水平与狼疮活动不平行。与SLE相关或无关的其他变量似乎也会影响这些水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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British journal of rheumatology

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