Bioactive compounds in health and disease最新文献

{"title":"ChoKs as a Promising Therapeutic Target for a Variety of Pathologies","authors":"S. Ibrahim","doi":"10.31989/bchd.v4i11.859","DOIUrl":"https://doi.org/10.31989/bchd.v4i11.859","url":null,"abstract":"Alterations in cell metabolism represent a common cause of human diseases. Changes in lipid profiles are not an exception to this rule, including those lipids that are produced via the choline kinase (ChoK) pathway. ChoK catalyzes the conversion of choline to phosphocholine via the transfer of a phosphate group from ATP to choline.","PeriodicalId":93079,"journal":{"name":"Bioactive compounds in health and disease","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44580299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of amaranth oil on autoantibodies in lupus prone mice","authors":"D. Martirosyan, J. Hutcheson, D. Sajitharan, Samantha Williams, C. Mohan","doi":"10.31989/bchd.v4i10.847","DOIUrl":"https://doi.org/10.31989/bchd.v4i10.847","url":null,"abstract":"Background: Autoimmune diseases, such as systemic lupus erythematosus, can have severe impacts on quality of life. They are one of the leading causes of death for women in the United States. Distinguished by the body damaging its own tissues and organs, they are often classified and diagnosed based on autoantibody levels. Treatments often include immunosuppressant drugs, which can have adverse effects. Aim of Study: Amaranth is a good functional food candidate, possessing antioxidants, bioactive compounds, and a variety of health benefits, such as lowering cholesterol, and aiding diabetes and hypertension. Previous studies have largely focused on the grain or seed, but amaranth oil is less explored. This study examines whether orally administered amaranth oil had any effects on autoantibodies and splenic immune cell populations in murine subjects.Methods: Mice in the experimental group (n = 3) were given 4μl of amaranth oil per gram of mouse weight for 5 days a week over 84 days. Control mice (n = 2) were sham treated on the same schedule with no oil. To determine autoantibody levels, enzyme-linked immunosorbent assays (ELISAs) were first conducted on wells pre-coated with double stranded DNA, single stranded DNA, histones, or double stranded DNA and then histones (nucleosomes). Autoantibody presence was quantified by measuring absorbance at 405nm. Splenic cell populations were examined with flow cytometry and compared using a student’s t-test. Results: Compared to the control group, the mice receiving amaranth oil showed decreased IgG and IgM histone autoantibody absorbance levels throughout the whole study. IgG dsDNA, ssDNA, and nucleosome autoantibody absorbances were lower than that of the control group for the first 42 days. IgM dsDNA, ssDNA, and nucleosome autoantibody absorbances were lower only for the first 14 days. There were no significant differences found amongst splenic immune cell populations between the control and experimental groups.Conclusion: These preliminary data show that amaranth oil may help decrease autoantibody levels in lupus prone murine subjects. However, given the small number of subjects in this study, further research is needed to confirm observed effects and determine the most effective dose and administration schedule. Keywords: autoantibody, IgG, IgM, histone, dsDNA, ssDNA, nucleosome, amaranth oil, immunoglobulin, lupus ","PeriodicalId":93079,"journal":{"name":"Bioactive compounds in health and disease","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47137238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hibiscus rosa sinensis L. anthocyanins prevent lipid peroxidation and improve antioxidant status in the liver of streptozotocin-induced diabetic rats","authors":"V. N. Kalpana, Jincy Mary, S. Mini, N. P. Soumya, S. Mondal","doi":"10.31989/bchd.v4i10.842","DOIUrl":"https://doi.org/10.31989/bchd.v4i10.842","url":null,"abstract":"Background:  Hyperglycemia and oxidative stress are hallmarks of diabetes mellitus (DM). Excessive oxidative stress is implicated in diabetic pathogenesis when endogenous antioxidants are defective.Objective: The present study evaluates the effects of anthocyanins present in the petals of Hibiscus rosa- sinensis on oxidative stress and antioxidant status in streptozotocin-induced diabetic rats.Materials and methods: Diabetes was induced in male Sprague-Dawley rats by a single intraperitoneal injection (30mg/kg) of streptozotocin. Hibiscus rosa sinensis anthocyanins (HA) extract (50 mg/kg body weight) orally administered to diabetic rats for 30 days. Results compared with diabetic rats provided with the standard drug metformin (150 mg/kg body weight).Results: Altered levels of glucose, glycated hemoglobin, toxicity markers and lipid profile in serum were significantly modulated upon the administration of HA in diabetic rats. A supplementation of HA to diabetic rats reduced oxidative stress, as well as increased the levels of antioxidant enzymes in the liver. The present study demonstrates that HA has a protective effect on diabetic ratsConclusion: The present study indicates that Hibiscus anthocyanin supplementation could protect diabetic rats' livers by protecting the hepatocytes from oxidative stress and increasing the antioxidant enzymes' activity.  Keywords: Diabetes mellitus, Hibiscus rosa sinensis anthocyanins, Oxidative stress","PeriodicalId":93079,"journal":{"name":"Bioactive compounds in health and disease","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45001104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical constituents and biological properties of domesticated capsicum species: a review","authors":"Aqsa Akhtar, Waqas Asghar, N. Khalid","doi":"10.31989/bchd.v4i9.837","DOIUrl":"https://doi.org/10.31989/bchd.v4i9.837","url":null,"abstract":"Pepper (Capsicum spp) is cultivated and consumed in almost every region of the world both as fresh vegetable and dried spice. Capsicum and its different varieties possess many valuable properties which distinguish them from other vegetables and in many food items as a spice for its strong pungent flavor that is produced during the secondary metabolism of the plant.Capsicum fruit exhibits a multiple color profile due to the presence of carotenoids which can be used as a natural coloring agent and antioxidant. Almost all the parts of the capsicum are considered a rich source of health-related bioactive compounds including polyphenols, flavonoids, and other aromatic compounds. One of the important biological properties of capsicum is its ability to act as antioxidants to reduce oxidative stress leading to the prevention of several degenerative diseases. The functional compounds of capsicum exhibit excellent antimicrobial properties, particularly against gram-positive pathogenic microorganisms. The nutraceutical functionality of phytogenic compounds obtained from capsicum also confirms the anticarcinogenic and cardio-preventive effectiveness. The essential oils from capsicum are also being used as anti-aging substances in cosmetic products. Accordingly, this article is an attempt to provide an overview of the chemical and functional properties of the bioactive compounds sourced from capsicum and their effective utilization in the medicine, food, agricultural, cosmetic, and textile industries.Keywords: Capsicum, capsaicinoids, capsaicin, carotenoids, pungency","PeriodicalId":93079,"journal":{"name":"Bioactive compounds in health and disease","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41576955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body weight, vitamin D and zinc: A review of associations with coronavirus disease (COVID-19)","authors":"M. Boaz, H. Salem, D. A. Navarro, V. Kaufman-Shriqui","doi":"10.31989/bchd.v4i9.839","DOIUrl":"https://doi.org/10.31989/bchd.v4i9.839","url":null,"abstract":"Obesity has been associated with adverse Coronavirus disease [COVID-19] outcomes; obesity is associated with sub-optimal immune function, including vitamin D and zinc deficiencies, two micronutrients essential for immune function, including anti-viral activity.  The co-occurrence of vitamin D and zinc deficiencies have been documented.  These exposures have been widely discussed in both scientific and popular literature.  Thus, a critical review of the association between obesity, vitamin D and zinc, in relation to the COVID pandemic, is appropriate. Evidence strongly associates  obesity and adverse COVID outcomes including hospitalization, intensive care hospitalization, need for mechanical ventilation and death. While the mechanisms associating vitamin D and zinc to immune function are well-delineated, clinical trials of these nutrients fail to identify efficacy in the prevention or treatment of COVID. Further studies are warranted in susceptible populations. It is important that healthcare professionals practice evidence-based care; thus at this point, neither vitamin D nor zinc can be recommended as a preventive or cure for COVID.               Keywords: COVID, body weight, obesity, vitamin D, zinc","PeriodicalId":93079,"journal":{"name":"Bioactive compounds in health and disease","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41631839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal plants and the communication on precautionary use of herbs during COVID-19 outbreak in Thailand","authors":"K. Chaiyasit, Wittayatorn Torkaew, Karn Boonsiri","doi":"10.31989/bchd.v4i8.825","DOIUrl":"https://doi.org/10.31989/bchd.v4i8.825","url":null,"abstract":"COVID-19 has become a new global health issue that spreads easily and has high mortality rates across the world. Consequently, it is essential to discover new treatments rapidly. According to Integrative Medicine, certain herbs are useful for treating COVID-19 when taken with standard treatments. Thailand is one of the countries experiencing outbreaks and treating patients with herbs. For instance, some Thai patients are treated with Fah Talai Jone (Andrographis paniculata) at a different quantity limit used for treating fever and sore throats. Fah Talai Jone must be used with high precaution in renal insufficiency, hepatitis, or drug induced liver damage patients.  In addition, finger root (Boesenbergia rotunda) and ginger (Zingiber officinale) are also used for managing COVID-19, but there is insufficient evidence about quantity limits and side effects of using them.  Therefore, specialists need to do more research about the herbs to ensure the efficiency and safety of treatments.Keywords: herb in COVID, Fah Talai Jone, andrographolide, finger root, ginger, COVID, herb communication","PeriodicalId":93079,"journal":{"name":"Bioactive compounds in health and disease","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47440196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of preoperative feeding with germinated brown rice supplement on clinical outcome of orthopaedic and gastrointestinal surgery patients","authors":"P. Thacker, S. Mandalika, R. Shah, N. Doctor","doi":"10.31989/BCHD.V4I7.799","DOIUrl":"https://doi.org/10.31989/BCHD.V4I7.799","url":null,"abstract":"Background: Malnutrition prior to surgery can lead to inflammation, increased length of hospital stay, bed sores, muscle weakness, poor quality of life and mortality post-surgery in patients. Therefore, preoperative drinks that have been enriched with vitamins, easily digestible carbohydrates and amino acids have been necessitated by ESPEN. Health benefits of brown rice, which is a good source of phytonutrients like GABA, Ferulic acid Oryzanol and B- complex, BCAA and maltodextrin, have been well researched.Methods: In the present study, a nutritious product was developed using germinated brown rice, salt and micronutrient mix (GBR Mix), analysed quantitatively (Proximate composition) and qualitatively (Phytochemicals). Major orthopaedic and gastrointestinal surgical patients in the age group of 40-65 years (n=124) were supplemented with GBR Mix in bouts of 3 meals (20gms x 3meals) namely lunch, mid-evening and bedtime time snack, 8 hrs prior to surgery unlike other patients who fasted for 12-16 hours prior to surgery. They were assessed for nutritional status, Serum Albumin, inflammatory markers (CRP and WBC), post-surgery complications and length of hospital stay.Results: Supplementation was found to improve blood sugar (p<0.05) in gastroenterology patients, reduce inflammatory markers like CRP(p=0.053) and WBC (p<0.001), reduced nausea and vomiting, improved food and fluid intake post-surgery in the patients. Additionally, length of hospital stay was also reduced (p=0.001).Conclusion: Thus, germinated brown rice could be recommended as an economical nutritious and anti-inflammatory pre surgery feed.Keywords: GBR, LOS, MUST, SGA, CRP, Micronutrient Mix ","PeriodicalId":93079,"journal":{"name":"Bioactive compounds in health and disease","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42449155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition communication about low FODMAP diet in irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO) in Thai healthcare practitioners","authors":"Varit Srisukthaveerat, Wittayatorn Tokaew, Supaporn Sridee, K. Chaiyasit","doi":"10.31989/bchd.v4i6.798","DOIUrl":"https://doi.org/10.31989/bchd.v4i6.798","url":null,"abstract":"Nowadays, communication is influential regarding the various communication channels that make the information spreading effectively to the audiences. Additionally, the senders are also another factor creating credibility to the receivers, particularly to the healthcare-related issue which is necessary to be guaranteed by the medical specialists. The Low FODMAP is a therapeutic diet which is recommended for Irritable Bowel Syndrome (IBS) and Small Intestinal Bacterial Overgrowth (SIBO) patients. However, this diet has not been practiced widespread among Thai healthcare practitioners. As a matter of fact, these practitioners are familiar with a great number of diseases and closely well-educated with healthcare issues, they would significantly hold credibility affecting the medical usage to the society. Consequently, this article aims to educate all the staff in the healthcare and medical industry to gain sufficient knowledge of low FODMAP and be able to apply for further development.Keywords: nutrition communication, Low FODMAP, IBS, SIBO","PeriodicalId":93079,"journal":{"name":"Bioactive compounds in health and disease","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44470632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"War as a separate and independent factor for rise in COVID-19 cases and death: how to use vitamins, and other bioactive compounds in the absence of vaccine","authors":"K. Gilbert, B. Pitts, A. Allen, D. Martirosyan","doi":"10.31989/bchd.v3i12.765","DOIUrl":"https://doi.org/10.31989/bchd.v3i12.765","url":null,"abstract":"Background: COVID-19 is recognized as an acute upper respiratory disease. As the current COVID-19 pandemic nears the anticipated second wave of cases, many countries are struggling with tactics on how to limit the spread of the virus. With the emergence of conflict in the Artsakh region in late September, there has been a sharp rise in COVID cases both in this region and in surrounding countries that appears to be dissimilar from global transmission rates. This trend indicates that war could be acting as an independent and separate factor to COVID-19 spread in this area. With vaccines still in development, alternative methods of curbing the disease and its symptoms are of the utmost importance.Methods: This article examines the historical context of war as a contributing factor in the spread of disease as well as the history of the Artsakh region. Comparing data gathered from the World Health Organization (WHO) on the conflicting region to case counts and death rates in neighboring countries and globally will reveal how transmission rates in this area may be different than others. A review of published literature on functional food ingredients to combat COVID-19 will also be used to frame guidelines and recommendations to reduce the spread of the virus.Results and Conclusions: Based on data from the WHO on the Artsakh region, war appears to act as a separate and independent factor in COVID-19 transmission rates.  To control the spread of COVID-19, it is important to eliminate war as a transmission factor by encouraging a ceasefire in areas of conflict and using materials and guidelines from the FFC to help control further spread. FFC guidelines include the use of functional food ingredients to mitigate intestinal and respiratory symptoms, while still promoting social distancing and the use of masks.Keywords: COVID-19, Artsakh region, war, WHO, functional food, bioactive compound, Vitamin C, Vitamin D, zinc, folate, iron, selenium, copper","PeriodicalId":93079,"journal":{"name":"Bioactive compounds in health and disease","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45741503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver protection: ancient empirical roots, marketing oversimplifications and novel molecular-biology-endowed compounds","authors":"F. Marotta, H. Sweed, R. Rastmanesh, D. Rasheedy, S. Rasulova, R. Catanzaro","doi":"10.31989/bchd.v3i12.768","DOIUrl":"https://doi.org/10.31989/bchd.v3i12.768","url":null,"abstract":"Editorials do not contain an abstract. Please view \"Full Article\" to read editorial.","PeriodicalId":93079,"journal":{"name":"Bioactive compounds in health and disease","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42072650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}