American journal of biomedical science & research最新文献

{"title":"Cutaneous and Mucous Sinus Tract of Dental Origin: What’s Behind it?","authors":"Fouad Brigui","doi":"10.34297/ajbsr.2023.18.002489","DOIUrl":"https://doi.org/10.34297/ajbsr.2023.18.002489","url":null,"abstract":"Dental Sinus Tract is an inflammatory channel putting in communication a deep peri-dental suppurative lesion with an exit orifice, it’s nature’s method of establishing drainage. A general practitioner commonly encounters in his practice this type of lesion. However, their discovery is very often delayed due to their chronic nature (asymptomatic) and their localization (hidden in the mucous folds or in skin furrows). The aim of this clinical case reports is to dissect the diagnostic difficulties and to discuss the therapeutic particularities of the management of mucous and cutaneous fistulas of dental origin. the first patient was referred to our service for the extraction of an impacted canine in whom we discovered by chance a mucous fistula that hides a cystic lesion perforating the vestibular alveolar table, after 2 weeks of intracanal calcium hydroxide and a root canal obturation, periapical surgery was performed with apical resection and 3 mm MTA plug. the second patient was referred by the maxillofacial department to verify a possible dental origin for the drainage of the cutaneous sinus tract in the left posterior part of the cheek, the radiographic analysis shows a decayed 36 with diffuse radiolucency and a resorbed distal root. The tooth was judged to be preserved and after root canal instrumentation and calcium hydroxide medication, the skin lesion shows signs of healing, therefore, the root canal filling was made with a bio-ceramic sealer and the patient was put under control. The key to the success of the treatment of mucous and cutaneous sinus tract of dental origin is, first of all, to know how to identify the etiology to their existence in order to not misdiagnose and initiate inappropriate therapies and, secondly, to be aware of the importance of post-operative follow-up. Finally, the treatment of the dental cause, conservative or not, leads generally to the disappearance of the fistula and a regression of the symptoms.","PeriodicalId":93072,"journal":{"name":"American journal of biomedical science & research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136243410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papilledema in Childhood for Diagnosis of Pseudotumor Cerebri or Late Hydrocephalus: A Case Report","authors":"Mariaelena Malvasi","doi":"10.34297/ajbsr.2023.18.002476","DOIUrl":"https://doi.org/10.34297/ajbsr.2023.18.002476","url":null,"abstract":"A case of hydrocephalus is presented in a 13-year-old female with transient loss of vision from 1 week and papilledema, previous ophthalmological history was negative. A visual field was performed, and neurological examination proved to be hydrocephalus. In literature few cases of Papilledema in adolescent children with hydrocephalus have been reported. The aim of this case report is to decode the signs, symptoms and factors associated with papilledema in children with hydrocephalus at an early stage in order to prevent a poor visual-functional residual (permanent low vision).","PeriodicalId":93072,"journal":{"name":"American journal of biomedical science & research","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135593899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Reprogramming and Cancer: 2022","authors":"Susinjan Bhattacharya","doi":"10.34297/ajbsr.2023.18.002465","DOIUrl":"https://doi.org/10.34297/ajbsr.2023.18.002465","url":null,"abstract":"Cancer is a disease that is considered a silent killer. Early therapeutic interventions can lead to a cure for the disease. The causal reasons for cancer are many. At the molecular level, metabolic reprogramming is a process for self-renewal and survival by cancer cells. Dietary constituents are an important factor that leads to metabolic transitions and induces cellular reprogramming. The process is initiated by inducing changes in metabolism leading to the supply of nutrients and energy to the tumour cells, and this is linked to the induction of epithelial mesenchymal transition (EMT) and vascular mimicry (VM). Thermodynamic changes that get distinguished between proliferating and non-proliferating cells might also be a possible reason for cellular reprogramming. The entire process of metabolic reprogramming is linked to diet-driven changes and bioenergetics. The work here elucidates in brief the dependency of metabolic reprogramming on different factors, or stages and highlights possibilities for therapeutic interventions as part of cancer therapeutics.","PeriodicalId":93072,"journal":{"name":"American journal of biomedical science & research","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135419736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of in-house Methods for Isolating Fungal DNA of Clinical Samples","authors":"D. Koffi, Yayé Yapi Guillaume, Francis K. Kouadjo, Koui S Tossea, Andre O. Toure, Allico J Djaman","doi":"10.12691/ajbr-11-1-2","DOIUrl":"https://doi.org/10.12691/ajbr-11-1-2","url":null,"abstract":"","PeriodicalId":93072,"journal":{"name":"American journal of biomedical science & research","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84518771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ward Health System in Nigeria: An Assessment of the Awareness and Role of Community Members","authors":"Ifeoma Anne Njelita, Patrick Anibbe Ikani, Chinyerem Cynthia Nwachukwu, Ifeanyi Gabriel Eyisi, Chijioke Amara Ezenyeaku, Chigozie Ozoemena Ifeadike, Chukwudi Uchenna Njelita","doi":"10.12691/ajbr-11-1-1","DOIUrl":"https://doi.org/10.12691/ajbr-11-1-1","url":null,"abstract":"","PeriodicalId":93072,"journal":{"name":"American journal of biomedical science & research","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85064711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EPIC Spinal Procedure with Sound Wave Technology Induces Biomechanical Alignment Putatively Influencing Pain Response.","authors":"Stan Pierce,&nbsp;Kenneth Blum,&nbsp;David Baron,&nbsp;John Giordano,&nbsp;Igor Elman,&nbsp;Rajendra D Badgaiyan,&nbsp;Ashim Gupta,&nbsp;Catherine Dennen,&nbsp;Anish Bajaj,&nbsp;Abdalla Bowirrat","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Spinal biomechanical alignment is now able to be altered through the use of unique sound wave technology. This methodological commentary will correlate recent studies demonstrating the ability of sound waves to carry mass, how the EPIC technique spinal procedure uses a sound wave impulse to create measurable changes in spinal alignment, and the clinical safety and efficacy of this approach. The EPIC technique is a direct genealogical descendant of the technique originally developed by the founding family of chiropractic. With sound wave therapies currently being used to break up kidney stones, called lithotripsy, in physical therapy for the treatment of soft tissue injuries, in the treatment of prostate cancer, and in the treatment of Alzheimer's disease, it is possible that the use of sound wave therapies may enter into the realm of altering joint biomechanics. Through a neurovascular examination, the EPIC technique spinal procedure can ascertain the presence of craniocervical subluxation, followed by acquiring multi-dimensional radiographic images for structural analysis. Currently using digital radiographic analysis, the EPIC technique acquires an epigenetic profile of structural asymmetries as well as a multi-directional biomechanical malposition profile of the spine, combining both profiles to ascertain the exact degrees for realignment. EPIC clinics have successfully utilized EPIC on over 20,000 cases. Comparison of pre-treatment biomechanical lateral displacement of the C1 vertebra around the Z-axis measured on digital radiographs, and post-treatment biomechanical lateral displacement of the C1 vertebra measured on digital radiographs immediately following the procedure, demonstrated an average 52% reduction in lateral biomechanical displacement around the Z-axis in a select group of over 2,000 cases. While more research is required, we are encouraged by these preliminary results. WC 265.</p>","PeriodicalId":93072,"journal":{"name":"American journal of biomedical science & research","volume":"19 6","pages":"709-715"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601340/pdf/nihms-1929258.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54232747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Model of Colorectal Cancer for Implementation of the HRMA Method for the Genetic Characterization of Human Pathologies","authors":"Safiatou T.G. Coulibaly, Valérie Mbengue Gbonon, Flore B. Diplo, David Ngolo Coulibaly, Solange Kakou Ngazoa, A. Sylla, M. Dosso","doi":"10.12691/ajbr-10-1-3","DOIUrl":"https://doi.org/10.12691/ajbr-10-1-3","url":null,"abstract":"Context: In developing countries and particularly in Sub-Saharan Africa, access to sequencing techniques is limited. In this context, it is necessary to adopt strategies that will allow researchers to work on molecular genetics and genomics and to allow the greatest number of people to benefit from a precision diagnosis that until now has been outsourced to laboratories in Western countries. The high-resolution curve analysis method (HRMA) for the detection of point mutations in diagnostic choices was evaluated here. Methodology and Results: Using genomic DNA from cell lines, the mutation detection sensitivity of the HRMA method was tested on samples containing different percentages of mutated DNA. The results obtained show that the HRMA method can discriminate wild-type samples from those containing a mutation, even for small amounts of mutated DNA in the sample. Conclusion: For the time being, systematic sequencing of all samples for research and diagnosis is a very expensive strategy in our context. The present evaluation allows to consider molecular genetic and genomic studies as well as molecular diagnosis in two steps: (i) screening of samples by the HRMA method; (ii) sequencing of samples containing a mutation by the Sanger method.","PeriodicalId":93072,"journal":{"name":"American journal of biomedical science & research","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73100662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Organic Acids on Kinetic Properties of Engineered Phlebia radiata MnP3 Enzymes (Wild-type and Mutants) during Mn (II) Oxidation","authors":"Usenobong F. Ufot, Imeh J. Okop, Dorcas U. Ufot, Aniefiok E. Ite, Monday I. Akpanabiatu","doi":"10.12691/ajbr-10-1-2","DOIUrl":"https://doi.org/10.12691/ajbr-10-1-2","url":null,"abstract":"","PeriodicalId":93072,"journal":{"name":"American journal of biomedical science & research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74197645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States","authors":"N. Tran, T. Garcia, M. Aniqa, S. Ali, A. Ally, SM Nauli","doi":"10.34297/ajbsr.2022.15.002087","DOIUrl":"https://doi.org/10.34297/ajbsr.2022.15.002087","url":null,"abstract":"Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a healthy cardiovascular system. The importance of eNOS can be emphasized from the genetic polymorphisms of the eNOS gene, uncoupling of eNOS dimerization, and its numerous signaling regulations. The activity of eNOS on the cardiac myocytes, vasculature, and the central nervous system are discussed. The effects of eNOS on the sympathetic autonomic nervous system (SANS) and the parasympathetic autonomic nervous system (PANS), both of which profoundly influence the cardiovascular system, will be elaborated. The relationship between the eNOS protein with cardiovascular autonomic reflexes such as the baroreflex and the Exercise Pressor Reflex will be discussed. For example, the effects of endogenous nitric oxide (NO) are shown to be mediated by the eNOS protein and that eNOS-derived endothelial NO is most effective in regulating blood pressure oscillations via modulating the baroreflex mechanisms. The protective action of eNOS on the CVS is emphasized here because dysfunction of the eNOS enzyme is intricately correlated with the pathogenesis of several cardiovascular diseases such as hypertension, arteriosclerosis, myocardial infarction, and stroke. Overall, our current understanding of the eNOS protein with a focus on its role in the modulation, regulation, and control of the cardiovascular system in a normal physiological state and in cardiovascular diseases are discussed.","PeriodicalId":93072,"journal":{"name":"American journal of biomedical science & research","volume":"15 1","pages":"153 - 177"},"PeriodicalIF":0.0,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46010033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States.","authors":"N Tran,&nbsp;T Garcia,&nbsp;M Aniqa,&nbsp;S Ali,&nbsp;A Ally,&nbsp;S M Nauli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a healthy cardiovascular system. The importance of eNOS can be emphasized from the genetic polymorphisms of the eNOS gene, uncoupling of eNOS dimerization, and its numerous signaling regulations. The activity of eNOS on the cardiac myocytes, vasculature, and the central nervous system are discussed. The effects of eNOS on the sympathetic autonomic nervous system (SANS) and the parasympathetic autonomic nervous system (PANS), both of which profoundly influence the cardiovascular system, will be elaborated. The relationship between the eNOS protein with cardiovascular autonomic reflexes such as the baroreflex and the <i>Exercise Pressor Reflex</i> will be discussed. For example, the effects of endogenous nitric oxide (NO) are shown to be mediated by the eNOS protein and that eNOS-derived endothelial NO is most effective in regulating blood pressure oscillations via modulating the baroreflex mechanisms. The protective action of eNOS on the CVS is emphasized here because dysfunction of the eNOS enzyme is intricately correlated with the pathogenesis of several cardiovascular diseases such as hypertension, arteriosclerosis, myocardial infarction, and stroke. Overall, our current understanding of the eNOS protein with a focus on its role in the modulation, regulation, and control of the cardiovascular system in a normal physiological state and in cardiovascular diseases are discussed.</p>","PeriodicalId":93072,"journal":{"name":"American journal of biomedical science & research","volume":"15 2","pages":"153-177"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39854734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}