Metabolic Reprogramming and Cancer: 2022

Abstract

Cancer is a disease that is considered a silent killer. Early therapeutic interventions can lead to a cure for the disease. The causal reasons for cancer are many. At the molecular level, metabolic reprogramming is a process for self-renewal and survival by cancer cells. Dietary constituents are an important factor that leads to metabolic transitions and induces cellular reprogramming. The process is initiated by inducing changes in metabolism leading to the supply of nutrients and energy to the tumour cells, and this is linked to the induction of epithelial mesenchymal transition (EMT) and vascular mimicry (VM). Thermodynamic changes that get distinguished between proliferating and non-proliferating cells might also be a possible reason for cellular reprogramming. The entire process of metabolic reprogramming is linked to diet-driven changes and bioenergetics. The work here elucidates in brief the dependency of metabolic reprogramming on different factors, or stages and highlights possibilities for therapeutic interventions as part of cancer therapeutics.