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Himalayan Pink Salt as a Healthier Substitute in Lowering the Risk of Dietary Salt Induced Cognitive Insults in Experimental Rats 喜马拉雅粉盐作为一种更健康的替代品在降低食盐引起的实验大鼠认知损伤的风险
Alzheimers disease & dementia Pub Date : 2021-12-31 DOI: 10.36959/734/384
P. Keerthana, Subramanian Sarada
{"title":"Himalayan Pink Salt as a Healthier Substitute in Lowering the Risk of Dietary Salt Induced Cognitive Insults in Experimental Rats","authors":"P. Keerthana, Subramanian Sarada","doi":"10.36959/734/384","DOIUrl":"https://doi.org/10.36959/734/384","url":null,"abstract":"Alzheimer’s disease (AD) belonging to the class of tauopathies, is a major cause of dementia globally. Observational studies in the aging population have reported that excessive dietary salt consumption is one of the risk factors that contribute to the pathological processes that underlie dementia and cognitive impairment. Regulation of the daily salt intake and consumption of alternative nutritional salts, if proven, may serve as a cost-effective and feasible approach in lowering the risk of dementia. With this background, the objective of the current study included assessment of the putative benefits of Himalayan pink salt with regard to its effects on spatial memory in comparison with that of common salt using rat as an experimental model. The results of the study showed that Himalayan pink salt, even at 5-10 fold higher concentrations of the salt over the permissible daily intake limits, could exhibit a positive effect on learning and memory in Barnes maze task and improved nitric oxide levels. Phosphorylated tau levels remained comparable to that of control group whereas common salt inflicted greater insults leading to elevated levels of pathological form of tau and compromised spatial memory. These findings suggest that Himalayan pink salt may serve as a healthier salt substitute towards lowering the risk or severity of dietary salt induced form of AD.","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48106546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photobiomodulation Improves Memory in Mild Cognitive Impairment: Three Case Reports 光生物调节改善轻度认知障碍患者的记忆:三例报告
Alzheimers disease & dementia Pub Date : 2021-06-14 DOI: 10.36959/734/383
S. ChanAgnes, Lee TszLok, Sze Sophia, R. HamblinMichael
{"title":"Photobiomodulation Improves Memory in Mild Cognitive Impairment: Three Case Reports","authors":"S. ChanAgnes, Lee TszLok, Sze Sophia, R. HamblinMichael","doi":"10.36959/734/383","DOIUrl":"https://doi.org/10.36959/734/383","url":null,"abstract":"Three patients (mean age = 62) received 18-sessions of PBM stimulation twice per week for nine weeks. Each patient was assessed with Rey- Osterrieth Complex Figure Test (Rey-O testing visual memory) and Hong Kong List Learning Test (HKLLT testing verbal memory), Clinical Dementia Rating Scale (CDR), Functional Activities Questionnaire (FAQ), Geriatric Anxiety Scale-10 Item Version (GAS-10) and Chinese Geriatric Depression Scale (CGDS) before and after PBM.","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45906857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Ameliorative Effects of Intranasal AntagomiR-125b in AD 鼻用安他哥米-125b对AD的改善作用
Alzheimers disease & dementia Pub Date : 2020-12-09 DOI: 10.36959/734/380
Xia Chun, C. Neelima
{"title":"Ameliorative Effects of Intranasal AntagomiR-125b in AD","authors":"Xia Chun, C. Neelima","doi":"10.36959/734/380","DOIUrl":"https://doi.org/10.36959/734/380","url":null,"abstract":"Alzheimer's disease (AD) is a global public health crisis. Currently, there are no treatments to prevent or halt the disease. Given the precedence of chronic neuroinflammation in triggering AD-like neurodegeneration and an observed upregulation of NFkB-driven miRs i.e. mir-125b positively correlating with AD, silencing specific micro-RNA with antisense-microRNA (antagomir) to miR-125b was undertaken to evaluate its efficacy in ameliorating AD-like neurodegeneration in 5XFAD transgenic mice modeling AD.","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45369378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The presence of moderate extrapyramidal signs predicts poorer outcomes in a community‐based cohort of multi‐ethnic demented elders: Developing topics 在以社区为基础的多民族痴呆老年人队列中，中度锥体外系体征的存在预示着较差的预后:发展中的主题
Alzheimers disease & dementia Pub Date : 2020-12-01 DOI: 10.7916/D8-ZNGM-BS85
A. Kociolek, K. Fernández, Yian Gu, Stephanie Cosentino, C. Zhu, Y. Stern
{"title":"The presence of moderate extrapyramidal signs predicts poorer outcomes in a community‐based cohort of multi‐ethnic demented elders: Developing topics","authors":"A. Kociolek, K. Fernández, Yian Gu, Stephanie Cosentino, C. Zhu, Y. Stern","doi":"10.7916/D8-ZNGM-BS85","DOIUrl":"https://doi.org/10.7916/D8-ZNGM-BS85","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86518459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of patient burden using online social media in mild cognitive impairment: Dementia care research (research projects; nonpharmacological) / Assessment and care planning 使用在线社交媒体评估轻度认知障碍患者负担:痴呆护理研究(研究项目;非药理学)/评估和护理计划
Alzheimers disease & dementia Pub Date : 2020-12-01 DOI: 10.7916/D8-S110-6M36
A. Monfared, Y. Stern, M. Irizarry, S. Doogan, Quanwu Zhang
{"title":"Evaluation of patient burden using online social media in mild cognitive impairment: Dementia care research (research projects; nonpharmacological) / Assessment and care planning","authors":"A. Monfared, Y. Stern, M. Irizarry, S. Doogan, Quanwu Zhang","doi":"10.7916/D8-S110-6M36","DOIUrl":"https://doi.org/10.7916/D8-S110-6M36","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76475401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of composite proxy measures of cognitive reserve: What can longitudinal cohorts tell us about the association between modifiable dementia risk factors and the ageing 认知储备的复合代理测量的验证:纵向队列可以告诉我们关于可改变的痴呆风险因素与衰老之间的关联
Alzheimers disease & dementia Pub Date : 2020-12-01 DOI: 10.7916/D8-T5QB-KM68
R. Boyle, S. Scarlett, S. Knight, C. Looze, Y. Stern, I. Robertson, Kenny Rose Anne, R. Whelan
{"title":"Validation of composite proxy measures of cognitive reserve: What can longitudinal cohorts tell us about the association between modifiable dementia risk factors and the ageing","authors":"R. Boyle, S. Scarlett, S. Knight, C. Looze, Y. Stern, I. Robertson, Kenny Rose Anne, R. Whelan","doi":"10.7916/D8-T5QB-KM68","DOIUrl":"https://doi.org/10.7916/D8-T5QB-KM68","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72994563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Left frontal hub connectivity enhances task‐related brain network segregation and cognition in aging: Implications for reserve: Neuroimaging/Normal brain aging 左额叶中枢连接增强任务相关的脑网络分离和认知:对储备的影响:神经成像/正常脑老化
Alzheimers disease & dementia Pub Date : 2020-12-01 DOI: 10.7916/D8-EA6B-PS43
Lukas Frontzkowski, N. Franzmeier, J. Neitzel, Ying Luan, C. Habeck, Y. Stern, M. Ewers
{"title":"Left frontal hub connectivity enhances task‐related brain network segregation and cognition in aging: Implications for reserve: Neuroimaging/Normal brain aging","authors":"Lukas Frontzkowski, N. Franzmeier, J. Neitzel, Ying Luan, C. Habeck, Y. Stern, M. Ewers","doi":"10.7916/D8-EA6B-PS43","DOIUrl":"https://doi.org/10.7916/D8-EA6B-PS43","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75017354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural‐cognitive changes across the lifespan: Evidence from reference ability neural network (RANN) Neuroimaging/Normal brain aging 贯穿整个生命周期的神经认知变化:来自参考能力神经网络(RANN)神经成像/正常大脑衰老的证据
Alzheimers disease & dementia Pub Date : 2020-12-01 DOI: 10.7916/D8-A47K-ET38
Georgette Argiris, Y. Stern, C. Habeck
{"title":"Neural‐cognitive changes across the lifespan: Evidence from reference ability neural network (RANN) Neuroimaging/Normal brain aging","authors":"Georgette Argiris, Y. Stern, C. Habeck","doi":"10.7916/D8-A47K-ET38","DOIUrl":"https://doi.org/10.7916/D8-A47K-ET38","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"152 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80400512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep duration genes associated with cognition across the adult age‐range: Developing topics 成人年龄范围内与认知相关的睡眠时间基因:发展中的主题
Alzheimers disease & dementia Pub Date : 2020-12-01 DOI: 10.7916/D8-J4PD-5967
A. Tsapanou, Yizhe Gao, Y. Stern, Sandra M. Barral Rodriguez
{"title":"Sleep duration genes associated with cognition across the adult age‐range: Developing topics","authors":"A. Tsapanou, Yizhe Gao, Y. Stern, Sandra M. Barral Rodriguez","doi":"10.7916/D8-J4PD-5967","DOIUrl":"https://doi.org/10.7916/D8-J4PD-5967","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"9 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79639068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Concept is Needed for Combating Alzheimer's Disease and NeuroHIV. 对抗阿尔茨海默病和神经hiv需要一个新的概念。
Alzheimers disease & dementia Pub Date : 2020-08-19 DOI: 10.36959/734/377
Xiu-Ti Hu
{"title":"A Novel Concept is Needed for Combating Alzheimer's Disease and NeuroHIV.","authors":"Xiu-Ti Hu","doi":"10.36959/734/377","DOIUrl":"https://doi.org/10.36959/734/377","url":null,"abstract":"<p><p>Both Alzheimer's disease (AD) and HIV-associated neurocognitive disorders (HAND) could progress to dementia, a severe consequence of neurodegenerative diseases. Cumulating evidence suggests that the β-amyloid (Aβ) theory, currently thought to be the predominant mechanism underlying AD and AD-related dementia (ADRD), needs re-evaluation, considering all treatments and new drug trials based upon this theory have been unsuccessful. Similar intention for treating HAND, including HIV-associated dementia (HAD), has also failed. Thus, novel theory, hypothesis, and therapeutic strategies are desperately needed for future study and effective treatments of AD/ADRD and HAND. There are numerous potential upstream mechanisms that may cause AD and/or HAND; but it is unrealistic to identify all of them. However, it is realistic and feasible to intervene the downstream mechanism of these two devastating neurodegenerative diseases by blocking the final common path to neurotoxicity mediated by overactivation of NMDA receptors (NMDARs) and voltage-gated calcium channels (VGCCs). Such a combined pharmacological intervention will likely ameliorate neuronal Ca<sup>2+</sup> homeostasis by diminishing overactivated NMDAR and VGCC-mediated Ca<sup>2+</sup> dysregulation (i.e., by reducing excessive Ca<sup>2+</sup> influx and intracellular levels, [Ca<sup>2+</sup>]in)-induced hyperactivity, injury, and death of neurons in the critical brain regions that regulate neurocognition in the context of AD/ADRD or HAND, especially during aging. Here we present a novel theoretical concept, hypothesis, and working model for switching the battlefield from searching-and-fighting the original mechanism that may cause AD or HAND, to abolishing AD- and neuroHIV-induced neurotoxicity mediated by NMDAR and VGCC over activation, which may ultimately improve the therapeutic strategies for treating AD and HAND.</p>","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"4 1","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2020-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38415523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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