发布求助
文献互助 智能选刊 最新文献

Alzheimers disease & dementia最新文献

筛选
英文 中文
Fear of memory decline predicts lower quality of life and increased memory failures in older adults: Preliminary findings from a novel fear-avoidance of memory decline scale. 对记忆力衰退的恐惧预示着老年人生活质量的下降和记忆力衰退的增加:一项新的恐惧-回避记忆力衰退量表的初步发现。
Alzheimers disease & dementia Pub Date : 2020-05-19 DOI: 10.31234/osf.io/vugny
F. Farina, M. Bennett, J. Griffith, Bert Lenaert
{"title":"Fear of memory decline predicts lower quality of life and increased memory failures in older adults: Preliminary findings from a novel fear-avoidance of memory decline scale.","authors":"F. Farina, M. Bennett, J. Griffith, Bert Lenaert","doi":"10.31234/osf.io/vugny","DOIUrl":"https://doi.org/10.31234/osf.io/vugny","url":null,"abstract":"Evidence concerning the impact of fear of memory decline on health-related outcomes is limited. To determine the relationship between fear-avoidance of memory decline, quality of life and subjective memory in older adults using a novel scale to measure fear of memory decline. Sixty-seven older adults (59-81 years) completed a 23-item self-report questionnaire designed to capture experiential, cognitive and behavioral components of fear of memory decline, known as the fear and avoidance of memory decline (FAM) scale. Memory performance was assessed using the Wechsler Memory Scale (WMS-IV) and the Memory Failures Scale (MFS). General anxiety was assessed using the Depression, Anxiety and Stress Scales (DASS) and the Geriatric Anxiety Inventory (GAI). Quality of life was assessed using the Older Person’s Quality of Life scale (OPQOL-35). The FAM scale demonstrated good reliability and validity. Three latent factors were observed including: (1) fear-avoidance, (2) problematic beliefs and (3) resilience. After adjusting for age, education, memory performance and general anxiety, higher fear-avoidance predicted lower quality of life (p=.021) and increased memory failures (p=.022). Increased fear of memory decline predicts lower quality of life and subjective memory failures in healthy older adults. Based on these findings, we propose a preliminary fear-avoidance model that explains the development and maintenance of dementia-related functional disability in terms of psychological processes.","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82325637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contribution of Sodium-Calcium Exchanger Isoform-3 in Aβ1-42 Induced Cell Death 钠钙交换物异构体-3在Aβ1-42诱导的细胞死亡中的作用
Alzheimers disease & dementia Pub Date : 2019-07-01 DOI: 10.4172/NEUROPSYCHIATRY.1000567
H. K. Afewerky, Hao Li, Pei Pang, Tongmei Zhang, Youming Lu
{"title":"Contribution of Sodium-Calcium Exchanger Isoform-3 in Aβ1-42 Induced Cell Death","authors":"H. K. Afewerky, Hao Li, Pei Pang, Tongmei Zhang, Youming Lu","doi":"10.4172/NEUROPSYCHIATRY.1000567","DOIUrl":"https://doi.org/10.4172/NEUROPSYCHIATRY.1000567","url":null,"abstract":"Aβ1-42 is a peptide which can alter intracellular calcium (Ca2+) homeostasis and subsequently cause cell death. The molecular mechanisms underlying Aβ1-42 induced Ca2+ dyshomeostasis and neurodegeneration are not fully elucidated. The third isoform of the sodium-calcium exchanger (NCX) family, NCX3, plays a vital role in adjusting excitable cells Ca2+ homeostasis. In this study, using NCX3 stably transfected baby hamster kidney (BHK) cells, we aim to study the role of NCX3 against Aβ1-42 induced cell death. Our result demonstrates that NCX3 stably transfected cells (BHK-NCX3) are more resistant to Aβ1-42 aggregation compared to their wild types (BHK-WT). The increased cellular loss in BHK-WT was correlated to increased cytoplasmic Ca2+ concentration ([Ca2+]i) induced by Aβ1-42. These results present that NCX3 protects against Aβ1-42 induced cell death and proclaim NCX3 and its downstream molecular pathways as critical components that take part in Aβ1-42 neurotoxicity. Our study substantiates molecular events through which Aβ1-42 can induce neurodegeneration such as Alzheimers disease and marks potential targets to slow down neuropathogenesis.","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"152 1","pages":"2220-2227"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79558813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Gender Difference in Behavioral and Psychological Symptoms of Alzheimer's Disease 阿尔茨海默病行为和心理症状的性别差异
Alzheimers disease & dementia Pub Date : 2019-02-25 DOI: 10.36959/734/375
Mu Nan, Huawang Wu, Madeline Ping, D. Rao, Junchang Yu, Qiaoting Huang, Tang Mouni, Zhang Ruoxi, Jiyang Pan
{"title":"Gender Difference in Behavioral and Psychological Symptoms of Alzheimer's Disease","authors":"Mu Nan, Huawang Wu, Madeline Ping, D. Rao, Junchang Yu, Qiaoting Huang, Tang Mouni, Zhang Ruoxi, Jiyang Pan","doi":"10.36959/734/375","DOIUrl":"https://doi.org/10.36959/734/375","url":null,"abstract":"Behavioral and psychological symptoms of dementia (BPSD) are important clinical manifestations of Alzheimer's Disease (AD), which may occur at the early stage or throughout the entire course of dementia. They can predict the progression of dementia and serve as the major causes for long-term hospitalization and reduction in caregiver's life quality. Current studies on gender difference of AD are only limited to the epidemiological aspect, but rarely on the clinical and neuropathology aspect.","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44355222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
AbstractPoster presentation: Tuesday posterP3-040: Memory complaints in non-demented individuals aged 75 do not predict a conversion to Alzheimer dementia within 30 months in the VITA study 摘要:在VITA研究中，75岁非痴呆个体的记忆抱怨不能预测在30个月内转化为阿尔茨海默氏痴呆
Alzheimers disease & dementia Pub Date : 2006-07-01 DOI: 10.1016/j.jalz.2006.05.1307
S. Jungwirth, K. Tragl, P. Fischer
{"title":"AbstractPoster presentation: Tuesday posterP3-040: Memory complaints in non-demented individuals aged 75 do not predict a conversion to Alzheimer dementia within 30 months in the VITA study","authors":"S. Jungwirth, K. Tragl, P. Fischer","doi":"10.1016/j.jalz.2006.05.1307","DOIUrl":"https://doi.org/10.1016/j.jalz.2006.05.1307","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"131 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jalz.2006.05.1307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72475303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AbstractPoster presentation: Tuesday posterP3-079: Cognitive Impairment Not Dementia (CIND): Level of education is important for the results of Rivermead memory test 摘要海报展示:周二海报p3 -079:认知障碍而非痴呆(CIND):教育水平对Rivermead记忆测试的结果很重要
Alzheimers disease & dementia Pub Date : 2006-07-01 DOI: 10.1016/J.JALZ.2006.05.1346
M. Rozenfeld, Jeanette Farina, R. D. Rodrigues, N. Maineri, Rafael Alves, J. V. Grossi, H. Kaefer, M. B. Bressel
{"title":"AbstractPoster presentation: Tuesday posterP3-079: Cognitive Impairment Not Dementia (CIND): Level of education is important for the results of Rivermead memory test","authors":"M. Rozenfeld, Jeanette Farina, R. D. Rodrigues, N. Maineri, Rafael Alves, J. V. Grossi, H. Kaefer, M. B. Bressel","doi":"10.1016/J.JALZ.2006.05.1346","DOIUrl":"https://doi.org/10.1016/J.JALZ.2006.05.1346","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79808160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AbstractPoster presentation: Tuesday posterP3-120: Predictors of dropout in clinical trials of subjects with mild cognitive impairment (MCI) 摘要海报展示:周二海报p3 -120:轻度认知障碍(MCI)受试者临床试验中退出的预测因素
Alzheimers disease & dementia Pub Date : 2006-07-01 DOI: 10.1016/J.JALZ.2006.05.1388
Jennifer A. Emond, Sheila Jin, Jacqueline Bochenek, L. Thal, R. Petersen, M. Sano, S. Edland
{"title":"AbstractPoster presentation: Tuesday posterP3-120: Predictors of dropout in clinical trials of subjects with mild cognitive impairment (MCI)","authors":"Jennifer A. Emond, Sheila Jin, Jacqueline Bochenek, L. Thal, R. Petersen, M. Sano, S. Edland","doi":"10.1016/J.JALZ.2006.05.1388","DOIUrl":"https://doi.org/10.1016/J.JALZ.2006.05.1388","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"715 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85411981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AbstractPoster presentation: Monday posterP2-273: PET-imaging of amyloid depositions and astrocytosis in severe ad and histopathological correlations in one patient 摘要:一名严重ad患者的淀粉样蛋白沉积和星形细胞增多症的pet成像与组织病理学相关
Alzheimers disease & dementia Pub Date : 2006-07-01 DOI: 10.1016/J.JALZ.2006.05.1112
H. Engler, Ulla M. Louhija, I. Savitcheva, Tommie Olofsson, H. Kalimo, L. Lannfelt, B. Långström
{"title":"AbstractPoster presentation: Monday posterP2-273: PET-imaging of amyloid depositions and astrocytosis in severe ad and histopathological correlations in one patient","authors":"H. Engler, Ulla M. Louhija, I. Savitcheva, Tommie Olofsson, H. Kalimo, L. Lannfelt, B. Långström","doi":"10.1016/J.JALZ.2006.05.1112","DOIUrl":"https://doi.org/10.1016/J.JALZ.2006.05.1112","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82342466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AbstractPoster presentation: Monday posterP2-372: Decline in cognitive performance and metabolism in a medial brain network during aging in healthy controls 摘要海报展示:周一海报p2 -372:在健康对照中，随着年龄的增长，大脑内侧网络的认知表现和代谢下降
Alzheimers disease & dementia Pub Date : 2006-07-01 DOI: 10.1016/J.JALZ.2006.05.1212
J. Pardo, Joel T. Lee, S. Sheikh, Christa Surerus-Johnson, Kristin R. Munch, J. Carlis, S. Lewis, M. Kuskowski, M. Dysken
{"title":"AbstractPoster presentation: Monday posterP2-372: Decline in cognitive performance and metabolism in a medial brain network during aging in healthy controls","authors":"J. Pardo, Joel T. Lee, S. Sheikh, Christa Surerus-Johnson, Kristin R. Munch, J. Carlis, S. Lewis, M. Kuskowski, M. Dysken","doi":"10.1016/J.JALZ.2006.05.1212","DOIUrl":"https://doi.org/10.1016/J.JALZ.2006.05.1212","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83378776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AbstractPoster presentation: Sunday posterP1-400: Identification of a novel APP interacting protein 摘要海报展示:周日海报p1 -400:一种新的APP相互作用蛋白的鉴定
Alzheimers disease & dementia Pub Date : 2006-07-01 DOI: 10.1016/J.JALZ.2006.05.778
Sara Domingues, M. Fardilha, S. Vieira, Wenjuan Wu, E. F. C. E. Silva, O. D. C. E. Silva
{"title":"AbstractPoster presentation: Sunday posterP1-400: Identification of a novel APP interacting protein","authors":"Sara Domingues, M. Fardilha, S. Vieira, Wenjuan Wu, E. F. C. E. Silva, O. D. C. E. Silva","doi":"10.1016/J.JALZ.2006.05.778","DOIUrl":"https://doi.org/10.1016/J.JALZ.2006.05.778","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74569552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AbstractPoster presentation: Sunday posterP1-401: The influence of the nervous system on mucociliary activity in the frog palate of Rana pipiens 摘要海报展示:周日海报p1 -401:神经系统对蛙蛙腭粘膜纤毛活动的影响
Alzheimers disease & dementia Pub Date : 2006-07-01 DOI: 10.1016/J.JALZ.2006.05.780
C. Hernández
{"title":"AbstractPoster presentation: Sunday posterP1-401: The influence of the nervous system on mucociliary activity in the frog palate of Rana pipiens","authors":"C. Hernández","doi":"10.1016/J.JALZ.2006.05.780","DOIUrl":"https://doi.org/10.1016/J.JALZ.2006.05.780","url":null,"abstract":"","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"217 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74173789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书