鼻用安他哥米-125b对AD的改善作用

Alzheimers disease & dementia Pub Date : 2020-12-09 DOI:10.36959/734/380

Xia Chun, C. Neelima

{"title":"鼻用安他哥米-125b对AD的改善作用","authors":"Xia Chun, C. Neelima","doi":"10.36959/734/380","DOIUrl":null,"url":null,"abstract":"Alzheimer's disease (AD) is a global public health crisis. Currently, there are no treatments to prevent or halt the disease. Given the precedence of chronic neuroinflammation in triggering AD-like neurodegeneration and an observed upregulation of NFkB-driven miRs i.e. mir-125b positively correlating with AD, silencing specific micro-RNA with antisense-microRNA (antagomir) to miR-125b was undertaken to evaluate its efficacy in ameliorating AD-like neurodegeneration in 5XFAD transgenic mice modeling AD.","PeriodicalId":93069,"journal":{"name":"Alzheimers disease & dementia","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ameliorative Effects of Intranasal AntagomiR-125b in AD\",\"authors\":\"Xia Chun, C. Neelima\",\"doi\":\"10.36959/734/380\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Alzheimer's disease (AD) is a global public health crisis. Currently, there are no treatments to prevent or halt the disease. Given the precedence of chronic neuroinflammation in triggering AD-like neurodegeneration and an observed upregulation of NFkB-driven miRs i.e. mir-125b positively correlating with AD, silencing specific micro-RNA with antisense-microRNA (antagomir) to miR-125b was undertaken to evaluate its efficacy in ameliorating AD-like neurodegeneration in 5XFAD transgenic mice modeling AD.\",\"PeriodicalId\":93069,\"journal\":{\"name\":\"Alzheimers disease & dementia\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimers disease & dementia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36959/734/380\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimers disease & dementia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36959/734/380","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

阿尔茨海默病(AD)是一个全球性的公共卫生危机。目前，还没有预防或阻止这种疾病的治疗方法。考虑到慢性神经炎症在引发AD样神经退行性变中的优先性，以及观察到nfkb驱动的mir(即mir-125b)与AD正相关的上调，我们采用反义microrna(安塔哥米)沉默mir-125b的特异性微rna，以评估其在5XFAD转基因AD小鼠中改善AD样神经退行性变的功效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Ameliorative Effects of Intranasal AntagomiR-125b in AD

Alzheimer's disease (AD) is a global public health crisis. Currently, there are no treatments to prevent or halt the disease. Given the precedence of chronic neuroinflammation in triggering AD-like neurodegeneration and an observed upregulation of NFkB-driven miRs i.e. mir-125b positively correlating with AD, silencing specific micro-RNA with antisense-microRNA (antagomir) to miR-125b was undertaken to evaluate its efficacy in ameliorating AD-like neurodegeneration in 5XFAD transgenic mice modeling AD.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Alzheimers disease & dementia

自引率

0.00%

发文量