Bone最新文献

{"title":"Clinical and radiological response of Maffucci related enchondromas to mutant IDH1 inhibitor Ivosidenib","authors":"Thomas Funck-Brentano ,&nbsp;Martine Cohen-Solal ,&nbsp;François Ducray ,&nbsp;Emmanuel Mandonnet","doi":"10.1016/j.bone.2024.117221","DOIUrl":"10.1016/j.bone.2024.117221","url":null,"abstract":"<div><p>Ollier Disease (OD) and Maffucci syndrome (MS) is a rare bone disorder that affects the growth and development of the bones, with an estimated prevalence of 1 in 100,000 people. It is associated with somatic mosaicism of isocitrate dehydrogenase-1 (IDH1) or 2 (IDH2) pathogenic variants. Ivosidenib is indicated for the treatment of acute myeloid leukemia and locally advanced or metastatic cholangiocarcinoma and is currently investigated in low-grade glioma with a susceptible isocitrate dehydrogenase-1 (IDH1) pathogenic variant, but its effects in patients with OD or MS are unknown. We here report the first case of a patient with MS who was treated with Ivosidenib for recurrent IDH-1 mutated glioma. Besides the stabilization of the tumor size, the patient observed significant improvement in his enchondromas that became stiffer, with reduced pain, and significant modification of the mineralization of the enchondromas observed on X-rays. This first case report provides hope for the medical management of patients suffering because of OD or MS. Future clinical research is urgently needed to evaluate long-term benefit risk profile of IDH inhibitors in these rare diseases.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"188 ","pages":"Article 117221"},"PeriodicalIF":3.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of asfotase alfa in patients with hypophosphatasia: A systematic review","authors":"Amirhossein Shirinezhad ,&nbsp;Sina Esmaeili ,&nbsp;Alireza Azarboo ,&nbsp;Yasaman Tavakoli ,&nbsp;Amir Human Hoveidaei ,&nbsp;Negar Zareshahi ,&nbsp;Amirhossein Ghaseminejad-Raeini","doi":"10.1016/j.bone.2024.117219","DOIUrl":"10.1016/j.bone.2024.117219","url":null,"abstract":"<div><h3>Background</h3><p>Hypophosphatasia (HPP) is a rare genetic disorder characterized by defective bone mineralization, leading to skeletal abnormalities and systemic complications. Asfotase alfa, a recombinant human tissue-nonspecific alkaline phosphatase (TNSALP) enzyme replacement therapy, has emerged as a promising treatment for HPP. However, a comprehensive evaluation of its efficacy and safety is warranted to guide clinical practice effectively.</p></div><div><h3>Methods</h3><p>The study followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in Prospective Register of Systematic Reviews (PROSPERO). A search strategy across databases found studies on asfotase alfa for HPP. Two researchers independently extracted and assessed data. This systematic review examined how the drug impacted clinical outcomes such as survival rates, musculoskeletal symptoms, respiratory function, growth measurements, dental health, quality of life, and laboratory results.</p></div><div><h3>Results</h3><p>This systematic review included 15 articles with a total of 455 HPP patients. Asfotase alfa was predominantly administered at a dose of 6 mg per kg per week among the reviewed studies. Notable findings included enhanced survival rates, relief from musculoskeletal pain, improvements in respiratory outcomes, growth parameters, dental health, and quality of life. Changes in laboratory variables indicated positive responses to treatment, including changes such as increase in alkaline phosphatase (ALP), decline in pyridoxal 5′-phosphate (PLP) and inorganic pyrophosphate (PPi) levels.</p></div><div><h3>Conclusion</h3><p>Asfotase alfa demonstrates efficacy in improving clinical outcomes and safety in patients with HPP. Its therapeutic benefits extend across various domains. However, Larger, age-stratified comparative studies are needed to further investigate the drug's effects in HPP patients.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"188 ","pages":"Article 117219"},"PeriodicalIF":3.5,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmembrane protein 53 craniotubular dysplasia (OMIM # 619727): The skeletal disease and consequent blindness of this new disorder","authors":"Michael P. Whyte ,&nbsp;Robert S. Weinstein ,&nbsp;Paul H. Phillips ,&nbsp;William H. McAlister ,&nbsp;Raghuhr H. Ramakrishnaiah ,&nbsp;G. Bradley Schaefer ,&nbsp;Rongsheng Cai ,&nbsp;Michele R. Hutchison ,&nbsp;Shenghui Duan ,&nbsp;Gary S. Gottesman ,&nbsp;Steven Mumm","doi":"10.1016/j.bone.2024.117218","DOIUrl":"10.1016/j.bone.2024.117218","url":null,"abstract":"<div><p><em>Craniotubular dysplasia</em>, <em>Ikegawa type</em> (OMIM #619727) denotes the autosomal recessive skeletal disease identified in 2021 featuring blindness acquired in childhood. Five young members of four Indian families harbored a homozygous indel within <em>TMEM53</em> (OMIM *619722), the gene that encodes transmembrane protein 53 (TMEM53). When intact, TMEM53 spans the nuclear envelope of osteoprogenitor cells, dampens BMP-SMAD signaling, and thereby slows bone formation. Consequently, defective TMEM53 accelerates osteogenesis. Herein, an American boy is compound heterozygous for a novel deletion and a novel missense mutation within <em>TMEM53</em>. His vision and sensorineural hearing became impaired. Radiographic survey revealed diploic thickening of his skull, broad calvarial and facial bones, skeletal modeling errors, vertebral body flattening, wide ribs, and osteopenia of expanded bones. DXA areal bone density (gm/cm²) <em>Z</em>-scores were low. His optic, auditory, and spinal canals were narrow. Mineral metabolism was intact. Serum alkaline phosphatase and osteocalcin levels were normal yet CTX was high. Iliac crest histomorphometry documented accelerated bone formation. His acute vision loss briefly improved following prednisone administration, optic canal decompression, and optic nerve sheath fenestration, but then progressed despite further surgeries and zoledronate treatment aimed to suppress bone turnover. Next generation sequencing of genes associated with elevated skeletal mass, including from high bone turnover, did not suggest an etiology. Whole genome sequencing then revealed within <em>TMEM53</em>: i) a paternally transmitted 54-base deletion, which included the mRNA splice acceptor site for exon 2 as well as 31 bases of exonic sequence (c. 62-23_92del), and ii) a maternally transmitted missense variant (c.650C &gt; T, p.Ser217Leu: NM_024587.4/NP_078863.2) which is extremely rare in gnomAD (frequency = 0.000036), replaces Ser217 highly conserved across species, and is scored as damaging by SIFT and Mutation Taster. We call this new osteopathy <em>TMEM53 craniotubular dysplasia</em>.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"188 ","pages":"Article 117218"},"PeriodicalIF":3.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the biological integration of massive bone allografts: A porcine preclinical in vivo pilot-study","authors":"Robin Evrard ,&nbsp;Julie Manon ,&nbsp;Louis Maistriaux ,&nbsp;Lies Fievé ,&nbsp;Tom Darius ,&nbsp;Olivier Cornu ,&nbsp;Benoit Lengelé ,&nbsp;Thomas Schubert","doi":"10.1016/j.bone.2024.117213","DOIUrl":"10.1016/j.bone.2024.117213","url":null,"abstract":"<div><p>Critical bone loss can have several origins: infections, tumors or trauma. Therefore, massive bone allograft can be a solution for limb salvage. Such a biological reconstruction should have the ideal biomechanical qualities. However, their complication rate remains too high. Perfusion-decellularization of massive allografts could promote the vitality of these grafts, thereby improving their integration and bone remodeling.</p><p>Three perfusion-decellularized massive bone allografts were compared to 3 fresh frozen massive bone allografts in a preclinical in vivo porcine study using an orthopedic surgery model. Three pigs each underwent a critical diaphyseal femoral defects followed by an allogeneic intercalary femoral graft on their both femurs (one decellularized and one conventional fresh frozen as “native”) to reconstruct the defect. Clinical imaging was performed over 3 months of follow-up. The grafts were then explanted and examined by non-decalcified histology, fluoroscopic microscopy and immunohistochemistry.</p><p>Bone consolidation was achieved in both groups at the same time. However, the volume of bone callus appeared to be greater in the decellularized group. Histology demonstrated a superior bone remodeling in the decellularized group, with a higher number of osteoclasts (<em>p</em> &lt; 0.001) and larger areas of osteoid matrix and newly formed bone as compared to the “native” group. Immunohistochemistry showed a superior vitality and remodeling in both the cortical and medullary cavities for osteocalcin (<em>p</em> &lt; 0.001), Ki67 (p &lt; 0.001), CD3 (p &lt; 0.001) and α-SMA (p &lt; 0.001) as compared the “native” group. Three months after implantation, the decellularized grafts were proven to be biologically more active compared to native grafts. Fluoroscopic microscopy revealed more ossification fronts in the depth of the decellularized grafts (<em>p</em> = 0.021).</p><p>This pilot study provides the first in vivo demonstration on the enhanced biological capacities of massive bone allograft decellularized by perfusion as compared to conventional massive bone allografts.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"187 ","pages":"Article 117213"},"PeriodicalIF":3.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S8756328224002023/pdfft?md5=f4d635469a7fe9be7d69af1e874634c0&pid=1-s2.0-S8756328224002023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium isotope composition in serum and urine for the assessment of bone mineral balance (BMB) – The Osteolabs post-market follow-up study","authors":"A. Eisenhauer ,&nbsp;A. Hastuti ,&nbsp;A. Heuser ,&nbsp;A. Kolevica ,&nbsp;B. Brandt ,&nbsp;R. Shroff ,&nbsp;J. Oehme ,&nbsp;M. Müller","doi":"10.1016/j.bone.2024.117210","DOIUrl":"10.1016/j.bone.2024.117210","url":null,"abstract":"<div><p>To further explore the clinical applicability of the calcium (Ca) isotope marker (CIM), we determined the ⁴⁴Ca/⁴²Ca isotope ratio in blood serum and urine. This ratio is expressed in the conventional δ-notation (as defined in the text below) specifically as CIM-serum for serum and as CIM-urine for urine. Our study tested the hypothesis that CIM values can differentiate between positive and negative bone mineral balance (BMB) across a diverse clinical population considering variables such as age, gender, and diet. The threshold values (CIM-serum: −0.85 ± 0.06 ‰ and CIM-urine: 0.23 ± 0.06 ‰) established in the OsteoGeo study (<span><span>NCT02967978</span><svg><path></path></svg></span>, Eisenhauer et al., 2019) were evaluated in 2320 participants as part of a surveillance study referred to as Osteolabs study. The earlier study revealed women with osteoporosis had an average CIM-serum value of −0.91 ± 0.21 ‰ (<em>N</em> = 24) and a CIM-urine value of 0.18 ± 0.33 ‰ (<em>N</em> = 71) that are significantly below the threshold values (<em>p</em> = 0.02 for urine, one-sided Wilcoxon rank test, <em>p</em> &lt; 0.001 for serum, one-sided Student's <em>t</em>-test). Diseases affecting BMB such as osteoporosis, acute and chronic kidney disease (CKD), hyperthyroidism, breast cancer, prostate cancer, and myeloma were associated with significantly lower average CIM values, falling below the equilibrium thresholds and indicating negative BMB. In contrast, patients receiving osteoprotective treatments such as denosumab, Romosozumab, bisphosphonates, or hormone replacement therapy for certain diseases, had CIM values above the equilibrium thresholds indicating a positive BMB. Additionally, Ca supplements taken by some of the patients ((<em>N</em> = 22 (serum), <em>N</em> = 49 (urine), median dose: 500 mg) showed a Ca isotope composition approximately 1 ‰ higher than that from a normal diet. Consequently, their CIM values need to be adjusted to account for the amount and duration of supplementation to be comparable to those with a normal diet. Participants taking vitamin D (237 women; 58 men) showed no significant difference from the average values of the study group. Counterintuitively, the possible impact of malnutrition on individual BMB was most pronounced in vegans, who exhibited the highest average CIM-urine values compared to patients on a normal diet (<em>p</em> &lt; 0.001, <em>N</em> = 17). The results of this study were consistent with the registered OsteoGeo study (<span><span>NCT02967978</span><svg><path></path></svg></span>) and other earlier published Ca isotope-based studies on BMB. We confirm that the CIM threshold values determined in the OsteoGeo study are generally valid for this much larger and diverse surveillance study group covering a diverse population encompassing various medical conditions and therapies.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"188 ","pages":"Article 117210"},"PeriodicalIF":3.5,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S8756328224001996/pdfft?md5=4d82bc028ad2d3ecbd62d1953836552e&pid=1-s2.0-S8756328224001996-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmenopausal changes in cortical bone quality","authors":"E.P. Paschalis ,&nbsp;S. Gamsjaeger ,&nbsp;S. Bare ,&nbsp;R. Recker ,&nbsp;M. Akhter","doi":"10.1016/j.bone.2024.117217","DOIUrl":"10.1016/j.bone.2024.117217","url":null,"abstract":"<div><p>Bone's resistance to fracture depends on its amount and quality, the latter including its structural and material/compositional properties. Bone material properties are dependent on bone turnover rates, which are significantly elevated immediately following menopause. Previously published data reported that following menopause, the amount of organic matrix synthesized at actively forming surfaces is significantly decreased, while glycosaminoglycan content was also modulated at resorbing surfaces, in the cancellous compartment.</p><p>In the present study, we used Raman microspectroscopic analysis of paired iliac crest biopsies obtained before and shortly after menopause (1 year after cessation of menses) in healthy females to investigate changes in material/compositional properties due to menopause, in the cortical compartment. Specifically, the mineral/matrix ratio, the relative proteoglycan content, the mineral maturity/crystallinity, and the relative pyridinoline collagen cross-link content were determined at actively forming intracortical surfaces (osteons) as a function of tissue age, as well as in interstitial bone.</p><p>Results indicated that it is the freshly synthesized organic matrix content that significantly declines following menopause, in agreement with what was previously reported for the cancellous compartment. This decline was not evident in the freshly deposited mineral content. None of the compositional/quality properties were altered following menopause either. Finally, no differences in any of the monitored parameters were evident in cortical interstitial bone.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"187 ","pages":"Article 117217"},"PeriodicalIF":3.5,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AFFnet - a deep convolutional neural network for the detection of atypical femur fractures from anteriorposterior radiographs","authors":"Hanh H. Nguyen ,&nbsp;Duy Tho Le ,&nbsp;Cat Shore-Lorenti ,&nbsp;Colin Chen ,&nbsp;Jorg Schilcher ,&nbsp;Anders Eklund ,&nbsp;Roger Zebaze ,&nbsp;Frances Milat ,&nbsp;Shoshana Sztal-Mazer ,&nbsp;Christian M. Girgis ,&nbsp;Roderick Clifton-Bligh ,&nbsp;Jianfei Cai ,&nbsp;Peter R. Ebeling","doi":"10.1016/j.bone.2024.117215","DOIUrl":"10.1016/j.bone.2024.117215","url":null,"abstract":"<div><p>Despite well-defined criteria for radiographic diagnosis of atypical femur fractures (AFFs), missed and delayed diagnosis is common. An AFF diagnostic software could provide timely AFF detection to prevent progression of incomplete or development of contralateral AFFs. In this study, we investigated the ability for an artificial intelligence (AI)-based application, using deep learning models (DLMs), particularly convolutional neural networks (CNNs), to detect AFFs from femoral radiographs. A labelled Australian dataset of pre-operative complete AFF (cAFF), incomplete AFF (iAFF), typical femoral shaft fracture (TFF), and non-fractured femoral (NFF) X-ray images in anterior-posterior view were used for training (<em>N</em> = 213, 49, 394, 1359, respectively). An AFFnet model was developed using a pretrained (ImageNet dataset) ResNet-50 backbone, and a novel Box Attention Guide (BAG) module to guide the model's scanning patterns to enhance its learning. All images were used to train and internally test the model using a 5-fold cross validation approach, and further validated by an external dataset. External validation of the model's performance was conducted on a Sweden dataset comprising 733 TFF and 290 AFF images. Precision, sensitivity, specificity, F1-score and AUC were measured and compared between AFFnet and a global approach with ResNet-50. Excellent diagnostic performance was recorded in both models (all AUC &gt;0.97), however AFFnet recorded lower number of prediction errors, and improved sensitivity, F1-score and precision compared to ResNet-50 in both internal and external testing. Sensitivity in the detection of iAFF was higher for AFFnet than ResNet-50 (82 % vs 56 %). In conclusion, AFFnet achieved excellent diagnostic performance on internal and external validation, which was superior to a pre-existing model. Accurate AI-based AFF diagnostic software has the potential to improve AFF diagnosis, reduce radiologist error, and allow urgent intervention, thus improving patient outcomes.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"187 ","pages":"Article 117215"},"PeriodicalIF":3.5,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S8756328224002047/pdfft?md5=1a34ba34232ff09c6be8bab065ab4af8&pid=1-s2.0-S8756328224002047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single bout of jumping exercise does not modulate serum markers of bone formation or bone resorption throughout a 24 h period","authors":"Luuk Hilkens ,&nbsp;Judith Bons ,&nbsp;Jean Nyakayiru ,&nbsp;Luc J.C. van Loon ,&nbsp;Jan-Willem van Dijk","doi":"10.1016/j.bone.2024.117216","DOIUrl":"10.1016/j.bone.2024.117216","url":null,"abstract":"<div><h3>Introduction</h3><p>This randomized, cross-over trial assessed the effect of a single bout of high-impact exercise on serum markers of bone formation and bone resorption over a 24 h period.</p></div><div><h3>Methods</h3><p>Twenty healthy males and females performed a single bout of brief jumping exercise (EXC) or no exercise (CON), 55 min following consumption of a standard breakfast. Blood markers of bone formation (P1NP) and bone resorption (CTX-I) were assessed before (<em>t</em> = 0 h) and over a 5 h period after breakfast, and following 24 h of post-exercise recovery (<em>t</em> = 24 h).</p></div><div><h3>Results</h3><p>Serum CTX-I concentrations decreased during the 5 h postprandial period (time-effect, <em>P</em> &lt; 0.001) with no differences between conditions (time x condition, <em>P</em> = 0.14). After a ~ 16 % decline during the first 30 min following breakfast, serum P1NP concentrations gradually returned to baseline values during the 5 h postprandial period, with no differences in the overall response between conditions (time-effect, <em>P</em> &lt; 0.001; time x condition, <em>P</em> = 0.25). Fasted serum CTX-I concentrations decreased from 0.33 ± 0.15 and 0.35 ± 0.15 ng/mL at baseline, to 0.31 ± 0.13 and 0.31 ± 0.16 ng/mL at <em>t</em> = 24 h in CON and EXC, respectively, with no differences between conditions (time-effect, <em>P</em> &lt; 0.01; time x condition, <em>P</em> = 0.70). Fasted serum P1NP concentrations did not change from baseline to <em>t</em> = 24 h in both CON (baseline: 76 ± 27 ng/mL, t = 24 h: 79 ± 26 ng/mL) and EXC (baseline: 80 ± 24 ng/mL, t = 24 h: 77 ± 29 ng/mL; time-effect, <em>P</em> = 0.89), with no differences between conditions (time x condition, <em>P</em> = 0.22).</p></div><div><h3>Conclusion</h3><p>High-impact exercise does not modulate the concentrations of the serum marker of bone formation P1NP and the serum marker of bone resorption CTX-I throughout a 24 h recovery period in healthy adults.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"188 ","pages":"Article 117216"},"PeriodicalIF":3.5,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S8756328224002059/pdfft?md5=e8e75b91e72d0d93f29e42a23cd784c7&pid=1-s2.0-S8756328224002059-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of dietary, lifestyle and sociodemographic factors on calcitonin levels in a healthy population","authors":"Ivana Gunjača ,&nbsp;Mirjana Babić Leko ,&nbsp;Nikolina Pleić ,&nbsp;Ante Jurić ,&nbsp;Dubravka Brdar ,&nbsp;Vesela Torlak ,&nbsp;Marko Vuletić ,&nbsp;Ante Punda ,&nbsp;Ozren Polašek ,&nbsp;Caroline Hayward ,&nbsp;Tatijana Zemunik","doi":"10.1016/j.bone.2024.117214","DOIUrl":"10.1016/j.bone.2024.117214","url":null,"abstract":"<div><p>Calcitonin (CT), a hormone secreted by thyroid parafollicular C cells, plays a role in calcium homeostasis and bone health. Understanding the relationship between CT levels and dietary, sociodemographic, and lifestyle factors is essential for public health and hormonal balance studies. This study encompassed 3323 healthy participants from the Croatian biobank. We utilized principal component analysis (PCA) to reduce food items into dietary patterns. Regression analysis was used to investigate the relationship between CT levels and data collected through questionnaires, accounting for age and sex. CT levels exhibited sex-specific differences, with higher values observed in males. Positive associations were found between CT levels and age, body mass index (BMI), as well as weekly consumption of white and red wine mixed with water. While height and sternal notch-finger length initially correlated positively with CT levels, this relationship reversed upon adjusting for age and sex. Regarding sport activities, CT levels were significantly increased in non-participants compared to occasional sport participants (<em>p</em> = 0.043). Dietary factors yielded intriguing findings, with frequent consumption of butter, animal fat and veal associated with lower CT levels, while higher CT levels were associated with the frequent consumption of white fish, blue fish, pasta, and rice. However, no significant correlation was found between CT levels and bone mineral density (BMD), weight, or body surface area (BSA). This study highlights the complex interplay of dietary, lifestyle, and sociodemographic factors influencing CT levels. These findings suggest that a broad range of factors should be considered in hormonal balance studies, underlining their potential implications for public health.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"187 ","pages":"Article 117214"},"PeriodicalIF":3.5,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden and trends analysis of malignant neoplasm of bone and articular cartilage from 1990 to 2021: A systematic analysis for the Global Burden of Disease Study 2021","authors":"Jianqiang Lai,&nbsp;Xianmin Li,&nbsp;Wei Liu,&nbsp;Qian Liufu,&nbsp;Chengfan Zhong","doi":"10.1016/j.bone.2024.117212","DOIUrl":"10.1016/j.bone.2024.117212","url":null,"abstract":"<div><h3>Background</h3><p>Malignant neoplasm of bone and articular cartilage (MNBAC) is one of the causes of cancer-related deaths worldwide. To date, there is a lack of detailed studies on the disease burden of MNBAC.</p></div><div><h3>Methods</h3><p>Data on the incidence, mortality, and disability-adjusted life years (DALYs) of MNBAC from 1990 to 2021 were obtained from the Global Burden of Disease study. We estimated the trends in the burden of MNBAC by calculating the estimated annual percentage change (EAPC) in age-standardized rates by region, country, and social development index.</p></div><div><h3>Results</h3><p>Globally, the cases of incidence and deaths of MNBAC showed a significant upward trend. In 2021, the global incidence cases of MNBAC were 91,375.1 (73,780.4–102,469.7), and the number of deaths was 66,114.3 (53,305.4–74,466.9). The age-standardized incidence, mortality, and DALYs rates were all on the rise, with EAPCs of 0.59 (0.51 to 0.68), 0.11 (0.02 to 0.21), and 0.08 (0 to 0.17), respectively. In 2021, China had the highest number of incidence cases and deaths. Two peaks in incidence cases and deaths were observed in the 15–19 and 65–69 age groups, with incidence rates and death rates generally increasing with age, and higher in males than females. The region with the highest incidence cases, deaths, and age-standardized incidence rate was East Asia, while Eastern Sub-Saharan Africa had the highest age-standardized mortality, and DALYs rates.</p></div><div><h3>Conclusion</h3><p>From 1990 to 2021, the global burden of MNBAC has continued to increase, particularly in East Asia, which faces the highest number of incidence cases and deaths, while Eastern Sub-Saharan Africa faces the highest ASMR and ASDR. To mitigate this burden, different regions should develop cancer control actions based on their respective epidemiological characteristics, with a focus on the elderly and adolescents, and control of risk factors.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"188 ","pages":"Article 117212"},"PeriodicalIF":3.5,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}