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Pulmonary function prediction in lung cancer resection candidates: the latest insights. 肺癌切除候选人肺功能预测：最新见解。
IF 2.3
Breathe Pub Date : 2025-07-15 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0041-2025
Riccardo Orlandi, Sara Degiovanni, Clarissa Uslenghi, Asia Anghinelli, Paola Besana, Alessandro Palleschi
{"title":"Pulmonary function prediction in lung cancer resection candidates: the latest insights.","authors":"Riccardo Orlandi, Sara Degiovanni, Clarissa Uslenghi, Asia Anghinelli, Paola Besana, Alessandro Palleschi","doi":"10.1183/20734735.0041-2025","DOIUrl":"10.1183/20734735.0041-2025","url":null,"abstract":"<p><p>Surgical resection remains the most effective curative option for early-stage nonsmall cell lung cancer (NSCLC) in fit patients. However, many individuals with NSCLC have comorbidities that elevate surgical risks and complicate postoperative recovery. These challenges necessitate thorough preoperative assessments to evaluate patient suitability and predict postoperative lung function. Pulmonary function tests (PFTs) and imaging modalities, including computed tomography (CT), ventilation-perfusion scintigraphy and ultrasound, are integral to these evaluations. Advances in technology, such as ventilation and perfusion single-photon emission computed tomography (SPECT)/CT, quantitative CT and magnetic resonance imaging (MRI) techniques, have enhanced the accuracy of postoperative predictions, offering valuable insights into respiratory mechanics and regional lung function. Despite these advancements, no comprehensive evaluation exists to establish the reliability of various prediction methods. This review explores the role of traditional and emerging preoperative tools in assessing lung resection candidates, emphasising their contributions to clinical decision-making. By improving the precision of postoperative lung function predictions, these tools not only optimise surgical outcomes but also support shared decision-making, balancing risks and patient preferences. Further refinement and integration of these methods promises to enhance the management of high-risk patients and advance the standard of care in thoracic surgery.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 3","pages":"250041"},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pathogenesis of bronchopulmonary dysplasia: "It is never the heart, it is always the lung" - myth or maxim? 支气管肺发育不良的发病机制：“不是心的问题，总是肺的问题”——是神话还是格言？
IF 2.3
Breathe Pub Date : 2025-07-15 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0102-2024
Alice Hadchouel, Christophe Delacourt
{"title":"The pathogenesis of bronchopulmonary dysplasia: \"It is never the heart, it is always the lung\" - myth or maxim?","authors":"Alice Hadchouel, Christophe Delacourt","doi":"10.1183/20734735.0102-2024","DOIUrl":"10.1183/20734735.0102-2024","url":null,"abstract":"<p><p>\"This is not the heart; this is the lung.\" Who among paediatric pulmonologists has never faced this situation with a cardiologist? Joking aside, discussions for some cases may be tricky and our common ultimate goal is always to provide the best care to the patients and their families. In this review, we will focus on the links between the heart, or more widely the cardiovascular system, and bronchopulmonary dysplasia, in order to determine if this quote is a myth or a maxim.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 3","pages":"240102"},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interventional pulmonology. 介入肺学。
IF 2.3
Breathe Pub Date : 2025-07-15 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0231-2025
Imran Sulaiman
{"title":"Interventional pulmonology.","authors":"Imran Sulaiman","doi":"10.1183/20734735.0231-2025","DOIUrl":"https://doi.org/10.1183/20734735.0231-2025","url":null,"abstract":"<p><p><b>This issue of <i>Breathe</i> focuses on interventional pulmonology</b> https://bit.ly/4ef45Lm.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 3","pages":"250231"},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung implantable devices: the issue with granulation tissue. 肺植入式装置：肉芽组织的问题。
IF 2.3
Breathe Pub Date : 2025-07-15 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0243-2024
Akash Gupta, Dirk-Jan Slebos, Simon D Pouwels
{"title":"Lung implantable devices: the issue with granulation tissue.","authors":"Akash Gupta, Dirk-Jan Slebos, Simon D Pouwels","doi":"10.1183/20734735.0243-2024","DOIUrl":"10.1183/20734735.0243-2024","url":null,"abstract":"<p><p>After decades of development and experience, lung implantable devices have proven to be invaluable in the management of respiratory diseases and complications. Unfortunately, granulation tissue hyperplasia remains a common and challenging complication, compromising implant function through obstruction, migration and increased susceptibility to infection, ultimately requiring frequent reinterventions. Reinterventions often involve bronchoscopy for tissue debulking or device replacement, all of which significantly affect patient wellbeing and healthcare resources. Granulation tissue hyperplasia results from an imbalance in the interactions between the host and the implant. While most patients achieve implant integration, persistent stressors cause chronic inflammation leading to granulation tissue hyperplasia. While several studies have provided insights, the disease endotype remains largely undefined. Variability in incidence and severity across devices and patient populations complicates characterisation. Surface factors, including implant material, adsorbed proteins and the colonising microorganisms, as well as geometrical and biomechanical mismatches with the airways may contribute to pathological tissue responses. Future research aimed at gaining a fundamental understanding of the stressors and biological mechanisms driving granulation tissue hyperplasia is essential for preventing and treating this complication. Ultimately, the goal is to reduce morbidity and improve the longevity of implants and treatment benefit.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 3","pages":"240243"},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mediastinal staging of nonsmall cell lung cancer: what's new? 非小细胞肺癌的纵隔分期：有什么新进展？
IF 2.3
Breathe Pub Date : 2025-07-15 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0191-2023
Claire Bradley, Nuria Novoa, Laura Riva, Sophia Lampaki, Sara Ricciardi, Michael Rovanias, Malek Chaabouni, Richard Turner, Antonia Zachariou, Georgia Hardavella, Neal Navani
{"title":"Mediastinal staging of nonsmall cell lung cancer: what's new?","authors":"Claire Bradley, Nuria Novoa, Laura Riva, Sophia Lampaki, Sara Ricciardi, Michael Rovanias, Malek Chaabouni, Richard Turner, Antonia Zachariou, Georgia Hardavella, Neal Navani","doi":"10.1183/20734735.0191-2023","DOIUrl":"10.1183/20734735.0191-2023","url":null,"abstract":"<p><p>In this review, we explore the importance of accurate mediastinal staging in nonsmall cell lung cancer, which directly impacts management options and prognosis. We outline the various means of staging, including radiological and interventional techniques, with a focus on the advantages and limitations of the different approaches. The review also identifies ways in which mediastinal staging has changed over time, particularly with the advent of effective endoscopic nodal sampling, and how emerging research and developments may lead to further adjustments in clinical practice. The role of multidisciplinary decision making, particularly in complex cases, remains integral to the process of mediastinal staging in lung cancer.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 3","pages":"230191"},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The latest in the management of pulmonary embolism. 肺栓塞治疗的最新进展。
IF 2.3
Breathe Pub Date : 2025-06-17 eCollection Date: 2025-04-01 DOI: 10.1183/20734735.0100-2024
Eugene Yuriditsky, Robert S Zhang, Tania Ahuja, Sripal Bangalore, James M Horowitz
{"title":"The latest in the management of pulmonary embolism.","authors":"Eugene Yuriditsky, Robert S Zhang, Tania Ahuja, Sripal Bangalore, James M Horowitz","doi":"10.1183/20734735.0100-2024","DOIUrl":"10.1183/20734735.0100-2024","url":null,"abstract":"<p><p>Therapeutic anticoagulation is the mainstay therapy in acute pulmonary embolism (PE), however, select patients benefit from emergent reperfusion to prevent or rescue acute right ventricular failure and haemodynamic collapse. Compared to other leading causes of cardiovascular mortality such as myocardial infarction and stroke, there is a substantial paucity of literature informing on advanced therapies in PE. Recent years have seen significant evolution in the armamentarium available for PE care with the uptake of several endovascular treatment modalities and increased use of mechanical circulatory support. While several ongoing randomised controlled trials may alter the therapeutic landscape and approach to PE management, at present, we are left with multiple selections with limited guidance. In this review, we discuss the latest therapeutic options available for acute PE and offer an approach to their implementation.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 2","pages":"240100"},"PeriodicalIF":2.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connective tissue disease-associated interstitial lung disease: a rheumatologist's perspective. 结缔组织病相关间质性肺病：风湿病学家的观点
IF 2.3
Breathe Pub Date : 2025-06-17 eCollection Date: 2025-04-01 DOI: 10.1183/20734735.0166-2024
Áine Connerton, Eoghan McCarthy, Laura Durcan
{"title":"Connective tissue disease-associated interstitial lung disease: a rheumatologist's perspective.","authors":"Áine Connerton, Eoghan McCarthy, Laura Durcan","doi":"10.1183/20734735.0166-2024","DOIUrl":"10.1183/20734735.0166-2024","url":null,"abstract":"<p><p>Pulmonary involvement is common in patients with underlying autoimmune and connective tissue diseases (CTDs) and can encompass a broad spectrum of disorders involving the airways, pleura, parenchyma, vascular system, bronchiectasis and nodules with significant overlap in these pathologies. Interstitial lung disease (ILD) is the most common pulmonary manifestation of systemic autoimmune rheumatic diseases and CTDs. Particular diseases, such as systemic sclerosis, rheumatoid arthritis and inflammatory myopathies, frequently associate with ILD and high-risk patients should be screened. Antibody profiling and imaging characteristics should be used to prognosticate where possible, along with regular surveillance to ensure therapies are optimised. Immunosuppressive therapies can be effective for patients with CTD-associated ILD, but difficulties arise in distinguishing between treatment failures and complications of immunosuppression.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 2","pages":"240166"},"PeriodicalIF":2.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accelerate your career: the power of the ERS interstitial lung disease mentorship programme. 加速你的职业生涯：ERS间质性肺病指导规划的力量。
IF 2.3
Breathe Pub Date : 2025-06-17 eCollection Date: 2025-04-01 DOI: 10.1183/20734735.0147-2025
Catharina C Moor, Laura Fabbri, Namrata Kewalramani, Karol Bączek, Nazia Chaudhuri, Heleen Demeyer, Michael Kreuter
{"title":"Accelerate your career: the power of the ERS interstitial lung disease mentorship programme.","authors":"Catharina C Moor, Laura Fabbri, Namrata Kewalramani, Karol Bączek, Nazia Chaudhuri, Heleen Demeyer, Michael Kreuter","doi":"10.1183/20734735.0147-2025","DOIUrl":"10.1183/20734735.0147-2025","url":null,"abstract":"<p><p><b>Assembly 12 has developed an online and onsite mentoring programme for early career members. This article discusses the content of the programme, experiences from mentees and mentors and future plans.</b> https://bit.ly/4iGBr6G.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 2","pages":"250147"},"PeriodicalIF":2.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connective tissue disease-related interstitial lung disease and pulmonary hypertension. 结缔组织病相关间质性肺病和肺动脉高压。
IF 2.3
Breathe Pub Date : 2025-06-17 eCollection Date: 2025-04-01 DOI: 10.1183/20734735.0173-2024
Caroline Motschwiller, David Morales, Roxana Sulica
{"title":"Connective tissue disease-related interstitial lung disease and pulmonary hypertension.","authors":"Caroline Motschwiller, David Morales, Roxana Sulica","doi":"10.1183/20734735.0173-2024","DOIUrl":"10.1183/20734735.0173-2024","url":null,"abstract":"<p><p>Pulmonary hypertension (PH) is an important cause of morbidity and mortality in connective tissue diseases (CTDs) and may develop either in isolation or in combination with interstitial lung disease (ILD). Based on the World Health Organization PH classification into five groups, patients with CTDs typically belong either to group 1 pulmonary arterial hypertension or to group 3 PH due to chronic lung disease and hypoxaemia (PH-ILD). Recent epidemiological studies have delineated the phenotypical complexity of CTD patients who present with both PH and ILD. This review explores the prevalence, diagnosis, pathophysiology, survival and management strategies for CTD-ILD-PH.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 2","pages":"240173"},"PeriodicalIF":2.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of breathlessness: a cardiologist's perspective. 呼吸困难的评估：心脏病专家的观点。
IF 2.3
Breathe Pub Date : 2025-06-17 eCollection Date: 2025-04-01 DOI: 10.1183/20734735.0097-2024
Brídóg Nic Aodha Bhuí, Eoin Fahy
{"title":"Assessment of breathlessness: a cardiologist's perspective.","authors":"Brídóg Nic Aodha Bhuí, Eoin Fahy","doi":"10.1183/20734735.0097-2024","DOIUrl":"10.1183/20734735.0097-2024","url":null,"abstract":"<p><p>\"Breathlessness\" or dyspnoea is a common, subjective symptom that can be multifactorial. It is a frequent complaint encountered by cardiologists, both in the outpatient and inpatient clinical setting. It requires a comprehensive clinical evaluation including accurate history taking and pursuing appropriate clinical investigations. It is imperative to distinguish cardiac causes of dyspnoea from other causes, including pulmonary, neurological and other systemic conditions. In this review we attempt to summarise the approach to the evaluation of dyspnoea.</p>","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 2","pages":"240097"},"PeriodicalIF":2.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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