IF 3.4

Breathe Pub Date : 2025-08-19 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0255-2024

Martina Sterclova, Martina Doubkova, Michael Doubek, Milan Macek

{"title":"The necessity of geneticist and pulmonologist collaboration in the treatment of monogenic interstitial lung diseases in adults.","authors":"Martina Sterclova, Martina Doubkova, Michael Doubek, Milan Macek","doi":"10.1183/20734735.0255-2024","DOIUrl":"10.1183/20734735.0255-2024","url":null,"abstract":"Interstitial lung diseases (ILDs) are a very heterogeneous group of diseases. Although the aetiology of many of these diseases is not fully understood, an association with specific pathogenic gene variants has been demonstrated for some of the diseases. The aim of this review is to provide genotype-phenotype correlation information on monogenic ILDs to provide guidance to pulmonologists on when to refer ILD patients for genetic testing. Most patients with monogenic ILDs suffer from multiorgan involvement and should be managed by a multidisciplinary team of specialists. Different syndromes are associated with a greater risk of (nonrespiratory) malignancies (Birt-Hogg-Dubé syndrome and telomeropathies). Isolated lung involvement has been described in surfactant-related gene variant carriers (SFTPA 1 and 2, SFTPC) and patients with pulmonary alveolar microlithiasis. The clinical suspicion of monogenic ILDs should be raised in young patients diagnosed with ILD, patients with a known family history of ILD or suspected telomeropathies, and patients suspected of having syndromes associated with ILD. Patients with suspected monogenic ILDs should be aware of the possibility of genetic counselling both to obtain a diagnosis and to select further follow-up by pulmonologists and other involved specialists. Raising awareness of monogenic ILDs and creating counselling platforms is necessary both to diagnose and manage patients with these rare diseases.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 3","pages":"240255"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

More than the method: contrasting experiences of compassion in interventional pulmonology. 不仅仅是方法：对比介入性肺科同情心的经验。

IF 3.4

Breathe Pub Date : 2025-08-19 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0189-2025

Justine Hamaide, Lucy Robinson

引用次数: 0

Multidisciplinary collaboration is key to advancement in respiratory medicine! Interview with the ECM award winner 2024. 多学科合作是呼吸医学进步的关键！采访2024年ECM奖得主。

IF 3.4

Breathe Pub Date : 2025-08-19 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0148-2025

Emily Hume, Viresh Jagesar, Job F M van Boven, Mathieu Marillier, Heleen Demeyer

引用次数: 0

Applications of positive expiratory pressure in spontaneous breathing: why, when and how? 呼气正压在自主呼吸中的应用：为什么、何时以及如何应用？

IF 3.4

Breathe Pub Date : 2025-08-19 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0164-2025

Monika Fagevik Olsén, Maria Sehlin, Jenny Danielsbacka, Malin Nygren-Bonnier, Anna Svensson-Raskh, Elisabeth Westerdahl, Louise Lannefors

{"title":"Applications of positive expiratory pressure in spontaneous breathing: why, when and how?","authors":"Monika Fagevik Olsén, Maria Sehlin, Jenny Danielsbacka, Malin Nygren-Bonnier, Anna Svensson-Raskh, Elisabeth Westerdahl, Louise Lannefors","doi":"10.1183/20734735.0164-2025","DOIUrl":"10.1183/20734735.0164-2025","url":null,"abstract":"In spontaneously breathing patients, breathing exercises with positive expiratory pressure (PEP) can be used in various physiological ways to reopen closed airways by increasing the functional residual capacity (FRC) in hypoventilating patients, handle dyspnoea by decreasing the FRC, or reopen clogged airways and maintain an expiratory flow at low lung levels as part of airway clearance therapy. To make the most out of the treatment, the caregiver needs to know the pathophysiology and desired physiological effect of the treatment plan. This article presents the background of the application of PEP and gives information about frequently asked clinical questions. Based on this knowledge, individual prescriptions should be given to each patient including correct instruction and training on how to use PEP and how to adjust when the situation/condition changes. If daily long-term treatment is recommended, the patient needs regular return visits to monitor the effectiveness and evaluate it together with the patient, and to re-educate the patient as soon as needed.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 3","pages":"250164"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 53-year-old woman with necrotising myopathy presenting with cough and respiratory distress: a diagnostic conundrum. 53岁女性坏死性肌病表现为咳嗽和呼吸窘迫：诊断难题。

IF 3.4

Breathe Pub Date : 2025-08-19 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0009-2025

Pinakjyoti Das, Prajwala Gupta, Desh Deepak, Kumari Archana, Ashish Kumar Duggal

引用次数: 0

Liquid biopsy in lung cancer. 肺癌的液体活检。

IF 3.4

Breathe Pub Date : 2025-08-19 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0051-2025

Sile Toland, Padraic Ridge, Emmet O'Brien, Ross Morgan, Sinead Toomey, Bryan T Hennessy, Daniel J Ryan

{"title":"Liquid biopsy in lung cancer.","authors":"Sile Toland, Padraic Ridge, Emmet O'Brien, Ross Morgan, Sinead Toomey, Bryan T Hennessy, Daniel J Ryan","doi":"10.1183/20734735.0051-2025","DOIUrl":"10.1183/20734735.0051-2025","url":null,"abstract":"Lung cancer is the leading cause of cancer-related mortality worldwide, with nonsmall cell lung cancer (NSCLC) accounting for the majority of cases. Despite advancements in therapeutics, outcomes remain poor due to late-stage diagnoses and the molecular complexity of the disease. Liquid biopsy, a minimally invasive diagnostic approach, has emerged as a potentially transformative tool in lung cancer. The detection of tumour-derived biomarkers, such as circulating-tumour DNA, circulating tumour cells and exosomes, can be analysed for molecular profiling, early detection and monitoring of disease progression. There have been significant advancements of liquid biopsy technologies, such as next-generation sequencing and droplet digital PCR, that identify actionable mutations, detect resistance mechanisms and improve therapeutic outcomes. While there are still challenges like detecting early-stage disease and the risk of false positives, the combination of multi-omics data and artificial intelligence has the potential for more personalised and precise cancer treatments. Liquid biopsy represents a paradigm shift in the early detection and personalised treatment of lung cancer, offering significant potential to improve patient outcomes.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 3","pages":"250051"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and deployment of robots in a bronchoscopy suite. 支气管镜检查套件中机器人的开发和部署。

IF 2.3

Breathe Pub Date : 2025-07-15 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0247-2024

Irene Riestra Guiance, Christopher Kapp

引用次数: 0

Present and future of paediatric interventional pulmonology: addressing global healthcare disparities. 儿科介入肺脏学的现在和未来：解决全球医疗保健差距。

IF 2.3

Breathe Pub Date : 2025-07-15 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0239-2024

Dirk Schramm, Nor Diyana Ismail

{"title":"Present and future of paediatric interventional pulmonology: addressing global healthcare disparities.","authors":"Dirk Schramm, Nor Diyana Ismail","doi":"10.1183/20734735.0239-2024","DOIUrl":"10.1183/20734735.0239-2024","url":null,"abstract":"Paediatric interventional pulmonology has evolved significantly since the introduction of flexible bronchoscopy in the 1970s, transforming the diagnosis and treatment of paediatric respiratory conditions. This review examines the current state and future directions of the field, emphasising the unique challenges in paediatric airways that necessitate specialised knowledge, instruments and expertise. Recent technological advances in bronchoscopy have expanded both diagnostic and therapeutic capabilities, enabling precise, minimally invasive procedures tailored to paediatric needs. These include airway dilation, stenting, cryotherapy, electrocautery, laser therapy and advanced imaging techniques such as endobronchial ultrasound (EBUS) and robotic navigation systems. However, significant global healthcare disparities persist in access to paediatric bronchoscopy services. While high-income countries offer comprehensive diagnostic and therapeutic capabilities, resource-limited settings face substantial gaps despite often having a higher burden of respiratory diseases, particularly tuberculosis. The review addresses implementation strategies for establishing bronchoscopy services in various resource settings and proposes innovative educational approaches for developing sustainable international training programmes. Future development of the field requires coordinated international efforts, including establishing robust networks between centres, increased funding support and addressing regulatory barriers to facilitate knowledge exchange. The advancement of paediatric interventional pulmonology as a distinct subspecialty, supported by standardised training pathways and international collaboration, is essential for ensuring optimal care for children with complex airway disorders worldwide.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 3","pages":"240239"},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indwelling pleural catheters and medical thoracoscopy. 留置胸膜导管和内科胸腔镜。

IF 2.3

Breathe Pub Date : 2025-07-15 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0251-2024

Valentina Luzzi, Anna L Lindahl, Sara Tomassetti

引用次数: 0

Fire: argon plasma coagulation, diathermy and laser. 火：氩等离子凝固、透热和激光。

IF 2.3

Breathe Pub Date : 2025-07-15 eCollection Date: 2025-07-01 DOI: 10.1183/20734735.0246-2024

Henny Azmanov, Fares Darawshy

{"title":"Fire: argon plasma coagulation, diathermy and laser.","authors":"Henny Azmanov, Fares Darawshy","doi":"10.1183/20734735.0246-2024","DOIUrl":"10.1183/20734735.0246-2024","url":null,"abstract":"Interventional pulmonology offers a range of minimally invasive techniques to manage airway pathologies, including central airway obstruction. This review examines three commonly used hot ablation therapies: argon plasma coagulation (APC), diathermy and laser. These modalities play a crucial role in treating intrinsic central airway obstruction caused by both benign and malignant conditions, as well as managing haemoptysis by achieving effective haemostasis. APC is a non-contact technique that delivers ionised argon gas to coagulate tissue, making it useful for superficial lesions and bleeding. Diathermy applies high-frequency electric currents through direct tissue contact, allowing tumour debulking, resection and coagulation. Laser therapy is most commonly non-contact and uses the heat produced for cutting and coagulation. These techniques can be used independently or in combination with other bronchoscopy techniques, such as cryotherapy or mechanical debulking. While these procedures are widely available and generally safe, their use must be guided by patient factors, lesion location and risk of complications. Understanding their indications, contraindications and safety considerations is essential for optimising patient outcomes. This review provides a perspective on technique selection, safety considerations and procedural nuances.","PeriodicalId":9292,"journal":{"name":"Breathe","volume":"21 3","pages":"240246"},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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