International journal of immunology and immunotherapy最新文献_第2页

Eosinophil Levels in Blood of COVID-19 Patient’s VS Seasonal Allergy COVID-19患者血嗜酸性粒细胞水平与季节性过敏的比较

International journal of immunology and immunotherapy Pub Date : 2022-01-01 DOI: 10.11648/j.iji.20221001.13

Taha Luqman Bilgrami, H. Saleem

引用次数: 0

The Effect of cART on Platelets/Lymphocytes Ratio and Viral Load Indices in HIV+ Subjects Initiating Therapy in a Tertiary Hospital in Port Harcourt, Nigeria cART对在尼日利亚哈科特港一家三级医院开始治疗的HIV+患者的血小板/淋巴细胞比率和病毒载量指数的影响

International journal of immunology and immunotherapy Pub Date : 2022-01-01 DOI: 10.11648/j.iji.20221001.12

Beatrice Wobiarueri Moore-Igwe, Ransom Baribefii Jacob, Serekara Gideon Christian, Evelyn Mgbeoma, Eze

引用次数: 0

A Review of Essential Microelements in the Immune System 免疫系统必需微量元素研究进展

International journal of immunology and immunotherapy Pub Date : 2022-01-01 DOI: 10.11648/j.iji.20221001.11

Ionut-Iulian Lungu, Ioana Babarus, Liliana Oniciuc, A. Stefanache

引用次数: 4

Understanding the Role of Lymphocytes in Vitiligo 了解淋巴细胞在白癜风中的作用

International journal of immunology and immunotherapy Pub Date : 2021-12-31 DOI: 10.23937/2378-3672/1410060

Awad Sherif S, Tadros Enas

引用次数: 2

A Fatal Case of Systemic Lupus Erythematosus Complicated with Diffuse Alveolar Hemorrhage 系统性红斑狼疮并发弥漫性肺泡出血1例死亡

International journal of immunology and immunotherapy Pub Date : 2021-10-28 DOI: 10.11648/J.IJI.20210904.11

P. Karunathilake, R. Jayasinghe, T. Jayalath, S. Abeyagunawardena, U. Ralapanawa

{"title":"A Fatal Case of Systemic Lupus Erythematosus Complicated with Diffuse Alveolar Hemorrhage","authors":"P. Karunathilake, R. Jayasinghe, T. Jayalath, S. Abeyagunawardena, U. Ralapanawa","doi":"10.11648/J.IJI.20210904.11","DOIUrl":"https://doi.org/10.11648/J.IJI.20210904.11","url":null,"abstract":"Introduction: SLE is a multisystem autoimmune disease with variable clinical presentation. DAH is a rare but catastrophic manifestation of SLE with high mortality, requiring early, intensive therapy. Case Presentation: A 31-year-old female presented with low-grade fever and joint pains for six weeks associated with alopecia, anorexia, and weight loss. She had pale and had cervical lymphadenopathy, moderate hepatomegaly, and splenomegaly. Hb level was 9.2mg/dL, with a platelet count of 144 × 103/µL. The ESR was 65mm/hour, and the CRP level was 36 mg/L with a UPCR of 332mg/g. She had low C3, C4 levels, positive ANA, and dsDNA titer. A renal biopsy revealed class 3 lupus nephritis. Twenty days after, she was readmitted with acute onset of pleuritic chest pain, cough, and dyspnea, where she was hemodynamically unstable with SpO2 of 85% on air. The Hb level was 8.6 g/dL with a platelet count of 106 × 103/µL. Her condition deteriorated despite standard medical care, where the Hb level and SpO2 dropped to 5.6 d/dL and 65%, respectively, even after blood transfusions, intubation, and artificial ventilation. The chest X-ray revealed bilateral large whitish hazy shadows, and the HRCT scan revealed diffuse bilateral pulmonary hemorrhages. Then she was transferred to the ICU, and there she was started with broad-spectrum antibiotics, methylprednisolone, and plasmapheresis. However, after one week of ICU stay, her renal functions worsened, and she was initiated on CRRT. However, despite all the resuscitation efforts, she succumbed following a cardiac arrest. Conclusion: DAH is a rare catastrophic complication of SLE, which usually presents in patients with an established diagnosis of SLE, even on medical therapy. The diagnosis of DAH is problematic because it mimics a severe pulmonary infection. Early detection and aggressive management are warranted to improve affected patients' outcomes and quality of life.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85353055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Recurrence/Refractory Mediastinal Hodgkin's Lymphoma Relapsed After Allogeneic Hematopoietic Stem Cell Transplantation: Immunotherapy Brings Hope 异基因造血干细胞移植后复发/难治性纵隔霍奇金淋巴瘤1例:免疫治疗带来希望

International journal of immunology and immunotherapy Pub Date : 2021-09-26 DOI: 10.11648/J.IJI.20210903.13

JiaXin Wang, Jiaxiong Tan, Yuhong Lu

{"title":"A Case of Recurrence/Refractory Mediastinal Hodgkin's Lymphoma Relapsed After Allogeneic Hematopoietic Stem Cell Transplantation: Immunotherapy Brings Hope","authors":"JiaXin Wang, Jiaxiong Tan, Yuhong Lu","doi":"10.11648/J.IJI.20210903.13","DOIUrl":"https://doi.org/10.11648/J.IJI.20210903.13","url":null,"abstract":"Hodgkin lymphoma (HL), is a B-cell lymphoma. HL is a common hematological malignancy, mostly seen in young and middle-aged people. According to NCCN guidelines, common treatment options include ABVD, BEACOPP, StandfordV, etc. Most HL have a good prognosis and even can be cured. However, some Refractory / Recurrent (R/R) HL, continue to progress during treatment or even relapse after the completion of a complete chemotherapy course 3 months. At this time, the best treatment for R/R HL is high-dose chemotherapy / Autologous Hematopoietic Stem Cell Transplantation (HDC/HSCT). This paper reports a case of Recurrence/Refractory (R/R) mediastinal Hodgkin's lymphoma that relapsed after Allogeneic Hematopoietic Stem Cell Transplantation. After receiving a variety of treatments, including chemotherapy, radiotherapy, autologous hematopoietic stem cell transplantation and so on, no long-term sustained remission was achieved. Traditional chemotherapy regimen has not brought ideal therapeutic effect to patients, but the rapid development of immunotherapy in recent years has brought new hope to patients. Finally sustained remission was achieved under the treatment of Brentuximab Vedotin combined with PD-1 inhibitor. This paper combined with the literature reports and discussed the clinical characteristics, treatment process and related experience and thinking methods of immunotherapy related to PD-1 inhibitors in this refractory and easy-to-relapse case. To provide more clinical data for the application of immunotherapy in R/R HL.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82734889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Treatment for Multiple Myeloma: Immune Checkpoint Inhibitors 多发性骨髓瘤的潜在治疗:免疫检查点抑制剂

International journal of immunology and immunotherapy Pub Date : 2021-09-26 DOI: 10.11648/J.IJI.20210903.14

JiaXin Wang, Jiaxiong Tan, Yuhong Lu

{"title":"Potential Treatment for Multiple Myeloma: Immune Checkpoint Inhibitors","authors":"JiaXin Wang, Jiaxiong Tan, Yuhong Lu","doi":"10.11648/J.IJI.20210903.14","DOIUrl":"https://doi.org/10.11648/J.IJI.20210903.14","url":null,"abstract":"Multiple myeloma (MM) is a malignant disease in which monoclonal plasma cells proliferate abnormally. The poor prognosis of MM is always closely related to the immunosuppression of T cells. Restore the immune function of suppressed T cells may reverse the immunodeficiency in the MM microenvironment and improve prognosis. In recent years, immunosuppressive receptors such as programmed cell death receptor-1 (PD-1), T cells immunoglobulin and ITIM domain (TIGIT), Lymphocyte-Activation Gene-3 (LAG-3), T cell immunoglobulin and mucin domain–containing molecule 3 (Tim-3), Leukocyte immunoglobulin-like receptor B1 (LILRB1) and Cytotoxic T- lymphocyte antigen 4 (CTLA-4) have been discovered playing a key role in the tumor immunodeficiency microenvironment. For patients with solid tumors and some leukemia, immunotherapy targeting such receptors can significantly improve the T cells immunodeficiency. However, similar positive results were not found in MM patients, which is related to the complex immunosuppressive mechanism. At present, the understanding of immunosuppressive receptors in MM is insufficient. In this review, this paper summarized part of the studies on PD-1, TCLA-4, Tim-3, TIGIT and other popular immunosuppressive receptors in MM, in order to attract more attention, and in-depth research on the immunotherapy also to promote the immunotherapy of MM from basic research to clinical transformation as soon as possible.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88627876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Regulatory Effect of ERK1 Pathway in the DNA Hypomethylation of MRL/lpr Mice ERK1通路在MRL/lpr小鼠DNA低甲基化中的调控作用

International journal of immunology and immunotherapy Pub Date : 2021-08-18 DOI: 10.11648/J.IJI.20210903.11

Miao-xuan Luo, Shanshan Wei, X. Mi, Tang‐de Zhang, Wu Zhang

{"title":"The Regulatory Effect of ERK1 Pathway in the DNA Hypomethylation of MRL/lpr Mice","authors":"Miao-xuan Luo, Shanshan Wei, X. Mi, Tang‐de Zhang, Wu Zhang","doi":"10.11648/J.IJI.20210903.11","DOIUrl":"https://doi.org/10.11648/J.IJI.20210903.11","url":null,"abstract":"Background: Defective ERK1 activity may regulate the DNA hypomethylation in T cells of lupus mice. Aims: To investigate the function of ERK1 in regulating DNA hypomethylation and explore the potential molecular mechanisms involved in lupus mice. Methods: CD4+T cells were isolated from MRL/lpr and BALB/c mice, activated in vitro in the presence or absence of 5-azacytidine (5-Aza) (a DNA methyltransferase inhibitor)/U0126 (a selective inhibitor of the ERK signaling pathway) respectively. The positive rate of CD4+T cell was measured by flow cytometry, and expression levels of CD70, ERK1, DNA transferase 1 (DNMT1) were estimated by RT-PCR and Western blot. The methylated DNA is detected using the Capture and Detection antibodies, then quantified colorimetrically. Results: The expression level of p-ERK1 in MRL/lpr mice was significantly lower than healthy control (P<0.05); Meanwhile, down regulation of DNMT1 and DNA hypomethylation were found in MRL/lpr mice T cells. In contrary, the expression levels of CD70 increased when compared with healthy control (P<0.05). The same changes were seen in healthy CD4+T cells treated with U0126. Conclusions: DNA hypomethylation regulating mechanisms in lupus T cells were associated with ERK1 signal pathway. U0126 could inhibit ERK1 signal transduction pathway in normal T cells, and induce DNA hypomethylation by regulating the expression of methylation sensitive gene CD70.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86713824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical Relevance of Antiphospholipid Antibodies Levels During the Course of Severe COVID-19 重症COVID-19过程中抗磷脂抗体水平的临床相关性

International journal of immunology and immunotherapy Pub Date : 2021-05-14 DOI: 10.11648/J.IJI.20210902.13

S. Nachate, Mahassine Moukaouim, L. Darfaoui, Z. Nassiri, I. Ibrahim, H. Rebahi, H. Chichou, A. Hachimi, M-A Semkaoui, R. Hazime, Lamiae Essaadouni, Brahim Admou

{"title":"Clinical Relevance of Antiphospholipid Antibodies Levels During the Course of Severe COVID-19","authors":"S. Nachate, Mahassine Moukaouim, L. Darfaoui, Z. Nassiri, I. Ibrahim, H. Rebahi, H. Chichou, A. Hachimi, M-A Semkaoui, R. Hazime, Lamiae Essaadouni, Brahim Admou","doi":"10.11648/J.IJI.20210902.13","DOIUrl":"https://doi.org/10.11648/J.IJI.20210902.13","url":null,"abstract":"The aim of this study was to determine the clinical significance of antiphospholipid antibodies (APLs) during the follow-up of nine severe COVID-19 patients admitted to the Intensive Care Unit of the University Hospital. The measurement of APLs (IgG and IgM anti-cardiolipin (aCL) and anti-β2-glycoprotein-1 (aB2GP1) was performed on the 1st day and after 15 days of admission, using the chemiluminescence assay (threshold =19 CU). The average age of patients was 64.7 ± 20, 44 years (ranges: 30-88 years), with a sex-ratio of 1.25. On day-1, APLs were positive in two cases, the first of which was positive for IgG aβ2GP1 (94.9 CU) and IgG aCL (24.8 CU), and the second was positive only for IgG aβ2GP1 (31.4 CU). On day-15, APLs showed negative results for both aβ2GP1 and aCL for the first case, and decreasing titers of aβ2GP1 for the second one. Interestingly, these two cases showed no thromboembolic events and had a good clinical outcome. Conversely, APL positivity occurred at day-15 in two cases, corresponding to IgG aB2GPI (49.3 CU) in one case, and IgG aCL (76 CU) in the other. Both cases presented with a prolonged activated-partial-thromboplastin-time, high levels of D-dimers and fibrinogen, associated with increased levels of ferritin and interleukin-6. Our series has shown that IgG aB2GPI or IgG aCL can be either transient or appear secondarily with significantly high titers. The latter condition was associated with a poor clinical outcome, which emphasizes the importance of APLs monitoring in severe COVID-19 as a potential prognostic factor.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88523593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistopathological Profile and Biomolecular Level of Central Nerve Tumors in Kinshasa, DRC According to the Classification of the World Health Organization 2016 刚果民主共和国金沙萨地区中枢神经肿瘤免疫组织病理学特征及生物分子水平(2016年世界卫生组织分类

International journal of immunology and immunotherapy Pub Date : 2021-05-14 DOI: 10.11648/J.IJI.20210902.12

Kisile Mikuo Olive, Kabongo Mpolesha Jean Marie, C. Manini

{"title":"Immunohistopathological Profile and Biomolecular Level of Central Nerve Tumors in Kinshasa, DRC According to the Classification of the World Health Organization 2016","authors":"Kisile Mikuo Olive, Kabongo Mpolesha Jean Marie, C. Manini","doi":"10.11648/J.IJI.20210902.12","DOIUrl":"https://doi.org/10.11648/J.IJI.20210902.12","url":null,"abstract":"The goal is to determine immunohistochemical histopathological profile and biomolecular level of Central nerve Tumors in Kinshasa, DRC. According to the classification of the World Health Organization (WHO) 2016. Our study is described on a series of cases that were studied using standard histopathological techniques, before undergoing specific immunohistochemical techniques for the detection of anti-IDH1antibodies in gliomas and biomolecular ones in the search for 1p19q deletion. Central nerve tumors account for 0.18% of all conditions, over a period of time. Meningothelial-type meningioma was the most common (60.9%). The most affected age group is over 50. The distribution of tumors by sex shows a predominance of woman (67.1%). The gliomas had constituted 29.6% of all nerve tumors recorded over the period considered and whose predominance was constituted by oligoastrocytomas with 42.1%. The immunohistochemical profile is characterized by a strong positivity with the anti-IDH1antibody in case of grade II oligoastrocytoma with 6.6%. Our study showed that central nerve tumors account for 0.18 of all conditions, gliomas are made up of 29.6% of all nerve tumors listed with a predominance of oligoastrocytomas. The immunohistochemical profile is characterized by a strong positivity with the anti-IDH1antibody in case of grade II.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76589427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0