Insights of biomedical research最新文献

{"title":"Iatrogenic Bile Duct Injury and Its Management with Intensive Care Unit Process: A Single-Center Experience","authors":"M. Ibrahim, Turan Sema, Tezcan Büşra, A. Bahar, Bostancı Erdal Birol, Odemis Bulent","doi":"10.36959/584/449","DOIUrl":"https://doi.org/10.36959/584/449","url":null,"abstract":"Background: The delayed recognition of bile duct injury (BDI) and the challenges in its diagnosis lead to clinical variability. The management of BDI is complicated and ranges from ERCP to liver transplantation. But infections related to BDI and sepsis control, prior to the bile flow reestablishment, are the mainstay of the treatment. In this study, we aimed to report the clinical outcomes of iatrogenic BDI and intensive care unit (ICU) process in a tertiary state hospital. Materials and methods: In this single-center, retrospective, cohort study, 17 patients admitted to our hospital with BDI after LC or ERCP were enrolled from January 2016 to July 2018. The outcomes of BDI were assessed only in short term period-as long as the length of hospital stay-and the statistical analysis was performed using SPSS version 20.0 for Windows (SPSS Inc., Chicago, IL, USA). Statistical significance was determined by a p value less than 0.05. Results: Throughout the study period, the patients with BDI were referred mostly after LC (n = 14, 82.4%). The mean age was 52.5 years and 14 of these patients were referred us from another hospital. 94.1% of the patients admitted to ICU in the first week after injury and the main symptom in the admission was right quadrant pain. Surgery was required only in seven cases (41.2%) and the in-hospital mortality rate was 17.6% (n = 3). It was clearly shown that mortality and sepsis relation was significant statistically (p < 0.001) whereas delayed admission was not related to morbidity or mortality statistically. Discussion: The rate of BDI after LC or ERCP varies and the challenge in the diagnosis of BDI is that they are not recognized at the time of LC or ERCP in the majority of cases. The identification of sepsis in the early phase leads to proper management of BDI while the morbidity and mortality rates are increasing in cases of major BDI, delayed referral and sepsis involvement. In our study, the in-hospital mortality rate was higher than the mortality rate related to BDI (17.2% vs. 7.2%) in the literature. There are many studies comparing surgical techniques and the timing of the definitive treatment while endoscopic methods have become more preferable than surgery in the early phase of BDI. Conclusion: In conclusion, early recognition of BDI after LC or ERCP is essential and the management of this feared complication requires a multidisciplinary approach with the contribution of a surgeon, gastroenterologist, and intensivist.","PeriodicalId":92909,"journal":{"name":"Insights of biomedical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49121837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Biophysical Analysis of the Twin Paradox: The Interaction between Velocity and the Variable Biological Clock","authors":"Thaheld Fh","doi":"10.36959/584/447","DOIUrl":"https://doi.org/10.36959/584/447","url":null,"abstract":"This study calculated the effects on serum sodium (Na) levels, after treatment with either of 2 drugs: The erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the certain influence, after the respective drug usage in an induced ischemia reperfusion (IR) animal experiment.","PeriodicalId":92909,"journal":{"name":"Insights of biomedical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43574264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Hyponatremic Effects of Erythropoietin and U-74389G","authors":"Tsompos Constantinos, P. Constantinos, Toutouzas Konstantinos, Triantafyllou Aggeliki, C ZografosGeorge, T. Kalliopi, Karamperi Maria, Papalois Apostolos","doi":"10.36959/584/446","DOIUrl":"https://doi.org/10.36959/584/446","url":null,"abstract":"This study calculated the effects on serum sodium (Na) levels, after treatment with either of 2 drugs: The erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the certain influence, after the respective drug usage in an induced ischemia reperfusion (IR) animal experiment.","PeriodicalId":92909,"journal":{"name":"Insights of biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42663311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Elderly Patients with Diabetes Mellitus from Patient-Centered Medicine","authors":"H. Bando","doi":"10.36959/584/445","DOIUrl":"https://doi.org/10.36959/584/445","url":null,"abstract":"Diabetes mellitus has been an increasingly important health problem worldwide. In the case of elderly diabetic patients, adequate control of not only glucose variability but also physical, psychological, social, nutritional management would be crucial. Recent important topics include frailty, sarcopenia and locomotive syndrome. From mentioned above, elderly diabetics need patient-centered medicine with bio-psycho-social, leading to satisfactory and significant life.","PeriodicalId":92909,"journal":{"name":"Insights of biomedical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49400341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Technical Aspects of Anti-Gene IGF-I Vaccines against Glioma","authors":"T. Jerzy, Guzman Andrea, Ly Adama, Quintero Gabriela, Castillo Tatiana, Rojas Carolina, M. Jefferson, Penagos Pedro, S. Alexander, Lone You-Chun, O. S. Herve, Gutierrez-Coronado Oscar, Bierwagen Maciej, Rojas Carlos, Kasprzak Heliodor, P. Tadeusz, Ayala Adis, X. YueXin, P. Edwin, Santander Ricardo, A. Alvaro, A. Jaime, E. Luis, D. A. Donald, Briceno Ignacio, Trojan Annabelle","doi":"10.36959/584/444","DOIUrl":"https://doi.org/10.36959/584/444","url":null,"abstract":"Research on glioblastoma has demonstrated a significant increase in IGF-I gene expression in this brain tumor. After suppression of IGF-I expression using anti-gene IGF-I technologies, glioma cells become immunogenic, expressing MHC-I. While injected in vivo, they induce an immune response mediated by T-CD8 lymphocytes. These cells, applied as autologous anti-cancer vaccines have increased the median survival of glioblastoma patients up to 18 months, but often up to two-three years. These differences in clinical results could be explained by variability in vaccine preparation standards.","PeriodicalId":92909,"journal":{"name":"Insights of biomedical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47255798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functions of Conserved Domains of Human Polynucleotide Phosphorylase on RNA Oxidation.","authors":"Sulochan Malla,&nbsp;Zhongwei Li","doi":"10.36959/584/448","DOIUrl":"https://doi.org/10.36959/584/448","url":null,"abstract":"<p><p>Human polynucleotide phosphorylase (hPNPase), an exoribonuclease that is primarily localized in mitochondria, plays an important role in reducing oxidized RNA and protecting cells under oxidative stress conditions. hPNPase contains two catalytic domains (RPH1 and RPH2) and two RNA binding domains (KH and S1), and an N-terminal mitochondrial translocation signal (MTS). In this study, we examined the potential roles of each domain in hPNPase function on controlling RNA oxidative damage. DNA encoding full-length hPNPase and its domain-deletion mutants were introduced into HeLa cells, and the levels of an oxidized RNA lesion, 8-hydroxyguanosine (8-oxo-Guo) were determined in mitochondrial and cytoplasmic RNA under oxidative stress conditions. Our study showed that the S1 RNA binding domain is crucial for reducing 8-oxo-Guo in both cytoplasm and mitochondria, while the MTS is required for 8-oxo-Guo reduction in mitochondria.</p>","PeriodicalId":92909,"journal":{"name":"Insights of biomedical research","volume":"3 1","pages":"62-67"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Need for Physician Empowerment in front of Artificial Intelligence Overruling","authors":"France Francis Roger","doi":"10.36959/584/443","DOIUrl":"https://doi.org/10.36959/584/443","url":null,"abstract":"AI is an area of computer sciences leading to the creation of intelligent automated machines. Innovative software and digital communication technologies allow computers and robots to work and react like humans. AI mimics “cognitive” functions such as reasoning and problem solving, with capabilities to compete humans in strategic games (such as chess), to operate autonomously car driving or to understand human speech. AI tools include knowledge representation, learning by experience, planning, natural language processing and objects manipulation. AI research developments include methods based on logic, statistics, conditional probabilities, computational intelligence, mathematical optimization, artificial neural networks and many others.","PeriodicalId":92909,"journal":{"name":"Insights of biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42138753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Confounding Evidence Based Risk Factors Triggering the Incidence of HIV Antibodies among Screened Population of Niger Delta Extraction","authors":"O. Azuonwu, Chikanka Azuonwu Testimonies","doi":"10.36959/584/436","DOIUrl":"https://doi.org/10.36959/584/436","url":null,"abstract":"","PeriodicalId":92909,"journal":{"name":"Insights of biomedical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44238926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}