T. Jerzy, Guzman Andrea, Ly Adama, Quintero Gabriela, Castillo Tatiana, Rojas Carolina, M. Jefferson, Penagos Pedro, S. Alexander, Lone You-Chun, O. S. Herve, Gutierrez-Coronado Oscar, Bierwagen Maciej, Rojas Carlos, Kasprzak Heliodor, P. Tadeusz, Ayala Adis, X. YueXin, P. Edwin, Santander Ricardo, A. Alvaro, A. Jaime, E. Luis, D. A. Donald, Briceno Ignacio, Trojan Annabelle
{"title":"抗神经胶质瘤igf - 1基因疫苗的体外技术研究","authors":"T. Jerzy, Guzman Andrea, Ly Adama, Quintero Gabriela, Castillo Tatiana, Rojas Carolina, M. Jefferson, Penagos Pedro, S. Alexander, Lone You-Chun, O. S. Herve, Gutierrez-Coronado Oscar, Bierwagen Maciej, Rojas Carlos, Kasprzak Heliodor, P. Tadeusz, Ayala Adis, X. YueXin, P. Edwin, Santander Ricardo, A. Alvaro, A. Jaime, E. Luis, D. A. Donald, Briceno Ignacio, Trojan Annabelle","doi":"10.36959/584/444","DOIUrl":null,"url":null,"abstract":"Research on glioblastoma has demonstrated a significant increase in IGF-I gene expression in this brain tumor. After suppression of IGF-I expression using anti-gene IGF-I technologies, glioma cells become immunogenic, expressing MHC-I. While injected in vivo, they induce an immune response mediated by T-CD8 lymphocytes. These cells, applied as autologous anti-cancer vaccines have increased the median survival of glioblastoma patients up to 18 months, but often up to two-three years. These differences in clinical results could be explained by variability in vaccine preparation standards.","PeriodicalId":92909,"journal":{"name":"Insights of biomedical research","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"In vitro Technical Aspects of Anti-Gene IGF-I Vaccines against Glioma\",\"authors\":\"T. Jerzy, Guzman Andrea, Ly Adama, Quintero Gabriela, Castillo Tatiana, Rojas Carolina, M. Jefferson, Penagos Pedro, S. Alexander, Lone You-Chun, O. S. Herve, Gutierrez-Coronado Oscar, Bierwagen Maciej, Rojas Carlos, Kasprzak Heliodor, P. Tadeusz, Ayala Adis, X. YueXin, P. Edwin, Santander Ricardo, A. Alvaro, A. Jaime, E. Luis, D. A. Donald, Briceno Ignacio, Trojan Annabelle\",\"doi\":\"10.36959/584/444\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Research on glioblastoma has demonstrated a significant increase in IGF-I gene expression in this brain tumor. After suppression of IGF-I expression using anti-gene IGF-I technologies, glioma cells become immunogenic, expressing MHC-I. While injected in vivo, they induce an immune response mediated by T-CD8 lymphocytes. These cells, applied as autologous anti-cancer vaccines have increased the median survival of glioblastoma patients up to 18 months, but often up to two-three years. These differences in clinical results could be explained by variability in vaccine preparation standards.\",\"PeriodicalId\":92909,\"journal\":{\"name\":\"Insights of biomedical research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Insights of biomedical research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36959/584/444\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Insights of biomedical research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36959/584/444","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In vitro Technical Aspects of Anti-Gene IGF-I Vaccines against Glioma
Research on glioblastoma has demonstrated a significant increase in IGF-I gene expression in this brain tumor. After suppression of IGF-I expression using anti-gene IGF-I technologies, glioma cells become immunogenic, expressing MHC-I. While injected in vivo, they induce an immune response mediated by T-CD8 lymphocytes. These cells, applied as autologous anti-cancer vaccines have increased the median survival of glioblastoma patients up to 18 months, but often up to two-three years. These differences in clinical results could be explained by variability in vaccine preparation standards.
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