Critical care (Houten, Netherlands)最新文献

{"title":"Volunteerism during humanitarian crises: a practical guide","authors":"H. Bailey, L. Kaplan","doi":"10.1186/s13054-022-03984-4","DOIUrl":"https://doi.org/10.1186/s13054-022-03984-4","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42643627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study","authors":"Frank A. Rasulo, S. Calza, C. Robba, F. Taccone, D. Biasucci, R. Badenes, Simone Piva, D. Savo, G. Citerio, J. Dibu, Francesco Curto, Martina Merciadri, Paolo Gritti, P. Fassini, Soojin Park, M. Lamperti, P. Bouzat, Paolo Malacarne, A. Chieregato, R. Bertuetti, R. Aspide, A. Cantoni, V. McCredie, Lucrezia Guadrini, N. Latronico","doi":"10.1186/s13054-022-03978-2","DOIUrl":"https://doi.org/10.1186/s13054-022-03978-2","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44461859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial","authors":"J. Xia, S. Gu, Wei Lei, Jihua Zhang, Hui Wei, Chaoling Liu, Han Zhang, Rongli Lu, Liqiong Zhang, Mingyan Jiang, Chao Hu, Zhenshun Cheng, Chaojie Wei, Yusheng Chen, Feng-ju Lu, Min Chen, Hong Bi, Hui Liu, C. Yan, H. Teng, Yang Yang, Chen Liang, Yanlei Ge, P. Hou, Jialin Liu, Weiwei Gao, Yi Zhang, Yingying Feng, Cheng Tao, Xu Huang, P. Pan, Hong Luo, Chunmei Yun, Q. Zhan","doi":"10.1186/s13054-022-03973-7","DOIUrl":"https://doi.org/10.1186/s13054-022-03973-7","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45302436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closed-loop oxygen control improves oxygen therapy in acute hypoxemic respiratory failure patients under high flow nasal oxygen: a randomized cross-over study (the HILOOP study)","authors":"O. Roca, Oriol Caritg, M. Santafé, Francisco-Javier Ramos, A. Pacheco, M. García-de-Acilu, R. Ferrer, M. Schultz, J. Ricard","doi":"10.1186/s13054-022-03970-w","DOIUrl":"https://doi.org/10.1186/s13054-022-03970-w","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43692734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum IL-17 levels are higher in critically ill patients with AKI and associated with worse outcomes.","authors":"Jason A Collett, Victor Ortiz-Soriano, Xilong Li, Alexander H Flannery, Robert D Toto, Orson W Moe, David P Basile, Javier A Neyra","doi":"10.1186/s13054-022-03976-4","DOIUrl":"10.1186/s13054-022-03976-4","url":null,"abstract":"<p><strong>Background: </strong>Interleukin-17 (IL-17) antagonism in rats reduces the severity and progression of AKI. IL-17-producing circulating T helper-17 (TH17) cells is increased in critically ill patients with AKI indicating that this pathway is also activated in humans. We aim to compare serum IL-17A levels in critically ill patients with versus without AKI and to examine their relationship with mortality and major adverse kidney events (MAKE).</p><p><strong>Methods: </strong>Multicenter, prospective study of ICU patients with AKI stage 2 or 3 and without AKI. Samples were collected at 24-48 h after AKI diagnosis or ICU admission (in those without AKI) [timepoint 1, T1] and 5-7 days later [timepoint 2, T2]. MAKE was defined as the composite of death, dependence on kidney replacement therapy or a reduction in eGFR of ≥ 30% from baseline up to 90 days following hospital discharge.</p><p><strong>Results: </strong>A total of 299 patients were evaluated. Patients in the highest IL-17A tertile (versus lower tertiles) at T1 had higher acuity of illness and comorbidity scores. Patients with AKI had higher levels of IL-17A than those without AKI: T1 1918.6 fg/ml (692.0-5860.9) versus 623.1 fg/ml (331.7-1503.4), p < 0.001; T2 2167.7 fg/ml (839.9-4618.9) versus 1193.5 fg/ml (523.8-2198.7), p = 0.006. Every onefold higher serum IL-17A at T1 was independently associated with increased risk of hospital mortality (aOR 1.35, 95% CI: 1.06-1.73) and MAKE (aOR 1.26, 95% CI: 1.02-1.55). The highest tertile of IL-17A (vs. the lowest tertile) was also independently associated with higher risk of MAKE (aOR 3.03, 95% CI: 1.34-6.87). There was no effect modification of these associations by AKI status. IL-17A levels remained significantly elevated at T2 in patients that died or developed MAKE.</p><p><strong>Conclusions: </strong>Serum IL-17A levels measured by the time of AKI diagnosis or ICU admission were differentially elevated in critically ill patients with AKI when compared to those without AKI and were independently associated with hospital mortality and MAKE.</p>","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":"107"},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44573087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Derivation and performance of an end-of-life practice score aimed at interpreting worldwide treatment-limiting decisions in the critically ill","authors":"S. Mentzelopoulos, Su-Chuan Chen, J. Nates, J. Kruser, C. Hartog, A. Michalsen, N. Efstathiou, G. Joynt, S. Lobo, A. Avidan, C. Sprung, Wesley Erwin J. O. Mervyn Charles Victoria Myrick C. John Ely Kompanje Mer Feldman Metaxa Shinall Myburgh Vr, W. Ely, E. Kompanje, M. Mer, C. Feldman, V. Metaxa, Myrick C. Shinall, J. Myburgh, C. Vrettou","doi":"10.1186/s13054-022-03971-9","DOIUrl":"https://doi.org/10.1186/s13054-022-03971-9","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43263654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients","authors":"R. Prével, R. Enaud, A. Orieux, Adrian Camino, P. Berger, A. Boyer, L. Delhaes, D. Gruson","doi":"10.1186/s13054-022-03980-8","DOIUrl":"https://doi.org/10.1186/s13054-022-03980-8","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44618981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of the 2020 ERC/ESICM prognostication strategy algorithm after cardiac arrest","authors":"C. Youn, K. Park, S. Kim, B. Lee, T. Cronberg, S. Oh, K. Jeung, I. Cho, S. Choi","doi":"10.1186/s13054-022-03954-w","DOIUrl":"https://doi.org/10.1186/s13054-022-03954-w","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42834890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel Vascular Leak Index identifies sepsis patients with a higher risk for in-hospital death and fluid accumulation.","authors":"Jay Chandra, Miguel A Armengol de la Hoz, Gwendolyn Lee, Alexandria Lee, Patrick Thoral, Paul Elbers, Hyung-Chul Lee, John S Munger, Leo Anthony Celi, David A Kaufman","doi":"10.1186/s13054-022-03968-4","DOIUrl":"10.1186/s13054-022-03968-4","url":null,"abstract":"<p><strong>Purpose: </strong>Sepsis is a leading cause of morbidity and mortality worldwide and is characterized by vascular leak. Treatment for sepsis, specifically intravenous fluids, may worsen deterioration in the context of vascular leak. We therefore sought to quantify vascular leak in sepsis patients to guide fluid resuscitation.</p><p><strong>Methods: </strong>We performed a retrospective cohort study of sepsis patients in four ICU databases in North America, Europe, and Asia. We developed an intuitive vascular leak index (VLI) and explored the relationship between VLI and in-hospital death and fluid balance using generalized additive models (GAM).</p><p><strong>Results: </strong>Using a GAM, we found that increased VLI is associated with an increased risk of in-hospital death. Patients with a VLI in the highest quartile (Q4), across the four datasets, had a 1.61-2.31 times increased odds of dying in the hospital compared to patients with a VLI in the lowest quartile (Q1). VLI Q2 and Q3 were also associated with increased odds of dying. The relationship between VLI, treated as a continuous variable, and in-hospital death and fluid balance was statistically significant in the three datasets with large sample sizes. Specifically, we observed that as VLI increased, there was increase in the risk for in-hospital death and 36-84 h fluid balance.</p><p><strong>Conclusions: </strong>Our VLI identifies groups of patients who may be at higher risk for in-hospital death or for fluid accumulation. This relationship persisted in models developed to control for severity of illness and chronic comorbidities.</p>","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":"103"},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42425662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma disappearance rate of albumin when infused as a 20% solution.","authors":"Markus Zdolsek, Patrick Y Wuethrich, Michaela Gunnström, Joachim H Zdolsek, Emma Hasselgren, Christian M Beilstein, Dominique Engel, Robert G Hahn","doi":"10.1186/s13054-022-03979-1","DOIUrl":"10.1186/s13054-022-03979-1","url":null,"abstract":"<p><strong>Background: </strong>The transcapillary leakage of albumin is increased by inflammation and major surgery, but whether exogenous albumin also disappears faster is unclear.</p><p><strong>Methods: </strong>An intravenous infusion of 3 mL/kg of 20% albumin was given over 30 min to 70 subjects consisting of 15 healthy volunteers, 15 post-burn patients, 15 patients who underwent surgery with minor bleeding, 10 who underwent surgery with major bleeding (mean, 1.1 L) and 15 postoperative patients. Blood Hb and plasma albumin were measured on 15 occasions over 5 h. The rate of albumin disappearance from the plasma was quantitated with population kinetic methodology and reported as the half-life (T_1/2).</p><p><strong>Results: </strong>No differences were observed for T_1/2 between volunteers, post-burn patients, patients who underwent surgery with minor bleeding and postoperative patients. The T_1/2 averaged 16.2 h, which corresponds to 3.8% of the amount infused per h. Two groups showed plasma concentrations of C-reactive protein of approximately 60 mg/L and still had a similarly long T_1/2 for albumin. By contrast, patients undergoing surgery associated with major hemorrhage had a shorter T_1/2, corresponding to 15% of the infused albumin per h. In addition, our analyses show that the T_1/2 differ greatly depending on whether the calculations consider plasma volume changes and blood losses.</p><p><strong>Conclusion: </strong>The disappearance rate of the albumin in 20% preparations was low in volunteers, in patients with moderately severe inflammation, and in postoperative patients.</p>","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":"104"},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45236585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}