{"title":"Termination-of-resuscitation rule in the emergency department for patients with refractory out-of-hospital cardiac arrest: a nationwide, population-based observational study","authors":"Y. Goto, A. Funada, T. Maeda, Y. Goto","doi":"10.1186/s13054-022-03999-x","DOIUrl":"https://doi.org/10.1186/s13054-022-03999-x","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49571540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mayuko Tonai, A. Shiraishi, Toshiyuki Karumai, A. Endo, Hirotada Kobayashi, K. Fushimi, Y. Hayashi
{"title":"Hospital-onset sepsis and community-onset sepsis in critical care units in Japan: a retrospective cohort study based on a Japanese administrative claims database","authors":"Mayuko Tonai, A. Shiraishi, Toshiyuki Karumai, A. Endo, Hirotada Kobayashi, K. Fushimi, Y. Hayashi","doi":"10.1186/s13054-022-04013-0","DOIUrl":"https://doi.org/10.1186/s13054-022-04013-0","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49627229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Vanhorebeek, A. Jacobs, L. Mebis, K. Dulfer, R. Eveleens, Hanna Van Cleemput, P. Wouters, Ines Verlinden, K. Joosten, S. Verbruggen, G. Van den Berghe
{"title":"Impact of critical illness and withholding of early parenteral nutrition in the pediatric intensive care unit on long-term physical performance of children: a 4-year follow-up of the PEPaNIC randomized controlled trial","authors":"I. Vanhorebeek, A. Jacobs, L. Mebis, K. Dulfer, R. Eveleens, Hanna Van Cleemput, P. Wouters, Ines Verlinden, K. Joosten, S. Verbruggen, G. Van den Berghe","doi":"10.1186/s13054-022-04010-3","DOIUrl":"https://doi.org/10.1186/s13054-022-04010-3","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46655294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemoperfusion: technical aspects and state of the art","authors":"C. Ronco, R. Bellomo","doi":"10.1186/s13054-022-04009-w","DOIUrl":"https://doi.org/10.1186/s13054-022-04009-w","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46615102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Stahl, Philipp Wand, B. Seeliger, P. Wendel-Garcia, Julius J Schmidt, Bernhard M. W. Schmidt, A. Sauer, Felix Lehmann, U. Budde, M. Busch, O. Wiesner, T. Welte, H. Haller, H. Wedemeyer, C. Putensen, M. Hoeper, C. Bode, S. David
{"title":"Clinical and biochemical endpoints and predictors of response to plasma exchange in septic shock: results from a randomized controlled trial","authors":"K. Stahl, Philipp Wand, B. Seeliger, P. Wendel-Garcia, Julius J Schmidt, Bernhard M. W. Schmidt, A. Sauer, Felix Lehmann, U. Budde, M. Busch, O. Wiesner, T. Welte, H. Haller, H. Wedemeyer, C. Putensen, M. Hoeper, C. Bode, S. David","doi":"10.1186/s13054-022-04003-2","DOIUrl":"https://doi.org/10.1186/s13054-022-04003-2","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47221399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Candel, Wouter Raven, H. Lameijer, W. Thijssen, F. Termorshuizen, Christiaan E. Boerma, N. D. de Keizer, E. de Jonge, B. de Groot
{"title":"Correction: The effect of treatment and clinical course during Emergency Department stay on severity scoring and predicted mortality risk in Intensive Care patients","authors":"B. Candel, Wouter Raven, H. Lameijer, W. Thijssen, F. Termorshuizen, Christiaan E. Boerma, N. D. de Keizer, E. de Jonge, B. de Groot","doi":"10.1186/s13054-022-04008-x","DOIUrl":"https://doi.org/10.1186/s13054-022-04008-x","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44727485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Molina, L. Botero, J. P. Isaza, L. Cano, L. López, L. Tamayo, António Torres
{"title":"Diagnostic concordance between BioFire® FilmArray® Pneumonia Panel and culture in patients with COVID-19 pneumonia admitted to intensive care units: the experience of the third wave in eight hospitals in Colombia","authors":"F. Molina, L. Botero, J. P. Isaza, L. Cano, L. López, L. Tamayo, António Torres","doi":"10.1186/s13054-022-04006-z","DOIUrl":"https://doi.org/10.1186/s13054-022-04006-z","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41969068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Inoue, T. Hifumi, T. Sakamoto, H. Okamoto, Jun Kunikata, Hideto Yokoi, Hirotaka Sawano, Yuko Egawa, S. Kato, K. Sugiyama, Naofumi Bunya, Takehiko Kasai, Shinichi Ijuin, S. Nakayama, J. Kanda, Seiya Kanou, Toru Takiguchi, S. Yokobori, Hiroaki Takada, Kazushige Inoue, I. Takeuchi, H. Honzawa, Makoto Kobayashi, Tomohiro Hamagami, W. Takayama, Y. Otomo, K. Maekawa, Takafumi Shimizu, S. Nara, M. Nasu, Kuniko Takahashi, Y. Hagiwara, S. Kushimoto, Reo Fukuda, T. Ogura, Shin‐ichiro Shiraishi, R. Zushi, N. Otani, M. Kikuchi, Kazuhiro Watanabe, T. Nakagami, Tomohisa Shoko, N. Kitamura, Takayuki Otani, Y. Matsuoka, M. Aoki, M. Sakuraya, H. Arimoto, K. Homma, H. Naito, Shunichiro Nakao, T. Okazaki, Y. Tahara, Y. Kuroda, Asae Hajime Atsunori Kanta Yoichi Nobuaki Masayuki Yuji Senda Suzuki Tanimoto Kitagawa Katayama Igarashi K, Asae Senda, Hajime Suzuki, Atsunori Tanimoto, Kanta Kitagawa, Y. Katayama, N. Igarashi, M. Kawano, Yuji Kuroki, Tadashi Umehara, Yukari Sasaki, N. Tominaga, Takuro Hamaguchi, Takuma Sakai, T.
{"title":"Extracorporeal cardiopulmonary resuscitation in adult patients with out-of-hospital cardiac arrest: a retrospective large cohort multicenter study in Japan","authors":"A. Inoue, T. Hifumi, T. Sakamoto, H. Okamoto, Jun Kunikata, Hideto Yokoi, Hirotaka Sawano, Yuko Egawa, S. Kato, K. Sugiyama, Naofumi Bunya, Takehiko Kasai, Shinichi Ijuin, S. Nakayama, J. Kanda, Seiya Kanou, Toru Takiguchi, S. Yokobori, Hiroaki Takada, Kazushige Inoue, I. Takeuchi, H. Honzawa, Makoto Kobayashi, Tomohiro Hamagami, W. Takayama, Y. Otomo, K. Maekawa, Takafumi Shimizu, S. Nara, M. Nasu, Kuniko Takahashi, Y. Hagiwara, S. Kushimoto, Reo Fukuda, T. Ogura, Shin‐ichiro Shiraishi, R. Zushi, N. Otani, M. Kikuchi, Kazuhiro Watanabe, T. Nakagami, Tomohisa Shoko, N. Kitamura, Takayuki Otani, Y. Matsuoka, M. Aoki, M. Sakuraya, H. Arimoto, K. Homma, H. Naito, Shunichiro Nakao, T. Okazaki, Y. Tahara, Y. Kuroda, Asae Hajime Atsunori Kanta Yoichi Nobuaki Masayuki Yuji Senda Suzuki Tanimoto Kitagawa Katayama Igarashi K, Asae Senda, Hajime Suzuki, Atsunori Tanimoto, Kanta Kitagawa, Y. Katayama, N. Igarashi, M. Kawano, Yuji Kuroki, Tadashi Umehara, Yukari Sasaki, N. Tominaga, Takuro Hamaguchi, Takuma Sakai, T.","doi":"10.1186/s13054-022-03998-y","DOIUrl":"https://doi.org/10.1186/s13054-022-03998-y","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43387436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ottavia Pallanch, Alessandro Ortalda, Paolo Pelosi, Nicola Latronico, Chiara Sartini, Gaetano Lombardi, Cristiano Marchetti, Nicolò Maimeri, Alberto Zangrillo, Luca Cabrini
{"title":"Effects on health-related quality of life of interventions affecting survival in critically ill patients: a systematic review.","authors":"Ottavia Pallanch, Alessandro Ortalda, Paolo Pelosi, Nicola Latronico, Chiara Sartini, Gaetano Lombardi, Cristiano Marchetti, Nicolò Maimeri, Alberto Zangrillo, Luca Cabrini","doi":"10.1186/s13054-022-03993-3","DOIUrl":"10.1186/s13054-022-03993-3","url":null,"abstract":"<p><p>Survival has been considered the cornerstone for clinical outcome evaluation in critically ill patients admitted to intensive care unit (ICU). There is evidence that ICU survivors commonly show impairments in long-term outcomes such as quality of life (QoL) considering them as the most relevant ones. In the last years, the concept of patient-important outcomes has been introduced and increasingly reported in peer-reviewed publications. In the present systematic review, we evaluated how many randomized controlled trials (RCTs) were conducted on critically ill patients and reporting a benefit on survival reported also data on QoL. All RCTs investigating nonsurgical interventions that significantly reduced mortality in critically ill patients were searched on MEDLINE/PubMed, Scopus and Embase from inception until August 2021. In a second stage, for all the included studies, the outcome QoL was investigated. The primary outcome was to evaluate how many RCTs analyzing interventions reducing mortality reported also data on QoL. The secondary endpoint was to investigate if QoL resulted improved, worsened or not modified. Data on QoL were reported as evaluated outcome in 7 of the 239 studies (2.9%). The tools to evaluate QoL and QoL time points were heterogeneous. Four interventions showed a significant impact on QoL: Two interventions improved survival and QoL (pravastatin in subarachnoid hemorrhage, dexmedetomidine in elderly patients after noncardiac surgery), while two interventions reduced mortality but negatively influenced QoL (caloric restriction in patients with refeeding syndrome and systematic ICU admission in elderly patients). In conclusion, only a minority of RCTs in which an intervention demonstrated to affect mortality in critically ill patients reported also data on QoL. Future research in critical care should include patient-important outcomes like QoL besides mortality. Data on this topic should be collected in conformity with PROs statement and core outcome sets to guarantee quality and comparability of results.</p>","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":"126"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42464906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early intubation and decreased in-hospital mortality in patients with coronavirus disease 2019.","authors":"Ryo Yamamoto, Daiki Kaito, Koichiro Homma, Akira Endo, Takashi Tagami, Morio Suzuki, Naoyuki Umetani, Masayuki Yagi, Eisaku Nashiki, Tomohiro Suhara, Hiromasa Nagata, Hiroki Kabata, Koichi Fukunaga, Kazuma Yamakawa, Mineji Hayakawa, Takayuki Ogura, Atsushi Hirayama, Hideo Yasunaga, Junichi Sasaki","doi":"10.1186/s13054-022-03995-1","DOIUrl":"10.1186/s13054-022-03995-1","url":null,"abstract":"<p><strong>Background: </strong>Some academic organizations recommended that physicians intubate patients with COVID-19 with a relatively lower threshold of oxygen usage particularly in the early phase of pandemic. We aimed to elucidate whether early intubation is associated with decreased in-hospital mortality among patients with novel coronavirus disease 2019 (COVID-19) who required intubation.</p><p><strong>Methods: </strong>A multicenter, retrospective, observational study was conducted at 66 hospitals in Japan where patients with moderate-to-severe COVID-19 were treated between January and September 2020. Patients who were diagnosed as COVID-19 with a positive reverse-transcription polymerase chain reaction test and intubated during admission were included. Early intubation was defined as intubation conducted in the setting of ≤ 6 L/min of oxygen usage. In-hospital mortality was compared between patients with early and non-early intubation. Inverse probability weighting analyses with propensity scores were performed to adjust patient demographics, comorbidities, hemodynamic status on admission and time at intubation, medications before intubation, severity of COVID-19, and institution characteristics. Subgroup analyses were conducted on the basis of age, severity of hypoxemia at intubation, and days from admission to intubation.</p><p><strong>Results: </strong>Among 412 patients eligible for the study, 110 underwent early intubation. In-hospital mortality was lower in patients with early intubation than those with non-early intubation (18 [16.4%] vs. 88 [29.1%]; odds ratio, 0.48 [95% confidence interval 0.27-0.84]; p = 0.009, and adjusted odds ratio, 0.28 [95% confidence interval 0.19-0.42]; p < 0.001). The beneficial effects of early intubation were observed regardless of age and severity of hypoxemia at time of intubation; however, early intubation was associated with lower in-hospital mortality only among patients who were intubated later than 2 days after admission.</p><p><strong>Conclusions: </strong>Early intubation in the setting of ≤ 6 L/min of oxygen usage was associated with decreased in-hospital mortality among patients with COVID-19 who required intubation. Trial Registration None.</p>","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":"124"},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41570578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}