Journal of endocrinology and thyroid research最新文献_第7页

GH-Producing Pituitary Adenoma: The Current Criteria of Biochemical Cure 垂体gh腺瘤:当前生化治疗标准

Journal of endocrinology and thyroid research Pub Date : 2019-08-16 DOI: 10.19080/jetr.2019.04.555647

F. Assaad

引用次数: 0

Long-Term Follow-Up in a Male Patient with Micro-TSH-Oma Diagnosed at 8-Yr-Old 一名8岁诊断为微小TSH奥马的男性患者的长期随访

Journal of endocrinology and thyroid research Pub Date : 2019-07-18 DOI: 10.19080/jetr.2019.04.555646

A. Cardoso-Demartini

{"title":"Long-Term Follow-Up in a Male Patient with Micro-TSH-Oma Diagnosed at 8-Yr-Old","authors":"A. Cardoso-Demartini","doi":"10.19080/jetr.2019.04.555646","DOIUrl":"https://doi.org/10.19080/jetr.2019.04.555646","url":null,"abstract":"Background : TSH-secreting pituitary adenomas (TSH-omas) are very rare and an infrequent cause of thyrotoxicosis. Case Report: A 7.9-yr-old boy was referred to our Pediatric Endocrinology Unit due to a goiter. On admission, patient was thyrotoxic with diffuse goiter. Laboratory evaluation suggested inappropriate TSH secretion as the cause of hyperthyroidism: high serum TSH in presence of elevated levels of TT 4 , TT 3 and fT 4 , and TSH unresponsive to TRH stimulation and to T 3 suppression. Initially, α-subunit (aSU) was in the upper limit of normalcy and pituitary MRI was normal. One year after, patient was still hyperthyroid, despite regular use of methimazole; TSH was 12.6 mU/mL, αSU was elevated and MRI detected a pituitary 8 mm width adenoma, establishing the diagnosis of TSH-oma. Peak GH (ng/dL) on ITT and TSH after TRH were 5.9 and 4.2, respectively. Cortisol and prolactin (PRL) responded normally to ITT and TRH tests. Transsphenoidal surgery was done and, postoperatively, transient diabetes insipidus and adrenal insufficiency ensued. Two and five months after surgery fT 4 , TT 4 and TT 3 were normal, albeit peak TSH after TRH was 1.54. PRL and GH were unresponsive to adequate stimuli. Fourteen months after surgery, TT 4 , TT 3 and fT 4 were low normal. He presented with low IGF-1, low GH peak on dinanic tests and hypogonadism and was treated with recombinant human growth hormone (rhGH) and testostenone. At 16 yr-old, we reached final height, above target height. Conclusion : TSH-oma may be an etiology of thyrotoxicosis in children. To our knowledge, this is one of the youngest patients with TSH-oma yet reported.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41527429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Managing diabetes mellitus in underserved subjects of Western China using a telemedicine system— A clinical trial 使用远程医疗系统管理中国西部服务不足人群中的糖尿病-一项临床试验

Journal of endocrinology and thyroid research Pub Date : 2019-07-12 DOI: 10.30564/JER.V1I1.671

Ya Li, Weiguo Ma, Jiao Bai, Chuanqing Xie, Yuanyuan Huo

{"title":"Managing diabetes mellitus in underserved subjects of Western China using a telemedicine system— A clinical trial","authors":"Ya Li, Weiguo Ma, Jiao Bai, Chuanqing Xie, Yuanyuan Huo","doi":"10.30564/JER.V1I1.671","DOIUrl":"https://doi.org/10.30564/JER.V1I1.671","url":null,"abstract":"Objective: To evaluate the effectiveness of Internet and telephone-based telemedicine system managing on patients’ glycemic index, blood pressure, and lipid level control in underserved subjects with type 2 diabetes in Western China. Research designs and methods: In a 3 years, randomized, controlled, single-blind, parallel-group treat-to-target study, 412 subjects with type 2 diabetes were randomized to telemedicine (Tel; n =208) group and usual care (control; n =204) group. We evaluated the effects of the intervention on blood sugar, blood pressure, and lipid levels at 1, 2, 3 years point, and investigated the cause of the loss during follow-up by phone call.Results: Intra-group comparison: in the Tel group, the FBS, 2HPG, HbA1c, and SBP at 1, 2, 3 years and DBP, TC, TG, BMI at 2, 3 years were significantly decreased compared with baseline level (P<0.05). Moreover, the Tel group had an obvious better control of their HbA1c at 2 and 3 years and 2HPG at 3 years of follow-up respectively compared with the outcomes at 1 year (P<0.05).Inter-group comparison: the FBS, 2HPG, and HbA1c of Tel group decreased significantly from the baseline to the 1 year more than those of control group (P<0.05 or P<0.01 ). In this analysis, all clinical measures of Tel group had a significant downward compared with the outcomes of Control group at 2 years, the FBS, HbA1c and BMI (P<0.001), the 2HPG and SBP (P<0.01) and DBP, TC, and TG (P<0.05) were statistically significant respectively. Logistic regression analysis showed that the subject loss during follow-up was associated with worse diabetes management (OR=3.842), low income (OR=3.201), low education level (OR=0.923), and greater distance to the hospital (OR=0.921).Conclusions: The study results indicated that the telemedicine may be a useful tool for managing diabetes mellitus.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86474763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute and chronic responses to exercise training-induced irisin in browning of white fat 运动训练诱导的鸢尾素对白色脂肪褐化的急性和慢性反应

Journal of endocrinology and thyroid research Pub Date : 2019-07-12 DOI: 10.30564/JER.V1I1.570

Sílvia Rocha Rodrigues

引用次数: 1

Phosphorylation of Protein Kinase Akt by Mtorc2 in Peripheral Blood Mononuclear Cells of Patients with Cancer and Diabetes Mtorc2在癌症和糖尿病患者外周血单个核细胞中磷酸化蛋白激酶Akt的作用

Journal of endocrinology and thyroid research Pub Date : 2019-07-12 DOI: 10.30564/JER.V1I1.674

T. Vatseba, L. Sokolova, V. V. Pushkarev, O. Kovzun, V. Pushkarev, B. Guda, M. Tronko

{"title":"Phosphorylation of Protein Kinase Akt by Mtorc2 in Peripheral Blood Mononuclear Cells of Patients with Cancer and Diabetes","authors":"T. Vatseba, L. Sokolova, V. V. Pushkarev, O. Kovzun, V. Pushkarev, B. Guda, M. Tronko","doi":"10.30564/JER.V1I1.674","DOIUrl":"https://doi.org/10.30564/JER.V1I1.674","url":null,"abstract":"Akt/mTOR/p70S6K1 signaling pathway plays an important role in the pathogenesis of cancer and diabetes. Macrophages and lymphocytes are involved in the pathogenesis of diabetes, diabetic atherosclerosis, formation of insulin resistance as well as immune response to cancer and tumor maintenance. The aim of the study was to determine the Akt activation by mTORC2 in peripheral blood mononuclear cell (PBMC) of patients with type 2 diabetes and cancer.The following groups were studied: control group, patients with type 2 diabetes, cancer patients and patients with both cancer and diabetes. The amounts of phospho-Akt (р-S473) and phospho-p70S6K1 (p-T389) were determined using ELISA kits.The amount of phosphorylated Akt significantly increases in PBMC of patients with cancer. There was no effect in PBMC from patients with type 2 diabetes and significant decrease in the amount of phospho-Akt in PBMC of the patients group both with cancer and diabetes. p70S6K1 activation was observed in PBMC of the groups 2 and 3 patients.Thus, chronic diseases such as type 2 diabetes and cancer can affect the signaling mechanisms in blood cells. The state of Akt phosphorylation in leukocytes can indicate the activity of mTORC1 and its substrates, which may be important for the evaluation of the pathological process and the efficacy of the drugs. ","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76905088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application Analysis of Diabetes Health Education in Endocrinology Nursing 糖尿病健康教育在内分泌科护理中的应用分析

Journal of endocrinology and thyroid research Pub Date : 2019-07-12 DOI: 10.30564/JER.V1I1.694

Y. Tao

{"title":"Application Analysis of Diabetes Health Education in Endocrinology Nursing","authors":"Y. Tao","doi":"10.30564/JER.V1I1.694","DOIUrl":"https://doi.org/10.30564/JER.V1I1.694","url":null,"abstract":"Objectives: To explore the clinical value of applying diabetes health education to endocrinology care. Methods: A total of 122 patients with diabetes admitted to our department from October 2016 to October 2017 were selected. After consulting patients, they were randomly divided into two groups, with 61 cases in each group. The control group performs routine care, and the experimental group provides patients with diabetes-specific health education. After three months, the compliance of the two groups of patients was compared. The ADL scores of the two groups of patients before and after treatment were compared. Results: Experimental group had significantly higher compliance rate than control group in all aspects. The difference was statistically significant (P<0.05). The ADL scores of both groups were significantly improved. The effects before and after the care were compared. The difference was statistically significant (P<0.05). The score of experimental group increased more significantly than that of the control group. The difference was statistically significant (P<0.05). Conclusions: In the endocrinology care, the implementation of diabetes special health education for patients can improve patient compliance and improve patients' daily living ability, which is an ideal nursing measure. It is worth promoting.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"348 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79700285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Analysis of Clinical Characters of Inpatients with Infection in the Department of Endocrinology 内分泌科住院感染患者临床特点分析

Journal of endocrinology and thyroid research Pub Date : 2019-07-12 DOI: 10.30564/JER.V1I1.729

Jianying Zhang

{"title":"An Analysis of Clinical Characters of Inpatients with Infection in the Department of Endocrinology","authors":"Jianying Zhang","doi":"10.30564/JER.V1I1.729","DOIUrl":"https://doi.org/10.30564/JER.V1I1.729","url":null,"abstract":"Objective: To analyze the clinical characters of 812 inpatients with infection in the Department of Endocrinology. Methods: Retrospective exhibition of these patients' clinical characters included undergoing diseases, infectious organs, history illness, blood glucose and glycosylated hemoglobin (HbA1C), biochemical indicators, pathogens training description and results, medical imagines, antibiotic utilization, length of stay and hospital costs, final diagnosis and situations. Results: Non-diabetic patients accounted for 176 (21.67%), who were the cases of untreated well hyperthyroidism, mainly suffered with respiratory tract infection. Diabetic patients accounted for 636 (78.33%). In the type2 diabetes patients 376 (59.12) suffered with urinary tract infection. 192 (30.19%) suffered with respiratory system infection, 124 (19.50%) were accompanied with diabetic foot infection, which had 74 (59.67%) patients with HbA1C＞9.0%.Statistical comparisons showed that the days of antibiotic use and average length of stay in hospital per capita in patients with HbA1C≥8% were more than ones with HbA1C＜8% in those with diabetic infections (P＜0.01) . The days of antibiotic use per capita in patients with HbA1C＞9% were more than ones with HbA1C＜7% in those with diabetic foot infections (P＜0.01). Conclusion: Endocrine diseases lack rigid and effective long-term control, which may result in the complications involved with urinary tract, respiratory tract and infections in other organs. The time of hospitalization per capita and the duration of antibiotic use rise are longer in diabetic patients with poor blood sugar control and diabetic foot infection.","PeriodicalId":92667,"journal":{"name":"Journal of endocrinology and thyroid research","volume":"129 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84732235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Primary Hyperaldosteronism as one of the most common forms of Secondary Arterial Hypertension- Clinical Case 原发性高醛固酮增多症是继发性动脉高血压最常见的形式之一-临床病例

Journal of endocrinology and thyroid research Pub Date : 2019-06-21 DOI: 10.19080/jetr.2019.04.555645

O. V Tsygankova

引用次数: 0

Efficacy of Voice Therapy in Total Thyroidectomy: A Single Case Study 语音治疗在甲状腺全切除术中的疗效:一个个案研究

Journal of endocrinology and thyroid research Pub Date : 2019-06-14 DOI: 10.19080/jetr.2019.04.555644

Reuben Thomas Varghese

引用次数: 0

APL: Retinoic Acid and Retinoid Pharmacology, A Breakthrough Trials Today APL:维甲酸和类维甲酸药理学，今天的突破性试验

Journal of endocrinology and thyroid research Pub Date : 2019-06-12 DOI: 10.19080/jetr.2019.04.555643

G. Zhu

引用次数: 4