Clinical microbiology and infectious diseases最新文献

{"title":"Photodegradation of ciprofloxacin and ofloxacin antibiotics and their photo-metabolites with sunlight","authors":"D. Sponza, Pelin Koyuncuoğlu","doi":"10.15761/cmid.1000149","DOIUrl":"https://doi.org/10.15761/cmid.1000149","url":null,"abstract":"","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67450908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of chronic HCV infection in people co-infected with HIV in a Spanish tertiary hospital and in relation to real life","authors":"Ferra Murcia S, Parrón Carreño T, Díez García LF, Collado Romacho A","doi":"10.15761/cmid.1000163","DOIUrl":"https://doi.org/10.15761/cmid.1000163","url":null,"abstract":"","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67451590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An update to middle east respiratory syndrome coronavirus and risk of a pandemic in 2019","authors":"Kazhal Mobaraki, J. Ahmadzadeh","doi":"10.15761/cmid.1000153","DOIUrl":"https://doi.org/10.15761/cmid.1000153","url":null,"abstract":"","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67451098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not the usual suspect: A case of Staphylococcus lugdunensis infective endocarditis","authors":"S. Pavey, M. Khwaja, N. Virgincar, A. Chatterjee","doi":"10.15761/cmid.1000156","DOIUrl":"https://doi.org/10.15761/cmid.1000156","url":null,"abstract":"This report summarises a case of S. lugdunensis infective endocarditis in an 86-year-old woman presenting with a 3-week history of increasing confusion and multiple falls. Although rare, the inherent properties of this bacteria mean that it can lead to a rapidly progressive endocarditis, and so the requirement for surgical intervention in addition to antimicrobial therapy is higher than when compared to other pathogens. Also, the presentation of infective endocarditis is often non-specific in elderly. These combination of factors mean that it is crucial to maintain a high index of suspicion for this disease. If S. lugdunensis is isolated from a blood culture, this should be regarded as a pathogen and prompt workup via transoesophageal echocardiography and Cardiology assessment should be done. *Correspondence to: Apurba Koomar Chatterjee, Consultant Physician, Elderly care medicine, Royal Berkshire Hospital, London Road, Berkshire RG1 5AN, UK, E-mail: Apurba.Chatterjee@royalberkshire.nhs.uk Received: June 12, 2019; Accepted: July 03, 2019; Published: July 05, 2019 Case report An 86-year-old woman was admitted following a 3-week history of increasing confusion and multiple falls. Past medical history included vascular dementia, ischaemic stroke and severe mitral regurgitation. The patient was disorientated with respiratory rate of 22 breaths/min, oxygen saturations of 93%, pulse of 80 bpm, blood pressure of 96/77 mmHg, temperature of 37.3C and NEWs score 7. Cardiovascularrespiratory examination demonstrated vesicular breath sounds with a loud pansystolic murmur. Her blood tests showed haemoglobin 124 g/ dL, white cell count 25.8 10^9/L, C reactive protein 186 mg/L, and platelets 121 10^9/L. Chest X-ray and abdominal ultrasound were normal, with sinus rhythm on ECG. Blood cultures were sent. She was commenced on intravenous fluids and antibiotics i.e. Teicoplanin and Gentamicin. By Day 3 of admission, blood cultures grew S. lugdunensis sensitive to flucloxacillin. Cardiology opinion was sought, and a transthoracic echocardiogram showed mitral valve vegetations consistent with infective endocarditis. She was deemed not fit for surgical intervention in view of her frailty and medical comorbidities (Figure 1). Her clinical condition improved initially on medical management, however, she later developed fast atrial fibrillation with flash pulmonary oedema secondary to acute deterioration of mitral valve functioning. The patient was managed with appropriate diuretics and discharged to a nursing home for palliation within the community as agreed with her family. She passed away four weeks later. Discussion Staphylococcus lugdunensis is a coagulase negative staphylococcus whose pathogenic potential should not be underestimated. Although a commensal of human skin, it is rarely a contaminant in blood culture and should be regarded as a pathogen [1-4]. Infective endocarditis (IE) Figure 1. Transthoracic echocardiogram showing mitral valve vegetations. caused ","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67451345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infective endocarditis related to the uncommon gram-negative pathogen Sphingobacterium spiritivorum","authors":"H. Abensur, Felipe Mb Dantas, M. Araújo, R. N. Campos, M. Araújo, J. Romão","doi":"10.15761/cmid.1000160","DOIUrl":"https://doi.org/10.15761/cmid.1000160","url":null,"abstract":"Volume 4: 1-3 10,800/uL) with neutrophilia (neutrophils 85%), and C reactive protein of 289 mg/L, and normal renal (serum creatinine 0.9 mg/dL) and liver function tests. A transoesophageal echocardiography revealed mitral valve prolapse, and an image suggesting mitral valve vegetation with moderate to severe grade regurgitation, and chordal rupture. Antibiotic (oxacylin) was changed to vancomycin and meropenem. During the follow up, patient’s clinical picture deteriorated, and pulmonary rales progressed up to upper lung levels. The patient was then taken to the operating room emergently where he had a mitral valve replacement. Intraoperative histopathological results of the mitral valve indicated marked acute inflammation, fibroinflammatory debris, and presence of Gram-negative rod. After two days of incubation of mitral valve debris, non-motile, oxidase positive, non-fermenting Gram-negative bacilli grew, identified as Sphingobacterium spiritivorum (Vitek 2, bioMérieux, Marcy-L’Etóile, France), and confirmed using the Vitek MS -MALDI-TOF (Matrix Assisted Laser Desorption Ionization – Time of Flight, bioMérieux, Marcy-L’Etóile, France). Antimicrobial susceptibility testing was performed by automated microdilution broth method (Vitek 2). The results were reported as the minimal inhibitory concentration – MIC (CLSI Table 2B-5, M 100-S25-2015) [6], according to breakpoint criteria: ceftazidime (MIC < 4 μg/mL), cefepime (MIC < 4 μg/mL), imipenem (MIC < 0.5 μg/mL), meropenem (MIC ≤ 0.25 μg/ mL), piperacillin/tazobactam (MIC < 8 μg/mL), ciprofloxacin (MIC MIC ≤ 0.25 μg /mL), and sulfamethoxazole/trimethoprim (MIV MIC ≤20 μg/mL). Finally, like other flavobacteria-like organisms, it was highly resistant to colistin, amikacin and gentamicin. Piperacillin/ tazobactam was associated to antibiotic treatment. He had no fever and his clinical picture was improved. Five weeks after surgical intervention, a new transoesophageal echocardiography did not show any evidence of vegetation or abscess. However, after two weeks the patient condition deteriorated, with fever, and haemodynamic instability. Blood cultures grew Acinetobacter baumannii. On the 40th day, the patient died of septic shock.","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67451302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial activity of natural compounds from Kalanchoe crenata against pathogenic bacteria","authors":"A. Sahin, M. A. Mou, A. Pervin, M. Karim, Abrar Tajwar, Muzammal Haque Asim, M. Salim, A. Mamun","doi":"10.15761/cmid.1000162","DOIUrl":"https://doi.org/10.15761/cmid.1000162","url":null,"abstract":"Microbial resistance to antibiotics is becoming a source of challenge and concern to public health has led to the evaluation of alternative, effective and affordable substitutes are essential if bacterial infections are to be properly controlled. Kalanchoe crenata (Crassulaceae) is a medicinal herb present throughout Bangladesh and is sources of phytochemicals which are able to initiate different biological activities including antimicrobials. Antibacterial potency of the natural compounds of Kalanchoe crenata was assessed using five human pathogenic bacteria (gram-negative and gram-positive by disc diffusion and agar well diffusion methods. All the test bacteria were susceptible to these natural compounds. There was no viable microorganism in the initial inoculums after five expositions in the natural compounds of Kalanchoe crenata. Our study reflects that these natural compounds obtained from Kalanchoe crenata shown strong antibacterial activity and can be serve as a good source for the invention of new therapeutic agents to kill pathogenic bacteria. *Correspondence to: Abdullah Al Mamun, Department of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Sylhet-3114, Bangladesh, Tel: +88-01714516919, Fax: +88-821-715257, E-mail: mssohel@ yahoo.com","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67451420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purple Urine Bags Syndrome masquerading as a bowel obstruction","authors":"D. McDonnell, A. Aldridge","doi":"10.15761/cmid.1000155","DOIUrl":"https://doi.org/10.15761/cmid.1000155","url":null,"abstract":"A 79-year-old patient who had undergone radical cystectomy with ileal conduit formation in 2015 presented to the surgical assessment unit with a week-long history of abdominal distention and constipation and raised inflammatory markers. A CT was performed which attributed the cause of the apparent obstruction to a right inguinal hernia containing several bowel loops. However, this hernia was easily reducible and an alternative explanation for the presentation was sought. On closer inspection of the patient’s abdomen, his urostomy bag was noticed to be purple in colour (Figure 1). A urine dip tested positive for leucocytes and nitrites, so the patient was treated with intravenous co-amoxiclav and fluid therapy. The patient’s bowels started to work once his clinical condition improved. Further urine analysis revealed the pH to be acidic, an unusual finding in purple urine bag syndrome, and a culture grew Staphylococcus aureus.","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67450833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of legionella control in france 1998-2018","authors":"Hartemann Philippe","doi":"10.15761/cmid.1000151","DOIUrl":"https://doi.org/10.15761/cmid.1000151","url":null,"abstract":"Due to mediatic outbreaks occurred in France at the end of the 90’s, a national proactive strategy for the control of Legionella both in the cooling towers and hot water distribution networks in public buildings has been defined. Regulations and guidelines were put into force from 1999 until recently, covering other possible reservoirs, including active surveillance of clinical cases, mandatory sampling and quantitative numerations of Legionella pneumophila, control measures and reporting. The results described in this article present the epidemiological situation and the actual decrease of the number of clinical cases, illustrating the efficacy of this strategy and the disappearance of outbreaks despite numerous remaining isolated cases without reported origin. *Correspondence to: Hartemann philippe, School of Medicine of Nancy, University of Lorraine, 7 Avenue de la forêt de Haye, 545àà Vandoeuvre-Nancy, France, E-mail : philippe.hartemann@univ-lorraine.fr Received: February 18, 2019; Accepted: February 22, 2019; Published: February 27, 2019 Introduction After the discovery of Legionella pneumophila in the US, some initiatives against the infections due to this bacterium have been taken in France but the initial shock occurred during year 1998. This was during the world football championship, organized in France, where the national team defeated the Brazilian one 3-0 during a memorable final play in Paris. In the same time a Legionellosis outbreak occurred, involving some foreign supporters who were diagnosed after their return at home, leading to an European alert via the EWGLI network. The epidemiological study performed retrospectively was able to identify the source of contamination in a Cooling Tower (CT) located in a very touristic street of Paris [1]. This strain is now known as Legionella pneumophila Paris. The French Ministry of Environment decided to make mandatory the notification and the microbiological control of CTs. In the same time the Ministry of Health decided to organize compulsorily an active surveillance of legionellosis cases and microbiological controls of water networks in Health Care settings. In September 2000 occurred the opening ceremony of the European Hospital Georges Pompidou in Paris, considered at this time as the most modern hospital of the country. Three months later appeared 11 cases of legionellosis (5 fatal issues) from December 2000 to June 2001 [2]. This outbreak turned into a « scandal » because some defects were evidenced in the hot water distribution network like stagnation, inadequate temperature, inadequate piping materials, etc. For the first time, point of use filters (porosity 0.22 micrometer) were largely used in patients’ rooms during the necessary period for the restructuration of both hot and cold water distribution networks. The decision of the court was to pinpoint characterized faults and decide manslaughter through negligence. The consequences of this outbreak were an intense pressure of t","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67450980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteria and cancer: Advances, perspectives and applications","authors":"Mariado Sl Rolim, Y. Montenegro, Antonio M Carneiro, Beatriz So Ceballos","doi":"10.15761/cmid.1000147","DOIUrl":"https://doi.org/10.15761/cmid.1000147","url":null,"abstract":"","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67451129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and antibacterial activity evaluation of novel rhodanine based amide derivatives","authors":"M. Tarahomi, R. Baharfar, M. Mohseni","doi":"10.15761/cmid.1000157","DOIUrl":"https://doi.org/10.15761/cmid.1000157","url":null,"abstract":"A novel series of rhodanine based amide derivatives have been prepared through multi-component reaction of rhodanine-N-acetic acid with aromatic aldehydes and alkyl isocyanides in the presence of aniline. The products were isolated in 85-95% yields by easy workup procedure. The synthesized compounds have also been evaluated for their antibacterial effects against four pathogenic bacteria, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. On the basis of the obtained results, some compounds showed moderate growth inhibitory effect against all tested bacteria. *Correspondence to: Robabeh Baharfar, Department of Microbiology, Faculty of Sciences, University of Mazandaran, Babolsar, Iran, E-mail: baharfar@umz.ac.ir","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67451400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}