Clinical microbiology and infectious diseases最新文献

Messenger RNA (mRNA) – A forgotten molecule; its past, present and future for therapeutics 信使RNA (mRNA)——被遗忘的分子;它是治疗学的过去，现在和未来

Clinical microbiology and infectious diseases Pub Date : 2021-01-01 DOI: 10.15761/cmid.1000190

Melin J. Khandekar, Janardan D. Khandekar

引用次数: 0

Evaluation an immunofluorescence-based antigen test for hospital point-of-care diagnosis of SARS-CoV-2 infection 评价基于免疫荧光的抗原检测在医院护理点诊断SARS-CoV-2感染中的作用

Clinical microbiology and infectious diseases Pub Date : 2021-01-01 DOI: 10.15761/cmid.1000192

M. Mbow, Papa Alioune Badara Dieye, Ndeye Khady Ba, Marouba Cisse, G. Lô, Moctar Gningue, I. Diallo, N. Lèye, M. Diouf, Yacine Amet Dia, Oumar Diop, Agbogbenkou Tevi Dela-del Lawson, A. Padane, Aminata Mboup, Djibril Wade, Josephine Khady Badiane, Doudou George Massar Niang, A. Dia, A. Ahouidi, B. Mbengue, Maguette Deme Sylla Niang, S. Diop, Papa Alassane Diaw, Tandakha Ndiaye Dieye, B. Cissé, Elhadji Mamadou Mbaye, S. Mboup, A. Dièye

引用次数: 0

Genomic Differences Between Carbapenem-susceptible and Carbapenem-resistant Escherichia Coli Analyzed by Whole-genome Sequencing 应用全基因组测序技术分析碳青霉烯敏感和碳青霉烯抗性大肠杆菌的基因组差异

Clinical microbiology and infectious diseases Pub Date : 2020-11-25 DOI: 10.21203/rs.3.rs-113332/v1

Qiong Wu, Jun Hu, Jianqiang Wang, Yungai Li, Yu-Jiao Pan, Ronglian Chen, Jin Tang

{"title":"Genomic Differences Between Carbapenem-susceptible and Carbapenem-resistant Escherichia Coli Analyzed by Whole-genome Sequencing","authors":"Qiong Wu, Jun Hu, Jianqiang Wang, Yungai Li, Yu-Jiao Pan, Ronglian Chen, Jin Tang","doi":"10.21203/rs.3.rs-113332/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-113332/v1","url":null,"abstract":"\u0000 Background The widespread resistance to carbapenem via Enterobacteriaceae is a major public health concern. To investigate the reason for the change of Escherichia coli from carbapenem-susceptible to carbapenem-resistant status after antibiotic therapy, whole-genome sequencing was applied for the analysis of genetic difference between the two isolates. The genome of the two isolates of Escherichia coli with distinct resistant phenotypes recovered from one patient was sequenced and compared. Single-nucleotide polymorphisms and insertions/deletions were analyzed using software MUMmer (http://mummer.sourceforge.net/). Results The homology of chromosomes, plasmid 1, and plasmid 2 between the two isolates was very high (>99.5%). However, the coverage ratio of plasmid 3 was only 7.13%. This plasmid harbored the IMP-4 carbapenemase-coding gene. The upstream of blaIMP-4 was the plasmid mobilization relaxosome protein Mobe gene and the downstream were class 1 integrom integrase IntI1 and IS6 family transposase IS15DIV, which may be related to carbapenemase gene capture. Conclusions Single-nucleotide mutation, insertion, and deletion could not result in the development of resistance to carbapenem, whereas acquisition of the IMP-4-encoding gene may be the reason for changes in resistance to carbapenem.","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43385301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indication for SARS-CoV-2 serology: first month follow-up SARS-CoV-2血清学适应证:第一个月随访

Clinical microbiology and infectious diseases Pub Date : 2020-07-03 DOI: 10.1101/2020.06.30.20140715

A. Coste, K. Jaton, M. Papadimitriou-Olivgeris, A. Croxatto, Gilbert GREUB

引用次数: 5

Viruses: Genetically encoded alarm messages for communication between individuals 病毒:基因编码的警报信息，用于个体之间的交流

Clinical microbiology and infectious diseases Pub Date : 2020-01-01 DOI: 10.15761/cmid.1000175

Alejandro Sousa

引用次数: 0

Self-care intervention guidelines on improving knowledge on self-care 提高自我护理知识的自我护理干预指南

Clinical microbiology and infectious diseases Pub Date : 2020-01-01 DOI: 10.15761/cmid.1000166

Balasaraswathi Seetharaman, Premila Lee, A. Zachariah, Reka R Kirubakaran

{"title":"Self-care intervention guidelines on improving knowledge on self-care","authors":"Balasaraswathi Seetharaman, Premila Lee, A. Zachariah, Reka R Kirubakaran","doi":"10.15761/cmid.1000166","DOIUrl":"https://doi.org/10.15761/cmid.1000166","url":null,"abstract":"the of intervention and identify the relationships of scores of on self-care Abstract Background: India has the third largest number of people living with HIV/AIDS and the majority of them (88.55%) are in the age group of 15-49 years. The nature of chronicity poses greater demands on PLHIV for comprehensive self- care in order to adopt positive living. The aim of this study was to develop and assess the effectiveness of Self- Care Intervention Guidelines (SCIG) on improving the knowledge on self-care and their Quality of Life (QOL). Methods: Systematic random sampling technique was used to select the subjects. Adult PLHIV in any clinical stage, on Antiretroviral Therapy (ART) and above 18 years were included in the study. An experimental research design was adopted with a questionnaire to assess the knowledge on self- care and WHO Quality of Life- BREF scale to measure QOL. A total of 150 PLHIV were recruited with 75 in the control group and 75 in the experimental group using the permuted block randomization. Data collection was done at three time points at the ART clinic. Results: The mean age of subjects in both the groups was almost similar (control-40.86 ± 8.74, experimental-39.34 ± 7.38) which reflects that PLHIV are in their productive age group. The mean score difference in knowledge on self- care and QOL between experimental and control group subjects was found to be statistically significant at p<0.001. Conclusion: Based on the findings, the study concluded that the SCIG is an essential and effective intervention in improving the knowledge on self-care and QOL of PLHIV.","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67451983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 pandemic is a unique opportunity to reinvent the hospital COVID-19大流行是重塑医院的独特机会

Clinical microbiology and infectious diseases Pub Date : 2020-01-01 DOI: 10.15761/CMID.1000176

M. Siguier, H. Goulet, M. Fartoukh, J. Cadranel, G. Grateau, E. Letavernier, M. Denis, G. Pialoux

引用次数: 0

Rapid detection of carbapenem resistant Klebsiella pneumoniae directly from positive blood cultures during an outbreak in the Tuscany region in Italy 在意大利托斯卡纳地区暴发期间，直接从阳性血培养物中快速检测出耐碳青霉烯类肺炎克雷伯菌

Clinical microbiology and infectious diseases Pub Date : 2020-01-01 DOI: 10.15761/cmid.1000167

Cesira Giordano, A. Vecchione, M. Menichini, A. Lupetti, S. Barnini

引用次数: 2

Impact of multiplex polymerase chain reaction testing for respiratory pathogens on early detection of influenza outbreak in adult patients at a Singapore hospital 新加坡一家医院呼吸道病原体多重聚合酶链反应检测对早期发现成年患者流感爆发的影响

Clinical microbiology and infectious diseases Pub Date : 2020-01-01 DOI: 10.15761/cmid.1000173

Acosta Allan Pablo, Oh May Lin Helen, Kalyankar Vivek Baliram, Vijaya S Alalageri

引用次数: 0

Investigation of Chlamydia trachomatis IgG and Treponema pallidum IgM antibodies among undergraduate female young stars of Niger Delta Extraction 尼日尔三角洲地区女大学生青年明星沙眼衣原体IgG和梅毒螺旋体IgM抗体的调查

Clinical microbiology and infectious diseases Pub Date : 2020-01-01 DOI: 10.15761/cmid.1000168

O. Azuonwu, Ossai Jennifer, Christian Serekara

{"title":"Investigation of Chlamydia trachomatis IgG and Treponema pallidum IgM antibodies among undergraduate female young stars of Niger Delta Extraction","authors":"O. Azuonwu, Ossai Jennifer, Christian Serekara","doi":"10.15761/cmid.1000168","DOIUrl":"https://doi.org/10.15761/cmid.1000168","url":null,"abstract":"We performed a cross sectional study which was aimed at evaluating the prevalence of Chlamydia trachomatis IgG and Treponema pallidum IgM antibodies in the sera of young women in Port Harcourt. Two millilitre of venous blood was drawn and was used to assay for Chlamydia trachomatis IgG and Treponema pallidum IgM antibodies from 205 female subjects, aged between 17-28 years, who was recruited into the study through convenience, random sampling research design. The prevalence of Chlamydia trachomatis IgG antibodies was 7.3% and Treponema pallidum IgM antibodies was 0.9%. There was a zero prevalence of co-infection. When prevalence was evaluated with stratified age groups, there was a significant difference (p < 0.0001) with Chlamydia trachomatis IgG antibodies but not with Treponema pallidum IgM antibodies (p =0.0548). Increased ages of subject were a predictive risk factor for the acquisition of Chlamydia trachomatis infection, hence, it is recommended that national multicentre study be created with varied platforms and settings, for continuous screening and monitoring of targeted sexually active young women in our communities. *Correspondence to: Obioma Azuonwu, Department of Medical Laboratory Science, Rivers State University, Port Harcourt, Nigeria, Tel: +234 8035519688, E-mail: bimajacobs@yahoo.co.uk","PeriodicalId":92491,"journal":{"name":"Clinical microbiology and infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67451938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0