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Journal of lung health and diseases最新文献

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Lgr6: From Stemness to Cancer Progression Lgr6:从干细胞到癌症进展
Journal of lung health and diseases Pub Date : 2019-01-01 DOI: 10.29245/2689-999X/2018/1.1144
E. Cortesi, J. Ventura
{"title":"Lgr6: From Stemness to Cancer Progression","authors":"E. Cortesi, J. Ventura","doi":"10.29245/2689-999X/2018/1.1144","DOIUrl":"https://doi.org/10.29245/2689-999X/2018/1.1144","url":null,"abstract":"Lung cancer is the leading cause of cancer-related deaths worldwide with poor prognosis, mainly due to the delay in the diagnosis. Adenocarcinoma, a subtype of non-small cell lung cancer, has the highest incidence and significant recurrence rates. Experimental and clinical researches suggested that the presence of cancer stem cells could support the development, malignization and resistance of lung cancer. Unfortunately, our knowledge in the field is still limited. Here we report our findings regarding a cell population expressing LGR6, an epithelial stem cell marker. Under the pressure of a fine regulated p38α MAPK/mir-17-92 axis, LGR6+ stem cells produce differentiated bronchioalveolar cells, in the normal lung. LGR6 is enriched in tumour cells during adenocarcinoma progression. Similar to normal stem cells, LGR6+ cancer cells show self-renewal and differentiation capacities, alongside with a higher oncogenic potential. Our studies suggest a disruption in the p38α MAPK/mir-17-92 network, that enhances Wnt pathway activity, could be responsible for the selection of malignant LGR6+ tumour cells. These results support the existence of a cell population with stem-like characteristics and strong oncogenic potential. This population could be useful for predictive diagnosis and a novel target for improved and more effective therapies against metastases and recurrences of lung adenocarcinomas.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"13 1","pages":"12 - 15"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82948789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Comments: Aneurysm of The Pulmonary Artery 评论:肺动脉动脉瘤
Journal of lung health and diseases Pub Date : 2018-06-01 DOI: 10.29245/2689-999X/2017/3.1138
S. Niang, St. Louis, Senegal, blockquote
{"title":"Comments: Aneurysm of The Pulmonary Artery","authors":"S. Niang, St. Louis, Senegal, blockquote","doi":"10.29245/2689-999X/2017/3.1138","DOIUrl":"https://doi.org/10.29245/2689-999X/2017/3.1138","url":null,"abstract":"The Rasmussen aneurysm develops, on the contrary, in contact with a chronic tuberculous cavern, at a distance from the acute phase. Its description has been the subject of numerous publications2,3. Rémy et al.4 emphasized this potentially lethal form of the false erosive aneurysm, highlighting their lack of knowledge, the concept of «sentinel» hemoptysis, a possible prelude to fatal hemoptysis, and, above all, the possibilities of interventional angiography5.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87689483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary: Factors Related to the Probable PTSD After the 9/11 World Trade Center Attack Among Asian Americans 评论:9/11世界贸易中心袭击后亚裔美国人可能患PTSD的相关因素
Journal of lung health and diseases Pub Date : 2018-06-01 DOI: 10.29245/2689-999x/2017/4.1142
W. Kung
{"title":"Commentary: Factors Related to the Probable PTSD After the 9/11 World Trade Center Attack Among Asian Americans","authors":"W. Kung","doi":"10.29245/2689-999x/2017/4.1142","DOIUrl":"https://doi.org/10.29245/2689-999x/2017/4.1142","url":null,"abstract":"","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81317608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Lung Microbiome: The essential to know 肺微生物群:必须知道
Journal of lung health and diseases Pub Date : 2018-06-01 DOI: 10.29245/2689-999X/2017/3.1135
Y. Mohammad, Section Pulmonary, blockquote
{"title":"Lung Microbiome: The essential to know","authors":"Y. Mohammad, Section Pulmonary, blockquote","doi":"10.29245/2689-999X/2017/3.1135","DOIUrl":"https://doi.org/10.29245/2689-999X/2017/3.1135","url":null,"abstract":"In a state of the art article of the ATS 2014: Authors highlighted that: Characterization of the microbiome can be done by sequencing regions of a conserved gene, such as the hypervariable regions of the 16S r RNA gene. This lead to different sequences in different microbes. The unit for research is the taxon, each microbe has taxons , characterized by operational taxonomic unit(OTU) [3 ]. The microbiota plays a particularly important role in the development and functional integrity of the immune system. Shifts or perturbations in the microbiota can lead to disease4","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73315383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interprofessional Education and Collaborative Practice: Are We There Yet? 跨专业教育与合作实践:我们做到了吗?
Journal of lung health and diseases Pub Date : 2018-06-01 DOI: 10.29245/2689-999x/2017/4.1139
K. Clark, P. M. I. R. C. Program, Clinical, Program, blockquote
{"title":"Interprofessional Education and Collaborative Practice: Are We There Yet?","authors":"K. Clark, P. M. I. R. C. Program, Clinical, Program, blockquote","doi":"10.29245/2689-999x/2017/4.1139","DOIUrl":"https://doi.org/10.29245/2689-999x/2017/4.1139","url":null,"abstract":"Interprofessional education (IPE) and collaborative practice have been debated for several decades in the health professions. Over that course of time there have been ebbs and flows of interest in IPE and collaborative practice. Health care reform has brought about a renewed interest. IPE is considered an important component in developing collaborative practice-ready health professionals. IPE readiness, effectiveness, and challenges are considerations for successful IPE implementation. Sufficient evidence exists to suggest that faculty and students are motivated to engage in IPE. Knowledge, skills, and attitudes have been shown to improve with IPE interventions. Questions remain, however, about the linkage of IPE to collaborative practice and health outcomes.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84135175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Commentary: Association of Anemia with Venous Thromboembolism in Acutely Ill Hospitalized Patients: An APEX Trial Substudy 评论:急性住院患者贫血与静脉血栓栓塞的关联:APEX试验亚研究
Journal of lung health and diseases Pub Date : 2018-06-01 DOI: 10.29245/2689-999x/2017/3.1133
Anmol Pitliya, Asrar Ahmad, H. Shaukat, Eiman Ghaffarpasand, Sadaf Sharfaei, Farima Kahe, S. H. Kazmi, G. Chi
{"title":"Commentary: Association of Anemia with Venous Thromboembolism in Acutely Ill Hospitalized Patients: An APEX Trial Substudy","authors":"Anmol Pitliya, Asrar Ahmad, H. Shaukat, Eiman Ghaffarpasand, Sadaf Sharfaei, Farima Kahe, S. H. Kazmi, G. Chi","doi":"10.29245/2689-999x/2017/3.1133","DOIUrl":"https://doi.org/10.29245/2689-999x/2017/3.1133","url":null,"abstract":"Page 10 of 13 Commentary: Association of Anemia with Venous Thromboembolism in Acutely Ill Hospitalized Patients: An APEX Trial Substudy Anmol Pitliya1, Asrar Ahmad2, Husnain Shaukat1, Eiman Ghaffarpasand1, Sadaf Sharfaei1, Farima Kahe1, Syed Hassan A. Kazmi1, Gerald Chi1* 1Division of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA 2Department of Medicine, Abington Memorial Hospital, Abington, Pennsylvania, USA","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86405732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Multidisciplinary Approach to Tumor Pathologies: State of the Art of a Single Center 肿瘤病理学的多学科方法:单一中心的现状
Journal of lung health and diseases Pub Date : 2018-06-01 DOI: 10.29245/2689-999x/2017/3.1132
A. G., Fabbri N, Marino S, R. G, Giaccari S, Tamburini N, Fiorica F, Cavallesco G
{"title":"Multidisciplinary Approach to Tumor Pathologies: State of the Art of a Single Center","authors":"A. G., Fabbri N, Marino S, R. G, Giaccari S, Tamburini N, Fiorica F, Cavallesco G","doi":"10.29245/2689-999x/2017/3.1132","DOIUrl":"https://doi.org/10.29245/2689-999x/2017/3.1132","url":null,"abstract":"Aim: The figure of cancer patient has changed. Some reasons are the increase of the average population and higher incidence of diseases related to old age (cardiovascular diseases, diabetes, etc.), but also diseases such as obesity are increasing in industrialized countries. For these reasons is necessary to choose an adequate and personalized treatment, taking into consideration the different risk of mortality and morbidity in therapeutic choices through a greater interaction between medical specialists. \u0000Experiment: we conducted a retrospective study that took into consideration all the patients who underwent surgery of rectosigmoid junction and rectum in our hospital before and after the institution of a multidisciplinary tumour board (MTB) from January 2007 to April 2017. Furthermore, a recent retrospective single-centre analysis was performed in the same hospital by Tamburini et al. on consecutive patients who underwent surgery for non-small cell lung cancer (NSCLC) between January 2008 and December 2015. \u0000Results: the advantage brought by the multidisciplinary evaluation teams are confirmed for the presence of benefits in terms of reduction of morbidity and improvement of the outcome of MTB patient group. \u0000Conclusions: we find that more study depth of neoplastic disease as well as of each individual patient leads to more accurate staging and to a weighted therapy based on the needs of the individual. According to our experience, multidisciplinary tumour board should be present in all hospitals where cancer diseases are treated.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89588117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary cryptococcocis in immunocompetent patient - a case report 免疫功能正常患者肺隐球菌感染1例
Journal of lung health and diseases Pub Date : 2018-06-01 DOI: 10.29245/2689-999x/2017/3.1128
C. Hing, A. Alaga, M. Razul, Alor Setar, Malaysia., blockquote
{"title":"Pulmonary cryptococcocis in immunocompetent patient - a case report","authors":"C. Hing, A. Alaga, M. Razul, Alor Setar, Malaysia., blockquote","doi":"10.29245/2689-999x/2017/3.1128","DOIUrl":"https://doi.org/10.29245/2689-999x/2017/3.1128","url":null,"abstract":"Pulmonary crytococcosis is a rare infection in immunocompetent patients. It is caused by encapsulated yeast-like fungus Cryptococcus neoformans. A young healthy gentleman presented with 1 day history of dyspnoea and fever, with 2 weeks history of weight loss. \u0000Clinical examination revealed left lung collapse. CT thorax done showed a mediastinal mass with left lung collapse. Tissue obtained from bronchoscopy confirmed presence of Cryptococcus neoformans. The left main bronchial mass was removed during rigid bronchoscopy to expand the left lung. He was given T fluconazole 400 mg OD for 6 months. He improved significantly after the removal of left bronchial mass.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81935739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Clinical Approach to Diagnosis and Treatment of Left Anterior Descending Artery Myocardial Bridge 左前降支心肌桥的临床诊断与治疗
Journal of lung health and diseases Pub Date : 2018-06-01 DOI: 10.29245/2689-999X/2017/4.1141
G. Tarantini, L. N. Fovino, Alberto Barioli, Alessandro Schiavo, C. Fraccaro, Thoracic, Padova, blockquote
{"title":"A Clinical Approach to Diagnosis and Treatment of Left Anterior Descending Artery Myocardial Bridge","authors":"G. Tarantini, L. N. Fovino, Alberto Barioli, Alessandro Schiavo, C. Fraccaro, Thoracic, Padova, blockquote","doi":"10.29245/2689-999X/2017/4.1141","DOIUrl":"https://doi.org/10.29245/2689-999X/2017/4.1141","url":null,"abstract":"The muscle overlying the intramyocardial segment of an epicardial coronary artery is defined as myocardial bridge (MB). The clinical relevance of MBs is extremely heterogeneous, ranging from incidental finding in asymptomatic patients to different clinical manifestations such as stable or unstable angina, arrhythmias, Takotsubo syndrome or other major cardiovascular events. Moreover, patients can evolve from “asymptomatic carriers” to “symptomatic carriers” over time. In this setting, haemodynamic assessment is challenging and optimal therapy still a matter of debate. This review summarizes epidemiology, pathophysiology, diagnostic work-up (including both morphological and functional assessment) and treatment of patients with MB involving the left anterior descending artery, suggesting a pragmatic clinical approach.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82443698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Anomalous Right Coronary Artery Originating from the pulmonary artery. (ARCAPA): A systematic review of literature 右冠状动脉异常起源于肺动脉。(ARCAPA):系统的文献综述
Journal of lung health and diseases Pub Date : 2018-06-01 DOI: 10.29245/2689-999x/2017/3.1134
H. Rawal, S. Mehta, Illinois., I. Street, blockquote
{"title":"Anomalous Right Coronary Artery Originating from the pulmonary artery. (ARCAPA): A systematic review of literature","authors":"H. Rawal, S. Mehta, Illinois., I. Street, blockquote","doi":"10.29245/2689-999x/2017/3.1134","DOIUrl":"https://doi.org/10.29245/2689-999x/2017/3.1134","url":null,"abstract":"Anomalous origin of the right coronary artery from the pulmonary artery (ARCAPA) is a very rare congenital heart defect. Most patients are asymptomatic and the anomaly is detected incidentally during evaluation for other problems. Occasionally, ARCAPA may lead to myocardial ischemia and/or sudden cardiac arrest. Here we highlight the presentation, diagnosis and available treatment modalities for the management of this rare anomaly.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84361212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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