Journal of lung health and diseases最新文献_第3页

Lgr6: From Stemness to Cancer Progression. Lgr6：从干细胞到癌症进展。

Journal of lung health and diseases Pub Date : 2019-06-18 Epub Date: 2019-02-05

Emanuela Cortesi, Juan-Jose Ventura

{"title":"Lgr6: From Stemness to Cancer Progression.","authors":"Emanuela Cortesi, Juan-Jose Ventura","doi":"","DOIUrl":"","url":null,"abstract":"Lung cancer is the leading cause of cancer-related deaths worldwide with poor prognosis, mainly due to the delay in the diagnosis. Adenocarcinoma, a subtype of non-small cell lung cancer, has the highest incidence and significant recurrence rates. Experimental and clinical researches suggested that the presence of cancer stem cells could support the development, malignization and resistance of lung cancer. Unfortunately, our knowledge in the field is still limited. Here we report our findings regarding a cell population expressing LGR6, an epithelial stem cell marker. Under the pressure of a fine regulated p38α MAPK/mir-17-92 axis, LGR6+ stem cells produce differentiated bronchioalveolar cells, in the normal lung. LGR6 is enriched in tumour cells during adenocarcinoma progression. Similar to normal stem cells, LGR6+ cancer cells show self-renewal and differentiation capacities, alongside with a higher oncogenic potential. Our studies suggest a disruption in the p38α MAPK/mir-17-92 network, that enhances Wnt pathway activity, could be responsible for the selection of malignant LGR6+ tumour cells. These results support the existence of a cell population with stem-like characteristics and strong oncogenic potential. This population could be useful for predictive diagnosis and a novel target for improved and more effective therapies against metastases and recurrences of lung adenocarcinomas.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"3 1","pages":"12-15"},"PeriodicalIF":0.0,"publicationDate":"2019-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37086267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complement Factor (C3) Level as Marker of Inflammation in Paediatric Asthma 补体因子(C3)水平作为儿童哮喘炎症的标志物

Journal of lung health and diseases Pub Date : 2019-04-08 DOI: 10.29245/2689-999X/2019/2.1151

A. Somashekar, K. Ramakrishnan, Vanitha Gowda

引用次数: 1

Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk. 上皮细胞-间充质转化通过上皮细胞/成纤维细胞的异常交叉对话导致肺纤维化。

Journal of lung health and diseases Pub Date : 2019-04-02

Charlotte Hill, Mark G Jones, Donna E Davies, Yihua Wang

{"title":"Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk.","authors":"Charlotte Hill, Mark G Jones, Donna E Davies, Yihua Wang","doi":"","DOIUrl":"","url":null,"abstract":"Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic interstitial lung disease. Median survival is only 3 years, and treatment options are limited. IPF is thought to be a result of a combination of genetic and environmental factors with repetitive micro-injuries to alveolar epithelial cells playing a central role. IPF is characterised by aberrant extra cellular matrix (ECM) deposition by activated myofibroblasts. Epithelial-mesenchymal transition (EMT) is a process where polarised epithelial cells undergo molecular changes allowing them to gain a mesenchymal phenotype, with a subsequent enhanced ability to produce ECM components and increased migration and/or invasion. The source of myofibroblasts in IPF has been debated for many years, and EMT has been proposed as a source of these cells. However, lineage tracing in transgenic mice suggests the contribution of epithelial cells, which have undergone EMT, to the fibroblast population may be negligible. Instead, recent findings suggest that alveolar epithelial type II (ATII) cells undergoing EMT promote a pro-fibrotic microenvironment through paracrine signalling activating local fibroblasts. This review paper explores the contribution of ATII cells, which have undergone EMT, in the context of pulmonary fibrosis.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"3 2","pages":"31-35"},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485666/pdf/emss-82493.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37194336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk. 上皮-间质转化通过异常上皮/成纤维细胞串扰促进肺纤维化。

Journal of lung health and diseases Pub Date : 2019-04-02 DOI: 10.29245/2689-999X/2019/2.1149

Charlotte N. Hill, Mark G. Jones, D. Davies, Yihua Wang

{"title":"Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk.","authors":"Charlotte N. Hill, Mark G. Jones, D. Davies, Yihua Wang","doi":"10.29245/2689-999X/2019/2.1149","DOIUrl":"https://doi.org/10.29245/2689-999X/2019/2.1149","url":null,"abstract":"Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic interstitial lung disease. Median survival is only 3 years, and treatment options are limited. IPF is thought to be a result of a combination of genetic and environmental factors with repetitive micro-injuries to alveolar epithelial cells playing a central role. IPF is characterised by aberrant extra cellular matrix (ECM) deposition by activated myofibroblasts. Epithelial-mesenchymal transition (EMT) is a process where polarised epithelial cells undergo molecular changes allowing them to gain a mesenchymal phenotype, with a subsequent enhanced ability to produce ECM components and increased migration and/or invasion. The source of myofibroblasts in IPF has been debated for many years, and EMT has been proposed as a source of these cells. However, lineage tracing in transgenic mice suggests the contribution of epithelial cells, which have undergone EMT, to the fibroblast population may be negligible. Instead, recent findings suggest that alveolar epithelial type II (ATII) cells undergoing EMT promote a pro-fibrotic microenvironment through paracrine signalling activating local fibroblasts. This review paper explores the contribution of ATII cells, which have undergone EMT, in the context of pulmonary fibrosis.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"1 1","pages":"31-35"},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88563733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 81

Pulmonary Nano-Drug Delivery Systems for Lung Cancer: Current Knowledge and Prospects 肺癌肺纳米药物递送系统:目前的知识和前景

Journal of lung health and diseases Pub Date : 2019-03-11 DOI: 10.29245/2689-999X/2019/2.1148

M. Amararathna, K. Goralski, D. Hoskin, H. Rupasinghe, C. Rm, Pictou Rd. Po Box, Truro, Canada., R. NsBH, blockquote

{"title":"Pulmonary Nano-Drug Delivery Systems for Lung Cancer: Current Knowledge and Prospects","authors":"M. Amararathna, K. Goralski, D. Hoskin, H. Rupasinghe, C. Rm, Pictou Rd. Po Box, Truro, Canada., R. NsBH, blockquote","doi":"10.29245/2689-999X/2019/2.1148","DOIUrl":"https://doi.org/10.29245/2689-999X/2019/2.1148","url":null,"abstract":"Treatment complexities and the cytotoxicity of anticancer drugs to normal cells often results in therapeutic failure. Biodegradable nanoparticles have gained attention as drug carriers due to their physicochemical characteristics. Nanoparticles are able to encapsulate anticancer drugs and deliver them to target malignant cells while sparing normal cells. Since lung cancer usually arises in lung epithelium, localized drug delivery could be an alternative strategy to effectively treat this disease. Encapsulation of lung cancer drugs in nanoparticles may facilitate intact drug delivery, avoid first-pass metabolism, and reduce cytotoxicity to normal cells, as well as being attractive to patients. However, nanoparticles should be formulated in such a way as to facilitate entrance, deposition, retention, and permeability on targeted lung tissues and escape mucociliary clearance and phagocytosis. Additionally, the patient’s diversity related to lung cancer type, stage of disease, and physical fitness should be considered when formulating a nanocarrier and a delivery device. The potential of localized drug delivery for lung cancer using nanoparticles is reviewed here. Abbreviations: PLGA, poly(lactide-co-glycolide); MRP1, multidrug resistance associated protein 1; GST, glutathione-s-transferase; NAT, N-acetyltransferease; SULT, sulfotransferases; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80590245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

The Relation between Ambient Temperature and Asthma Exacerbation in Children: A Systematic Review 环境温度与儿童哮喘加重的关系:一项系统综述

Journal of lung health and diseases Pub Date : 2019-01-04 DOI: 10.29245/2689-999X/2018/1.1146

H. Shoraka, Moslem Taheri Soodejani, Omid Abobakri, N. Khanjani, Kerman, Bojnurd, blockquote

{"title":"The Relation between Ambient Temperature and Asthma Exacerbation in Children: A Systematic Review","authors":"H. Shoraka, Moslem Taheri Soodejani, Omid Abobakri, N. Khanjani, Kerman, Bojnurd, blockquote","doi":"10.29245/2689-999X/2018/1.1146","DOIUrl":"https://doi.org/10.29245/2689-999X/2018/1.1146","url":null,"abstract":"Background: Asthma is one of the most common chronic non-communicable diseases which is seen more in the developed than developing countries of the world. Recurrence and exacerbations of the disease are common among patients and often lead to hospitalization and therapeutic interventions. Ambient air temperature might be related to the relapse of asthma. This review was conducted to investigate the relation between ambient temperature and exacerbations of asthma in children. \u0000Methods: Related articles were searched in PubMed, Web of Science, Science Direct, and Scopus databases with appropriate keywords and no specific limitation on October 1, 2018. Initially, the relevance of the articles was examined using the title and abstract. Out of 2633 articles, 23 articles were eligible according to the inclusion and exclusion criteria. \u0000Results: Fourteen studies had reported inverse relations; and showed as the temperature dropped, the number of asthma attacks increased in children. Nine papers observed a relation between hot weather and asthma attacks, 3 studies reported a relation between temperature differences and asthma attacks, and two studies did not show any relation. Some studies suggested the increased incidence of asthma in the 5-14 year old age group was associated with the start of the school year and probably due to the spread of viral diseases, not temperature changes. \u0000Conclusion: Extreme temperatures are likely to cause exacerbation of childhood asthma.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86172706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Commentary on "Effect of Humidified Noninvasive Ventilation on the Development of Facial Skin Breakdown" “加湿无创通气对面部皮肤破裂发展的影响”综述

Journal of lung health and diseases Pub Date : 2019-01-01 DOI: 10.29245/2689-999x/2018/1.1147

J. Alqahtani

引用次数: 0

Commentary: Novel Insight into the Genetic Basis of High Altitude Pulmonary Hypertension in Kyrgyz Highlanders. 评论:对吉尔吉斯高原人高海拔肺动脉高压遗传基础的新见解。

Journal of lung health and diseases Pub Date : 2019-01-01 Epub Date: 2019-03-19

Tsering Stobdan, Gabriel G Haddad

引用次数: 0

A summary of Evaluation of Asthma Control in Children Using Childhood-Asthma Control Test (CACT) and Asthma Therapy Assessment Questionnaire (ATAQ) 儿童哮喘控制试验(CACT)和哮喘治疗评估问卷(ATAQ)对儿童哮喘控制的评价综述

Journal of lung health and diseases Pub Date : 2019-01-01 DOI: 10.29245/2689-999x/2018/1.1124

A. Somashekar, K. Ramakrishnan

引用次数: 0

Fluticasone Furoate: A Once Daily Preparation in Patients with Persistent Asthma 糠酸氟替卡松:持续性哮喘患者每日一次的制剂

Journal of lung health and diseases Pub Date : 2019-01-01 DOI: 10.29245/2689-999X/2018/1.1143

Paul Lilburn, H. Ainge-Allen, P. Thomas, Nsw, Australia, blockquote

{"title":"Fluticasone Furoate: A Once Daily Preparation in Patients with Persistent Asthma","authors":"Paul Lilburn, H. Ainge-Allen, P. Thomas, Nsw, Australia, blockquote","doi":"10.29245/2689-999X/2018/1.1143","DOIUrl":"https://doi.org/10.29245/2689-999X/2018/1.1143","url":null,"abstract":"Asthma affects approximately 240 million people worldwide. It is characterised by an allergic pattern of smooth muscle constriction and airway inflammation, and if chronic, the inflammation can lead to structural changes and fixed airflow obstruction. Bronchodilators relieve the bronchoconstriction, while inhaled corticosteroids reduce the airway inflammation. This paper reviews fluticasone furoate (FF), a novel inhaled corticosteroid with 24-hour duration of action. It is a synthetic fluorinated corticosteroid with agonist activity at the glucocorticoid receptor (GRE). It is reported to have a fast association and slow dissociation from the GRE compared to other ICSs. FF has been found to have a greater lung retention time than all other ICS preparations which may contribute to the extended duration of anti-inflammatory action. FF has extensive first pass hepatic metabolism resulting in a low gastrointestinal bioavailability which is consistent with the findings for other ICS preparations. FF, however, will pass from the lung into the systemic circulation and therefore an adverse profile similar to all ICS is likely, but long term data are needed. \u0000FF has demonstrated treatment efficacy for asthma between 100μg and 200μg alone, but in combination with the long-acting beta agonist, vilanterol (FF/VIL 200μg/50μg OD) there were further improvements in lung function relative to monotherapy. There is an increased risk of pneumonia identified in patients with airways disease in associated with ICS preparations and surveillance will be required to determine if this also applies to FF. Once daily therapy, such as FF, may improve compliance and could hopefully be translated into further improvements in asthma-related outcomes.","PeriodicalId":92410,"journal":{"name":"Journal of lung health and diseases","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73869854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0