Journal of laboratory and precision medicine最新文献_第3页

Modern hematology analyzers: beyond the simple blood cells count (with focus on the red blood cells) 现代血液分析仪：超越简单的血细胞计数（重点是红细胞）

Journal of laboratory and precision medicine Pub Date : 2024-01-01 DOI: 10.21037/jlpm-23-32

Massimo Daves, V. Roccaforte, Fortunata Lombardi, Rossella Panella, S. Pastori, Marta Spreafico, Erika Jani, Andrea Piccin

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Preliminary evaluation of concordance between Bence Jones protein and urine free light chain (FLC) 初步评估本斯-琼斯蛋白与尿液游离轻链（FLC）之间的一致性

Journal of laboratory and precision medicine Pub Date : 2024-01-01 DOI: 10.21037/jlpm-23-51

Massimo Daves, Erika Jani, Marta Spreafico, Andrea Piccin, V. Roccaforte

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Laboratory medicine in diabetic kidney disease: challenges and perspectives 糖尿病肾病的检验医学:挑战与展望

Journal of laboratory and precision medicine Pub Date : 2023-10-01 DOI: 10.21037/jlpm-23-58

Rafael Noal Moresco

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Identification of interferences in free thyroxin assay—establishment of acceptable recovery limits for the dilution test 游离甲状腺素测定中干扰物的鉴定——稀释试验可接受回收率的建立

Journal of laboratory and precision medicine Pub Date : 2023-10-01 DOI: 10.21037/jlpm-23-34

Ruggero Dittadi, Sabrina Lombino, Paolo Carraro

{"title":"Identification of interferences in free thyroxin assay—establishment of acceptable recovery limits for the dilution test","authors":"Ruggero Dittadi, Sabrina Lombino, Paolo Carraro","doi":"10.21037/jlpm-23-34","DOIUrl":"https://doi.org/10.21037/jlpm-23-34","url":null,"abstract":": One of the simplest and most effective methods to verify the presence of analytical interferences in immunoassays is the dilution test. Use of this test is generally not recommended in free T4 (fT4) immunoassays, but it has been previously successfully used for the detection of interferences. The aim of this study was to confirm the data previously published and to determine an acceptable range for recovery, beyond which the presence of interference can be considered probable. fT4 were measured with Access Free T4 assay (Beckman Coulter Inc., Brea, CA, USA). After preliminary evaluation of this method’s performance in a dilution test of 13 samples of patients with different binding capacities, the acceptable range of recovery of the dilution test was evaluated using 121 analytically and clinically plausible specimens within the measurement range of the assay. Moreover, 44 cases were evaluated with inconsistent results among the measured thyroid hormones. The acceptability range (2.5th–97.5th percentile) of recovery was between 77.4% and 121.7%. In 23 of the 44 suspected cases evaluated, the result of dilution showed recoveries within the established acceptability range, and the value of fT4 was also confirmed on another analytical platform (Liason XL). In the 21 cases where the recoveries were outside the acceptability range, the concentrations measured on Liaison XL were instead markedly different from the Access method and showed probable interferences. In conclusion, it has been verified that the Access fT4 method allows to obtain an excellent recovery at the dilution test, at least up to the 1/10 dilution. The reference ranges established for the acceptability of recovery under non-interference conditions allow to identify a possible analytical interference in a simple and reproducible way.","PeriodicalId":92408,"journal":{"name":"Journal of laboratory and precision medicine","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Humoral response is enhanced after ipsilateral double intramuscular injection of BNT162b2 COVID-19 vaccine 同侧双肌注射BNT162b2 COVID-19疫苗后，体液反应增强

Journal of laboratory and precision medicine Pub Date : 2023-10-01 DOI: 10.21037/jlpm-23-56

Laura Pighi, Brandon M. Henry, Gian Luca Salvagno, Giuseppe Lippi

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Impact of COVID-19 pandemic on serum 25-hydroxyvitamin D levels in Brazilian patients COVID-19大流行对巴西患者血清25-羟基维生素D水平的影响

Journal of laboratory and precision medicine Pub Date : 2023-10-01 DOI: 10.21037/jlpm-23-35

Gabriel Pissolati M. Bretz, João Rodrigo Campos, Adriano Alonso Veloso, Karina Braga Gomes, Adriano Basques Fernandes

{"title":"Impact of COVID-19 pandemic on serum 25-hydroxyvitamin D levels in Brazilian patients","authors":"Gabriel Pissolati M. Bretz, João Rodrigo Campos, Adriano Alonso Veloso, Karina Braga Gomes, Adriano Basques Fernandes","doi":"10.21037/jlpm-23-35","DOIUrl":"https://doi.org/10.21037/jlpm-23-35","url":null,"abstract":": Governmental actions and public health recommendations during the coronavirus disease 2019 (COVID-19) pandemic resulted in several restrictions on daily living, including social distancing. The impact of these long-term restrictions on health behaviors and lifestyles are unclear, but it could be related to vitamin D (VitD) deficiency. This study aimed to compare VitD levels in patients in pre-pandemic (PP) period and during the most important isolation period in pandemic (DP). We investigated 363,158 results of 25-hydroxyvitamin D (25OH-D) levels from individuals who underwent health checks. The data was obtained from medical records during 2018–2019 (PP); and those results obtained from 2020 to 2021 (DP). 25OH-D levels were measured using a chemiluminescent assay (Siemens®). R software was used to statistical analysis and P value <0.05 was considered significant. 25OH-D levels were compared also regarding age ranges (<18, 18–64 and ≥65 years old) and sex of the individuals. The men group presented higher 25OH-D levels than women only in PP period. During the PP period, individuals <18 years old also showed higher 25OH-D levels. All age groups presented lower 25OH-D levels in DP period, however, the greatest reduction was observed in the group <18 years old. VitD evaluation and supplementation should be considered for overall population submitted to home confinement and social distancing due to COVID-19.","PeriodicalId":92408,"journal":{"name":"Journal of laboratory and precision medicine","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136127333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Analytical performance of point-of-care device QuikRead go in HbA1c analysis 即时护理设备QuikRead go在HbA1c分析中的分析性能

Journal of laboratory and precision medicine Pub Date : 2023-10-01 DOI: 10.21037/jlpm-23-21

Anna Linko-Parvinen, Johanna Dahlström, Hanna-Mari Pallari

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Woman with cryptic chronic back pain: a case report 女性隐蔽性慢性背痛:1例报告

Journal of laboratory and precision medicine Pub Date : 2023-10-01 DOI: 10.21037/jlpm-23-33

Say Min Lim, Pei Chi Ling, Tze Ping Loh

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Continuous effort—not strength or intelligence—is the key to unlocking our potential—Winston Churchill—we are still underway to find biomarkers in cardiovascular diseases 持续的努力——而不是力量或智力——是释放我们潜能的关键——温斯顿·丘吉尔——我们仍在寻找心血管疾病的生物标志物

Journal of laboratory and precision medicine Pub Date : 2023-10-01 DOI: 10.21037/jlpm-23-44

Tatsuo Shimosawa

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Is mixing of blood gas syringes after collection really necessary? 采集后的血气注射器真的需要混合吗?

Journal of laboratory and precision medicine Pub Date : 2023-10-01 DOI: 10.21037/jlpm-23-47

Laura Pighi, Gian Luca Salvagno, Giuseppe Lippi

引用次数: 0