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Journal of glycobiology最新文献

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Glycobiology – study of Glycans 糖生物学-聚糖的研究
Journal of glycobiology Pub Date : 2020-01-01 DOI: 10.35248/2168-958X.20.9.E004
F. Aziz
{"title":"Glycobiology – study of Glycans","authors":"F. Aziz","doi":"10.35248/2168-958X.20.9.E004","DOIUrl":"https://doi.org/10.35248/2168-958X.20.9.E004","url":null,"abstract":"Journal of Glycobiology is an worldwide conspicuous diary which distributed articles universally within the prime field of capacities of diverse saccharides, glycans, oligosaccharides or the diverse proteins which connected with the glycans to the forefront of conceptual advancements within the discipline.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"9 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69995031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
G protein couple receptors used as Drug target G蛋白偶联受体作为药物靶点
Journal of glycobiology Pub Date : 2020-01-01 DOI: 10.35248/2168-958X.21.9.143
L. Nikitha
{"title":"G protein couple receptors used as Drug target","authors":"L. Nikitha","doi":"10.35248/2168-958X.21.9.143","DOIUrl":"https://doi.org/10.35248/2168-958X.21.9.143","url":null,"abstract":"The G- Protein coupled receptors are the largest class of cell-surface receptors and are encoded by > 1000 genes in the human genome. G-protein coupled receptors represented by far the largest class of targets for modern drugs. The current thinking surrounding GPCR homo-oilgomerization, hetero- oilgomerization and shows how new models point towards unexplored avenues in the development of new therapies. Numerous diseases and disorders have been linked mutations and Polymorphisms in GPCRs. They are the targets of an increasingly large number of therapeutic agents. It has been estimated that 50% of all modern drugs and almost one-quarter of the top 200 best – sellingdrugs in 2000 modulate GPCR activity. For many other classes of receptors such as tyrosine – kinase, ligand induced oilgomerization has long been known to be the essential for signalling. The greatest challenge facing the pharmaceutical industry will be to integrate GPCR homo- and hetero- oilgomerization into the molecular models that are used in the development of novel and improved therapeutics. The incorporation of oilgomerization receptor models into strategies for GPCR drug discovery might result in better therapeutic agents that target these receptors.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69995987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycosphingolipids and Cell death 鞘糖脂与细胞死亡
Journal of glycobiology Pub Date : 2020-01-01 DOI: 10.35248/2168-958X.20.9.151
N. Akshara.
{"title":"Glycosphingolipids and Cell death","authors":"N. Akshara.","doi":"10.35248/2168-958X.20.9.151","DOIUrl":"https://doi.org/10.35248/2168-958X.20.9.151","url":null,"abstract":"Glycosphingolipids (GSLs) are a family of bioactive lipids that in expansion to their part within the control of basic properties of layer bilayers have developed as vital players in numerous natural forms and signal transduction pathways. Instead of being consistently conveyed inside layer bilayers, GSLs are localized in specific spaces called lipid rafts where numerous signaling stages work. One of the foremost imperative capacities of GSLs, especially ceramide, is their capacity to direct cell passing pathways and subsequently cell destiny. This complex part is fulfilled by the capacity of GSLs to act in unmistakable subcellular key centers, such as mitochondria, endoplasmic reticulum (ER) or lysosomes to intercede apoptosis, ER push, autophagy, lysosomal layer permeabilization and necroptosis. Thus superior understanding the part of GSLs in cell passing may be of significance for a number of neurotic forms and infections, counting neurodegeneration, metabolic liver diseases and cancer.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"9 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69994979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential O- and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells 人胰腺腺癌细胞中O-和鞘糖脂糖基化的差异
Journal of glycobiology Pub Date : 2020-01-01 DOI: 10.35248/2168-958X.21.9.142
A. Shilpa
{"title":"Differential O- and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells","authors":"A. Shilpa","doi":"10.35248/2168-958X.21.9.142","DOIUrl":"https://doi.org/10.35248/2168-958X.21.9.142","url":null,"abstract":"Changes within the glycosylation profile of cancer cells have been unequivocally associated with cancer movement. To extend our experiences into the part of glycosylation in human pancreatic ductal adenocarcinoma (PDAC), we performed a ponder on O-glycans and glycosphingolipid (GSL) glycans of the PDAC cell lines Pa-Tu-8988T (PaTuT) and Pa-Tu-8988S (PaTu-S). These cell lines are determined from the same understanding, but appear an nearly inverse phenotype, morphology and capacity to metastasize, and may in this way give an appealing demonstrate to ponder the part of glycosylation in movement of PDAC. Gene-array examination uncovered that 24% of the glycosylation-related qualities appeared a ≥ 1.5-fold distinction in expression level between the two cell lines.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69995875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid Self-Assembly and Lectin-induced Reorganization of the Plasma Layer 脂质自组装和凝集素诱导的血浆层重组
Journal of glycobiology Pub Date : 2020-01-01 DOI: 10.35248/2168-958X.20.9.150
P. Shravya
{"title":"Lipid Self-Assembly and Lectin-induced Reorganization of the Plasma Layer","authors":"P. Shravya","doi":"10.35248/2168-958X.20.9.150","DOIUrl":"https://doi.org/10.35248/2168-958X.20.9.150","url":null,"abstract":"The plasma layer speaks to an extraordinary case of selforganization in science. It plays a crucial part in securing the keenness of the cell insides and directs fastidiously the moment and trade of assorted substances. Its major building pieces are proteins and lipids, which self-assemble to a liquid lipid bilayer driven basically by hydrophobic strengths. Indeed in case the plasma layer appears—globally speaking—homogeneous at physiological temperatures, the presence of specialized nanoto micrometre-sized spaces of raft-type character inside cellular and engineered film frameworks has been detailed. It is hypothesized that these spaces are the beginning of a plenty of cellular forms, such as flagging or vesicular trafficking.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"9 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69994941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significance of Essential Carbohydrates counting its Appalling impact on Pregnant Women 必需碳水化合物的重要性，计算其对孕妇的可怕影响
Journal of glycobiology Pub Date : 2020-01-01 DOI: 10.35248/2168-958X.20.9.145
C. Keerthi
{"title":"Significance of Essential Carbohydrates counting its Appalling impact on Pregnant Women","authors":"C. Keerthi","doi":"10.35248/2168-958X.20.9.145","DOIUrl":"https://doi.org/10.35248/2168-958X.20.9.145","url":null,"abstract":"Carbohydrates are made up of starches, sugars, fiber, and filaments found in natural products, grains, vegetables and drain items. Although regularly censured in stylish diets, carbohydrates one of the fundamental nourishment bunches are imperative to a solid count calorie. Carbohydrates are the body's fundamental source of vitality: They makes a difference to fuel brain kidneys heart muscles and central anxious framework.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69994865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Carbohydrates in Food 碳水化合物在食物中的作用
Journal of glycobiology Pub Date : 2020-01-01 DOI: 10.35248/2168-958X.20.9.147
S. Reddy
{"title":"Role of Carbohydrates in Food","authors":"S. Reddy","doi":"10.35248/2168-958X.20.9.147","DOIUrl":"https://doi.org/10.35248/2168-958X.20.9.147","url":null,"abstract":"Carbohydrates are polyhydroxyaldehydes (aldoses) or polyhydroxyketones (ketoses) composed of C, H, and O. They are classified into monosaccharides, oligosaccharides, and polysaccharides. Glucose is an aldohexose and the most important monosaccharide in humans, used as fuel by cells.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69994936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
N-Glycosylation Site Analysis n -糖基化位点分析
Journal of glycobiology Pub Date : 2020-01-01 DOI: 10.35248/2168-958X.21.9.141
K. Nayak
{"title":"N-Glycosylation Site Analysis","authors":"K. Nayak","doi":"10.35248/2168-958X.21.9.141","DOIUrl":"https://doi.org/10.35248/2168-958X.21.9.141","url":null,"abstract":"The components driving to the improvement of human B-cell interceded autoimmunity are not completely caught on. In specific, it is hazy how auto reactive B cells emerge and elude resilience checkpoints that ordinarily control their improvement and extension. Whereas temporal, short-lived autoreactive B-cell reactions are regularly watched within the setting of outside, natural triggers such as contaminations, the advancement of long-lived, auto reactive B and plasma cells within the setting of immune system infection likely requires T-cell offer assistance and the inclusion of germinal centers (GCs) in lymph hubs or GC-like structures in aroused tissues. As these specialized structures are prepared with different control components to anticipate the advancement of auto reactivity , it is critical to understand why and how these defensive components come up short within the improvement of human autoimmunity.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69995858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolism of Oligosaccharides and Starch in Lactobacilli 乳酸菌中低聚糖和淀粉的代谢
Journal of glycobiology Pub Date : 2020-01-01 DOI: 10.35248/2168-958X.20.9.146
S. Prasanna
{"title":"Metabolism of Oligosaccharides and Starch in Lactobacilli","authors":"S. Prasanna","doi":"10.35248/2168-958X.20.9.146","DOIUrl":"https://doi.org/10.35248/2168-958X.20.9.146","url":null,"abstract":"Oligosaccharides are carbohydrates, composed of up to twenty monosaccharides connected by glycosydic bonds, broadly utilized in nourishment and pharmaceutical businesses. These compounds can be gotten by extraction from characteristic sources (drain, vegetables, natural products), and by chemical or biotechnological forms. Within the final case, chemical structures and composition of the produced oligosaccharides depend on the sort and source of proteins, and on prepare conditions, counting the starting concentration of substrate. Among the different capacities of nondigestible oligosaccharides, one that has pulled in consideration is its prebiotic potential. The intestinal benefits of prebiotics, such as fructooligosaccharides and inulin as well as their advantageous affiliation with probiotic microbes, include avoidance and treatment of irresistible infections, counting viral or bacterial loose bowels, and incessant fiery illnesses such as ulcerative colitis. Other benefits ascribed to prebiotics and probiotics.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69994929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Monosaccharides are the Basic Structural Units of Glycans 单糖是聚糖的基本结构单位
Journal of glycobiology Pub Date : 2020-01-01 DOI: 10.35248/2168-958X.21.9.140
Prasanna Kattekola
{"title":"Monosaccharides are the Basic Structural Units of Glycans","authors":"Prasanna Kattekola","doi":"10.35248/2168-958X.21.9.140","DOIUrl":"https://doi.org/10.35248/2168-958X.21.9.140","url":null,"abstract":"Free monosaccharides can exist in open-chain or ring structures. Ring types of the monosaccharides are the standard in oligosaccharides, which are straight or stretched chains of monosaccharides appended to each other by means of glycosidic linkages the expression \"polysaccharide\" is regularly utilized for enormous glycans made out of rehashing oligosaccharide themes. Glycobiology is the investigation of the structure, capacity and science of starches, additionally called glycans. Glycans are available in each living being. Glycobiology is a quickly developing field in science, with importance to biomedicine, biotechnology and essential exploration. In eukaryotic cells, most of proteins are post-translationally altered. One of the most widely recognized alterations, basic for cell reasonability, is the connection of glycans, or \"glycosylation\". There are two sorts of glycosylation: N-connected (the glycan is joined to an asparagine) and O- connected (the glycan is appended to a serine or threonine).","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69995811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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