Glycosphingolipids and Cell death

Abstract

Glycosphingolipids (GSLs) are a family of bioactive lipids that in expansion to their part within the control of basic properties of layer bilayers have developed as vital players in numerous natural forms and signal transduction pathways. Instead of being consistently conveyed inside layer bilayers, GSLs are localized in specific spaces called lipid rafts where numerous signaling stages work. One of the foremost imperative capacities of GSLs, especially ceramide, is their capacity to direct cell passing pathways and subsequently cell destiny. This complex part is fulfilled by the capacity of GSLs to act in unmistakable subcellular key centers, such as mitochondria, endoplasmic reticulum (ER) or lysosomes to intercede apoptosis, ER push, autophagy, lysosomal layer permeabilization and necroptosis. Thus superior understanding the part of GSLs in cell passing may be of significance for a number of neurotic forms and infections, counting neurodegeneration, metabolic liver diseases and cancer.