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Pharmacological Inhibition of cFLIP Targets Breast Cancer Stem Cells. cFLIP对乳腺癌干细胞的药理抑制作用。
Journal of cancer treatment & diagnosis Pub Date : 2025-08-08 DOI: 10.29245/2578-2967/2025/2.1210
Rhiannon French, Olivia Hayward, Andreia Ribeiro da Silva, Timothy Robinson, Gillian Seaton, Richard Clarkson
{"title":"Pharmacological Inhibition of cFLIP Targets Breast Cancer Stem Cells.","authors":"Rhiannon French, Olivia Hayward, Andreia Ribeiro da Silva, Timothy Robinson, Gillian Seaton, Richard Clarkson","doi":"10.29245/2578-2967/2025/2.1210","DOIUrl":"10.29245/2578-2967/2025/2.1210","url":null,"abstract":"<p><p>Therapeutic targeting of tumour initiating, cancer stem cells (CSCs), offers the potential to improve long-term responses to cancer treatments. The apoptosis related protein Cellular FLICE-Like Inhibitory Protein (cFLIP) has previously been reported to protect breast cancer cells and breast CSCs from the cytotoxic effects of chemotherapy and apoptosis-inducing agents. We recently described the development of a small-molecule protein-protein inhibitor of cFLIP (OH14) that sensitizes refractory breast cancer cells to the death-receptor agonist Tumour Necrosis Factor Alpha Receptor Apoptosis Inducing Ligand (TRAIL). Here we investigated whether the pharmacological inhibition of cFLIP also targeted breast CSCs. Human breast cancer cell lines and primary-derived breast cancer samples were subjected to OH14 with or without TRAIL and assessed for bCSC viability by colony-formation and tumoursphere assay <i>in vitro</i> and xenograft tumour initiation <i>in vivo</i>. OH14 potentiated a reduction in the number of bCSCs after TRAIL treatment, mimicking the sensitizing effects previously observed with epigenetic silencing of cFLIP. Moreover, prolonged inhibition of cFLIP alone, either by shRNA knockdown or treatment with OH14, reduced the bCSC pool, an outcome that was independent of caspases. These data provide proof-of-principle for the use of pharmacological inhibitors of cFLIP to target bCSCs and highlights for the first time both apoptosis-dependent and independent mechanisms for cFLIP-mediated regulation of the breast cancer stem cell pool.</p>","PeriodicalId":92397,"journal":{"name":"Journal of cancer treatment & diagnosis","volume":"8 2","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7618230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extranodal NK/T-Cell Lymphoma, Nasal Type: A Case Series 鼻型结外NK/T细胞淋巴瘤：一个病例系列
Journal of cancer treatment & diagnosis Pub Date : 2022-10-19 DOI: 10.29245/2578-2967/2022/3.1200
Jennifer A. Marks, Zahraa Ghandour, V. Collins, J. Schmieg, T. Atkinson
{"title":"Extranodal NK/T-Cell Lymphoma, Nasal Type: A Case Series","authors":"Jennifer A. Marks, Zahraa Ghandour, V. Collins, J. Schmieg, T. Atkinson","doi":"10.29245/2578-2967/2022/3.1200","DOIUrl":"https://doi.org/10.29245/2578-2967/2022/3.1200","url":null,"abstract":"Extranodal Natural Killer/T-cell lymphoma, Nasal Type is a rare and aggressive Non-Hodgkins Lymphoma associated with the Epstein-Barr Virus and Hemophagocytic Lymphohistiocytosis. We describe three patient presentations at two medical centers in New Orleans, Louisiana, observed within a six-month interval. Although the disease has a lower incidence in the US than in Asia and Latin America, the incidence appears to be on the rise. Due to the spectrum of clinical presentations and low index of suspicion for the disease, presenting signs and symptoms of ENKL may be misattributed to a non-neoplastic condition, resulting in a delay in diagnosis. Increased awareness of the clinical and pathologic spectrum of ENKL, particularly in non-endemic areas, remains an essential means of preventing delay in diagnosis and early initiation of treatment.","PeriodicalId":92397,"journal":{"name":"Journal of cancer treatment & diagnosis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42725499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mini-Review: Pancreatic Cancer Presenting as a Bowel Obstruction and the Role of Next-Generation Sequencing 小型综述:胰腺癌表现为肠梗阻和新一代测序的作用
Journal of cancer treatment & diagnosis Pub Date : 2022-04-04 DOI: 10.29245/2578-2967/2022/2.1199
B. Ardalan, J. Azqueta, Jonathan England, D. Sleeman, Rene Hartmann
{"title":"Mini-Review: Pancreatic Cancer Presenting as a Bowel Obstruction and the Role of Next-Generation Sequencing","authors":"B. Ardalan, J. Azqueta, Jonathan England, D. Sleeman, Rene Hartmann","doi":"10.29245/2578-2967/2022/2.1199","DOIUrl":"https://doi.org/10.29245/2578-2967/2022/2.1199","url":null,"abstract":"Pancreatic adenocarcinoma has increasingly become one of the leading causes of death in western countries. However, presentation with colonic metastases is far less frequently reported in the literature and may be misdiagnosed as colonic adenocarcinoma. This is a case of a female patient with metastatic pancreatic adenocarcinoma that presented with a sigmoid obstruction.","PeriodicalId":92397,"journal":{"name":"Journal of cancer treatment & diagnosis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42092648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ASPP2, a New Regulator of the Mevalonate Pathway in Cancer ASPP2:甲羟戊酸途径在癌症中的新调控因子
Journal of cancer treatment & diagnosis Pub Date : 2022-03-22 DOI: 10.29245/2578-2967/2022/1.1198
Beibei Liang, Yangyang Xie, Lisha Zhang, Jian Zhao
{"title":"ASPP2, a New Regulator of the Mevalonate Pathway in Cancer","authors":"Beibei Liang, Yangyang Xie, Lisha Zhang, Jian Zhao","doi":"10.29245/2578-2967/2022/1.1198","DOIUrl":"https://doi.org/10.29245/2578-2967/2022/1.1198","url":null,"abstract":"","PeriodicalId":92397,"journal":{"name":"Journal of cancer treatment & diagnosis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43608239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target. 迷你综述：PDPK1(3-磷酸肌肽依赖蛋白激酶-1)，一个新兴的癌症干细胞靶点。
Journal of cancer treatment & diagnosis Pub Date : 2021-04-30 DOI: 10.29245/2578-2967/2021/1.1194
Bogdan Domrachev, Sitanshu Singh, Dandan Li, Udo Rudloff
{"title":"Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target.","authors":"Bogdan Domrachev, Sitanshu Singh, Dandan Li, Udo Rudloff","doi":"10.29245/2578-2967/2021/1.1194","DOIUrl":"10.29245/2578-2967/2021/1.1194","url":null,"abstract":"<p><p>Cancer stem cells (CSCs) are subpopulations of tumor cells that possess abilities for self-renewal, differentiation, and tumor initiation. These rare but therapy-recalcitrant cells are assumed to repopulate tumors following administration of systemic chemotherapy driving therapy failure, tumor recurrence, and disease progression. In early clinical trials, anti-CSC therapies have found limited success to-date possibly due to the inherent heterogeneity and plasticity of CSCs and the incomplete characterization of essential CSC targets. Here, we review the role of 3-phosphoinositide dependent protein kinase-1 (PDPK1) as an emerging CSC target. While most previous studies have relied on CSC models which are based on lineage and tissue-specific marker profiles to define the relationships between putative target and CSC traits, this review discusses PDPK1 and its role in CSC biology with an emphasis on CSC systems which are based on proposed function like label-retaining cancer cells (LRCCs).</p>","PeriodicalId":92397,"journal":{"name":"Journal of cancer treatment & diagnosis","volume":"5 1","pages":"30-35"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39054108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ex-Vivo Detection of Breast Cancer with a Bio-Impedance Sensor 生物阻抗传感器在离体乳腺癌检测中的应用
Journal of cancer treatment & diagnosis Pub Date : 2021-03-30 DOI: 10.29245/2578-2967/2021/1.1193
Justina Ugwaha, N. Savage, W. Messina, Y. Wanga, E. Whelton, A. O’Donovan, M. J. O'Sullivan, B. O. Donnell, E. Moore
{"title":"Ex-Vivo Detection of Breast Cancer with a Bio-Impedance Sensor","authors":"Justina Ugwaha, N. Savage, W. Messina, Y. Wanga, E. Whelton, A. O’Donovan, M. J. O'Sullivan, B. O. Donnell, E. Moore","doi":"10.29245/2578-2967/2021/1.1193","DOIUrl":"https://doi.org/10.29245/2578-2967/2021/1.1193","url":null,"abstract":"Bioimpedance is the opposition to flow of an applied electrical current through biological tissues1. Our research group designed and fabricated bipolar micro-sensors on the tip of a silicone probe, capable of measuring biological tissue impedance. It is known that the bioimpedance of cultured cancer cells differs substantially from that of healthy cell lines. We hypothesised that the bioimpedance of cancer in surgically excised human tissue would be significantly different to surrounding healthy tissue. To test this hypothesis, we designed a study to evaluate the bioimpedance of healthy and diseased breast tissue in surgically excised breast specimens. This manuscript reports the outcome of this study.","PeriodicalId":92397,"journal":{"name":"Journal of cancer treatment & diagnosis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48111925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Recent Advances in Development of New Technology in Pre and Intra Operative Breast Cancer Diagnoses 乳腺癌术前及术中诊断新技术的最新进展
Journal of cancer treatment & diagnosis Pub Date : 2021-01-01 DOI: 10.29245/2578-2967/2021/2.1192
Justina A. Ugwah, Martin J. O'Sullivan, B. O'Donnell, E. Moore
{"title":"Recent Advances in Development of New Technology in Pre and Intra Operative Breast Cancer Diagnoses","authors":"Justina A. Ugwah, Martin J. O'Sullivan, B. O'Donnell, E. Moore","doi":"10.29245/2578-2967/2021/2.1192","DOIUrl":"https://doi.org/10.29245/2578-2967/2021/2.1192","url":null,"abstract":"Breast cancer is the second most occurring malignant disease in women. 1 in 9 women will be affected by this disease in their lifetime. The gold standard for breast cancer screening is the mammographic technique, which has its limitations especially for women aged below 40 as a result of breast density. Ongoing research are exploring techniques that can improve detection accuracy as well as reduce time and money spent in advanced stage treatment options. This review paper highlights the different technologies that have been developed for breast cancer diagnoses.","PeriodicalId":92397,"journal":{"name":"Journal of cancer treatment & diagnosis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69850743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Commentary: “My Husband Affects Me More Than My Cancer”: Reflections on Simultaneous Intimate Partner Violence and Breast Cancer Experience in a 48-Year-Old Woman' 评论：“我丈夫比我的癌症更影响我”：对一名48岁女性同时发生亲密伴侣暴力和癌症经历的反思
Journal of cancer treatment & diagnosis Pub Date : 2020-06-01 DOI: 10.29245/2578-2967/2020/2.1181
F. Dionigi, V. Martinelli, E. Trotti, A. Ferrari, Carlo Etienne, A. D. Valle, D. Grasso, E. Ferraris, G. Rizzo, A. Lasagna, V. Praticò, P. Pedrazzoli, P. Politi, A. Sgarella
{"title":"Commentary: “My Husband Affects Me More Than My Cancer”: Reflections on Simultaneous Intimate Partner Violence and Breast Cancer Experience in a 48-Year-Old Woman'","authors":"F. Dionigi, V. Martinelli, E. Trotti, A. Ferrari, Carlo Etienne, A. D. Valle, D. Grasso, E. Ferraris, G. Rizzo, A. Lasagna, V. Praticò, P. Pedrazzoli, P. Politi, A. Sgarella","doi":"10.29245/2578-2967/2020/2.1181","DOIUrl":"https://doi.org/10.29245/2578-2967/2020/2.1181","url":null,"abstract":"Page 36 of 38 Commentary: “My Husband Affects Me More Than My Cancer”: Reflections on Simultaneous Intimate Partner Violence and Breast Cancer Experience in a 48-Year-Old Woman Francesca Dionigi1,2*, Valentina Martinelli3, Eugenia Trotti3, Alberta Ferrari2,5, Carlos Alberto Garcia Etienne2, Angelica Della Valle2, Donatella Grasso6, Elisa Ferraris6, Gianpiero Rizzo6,Angioletta Lasagna6, Vincenza Praticò2, Paolo Pedrazzoli,Pierluigi Politi6, Adele Sgarella2,5 1Dottorato di Ricerca in Medicina Sperimentale, Università degli Studi di Pavia, 27100, Pavia, Italy 2Fondazione IRCCS Policlinico “San Matteo”, Unità Operativa Complessa di Chirurgia Generale III a indirizzo Senologico e dei tessuti molli, viale Golgi 19, 27100, Pavia, Italy 3Dipartimento di Medicina e Sanità Pubblica, Università dell’Insubria, via Ottorino Rossi 9, 21010 Varese, Italy 4Department of Biotechnology and Life Sciences, Università degli Studi dell’Insubria, via Ottorino Rossi 9, 21010, Varese, Italy 5Università degli Studi di Pavia, Pavia, Italy 6Fondazione IRCCS Policlinico “San Matteo”, Unità Operativa Complessa di Oncologia Medica, Pavia, Italy","PeriodicalId":92397,"journal":{"name":"Journal of cancer treatment & diagnosis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43837783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcomatoid Transformation in Carcinomas: Is Precision Medicine the Answer? 肿瘤的肉瘤样转化:精准医学是答案吗?
Journal of cancer treatment & diagnosis Pub Date : 2020-06-01 DOI: 10.29245/2578-2967/2020/2.1178
J. Arshi, F. Yin
{"title":"Sarcomatoid Transformation in Carcinomas: Is Precision Medicine the Answer?","authors":"J. Arshi, F. Yin","doi":"10.29245/2578-2967/2020/2.1178","DOIUrl":"https://doi.org/10.29245/2578-2967/2020/2.1178","url":null,"abstract":"Sarcomatoid transformation in a carcinoma is a rare event but frequently associated with advanced disease stage, aggressive clinical behavior and dismal prognosis. It’s likely a result of stepwise gene mutations in pluripotent stem cell and involves the epithelial to mesenchymal transition (EMT). In this review, we discuss the sarcomatoid transformation in various types of cancers. Sarcomatoid transformation in a carcinoma should always be in the differential when there is a sudden increase in size of the tumor during neoadjuvant therapy. Use of agents that interfere with the tyrosine kinase pathway might be the new potential addition to the chemotherapy regimen in these cases. Precision medicine, a rapidly emerging field, seems to be promising in the management of these cancers.","PeriodicalId":92397,"journal":{"name":"Journal of cancer treatment & diagnosis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47266064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Commentary: “Evaluation of Small Molecule Drug Uptake in Patient-Derived Prostate Cancer Explants by Mass Spectrometry” 评论:“用质谱法评价患者来源的前列腺癌外植体的小分子药物摄取”
Journal of cancer treatment & diagnosis Pub Date : 2020-05-29 DOI: 10.29245/2578-2967/2020/2.1183
Ryan Nguyen, Peer Cody John, W. Figg
{"title":"Commentary: “Evaluation of Small Molecule Drug Uptake in Patient-Derived Prostate Cancer Explants by Mass Spectrometry”","authors":"Ryan Nguyen, Peer Cody John, W. Figg","doi":"10.29245/2578-2967/2020/2.1183","DOIUrl":"https://doi.org/10.29245/2578-2967/2020/2.1183","url":null,"abstract":"Herein, the strengths and weaknesses of a study previously published in Scientific Reports will be discussed. The major aim of this study was to investigate the spatial uptake of enzalutamide by intact prostate tissue using matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) and histological staining. Additionally, quantitative analysis of in situ tissue enzalutamide concentration was achieved by conventional liquid chromatography-tandem mass spectrometry (LC-MS/MS). The authors demonstrated that enzalutamide rapidly permeates prostate tissue and accumulates in regions containing high epithelial cell counts. While these findings have potential to inform future pharmacodynamic experimental designs and endpoints, this study is limited in its scope by the current state of MALDI-MSI technology, which is not yet sensitive enough to investigate clinically relevant in situ enzalutamide concentrations.","PeriodicalId":92397,"journal":{"name":"Journal of cancer treatment & diagnosis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43416414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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