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Proteomics—a new approach to identify targets and biomarkers for hepatocellular carcinoma? 蛋白质组学——鉴别肝癌靶点和生物标志物的新方法?
Biotarget Pub Date : 2019-08-05 DOI: 10.21037/BIOTARGET.2019.04.03
M. Ocker
{"title":"Proteomics—a new approach to identify targets and biomarkers for hepatocellular carcinoma?","authors":"M. Ocker","doi":"10.21037/BIOTARGET.2019.04.03","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2019.04.03","url":null,"abstract":"Primary liver cancer, hepatocellular carcinoma (HCC), remains a global medical burden. Incidence rates are still high due to high prevalence of chronic viral hepatitis and the increasing numbers of obese and diabetic patients that develop non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) which are nowadays considered major drivers for HCC development (1,2). Treatment options for advanced disease stages are still limited and overall prognosis of HCC remains dismal, although immune checkpoint inhibitors seem to hold some promise over the previously established tyrosine kinase inhibitors (3).","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/BIOTARGET.2019.04.03","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42855310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Fatty acid oxidation (FAO) metabolic switch: metastasis in lymph nodes driven by yes-associated protein (YAP) activation. 脂肪酸氧化（FAO）代谢转换：由yes相关蛋白（YAP）激活驱动的淋巴结转移。
Biotarget Pub Date : 2019-08-01 Epub Date: 2019-08-13 DOI: 10.21037/biotarget.2019.07.03
Thomas Wang, Costa Frangou, Jianmin Zhang
{"title":"Fatty acid oxidation (FAO) metabolic switch: metastasis in lymph nodes driven by yes-associated protein (YAP) activation.","authors":"Thomas Wang, Costa Frangou, Jianmin Zhang","doi":"10.21037/biotarget.2019.07.03","DOIUrl":"10.21037/biotarget.2019.07.03","url":null,"abstract":"","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/biotarget.2019.07.03","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42603022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Fragmentation patterns of circulating cell-free DNA demonstrate biomarker potential for human cancers. 循环无细胞DNA的碎片模式证明了人类癌症的生物标志物潜力。
Biotarget Pub Date : 2019-08-01 Epub Date: 2019-08-29 DOI: 10.21037/biotarget.2019.08.02
Zhou Zhang, Wei Zhang
{"title":"Fragmentation patterns of circulating cell-free DNA demonstrate biomarker potential for human cancers.","authors":"Zhou Zhang, Wei Zhang","doi":"10.21037/biotarget.2019.08.02","DOIUrl":"10.21037/biotarget.2019.08.02","url":null,"abstract":"","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41706143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
YAP-dependent metabolic remodeling in local lymph node boosts the function of cancer cells. 局部淋巴结YAP依赖性代谢重塑增强癌症细胞的功能。
Biotarget Pub Date : 2019-08-01 DOI: 10.21037/BIOTARGET.2019.08.01
T. Kashihara, Daniela K. Zablocki, J. Sadoshima
{"title":"YAP-dependent metabolic remodeling in local lymph node boosts the function of cancer cells.","authors":"T. Kashihara, Daniela K. Zablocki, J. Sadoshima","doi":"10.21037/BIOTARGET.2019.08.01","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2019.08.01","url":null,"abstract":"Cancer cells are remarkably flexible in their ability to adapt to various local environments to promote their survival, growth and invasion. A recent study by Koh’s laboratory suggests that metastatic cancer cells upregulate fatty acid oxidation (FAO) through activation of yes-associated protein (YAP), a major effector of the Hippo pathway, at local lymph nodes (LNs), which boosts the ability of the cancer cells to invade distant organs (1). We here discuss how YAP mediates the metabolic flexibility in metastatic cancer cells.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/BIOTARGET.2019.08.01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43011534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
FXR regulates intestinal stem cells response to bile acids in a high fat diet FXR调节高脂肪饮食中肠道干细胞对胆汁酸的反应
Biotarget Pub Date : 2019-07-29 DOI: 10.21037/BIOTARGET.2019.07.01
L. Parry, T. Phesse
{"title":"FXR regulates intestinal stem cells response to bile acids in a high fat diet","authors":"L. Parry, T. Phesse","doi":"10.21037/BIOTARGET.2019.07.01","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2019.07.01","url":null,"abstract":"Although a high fat diet (HFD) is known to be associated with a poor clinical outcome for colorectal cancer (CRC) patients, the precise mechanisms underlying this are poorly understood. Fu and colleagues have recently identified high levels of bile acid (BA) in a preclinical mouse model of colon cancer, and that a HFD increases BA further which in turn promotes proliferation in Lgr5+ stem cells, via inhibition of farnesoid X receptor (FXR), to drive tumour progression (1).","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/BIOTARGET.2019.07.01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43615970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A multi-layer post-transcriptional gene regulatory program fuels cancer angiogenesis and metastasis 一个多层的转录后基因调控程序促进了癌症血管生成和转移
Biotarget Pub Date : 2019-07-25 DOI: 10.21037/BIOTARGET.2019.07.02
A. Nehme, H. Najafabadi, Y. Riazalhosseini
{"title":"A multi-layer post-transcriptional gene regulatory program fuels cancer angiogenesis and metastasis","authors":"A. Nehme, H. Najafabadi, Y. Riazalhosseini","doi":"10.21037/BIOTARGET.2019.07.02","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2019.07.02","url":null,"abstract":"Metastasis is the process by which cancer cells spread from the primary tumor to surrounding tissues and to distant organs. It is the primary cause of cancer morbidity and mortality, and represent a major clinical problem, where it is estimated to account for ~90% of cancer deaths (1). It has been suggested that metastasis can be represented as a biphasic process, starting with the physical translocation of cancer cells to a distant organ, followed by their capacity to spread, invade, and thrive in non-native environments (1). Several hypotheses have been proposed to describe the cellular processes involved in cancer metastasis such as epithelial mesenchymal transition, accumulation of mutations, macrophage facilitation process, and macrophage transformation or fusion hybridization with neoplastic cells. However, metastasis process remains one of the most inexplicable aspects of cancer at the molecular level (1). Therefore, finding the right molecular targets for therapeutic intervention is crucial for prevention and treatment success.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/BIOTARGET.2019.07.02","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47837255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR screens and the best cancer drug targets: picking the needle out of the haystack CRISPR筛选和最佳抗癌药物靶标:大海捞针
Biotarget Pub Date : 2019-07-18 DOI: 10.21037/BIOTARGET.2019.06.02
F. Pentimalli
{"title":"CRISPR screens and the best cancer drug targets: picking the needle out of the haystack","authors":"F. Pentimalli","doi":"10.21037/BIOTARGET.2019.06.02","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2019.06.02","url":null,"abstract":"In the past two decades, the clinical management of cancer patients, mostly based on the use of surgery, chemotherapy and radiotherapy, has been revolutionized by the development of precision medicine and new immunotherapy approaches, two new pillars in cancer therapeutics. The ways to treat cancer have enormously increased providing more tailored approaches to cancer patients, who can be offered a wider range of therapeutic options. Despite such progress, however, the huge heterogeneity of tumors and their ability to develop resistance to therapies make cancer a moving target. Cancer-specific dependencies and the best drug targets need to be identified to increase even more the arsenal of weapons that can be used at different stages of treatment in a sequential manner to defeat the disease or make it become chronic.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/BIOTARGET.2019.06.02","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41845032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quaking as a novel target of miR-200b to regulate tumor cell cycle progression mediated angiogenesis and metastasis 作为miR-200b调节肿瘤细胞周期进程介导的血管生成和转移的新靶点
Biotarget Pub Date : 2019-06-21 DOI: 10.21037/BIOTARGET.2019.06.01
Tina H Nguyen, S. Alahari
{"title":"Quaking as a novel target of miR-200b to regulate tumor cell cycle progression mediated angiogenesis and metastasis","authors":"Tina H Nguyen, S. Alahari","doi":"10.21037/BIOTARGET.2019.06.01","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2019.06.01","url":null,"abstract":"Tumor growth is mediated by several factors including metabolic function, intracellular signaling, evasion of apoptosis, tissue invasion and metastasis, and angiogenesis. Of these factors, angiogenesis is a crucial component due to its part in both delivering nutrients and providing a conduit for metastasis. Current anti-angiogenic therapies focus on tumor-derived VEGF signaling; however, these efforts are modest and prone to resistance by upregulation of other pro-angiogenic signaling (1,2). Due to incomplete knowledge of endothelial cell (EC) biology, other methods of impeding tumor angiogenesis are not available.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49067184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BASCs, respiratory epithelial progenitors with geo-advantage BASCs，具有地理优势的呼吸上皮祖细胞
Biotarget Pub Date : 2019-05-24 DOI: 10.21037/BIOTARGET.2019.05.02
H. Ji, Yang Liu
{"title":"BASCs, respiratory epithelial progenitors with geo-advantage","authors":"H. Ji, Yang Liu","doi":"10.21037/BIOTARGET.2019.05.02","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2019.05.02","url":null,"abstract":"The lung is a much-branched organ consists of heterogeneous lineages of cells derived from both endoderm and mesoderm (1,2). Lung epithelial progenitor cells are orchestrated with endothelial and mesenchymal cells in a complicated manner to maintain the homeostasis of lung epithelium.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/BIOTARGET.2019.05.02","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41687802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bronchioalveolar stem cells: the crossroads of lung regeneration 细支气管肺泡干细胞:肺再生的十字路口
Biotarget Pub Date : 2019-05-24 DOI: 10.21037/BIOTARGET.2019.05.01
Tyler T. Cooper, D. Hess
{"title":"Bronchioalveolar stem cells: the crossroads of lung regeneration","authors":"Tyler T. Cooper, D. Hess","doi":"10.21037/BIOTARGET.2019.05.01","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2019.05.01","url":null,"abstract":"Mammalian lungs are encased in dense endothelial cell networks to support systemic delivery of oxygen to vital organs (1-3), and to provide host pathogen defense by physical or chemical removal of foreign bodies (3,4). The evolutionary-refined architecture of mammalian lungs is primarily comprised of endoderm-derived epithelial cell populations (5); however, the lungs also harbour mesoderm-derived cells which contribute to the renin-angiotensin axis (6), innate immunity (3,4), and platelet production (7). Oronasal to parenchymal, the respiratory system is organized from the trachea, bronchi, bronchioles to the alveoli; the primary site of gas exchange (1,2).","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/BIOTARGET.2019.05.01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48781018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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