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引用次数: 6
脂肪酸氧化（FAO）代谢转换：由yes相关蛋白（YAP）激活驱动的淋巴结转移。
首次在果蝇中发现的Hippo信号通路通过调节细胞的增殖、分化和死亡来指导许多多细胞生物的器官生长（1，2）。由于该途径为抗癌药物提供了潜在的靶点，因此在生物医学研究中具有很大的兴趣。哺乳动物Hippo通路的关键效应子是原癌基因的yes相关蛋白（YAP）及其与PDZ结合基序（TAZ）的同源转录辅激活子。
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