Advances in bioscience and clinical medicine最新文献

{"title":"Accuracy of MRI Sequences in Detecting Multiple Sclerosis (MS) Lesions: A Systematic Review","authors":"Abdullah Dhaifallah Almutairi, R. Mahmud, S. Suppiah, H. Hassan","doi":"10.7575/AIAC.ABCMED.V.7N.2P.39","DOIUrl":"https://doi.org/10.7575/AIAC.ABCMED.V.7N.2P.39","url":null,"abstract":"Introduction: Multiple sclerosis (MS) is one of the chronic autoimmune central nervous system disorder that characterized by demyelination of axon in brain cortex and the other grey and white matter regions and it makes several symptoms. Magnetic Resonance Imaging (MRI) with high sensitivity is the most important preclinical tool for the diagnosis of MS. The aim is to conduct systematic review studies carried out on accuracy of MRI sequences in detecting Multiple Sclerosis (MS) lesions. Methods: This study was systematic review. The related studies accomplished about using MRI in detecting MS lesions in worldwide included by searching in database and journal websites, including PubMed, Google Scholar and Medline. These articles searched by main keywords such as MRI, MS, lesions, sequence, and detecting. Conclusion: Our reviewing study showed that Double Inversion Recovery (DIR) Sequence in MRI has a high sensitivity to detect of lesion of MS. Furthermore, we recommend that the physicians add DIR sequence in routine MR protocols for diagnostic MS in patients.","PeriodicalId":92322,"journal":{"name":"Advances in bioscience and clinical medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44036948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Simultaneous Expression of miR-146a-5p and miR-193a-5p on the Expression of MMP-9 Gene in Colorectal Cancer (HT-29 cell line)","authors":"Saeed Noorolyai, A. Mokhtarzadeh","doi":"10.7575/AIAC.ABCMED.V.7N.2P.7","DOIUrl":"https://doi.org/10.7575/AIAC.ABCMED.V.7N.2P.7","url":null,"abstract":"Background and Purpose: Colorectal cancer is the third leading cause of cancer death in the worldwide. microRNAs are a group of non-coding small RNAs that inhibit target mRNA translation. miR-146a-5p and miR-193a-5p are known as tumor-suppressors, which down expressed in many cancers. In this study, the purpose was to restore the expression level of miR-146a-5p and miR-193a-5p up to normal level, and to investigate their synergetic effects on MMP-9 gene expression in HT-29 cells. Materials and Methods: The HT-29 cell line from colorectal cancer was cultured in RPMI-1640 culture media. Then, miR-146a and miR-193a were transfected with Jet-PEI reagent.The expression of miR-146a, miR-193a and MMP-9 gene in transfected HT-29 cells and control cells were evaluated by using the qR-PCR technique. Statistical analyzes were performed using GraphPad Prism 6 statistical software. Results: Our results show that the expression levels of miR-193a and miR-146a were increased after transfection, and in comparison with un-transfected cells, the expression level of MMP-9 was decreased. Conclusion: The results of this study showed that the simultaneous replacement of miR-146a and miR-193a may act as a potent tumor-suppressor and has an important role in cancer cell migration by influencing molecules such as MMP-9. Thus, simultaneous use of these two microRNAs may be suggested as a potential therapeutic goal in the treatment of colorectal cancer.","PeriodicalId":92322,"journal":{"name":"Advances in bioscience and clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41471508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetaminophen Serum Levels in Patients with unknown Poisoning and Loss of Consciousness","authors":"A. Ala, S. Vahdati, Ghader Bakhsh Rigi, P. Habibollahi, Shahrad Tajodini, Kobra Jannati","doi":"10.7575/AIAC.ABCMED.V.7N.2P.20","DOIUrl":"https://doi.org/10.7575/AIAC.ABCMED.V.7N.2P.20","url":null,"abstract":"Background: The aim of this study was to evaluate the serum levels of acetaminophen in patients with unknown poisoning and loss of consciousness, and to assess whether measuring serum acetaminophen level in all patients with drug overdose or decreased level of consciousness changes outcome. Methods & Materials: In a descriptive-analytical study, 300 patients with loss of consciousness and a history of drug toxicity with an unknown drug that referred to the emergency unit constituted the study sample. Serum acetaminophen levels of patients, the outcome, mortality, and morbidity of patients were evaluated. Results: The mean age of patients was 28.88±8.67 years. The minimum age of patients was 15 years and the maximum age of patients was 58 years. The mean serum level of acetaminophen in patients was 0.62±0.55 μg/ml. The highest level and the lowest level of acetaminophen in patients were 2.8 μg/ml and 0.2 μg/ml respectively. Serum acetaminophen level in patients was less than the toxic level (less than 30 μg/ml). Conclusion: Based on the findings of this study, acetaminophen as a widely used and available drug is not a common cause of poisoning in patients with loss of consciousness in our region.","PeriodicalId":92322,"journal":{"name":"Advances in bioscience and clinical medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42999565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Temporal Bone Tomography Findings of Chronic Otitis Media with Intraoperative Findings","authors":"Y. J. Moghaddam, Farnaz Chalabianloo","doi":"10.7575/AIAC.ABCMED.V.7N.2P.17","DOIUrl":"https://doi.org/10.7575/AIAC.ABCMED.V.7N.2P.17","url":null,"abstract":"Background and Objectives: Chronic otitis media is considered a common disease in our region. There are various methods for evaluation of chronic suppurative otitis media including otoscopy, CT scan, X-ray, and MRI. Nowadays, computed tomography or CT scan is used as the selected method to investigate the temporal bone. This study aims to collect the intraoperative findings and compare them with preoperative reports of temporal bone CT scans. Materials and Methods: The patients’ data with chronic otitis media who were reviewed tomographically, hospitalized and operated between 2012 and 2014 in Tabriz Sina Hospital by only one otolarynologist included in this study collected. Results: The most common lesion based on the highest frequency and percentage is Tympanosclerosis. 21.4 percent of patients whom Tympanosclerosis were not diagnosed preoperatively, found during the surgery. 78.9 And 21.1 percent of bone erosions have been diagnosed by CT scan and by direct vision, respectively. Conclusion: Although preoperative CT of Middle ear lesions is useful for surgery planning but some lesion may not be completely diagnosed by CT scan and intraoperative assessment of surgical field is crucial.","PeriodicalId":92322,"journal":{"name":"Advances in bioscience and clinical medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49059154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-nodular Desmoplastic Medulloblastoma in a Child: A Rare Radiological Physiognomy","authors":"Song-ping Zheng, S. Richard, Yiyun Fu, Yan Ju, C. You","doi":"10.7575/AIAC.ABCMED.V.7N.1P.49","DOIUrl":"https://doi.org/10.7575/AIAC.ABCMED.V.7N.1P.49","url":null,"abstract":"Introduction: Nodular desmoplastic variant of medulloblastoma although very common, can present with very challenging radiological feature that mimics others lesions in the inferior and lower vermis in children. We present a case of rare radiological appearance of desmoplastic medullobastoma. Case Presentation: A one year and nine months old male presented with unstable walking and projectile vomiting of two weeks’ duration. He was apparently walking well prior this illness. The vomiting was usually in the morning and associated with headaches. Radiological imaging revealed very unusual masses in the cerebellum vermin region with obvious bilateral ventricular enlargement as well as the third ventricle, indicating hydrocephalus. Surgery was successful carried out and microscopic as well as immunohistochemistry confirmed desmoplastic medullobastoma. Conclusion: Desmoplastic medulloblastoma although not very rare can be very problematic in terms of radiological diagnosis. We are of the option that our imaging finding will throw more light on the radiological features of this tumor.","PeriodicalId":92322,"journal":{"name":"Advances in bioscience and clinical medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47648612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of Senior Dental Students on Odontogenic Infections","authors":"S. Arta, J. Yazdani, Milad Ghanizadeh, Shahrzad Seyvani, M. Ghavimi","doi":"10.7575/AIAC.ABCMED.V.7N.1P.16","DOIUrl":"https://doi.org/10.7575/AIAC.ABCMED.V.7N.1P.16","url":null,"abstract":"Odontogenic infections are the most common infections that require early diagnosis and proper treatment. Given the sensitivity of the issue, the dental community needs to have correct information about the current status. Therefore, this study aimed to assess the knowledge of students in Tabriz University of Medical Sciences about the treatment of odontogenic infections in 2017. In this descriptive‒analytical study, all the senior students of Tabriz Faculty of Dentistry were evaluated. Data were collected using a questionnaire consisting of 20 questions related to students’ awareness about the treatment of odontogenic infection. Data were analyzed with descriptive statistics and chi-squared test. The results indicated that the mean knowledge score of the students was 8.64±2.6. Knowledge of 77.4 % of students was low, 20.8 % had moderate knowledge and 1.8 % had a high level of knowledge. There were no significant differences in knowledge between male and female students. Knowledge of senior dental students in Tabriz University of Medical Sciences was poor, with no difference between male and female students.","PeriodicalId":92322,"journal":{"name":"Advances in bioscience and clinical medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45709959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectivity of Mirror Therapy on Arm Motoric Improvement in Acute Ischemic Stroke Patients","authors":"Jumraini Tammasse, Machyono Andi Kurnia Bintang","doi":"10.7575/AIAC.ABCMED.V.7N.1P.6","DOIUrl":"https://doi.org/10.7575/AIAC.ABCMED.V.7N.1P.6","url":null,"abstract":"Cerebrovascular diseases (stroke) ranked the second cause of death worldwide. This research aimed at investigating the effectiveness of mirror therapy on artery therapy by ARAT (ARAT) score. The research was carried out by the clinical trials study towards 32 acute ischemic stroke patients who were divided into an experimental group got the combination of mirror therapy and standard therapy, and the control group only got the standard therapy. The level of the motor action was tested by Action Research Arm Test (ARAT) score. The research then compared the ARAT score difference between the two groups. The result of the research reveals that the ARAT score differences on the group who gets the combination of mirror therapy and standard therapy (15.56±4.38) higher than the group who only gets the standard therapy (7.69±1, 66). By using T-test, it is obtained the significant difference of P <0.05 (0.001).","PeriodicalId":92322,"journal":{"name":"Advances in bioscience and clinical medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47680011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Spleen, Liver and Kidney Volume and Span using Multiplanar CT Scan vs. Ultrasonography in 1-12 year-old Patients","authors":"Hasan Mohamad Rezaie, P. Hajalioghli, Amirreza Jahanshahi, Iman Yazdani Nia, Armin Zarrintan, M. Aghazadeh","doi":"10.7575/AIAC.ABCMED.V.7N.1P.36","DOIUrl":"https://doi.org/10.7575/AIAC.ABCMED.V.7N.1P.36","url":null,"abstract":"Background: Evaluating of internal organs of abdomen in clinical assessments especially in children is so important. Ultrasonography is useful, safe, and available method for evaluation of size of abdomen internal organs. Also computerized tomography (CT) scan is accurate method in evaluation of children problem. The aim of present study was to compare of spleen volume and span and liver and kidney span using multiplanar CT scan vs. ultrasonography in 1-12 years old patients at Tabriz Children Hospital. Methods and Materials: In a descriptive analytical study, 35 children whom candidate for pelvic & abdomen CT scan and referred to Children Educational Medical Center of Tabriz University of Medical Sciences, were included the study and evaluated. Children were evaluated also by ultrasound modality. Age, sex, spleen span, spleen width, spleen thickness, length of right & left kidney, liver span in midclavicular line, and spleen volume based on ultrasonography & CT scan findings, were evaluated. Results: Based on CT scan report, spleen span, liver span, and spleen width were 101.31±32.28 mm, 101.57±29.25 mm, and 70.28±23.14 mm respectively, and based on ultrasonography report were 99.65±31.77 mm. 102.02±29.47 mm, & 68.31±22.04 mm. There were no significant differences in spleen span (P=0.063), liver span (P=0.609), and spleen width (P=0.082) between ultrasonography & CT scan findings. Conclusion: Based on the findings of present study; due to no significant differences between ultrasonography & CT scan findings in evaluating right and left kidney, liver & spleen span, and spleen width, they can use alternatively.","PeriodicalId":92322,"journal":{"name":"Advances in bioscience and clinical medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45601575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Intravenous Acetaminophen on Pain and Peritoneal Irritation Signs in Patients with Acute Surgical Abdomen in the Emergency Department","authors":"M. Pouraghaei, Peiman Imamverdizadeh, Payman Moharramzadeh, S. Vahdati","doi":"10.7575/AIAC.ABCMED.V.7N.1P.12","DOIUrl":"https://doi.org/10.7575/AIAC.ABCMED.V.7N.1P.12","url":null,"abstract":"Introduction: Acute surgery abdomen was one of the most common causes of emergency surgery in worldwide and a major cause of severe abdominal pain and sometimes harrowing and intolerable patients are presenting to the emergency department. The duty of every physician especially Emergency physician reduction of pain of patients that is considered as a major priority in new emergency medical treatment. The aim of this study was evaluation of effect IV Acetaminophen on abdominal pain in patients referred to emergency ward. Methods: In a double blind clinical trial that performed in emergency department on patients with abdominal pain, effect IV Acetaminophen on abdominal pain in patients referred to emergency ward evaluated. Results and Conclusion:155 of patients were male and 85 of them were female. Mean age of patients in acetaminophen group was 45.45 ± 20.47 and in Morphine group was 50.99 ± 19.40 year(P=0.0054). Mean of pre injection pain score in male was 8.69 ± 1.29 and in female patients was 9.17 ± 1.27(P=0.848). Mean of pre injection pain score in Morphine group patients was 8.80 ± 1.35 and Mean of post injection pain score in Morphine group patients was 4.06 ± 1.71(P<0.001). Mean of pre injection pain score in acetaminophen group patients was 8.92 ± 1.25 and Mean of post injection pain score in acetaminophen group patients was 6.46 ± 2.25(P<0.001). Mean of post injection pain score in acetaminophen group patients was significantly higher than patient’s of Morphine group. Significant liner direct correlation was found between pre injection and post injection pain score in the studied patients.","PeriodicalId":92322,"journal":{"name":"Advances in bioscience and clinical medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43253863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Hormone Replacement Therapy in Critically Ill Patients: Lack of Promising Evidence for Physiologically Sound Approaches","authors":"Tara Sabzevari, Masoumeh Emamvidri","doi":"10.7575/AIAC.ABCMED.V.7N.1P.48","DOIUrl":"https://doi.org/10.7575/AIAC.ABCMED.V.7N.1P.48","url":null,"abstract":"The sick euthyoid syndrome, also known as nonthyroidal illness syndrome, refers to changes seen in patient thyroid function tests administered in the medical intensive care unit during episodes of critical illness(1). Low serum T3 is the most common abnormality in euthyroid sick syndrome. Both low T3 and low T4 syndrome are reported in critically ill patients and low serum T4 is related with worst outcome. These features in laboratory findings of sick euthyroid patients have been explained by circulating thyroid binding hormone inhibitor (2). Thyroid hormone signalling regulates crucial biological functions, including energy expenditure, thermogenesis, development and growth. Fliers et al. (3), in their review “Thyroid function in critically ill patients”, concluded that routine thyroid hormone replacement therapy is not recommended in non-thyroid illness syndrome in critically ill patients. As we know, decreased plasma concentrations of thyroid hormones, especially T3, in critically ill patients represent the severity of the disorder and are associated with poor outcomes. On the other hand, thyroid hormone administration has been reported to be associated with improved hemodynamics, increased cardiac output, decreased ICU length of stay, reduced need for inotropic agents and mechanical devices, decreased incidence of myocardial ischaemia and decreased incidence of atrial fibrillation and pacemaker therapy (4-6). There are some studies reported the link between low levels of thyroid hormone and sarcopenia which leads to critical ill weakness (7.8). So it may be a rational to use hormone replacement therapy in selected critically ill patients with sick euthyroid syndrome.Not to implement physiologically sound approaches just because “evidence is lacking” might be disadvantageous for these patients over time as it might probably take years until clinical evidence become available. Subsequently, based on previous trials that have introduced effectiveness or at least no effects of hormone replacement therapy for non-thyroid illness syndrome, it seems that critically ill patients without limiting conditions such as advanced age or cardiac dysfunction (e.g. CHF or ACS) might benefit from thyroid replacement therapy and depriving these patients from what they might have benefited seems unethical.As we mentioned sick euthyroid syndrome occurs with different faces in critically ill patients with some good and some bad characteristics. Tolerating the early onset hibernation response with its concomitant changes in thyroid hormone parameters seems to be beneficial and safe. But the other type of sick euthyroid syndrome which develops later during prolong ICU admission may have a different face and needs some interventions as it has impact on patients outcome.","PeriodicalId":92322,"journal":{"name":"Advances in bioscience and clinical medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46729659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}