Effect of Intravenous Acetaminophen on Pain and Peritoneal Irritation Signs in Patients with Acute Surgical Abdomen in the Emergency Department

Abstract

Introduction: Acute surgery abdomen was one of the most common causes of emergency surgery in worldwide and a major cause of severe abdominal pain and sometimes harrowing and intolerable patients are presenting to the emergency department. The duty of every physician especially Emergency physician reduction of pain of patients that is considered as a major priority in new emergency medical treatment. The aim of this study was evaluation of effect IV Acetaminophen on abdominal pain in patients referred to emergency ward. Methods: In a double blind clinical trial that performed in emergency department on patients with abdominal pain, effect IV Acetaminophen on abdominal pain in patients referred to emergency ward evaluated. Results and Conclusion:155 of patients were male and 85 of them were female. Mean age of patients in acetaminophen group was 45.45 ± 20.47 and in Morphine group was 50.99 ± 19.40 year(P=0.0054). Mean of pre injection pain score in male was 8.69 ± 1.29 and in female patients was 9.17 ± 1.27(P=0.848). Mean of pre injection pain score in Morphine group patients was 8.80 ± 1.35 and Mean of post injection pain score in Morphine group patients was 4.06 ± 1.71(P<0.001). Mean of pre injection pain score in acetaminophen group patients was 8.92 ± 1.25 and Mean of post injection pain score in acetaminophen group patients was 6.46 ± 2.25(P<0.001). Mean of post injection pain score in acetaminophen group patients was significantly higher than patient’s of Morphine group. Significant liner direct correlation was found between pre injection and post injection pain score in the studied patients.