Brain Tumor Pathology最新文献_第8页

A primary DICER1-sarcoma with KRAS and TP53 mutations in a child with suspected ECCL 疑为ECCL患儿的原发性dicer1肉瘤合并KRAS和TP53突变

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-06-06 DOI: 10.1007/s10014-022-00437-2

Kaiyun Yang, Justin Z. Wang, Nisha Kanwar, A. Villani, O. Ajani, A. Fleming, V. Patil, Y. Mamatjan, Qingxia Wei, D. Malkin, A. Shlien, G. Zadeh, J. Provias

引用次数: 1

Revisiting the definition of glioma recurrence based on a phylogenetic investigation of primary and re-emerging tumor samples: a case report 基于原发性和复发性肿瘤样本的系统发育研究，重新定义胶质瘤复发：一例报告

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-06-06 DOI: 10.1007/s10014-022-00438-1

Toru Umehara, H. Arita, F. Miya, Takamune Achiha, T. Shofuda, E. Yoshioka, D. Kanematsu, Tomoyoshi Nakagawa, M. Kinoshita, Naoki Kagawa, Y. Fujimoto, N. Hashimoto, H. Kiyokawa, Eiichi Morii, T. Tsunoda, Y. Kanemura, H. Kishima

引用次数: 0

Diffusely infiltrating glioma with CREBBP–BCORL1 fusion showing overexpression of not only BCORL1 but BCOR: A case report CREBBP-BCORL1融合的弥漫性浸润性胶质瘤显示BCORL1和BCOR的过度表达：一例报告

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-05-21 DOI: 10.1007/s10014-022-00435-4

Ayako Yamazaki, Y. Arai, K. Fukuoka, Y. Nakano, N. Hama, S. Nakata, K. Makino, J. Kuroda, N. Shinojima, A. Mukasa, Yoshiki Mikami, K. Ichimura, T. Shibata, H. Yokoo, S. Nobusawa

引用次数: 2

Clinical and radiological findings of glioblastomas harboring a BRAF V600E mutation 含有BRAF V600E突变的胶质母细胞瘤的临床和放射学表现

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 DOI: 10.1007/s10014-022-00432-7

Yukitomo Ishi, S. Yamaguchi, Michinari Okamoto, R. Sawaya, S. Endo, Hiroaki Motegi, S. Terasaka, Zen-ichi Tanei, K. Hatanaka, Shinya Tanaka, M. Fujimura

引用次数: 5

A patient with two gliomas with independent oligodendroglioma and glioblastoma biology proved by DNA-methylation profiling: a case report and review of the literature. 2例胶质瘤患者，具有独立的少突胶质细胞瘤和胶质母细胞瘤生物学，dna甲基化分析证实:病例报告和文献复习。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 Epub Date: 2022-01-11 DOI: 10.1007/s10014-021-00423-0

Theo F J Kraus, Christoph Schwartz, Lukas Machegger, Barbara Zellinger, Dorothee Hölzl, Hans U Schlicker, Johannes Pöppe, Barbara Ladisich, Mathias Spendel, Michael Kral, Karl Sotlar

{"title":"A patient with two gliomas with independent oligodendroglioma and glioblastoma biology proved by DNA-methylation profiling: a case report and review of the literature.","authors":"Theo F J Kraus, Christoph Schwartz, Lukas Machegger, Barbara Zellinger, Dorothee Hölzl, Hans U Schlicker, Johannes Pöppe, Barbara Ladisich, Mathias Spendel, Michael Kral, Karl Sotlar","doi":"10.1007/s10014-021-00423-0","DOIUrl":"https://doi.org/10.1007/s10014-021-00423-0","url":null,"abstract":"Here, we report on a patient presenting with two histopathologically distinct gliomas. At the age of 42, the patient underwent initial resection of a right temporal oligodendroglioma IDH mutated 1p/19q co-deleted WHO Grade II followed by adjuvant radiochemotherapy with temozolomide. 15 months after initial diagnosis, the patient showed right hemispheric tumor progression and an additional new left frontal contrast enhancement in the subsequent imaging. A re-resection of the right-sided tumor and resection of the left frontal tumor were conducted. Neuropathological work-up showed recurrence of the right-sided oligodendroglioma with features of an anaplastic oligodendroglioma WHO Grade III, but a glioblastoma WHO grade IV for the left frontal lesion. In depth molecular profiling revealed two independent brain tumors with distinct molecular profiles of anaplastic oligodendroglioma IDH mutated 1p/19q co-deleted WHO Grade III and glioblastoma IDH wildtype WHO grade IV. This unique and rare case of a patient with two independent brain tumors revealed by in-depth molecular work-up and epigenomic profiling emphasizes the importance of integrated work-up of brain tumors including methylome profiling for advanced patient care.","PeriodicalId":9226,"journal":{"name":"Brain Tumor Pathology","volume":"39 2","pages":"111-119"},"PeriodicalIF":3.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39689454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

T2-fluid-attenuated inversion recovery mismatch sign in lower grade gliomas: correlation with pathological and molecular findings 低级别胶质瘤T2液衰减反转恢复失配征与病理和分子表现的相关性

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 DOI: 10.1007/s10014-022-00433-6

Shinji Yamashita, H. Takeshima, Y. Kadota, M. Azuma, T. Fukushima, Natsuki Ogasawara, T. Kawano, Mitsuru Tamura, Jyunichiro Muta, Kiyotaka Saito, G. Takeishi, A. Mizuguchi, Takashi Watanabe, H. Ohta, K. Yokogami

引用次数: 2

The 2021 WHO classification of tumors, 5th edition, central nervous system tumors: the 10 basic principles. 2021年世界卫生组织肿瘤分类，第5版，中枢神经系统肿瘤:10项基本原则。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 DOI: 10.1007/s10014-022-00428-3

Takashi Komori

引用次数: 17

Histopathological predictors of progression-free survival in atypical meningioma: a single-center retrospective cohort and meta-analysis. 非典型脑膜瘤无进展生存期的组织病理学预测因素:单中心回顾性队列和荟萃分析。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 Epub Date: 2022-01-15 DOI: 10.1007/s10014-021-00419-w

Min-Sung Kim, Se-Woong Chun, Yun-Sik Dho, Youngbeom Seo, Joo Ho Lee, Jae Kyung Won, Jin Wook Kim, Chul-Kee Park, Sung-Hye Park, Yong Hwy Kim

{"title":"Histopathological predictors of progression-free survival in atypical meningioma: a single-center retrospective cohort and meta-analysis.","authors":"Min-Sung Kim, Se-Woong Chun, Yun-Sik Dho, Youngbeom Seo, Joo Ho Lee, Jae Kyung Won, Jin Wook Kim, Chul-Kee Park, Sung-Hye Park, Yong Hwy Kim","doi":"10.1007/s10014-021-00419-w","DOIUrl":"https://doi.org/10.1007/s10014-021-00419-w","url":null,"abstract":"To determine the prognostic significance of histopathological features included in the diagnostic criteria of atypical meningioma for progression-free survival (PFS). We performed a retrospective cohort study and meta-analysis. Brain invasion, mitotic index, spontaneous necrosis, sheeting, prominent nucleoli, high cellularity, and small cells were the histopathological features of interest. The data from 25 studies involving 3590 patients including our cohort (n = 262) were included. The pooled HR of mitotic index at a cutoff value of 4 showed no statical significance in the gross analysis (pooled HR, 1.09; 95% CI 0.61-1.96; p = 0.7699). Furthermore, it failed to prognosticate PFS in other pooled analyses. For brain invasion, no consistent association with the progression was found in each pooled analysis according to the included studies. Among the remaining five atypical features, spontaneous necrosis, sheeting, and prominent nucleoli showed a significant correlation with PFS in the gross analysis. In the analysis that pooled the HRs from the multivariate analyses, only spontaneous necrosis had significant association with PFS. The available evidence supports that the current cutoff value of mitotic index for diagnosing atypical meningioma might be improper to have prognostic value. The prognostic significance of brain invasion also needs further evaluation.","PeriodicalId":9226,"journal":{"name":"Brain Tumor Pathology","volume":"39 2","pages":"99-110"},"PeriodicalIF":3.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39912555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Emerging glioneuronal and neuronal tumors: case-based review. 新发胶质神经元和神经元肿瘤:基于病例的回顾。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 Epub Date: 2022-01-20 DOI: 10.1007/s10014-021-00420-3

So Dug Lim, Seong Ik Kim, Jin Woo Park, Jae Kyung Won, Seung-Ki Kim, Ji Hoon Phi, Chun-Kee Chung, Seung-Hong Choi, Hongseok Yun, Sung-Hye Park

{"title":"Emerging glioneuronal and neuronal tumors: case-based review.","authors":"So Dug Lim, Seong Ik Kim, Jin Woo Park, Jae Kyung Won, Seung-Ki Kim, Ji Hoon Phi, Chun-Kee Chung, Seung-Hong Choi, Hongseok Yun, Sung-Hye Park","doi":"10.1007/s10014-021-00420-3","DOIUrl":"https://doi.org/10.1007/s10014-021-00420-3","url":null,"abstract":"Glioneuronal and neuronal tumors (GNTs) are rare heterogeneous central nervous system tumors characterized by slow growth and favorable outcomes, but are often associated with diagnostic difficulties. A thorough analysis of three rare and recently recognized GNTs was performed in the context of clinicopathological features and molecular genetic characterization. The current spinal diffuse leptomeningeal glioneuronal tumor (DLGNT) was characterized with oligodendroglioma-like tumor with chromosome 1p/19q codeletion without IDH mutations and KIAA1549:BRAF fusion. The current occipital multinodular and vacuolating neuronal tumor (MVNT) was characteristic of the variable-sized vague nodules consisted of gangliocytic tumor cells with intracytoplasmic and pericellular vacuolation and the next-generation sequencing (NGS) revealed MAP2K1 p.Q56_V60del. A diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (DGONC) of the amygdala was characterized by oligodendroglia-like cells and nuclear clusters, and monosomy 14. From the current cases and literature review, we found that DLGNT commonly occurs in the spinal cord and can make mass and more commonly have KIAA1549:BRAF fusion; MVNT is a neoplasm rather than malformation and MAP2K1 deletion is one of the hallmarks of this tumor; although DGONC may require a methylation profile, we can reach a diagnosis through its unique histology, monosomy 14, and exclusion diagnosis without a methylation profile.","PeriodicalId":9226,"journal":{"name":"Brain Tumor Pathology","volume":"39 2","pages":"65-78"},"PeriodicalIF":3.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39924951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preface for Brain Tumor Pathology vol. 39 issue 2 脑肿瘤病理学导论第39卷第2期

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 DOI: 10.1007/s10014-022-00430-9

H. Takeshima

引用次数: 1