Brain Tumor Pathology最新文献_第9页

The 2021 WHO classification of tumors, 5th edition, central nervous system tumors: the 10 basic principles. 2021年世界卫生组织肿瘤分类，第5版，中枢神经系统肿瘤:10项基本原则。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 DOI: 10.1007/s10014-022-00428-3

Takashi Komori

引用次数: 17

Histopathological predictors of progression-free survival in atypical meningioma: a single-center retrospective cohort and meta-analysis. 非典型脑膜瘤无进展生存期的组织病理学预测因素:单中心回顾性队列和荟萃分析。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 Epub Date: 2022-01-15 DOI: 10.1007/s10014-021-00419-w

Min-Sung Kim, Se-Woong Chun, Yun-Sik Dho, Youngbeom Seo, Joo Ho Lee, Jae Kyung Won, Jin Wook Kim, Chul-Kee Park, Sung-Hye Park, Yong Hwy Kim

{"title":"Histopathological predictors of progression-free survival in atypical meningioma: a single-center retrospective cohort and meta-analysis.","authors":"Min-Sung Kim, Se-Woong Chun, Yun-Sik Dho, Youngbeom Seo, Joo Ho Lee, Jae Kyung Won, Jin Wook Kim, Chul-Kee Park, Sung-Hye Park, Yong Hwy Kim","doi":"10.1007/s10014-021-00419-w","DOIUrl":"https://doi.org/10.1007/s10014-021-00419-w","url":null,"abstract":"To determine the prognostic significance of histopathological features included in the diagnostic criteria of atypical meningioma for progression-free survival (PFS). We performed a retrospective cohort study and meta-analysis. Brain invasion, mitotic index, spontaneous necrosis, sheeting, prominent nucleoli, high cellularity, and small cells were the histopathological features of interest. The data from 25 studies involving 3590 patients including our cohort (n = 262) were included. The pooled HR of mitotic index at a cutoff value of 4 showed no statical significance in the gross analysis (pooled HR, 1.09; 95% CI 0.61-1.96; p = 0.7699). Furthermore, it failed to prognosticate PFS in other pooled analyses. For brain invasion, no consistent association with the progression was found in each pooled analysis according to the included studies. Among the remaining five atypical features, spontaneous necrosis, sheeting, and prominent nucleoli showed a significant correlation with PFS in the gross analysis. In the analysis that pooled the HRs from the multivariate analyses, only spontaneous necrosis had significant association with PFS. The available evidence supports that the current cutoff value of mitotic index for diagnosing atypical meningioma might be improper to have prognostic value. The prognostic significance of brain invasion also needs further evaluation.","PeriodicalId":9226,"journal":{"name":"Brain Tumor Pathology","volume":"39 2","pages":"99-110"},"PeriodicalIF":3.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39912555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Emerging glioneuronal and neuronal tumors: case-based review. 新发胶质神经元和神经元肿瘤:基于病例的回顾。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 Epub Date: 2022-01-20 DOI: 10.1007/s10014-021-00420-3

So Dug Lim, Seong Ik Kim, Jin Woo Park, Jae Kyung Won, Seung-Ki Kim, Ji Hoon Phi, Chun-Kee Chung, Seung-Hong Choi, Hongseok Yun, Sung-Hye Park

{"title":"Emerging glioneuronal and neuronal tumors: case-based review.","authors":"So Dug Lim, Seong Ik Kim, Jin Woo Park, Jae Kyung Won, Seung-Ki Kim, Ji Hoon Phi, Chun-Kee Chung, Seung-Hong Choi, Hongseok Yun, Sung-Hye Park","doi":"10.1007/s10014-021-00420-3","DOIUrl":"https://doi.org/10.1007/s10014-021-00420-3","url":null,"abstract":"Glioneuronal and neuronal tumors (GNTs) are rare heterogeneous central nervous system tumors characterized by slow growth and favorable outcomes, but are often associated with diagnostic difficulties. A thorough analysis of three rare and recently recognized GNTs was performed in the context of clinicopathological features and molecular genetic characterization. The current spinal diffuse leptomeningeal glioneuronal tumor (DLGNT) was characterized with oligodendroglioma-like tumor with chromosome 1p/19q codeletion without IDH mutations and KIAA1549:BRAF fusion. The current occipital multinodular and vacuolating neuronal tumor (MVNT) was characteristic of the variable-sized vague nodules consisted of gangliocytic tumor cells with intracytoplasmic and pericellular vacuolation and the next-generation sequencing (NGS) revealed MAP2K1 p.Q56_V60del. A diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (DGONC) of the amygdala was characterized by oligodendroglia-like cells and nuclear clusters, and monosomy 14. From the current cases and literature review, we found that DLGNT commonly occurs in the spinal cord and can make mass and more commonly have KIAA1549:BRAF fusion; MVNT is a neoplasm rather than malformation and MAP2K1 deletion is one of the hallmarks of this tumor; although DGONC may require a methylation profile, we can reach a diagnosis through its unique histology, monosomy 14, and exclusion diagnosis without a methylation profile.","PeriodicalId":9226,"journal":{"name":"Brain Tumor Pathology","volume":"39 2","pages":"65-78"},"PeriodicalIF":3.3,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39924951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preface for Brain Tumor Pathology vol. 39 issue 2 脑肿瘤病理学导论第39卷第2期

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 DOI: 10.1007/s10014-022-00430-9

H. Takeshima

引用次数: 1

Implications of immune cells in oncolytic herpes simplex virotherapy for glioma 免疫细胞在胶质瘤溶瘤性单纯疱疹病毒治疗中的意义

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 DOI: 10.1007/s10014-022-00431-8

Yoshihiro Otani, J. Yoo, Toshihiko Shimizu, K. Kurozumi, I. Date, B. Kaur

引用次数: 7

Ribosomal proteins induce stem cell-like characteristics in glioma cells as an “extra-ribosomal function” 核糖体蛋白作为“核糖体外功能”诱导胶质瘤细胞的干细胞样特征

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-04-01 DOI: 10.1007/s10014-022-00434-5

T. Hide, Ichiyo Shibahara, M. Inukai, Ryota Shigeeda, Y. Shirakawa, H. Jono, N. Shinojima, A. Mukasa, T. Kumabe

引用次数: 2

Molecular subgrouping of ependymoma across three anatomic sites and their prognostic implications 三个解剖部位室管膜瘤的分子亚组及其预后意义

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-03-29 DOI: 10.1007/s10014-022-00429-2

Dheeraj Chinnam, K. Gupta, T. Kiran, Aastha Saraswati, P. Salunke, R. Madan, Narendra Kumar, B. Radotra

引用次数: 2

The oligodendroglial histological features are not independently predictive of patient prognosis in lower-grade gliomas 低级别胶质瘤的少突胶质组织学特征不能独立预测患者预后

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-03-15 DOI: 10.1007/s10014-022-00426-5

E. Pareira, M. Shibuya, Kentaro Ohara, Yu Nakagawa, Tokunori Kanazawa, Dai Kamamoto, Y. Kato, Eri Arai, E. Aimono, Kazunari Yoshida, H. Nishihara, Y. Kanai, H. Sasaki

引用次数: 1

Epithelioid inflammatory myofibroblastic sarcoma with VCL-ALK fusion of central nervous system: case report and brief review of the literature. 中枢神经系统VCL-ALK融合的上皮样炎性肌纤维母细胞肉瘤1例报告及文献复习。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-01-01 Epub Date: 2021-11-06 DOI: 10.1007/s10014-021-00416-z

Shefali Chopra, Nolan Maloney, Wei Lien Wang

引用次数: 8

Molecular subtyping of ependymoma and prognostic impact of Ki-67. 室管膜瘤分子分型及Ki-67对预后的影响。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2022-01-01 Epub Date: 2021-11-23 DOI: 10.1007/s10014-021-00417-y

Ka Young Lim, Kwanghoon Lee, Yumi Shim, Jin Woo Park, Hyunhee Kim, Jeongwan Kang, Jae Kyung Won, Seung-Ki Kim, Ji Hoon Phi, Chul-Kee Park, Chun-Kee Chung, Hongseok Yun, Sung-Hye Park

{"title":"Molecular subtyping of ependymoma and prognostic impact of Ki-67.","authors":"Ka Young Lim, Kwanghoon Lee, Yumi Shim, Jin Woo Park, Hyunhee Kim, Jeongwan Kang, Jae Kyung Won, Seung-Ki Kim, Ji Hoon Phi, Chul-Kee Park, Chun-Kee Chung, Hongseok Yun, Sung-Hye Park","doi":"10.1007/s10014-021-00417-y","DOIUrl":"https://doi.org/10.1007/s10014-021-00417-y","url":null,"abstract":"Although ependymomas (EPNs) have similar histopathology, they are heterogeneous tumors with diverse immunophenotypes, genetics, epigenetics, and different clinical behavior according to anatomical locations. We reclassified 141 primary EPNs from a single institute with immunohistochemistry (IHC) and next-generation sequencing (NGS). Supratentorial (ST), posterior fossa (PF), and spinal (SP) EPNs comprised 12%, 41%, and 47% of our cohort, respectively. Fusion genes were found only in ST-EPNs except for one SP-EPN with ZFTA-YAP1 fusion, NF2 gene alterations were found in SP-EPNs, but no driver gene was present in PF-EPNs. Surrogate IHC markers revealed high concordance rates between L1CAM and ZFTA-fusion and H3K27me3 loss or EZHIP overexpression was used for PFA-EPNs. The 7% cut-off of Ki-67 was sufficient to classify EPNs into two-tiered grades at all anatomical locations. Multivariate analysis also delineated that a Ki-67 index was the only independent prognostic factor in both overall and progression-free survivals. The gain of chromosome 1q and CDKN2A/2B deletion were associated with poor outcomes, such as multiple recurrences or extracranial metastases. In this study, we propose a cost-effective schematic diagnostic flow of EPNs by the anatomical location, three biomarkers (L1CAM, H3K27me3, and EZHIP), and a cut-off of a 7% Ki-67 labeling index.","PeriodicalId":9226,"journal":{"name":"Brain Tumor Pathology","volume":"39 1","pages":"1-13"},"PeriodicalIF":3.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12