Brain Tumor Pathology最新文献_第5页

Oligodendroglioma, IDH-mutant and 1p/19q-codeleted-prognostic factors, standard of care and chemotherapy, and future perspectives with neoadjuvant strategy. 寡树突胶质细胞瘤、IDH突变和1p/19q编码缺失--预后因素、标准治疗和化疗，以及新辅助策略的未来展望。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2024-04-01 Epub Date: 2024-04-02 DOI: 10.1007/s10014-024-00480-1

Hikaru Sasaki, Yohei Kitamura, Masahiro Toda, Yuichi Hirose, Kazunari Yoshida

引用次数: 0

Correction: Beyond the WHO 2021 classification of the tumors of the central nervous system: transitioning from the 5th edition to the next. 更正：超越世界卫生组织 2021 年中枢神经系统肿瘤分类：从第五版过渡到下一版。

IF 2.7 3区医学

Brain Tumor Pathology Pub Date : 2024-04-01 DOI: 10.1007/s10014-024-00478-9

Takashi Komori

引用次数: 0

Pediatric diffuse glioma with EP300::BCOR fusion manifesting as low-grade epilepsy-associated neuroepithelial tumor: a case presentation. 小儿弥漫性胶质瘤伴EP300::BCOR融合，表现为低度癫痫相关神经上皮肿瘤：一个病例。

IF 2.7 3区医学

Brain Tumor Pathology Pub Date : 2024-01-01 Epub Date: 2023-12-22 DOI: 10.1007/s10014-023-00475-4

Satoshi Nakata, Yasuhito Arai, Kohei Fukuoka, Takahiro Shirakura, Ayako Yamazaki, Sho Osawa, Natsuko Hama, Tatsuhiro Shibata, Takaaki Miyagishima, Keishi Horiguchi, Masahiko Tosaka, Hideaki Yokoo, Yuhei Yoshimoto, Sumihito Nobusawa

引用次数: 0

Beyond the WHO 2021 classification of the tumors of the central nervous system: transitioning from the 5th edition to the next. 超越世卫组织 2021 年中枢神经系统肿瘤分类：从第五版过渡到下一版。

IF 2.7 3区医学

Brain Tumor Pathology Pub Date : 2024-01-01 DOI: 10.1007/s10014-023-00474-5

Takashi Komori

引用次数: 0

A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review 一例罕见的原发性中枢神经系统组织细胞肉瘤，携带新型 ARHGAP45::BRAF 融合基因：病例报告和文献综述

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2023-12-15 DOI: 10.1007/s10014-023-00471-8

Luyi Zhang, Gang Zhang, Han Zheng, Bin Jiang, Yongzhi Ju, Qianqian Duan, Lu An, Hangyu Shi

{"title":"A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review","authors":"Luyi Zhang, Gang Zhang, Han Zheng, Bin Jiang, Yongzhi Ju, Qianqian Duan, Lu An, Hangyu Shi","doi":"10.1007/s10014-023-00471-8","DOIUrl":"https://doi.org/10.1007/s10014-023-00471-8","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3>Patients with histiocytic sarcoma occurring in the central nervous system (CNS) are rare and have a very poor prognosis. The increased use of molecular diagnostic approaches in solid tumors has brought more opportunities for the diagnosis and treatment of central nervous system histiocytic sarcoma (CNSHS).<h3 data-test=\"abstract-sub-heading\">Case description</h3>A 9-year-old girl was admitted to the hospital with pain in her head and neck, as well as vomiting. Imaging scans showed a prominent abnormality in the anterior falciform region, and histopathology revealed the presence of CD68 (+) and CD163 (+) cells, leading to a preliminary diagnosis of primary intracerebral CNSHS. Molecular profiling tests identified a new variant of ARHGAP45::BRAF fusion in this case, which has not been reported in any other tumor. The patient underwent surgical removal of the tumor and will require long-term monitoring.<h3 data-test=\"abstract-sub-heading\">Conclusion</h3>The presence of the BRAF point mutation, predominantly BRAF p.V600E, has been documented in prior literature of CNSHS. This is the first case of pediatric histiocytic sarcoma in the anterior falciform region who has a unique ARHGAP45::BRAF fusion. The findings of our study indicate that a broader range of molecular assays should be employed in the diagnosis of CNSHS and opens up new possibilities for the treatment of the patient.","PeriodicalId":9226,"journal":{"name":"Brain Tumor Pathology","volume":"28 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138692827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma FISH 分析显示 CDKN2A 和 IFNA14 共同缺失具有异质性，是胶质母细胞瘤的一个显著特征

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2023-12-14 DOI: 10.1007/s10014-023-00473-6

{"title":"FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma","authors":"","doi":"10.1007/s10014-023-00473-6","DOIUrl":"https://doi.org/10.1007/s10014-023-00473-6","url":null,"abstract":"<h3>Abstract</h3> Deletion of CDKN2A occurs in 50% of glioblastomas (GBM), and IFNA locus deletion in 25%. These genes reside closely on chromosome 9. We investigated whether CDKN2A and IFNA were co-deleted within the same heterogeneous tumour and their prognostic implications. We assessed CDKN2A and IFNA14 deletions in 45 glioma samples using an in-house three-colour FISH probe. We examined the correlation between p16INK4a protein expression (via IHC) and CDKN2A deletion along with the impact of these genomic events on patient survival. FISH analyses demonstrated that grades II and III had either wildtype (wt) or amplified CDKN2A/IFNA14, whilst 44% of GBMs harboured homozygous deletions of both genes. Cores with CDKN2A homozygous deletion (n = 11) were negative for p16INK4a. Twenty p16INK4a positive samples lacked CDKN2A deletion with some of cells showing negative p16INK4a. There was heterogeneity in IFNA14/CDKN2A ploidy within each GBM. Survival analyses of primary GBMs suggested a positive association between increased p16INK4a and longer survival; this persisted when considering CDKN2A/IFNA14 status. Furthermore, wt (intact) CDKN2A/IFNA14 were found to be associated with longer survival in recurrent GBMs. Our data suggest that co-deletion of CDKN2A/IFNA14 in GBM negatively correlates with survival and CDKN2A-wt status correlated with longer survival, and with second surgery, itself a marker for improved patient outcomes.","PeriodicalId":9226,"journal":{"name":"Brain Tumor Pathology","volume":"16 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138679981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary papillary epithelial tumor of the sella: a case report of an emerging tumor type 蝶鞍原发性乳头状上皮肿瘤：一种新兴肿瘤类型的病例报告

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2023-12-13 DOI: 10.1007/s10014-023-00472-7

S. Rima, Shilpa Rao, Pulak Nigam, Rajneesh Kacchara

引用次数: 0

Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis-a case report. 三叉神经神经鞘瘤的自发恶性转化：考虑致瘤基因的改变一例报告。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2023-10-01 Epub Date: 2023-07-29 DOI: 10.1007/s10014-023-00466-5

Natsuki Ogasawara, Shinji Yamashita, Koji Yamasaki, Tomoki Kawano, Tomohiro Kawano, Junichiro Muta, Fumitaka Matsumoto, Takashi Watanabe, Hajime Ohta, Kiyotaka Yokogami, Tsuyoshi Fukushima, Yuichiro Sato, Hideo Takeshima

{"title":"Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis-a case report.","authors":"Natsuki Ogasawara, Shinji Yamashita, Koji Yamasaki, Tomoki Kawano, Tomohiro Kawano, Junichiro Muta, Fumitaka Matsumoto, Takashi Watanabe, Hajime Ohta, Kiyotaka Yokogami, Tsuyoshi Fukushima, Yuichiro Sato, Hideo Takeshima","doi":"10.1007/s10014-023-00466-5","DOIUrl":"10.1007/s10014-023-00466-5","url":null,"abstract":"Malignant peripheral nerve sheath tumors (MPNSTs) arising from the trigeminal nerves are extremely rare (only 45 cases, including the present case, have been published) and have been reported to develop de novo from the peripheral nerve sheath and are not transformed from a schwannoma or neurofibroma. Here, we report a case of MPNSTs of the trigeminal nerve caused by the malignant transformation of a trigeminal schwannoma, with a particular focus on genetic considerations. After undergoing a near-total resection of a histologically typical benign schwannoma, the patient presented with regrowth of the tumor 10 years after the primary excision. Histopathologic and immunochemical examinations confirmed the recurrent tumor to be an MPNST. Comprehensive genomic analyses (FoundationOne panel-based gene assay) showed that only the recurrent MPNST sample, not the initial diagnosis of schwannoma, harbored genetic mutations, including NF1-p.R2637* and TP53-p.Y234H, candidate gene mutations associated with malignant transformation. Moreover, the results of reverse transcription polymerase chain reaction showed that the fusion of SH3PXD2A and HTRA1, which has been reported as one of the responsible genetic aberrations of schwannoma, was detected in the recurrent tumor. Taken together, we could illustrate the accumulation process of gene abnormalities for developing MPNSTs from normal cells via schwannomas.","PeriodicalId":9226,"journal":{"name":"Brain Tumor Pathology","volume":" ","pages":"222-229"},"PeriodicalIF":3.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9891974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs' surgical margins. 接触印迹细胞学检查有助于PitNETs手术边缘的术中病理诊断。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2023-10-01 Epub Date: 2023-10-06 DOI: 10.1007/s10014-023-00470-9

Noriaki Tanabe, Naoko Inoshita, Atsushi Ishida, Masataka Kato, Haruko Yoshimoto, Hideki Shiramizu, Hidetaka Suga, Toru Tateno, Kenichi Ohashi, Shozo Yamada

{"title":"Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs' surgical margins.","authors":"Noriaki Tanabe, Naoko Inoshita, Atsushi Ishida, Masataka Kato, Haruko Yoshimoto, Hideki Shiramizu, Hidetaka Suga, Toru Tateno, Kenichi Ohashi, Shozo Yamada","doi":"10.1007/s10014-023-00470-9","DOIUrl":"10.1007/s10014-023-00470-9","url":null,"abstract":"Touch imprint cytology (TIC) and frozen section (FS) procedures are essential for intraoperative pathological diagnosis (IPD). They are invaluable tools for therapeutic decision-making, helping surgeons avoid under or overtreatment of patients. Pituitary neuroendocrine tumors (PitNETs) are generally small, slow-growing tumors with low-grade malignancy located at the base of the skull where it is impossible to maintain a wide tumor margin. Therefore, transsphenoidal surgery (TSS) should be performed with necessary caution, and with sufficient and minimal resection. Thus, this study aimed to evaluate the diagnostic accuracy of TIC for the diagnosis of PitNET and determine its ability to accurately evaluate the surgical margin compared to the FS procedure. A total of 104 fresh specimens from 28 patients who underwent TSS for PitNETs were examined using TIC and FS. TIC specimens were categorized according to the cell imprinting pattern. All specimens with a large number of neuroendocrine cells diffusely attached to the glass surfaces had PitNET components. Contrarily, no rich or diffuse cell attachments were observed in any non-tumoral endocrine cells. In conclusion, recognizing a pattern of endocrine cell adherence to glass is highly effective in IPD to certify the existence of a PitNET component.","PeriodicalId":9226,"journal":{"name":"Brain Tumor Pathology","volume":" ","pages":"215-221"},"PeriodicalIF":3.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41178087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma. 多种方法的综合分析揭示了髓母细胞瘤免疫微环境的特征。

IF 3.3 3区医学

Brain Tumor Pathology Pub Date : 2023-10-01 Epub Date: 2023-08-09 DOI: 10.1007/s10014-023-00467-4

Kaiyu Fan, Yifan Wei, Yunwei Ou, Jian Gong

{"title":"Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma.","authors":"Kaiyu Fan, Yifan Wei, Yunwei Ou, Jian Gong","doi":"10.1007/s10014-023-00467-4","DOIUrl":"10.1007/s10014-023-00467-4","url":null,"abstract":"To explore the characteristics of the immune microenvironment (IME) of medulloblastoma (MB) by four methods: flow cytometry (FCM), immunohistochemical (IHC), bulk RNA expression and single cell RNA sequencing (scRNA-seq), we collected the intraoperative specimens of MB, ependymoma (EPN), high-grade glioma (HGG), and low-grade glioma (LGG) to make a cross-cancer comparison. The specimens were subjected to FCM and IHC respectively, and deconvolution from bulk RNA expression data and scRNA-seq analysis were performed in MB from the GEO database. FCM and IHC analysis found that the proportion of lymphocytes (LC) and T cells between MB and other brain tumors were significantly different. The deconvolution of bulk RNA expression data showed that only the proportion of cell types in MCPCOUNTER changed greatly. scRNA-seq found that the proportion of various immune cells in the IME of MB differed between different subtypes. Techniques such as FCM, IHC, bulk RNA expression, and scRNA-seq can sort out different immune cell subsets to a certain extent and quantify their proportions. The four methods have their own strengthens and limitations, but for highly heterogeneous tumor such as MB, integrated analysis of multiple methods is a better choice.","PeriodicalId":9226,"journal":{"name":"Brain Tumor Pathology","volume":" ","pages":"191-203"},"PeriodicalIF":3.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9966881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0