Breast disease最新文献_第5页

Breast reconstruction for locally advanced breast cancer previously submitted to mastectomy and an ipsilateral thoracoabdominal dermofat (ITADE) flap. 局部晚期乳腺癌的乳房重建先前提交乳房切除术和同侧胸腹真皮脂肪(ITADE)皮瓣。

Breast disease Pub Date : 2023-01-01 DOI: 10.3233/BD-220057

René Aloisio da Costa Vieira, An Wan Ching, Idam de Oliveira-Junior

引用次数: 0

GLIS2 and CCND1 expression levels in breast cancer patients. GLIS2和CCND1在乳腺癌患者中的表达水平。

Breast disease Pub Date : 2023-01-01 DOI: 10.3233/BD-220068

Minoosh Sadeghi, Majid Gholizadeh, Neda Safataj, Mahsa Tahmasebivand, Gholamreza Mohajeri, Hajie Lotfi, Saber Yari Bostanabad, Behnaz Safar, Mansoor Salehi

引用次数: 0

Study of risk factors and marker status in women with breast cancer in Brunei Darussalam. 文莱达鲁萨兰国妇女乳腺癌危险因素及标志物状况的研究。

Breast disease Pub Date : 2023-01-01 DOI: 10.3233/BD-239001

Chieng Bing Wong, Aklimah Mustapa, Siti Nur Idayu Matusin, Muhammad Syafiq Abdullah, Andi Nilawati Usman, Mas Rina Wati Haji Abdul Hamid

{"title":"Study of risk factors and marker status in women with breast cancer in Brunei Darussalam.","authors":"Chieng Bing Wong, Aklimah Mustapa, Siti Nur Idayu Matusin, Muhammad Syafiq Abdullah, Andi Nilawati Usman, Mas Rina Wati Haji Abdul Hamid","doi":"10.3233/BD-239001","DOIUrl":"https://doi.org/10.3233/BD-239001","url":null,"abstract":"Objective: To investigate the associations between breast cancer staging and body mass index (BMI), menopausal status, and family history of breast cancer, as well as to assess the expression of tumor markers in women with breast cancer in Brunei Darussalam.Methods: A retrospective cross-sectional study was carried out at The Brunei Cancer Centre. Cases of women with breast cancer between 2000 and 2013 were retrieved from the medical records section and entered into a clinical proforma. These were reviewed and analyzed using appropriate statistical methods.Results: Overall, the mean age at diagnosis was 53.6 years ± 9.83. The postmenopausal women had a significantly higher risk of being diagnosed with late-onset breast cancer than premenopausal women (P = 0.022). The expressions of PR (P = 0.034), Her2 (P = 0.046), and CatD (P = 0.004) were significantly different in breast cancer staging. Other factors did not have a statistically-significant association with breast cancer staging.Conclusion: While most of the factors studied were not significantly different in breast cancer staging, our findings showed that it is recommended that high-risk women perform regular breast screening after the age of 40 years old. A future study highly appreciates comparing breast cancer risk factors among the Bruneian and Western populations.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"42 1","pages":"183-189"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10060047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical presentations and outcomes of young women aged <40 yrs with Ductal carcinoma in situ. 40岁以下年轻女性原位导管癌的临床表现和结果。

Breast disease Pub Date : 2023-01-01 DOI: 10.3233/BD-230018

Zhiyan Yan, Joanne Ngeow, John Allen, Geok Hoon Lim

{"title":"Clinical presentations and outcomes of young women aged <40 yrs with Ductal carcinoma in situ.","authors":"Zhiyan Yan, Joanne Ngeow, John Allen, Geok Hoon Lim","doi":"10.3233/BD-230018","DOIUrl":"10.3233/BD-230018","url":null,"abstract":"Introduction: Ductal carcinoma in situ (DCIS) in young women is rare and not well studied. Since they do not qualify for mammographic screening, they are more likely to present with symptoms. Young women have also been associated with poorer outcomes, but it is unknown whether presentation mode affects outcome. We aimed to compare characteristics of DCIS patients <40 years of age presenting with symptoms versus those without, and determine whether presentation mode affects recurrence.Methods: Pure DCIS patients aged <40 years were retrospectively analyzed. Clinical presentation, pathology and recurrence data were collected. Statistical analysis was performed to investigate the correlation of presentation mode with outcomes.Results: 40 patients with 41 cases were included. The mean age at diagnosis was 32.3 years (range 17-39). 73.2% and 26.8% presented with symptoms or abnormal imaging respectively. Of the cases who presented with symptoms, 86.7%, 10.0% and 3.3% had palpable lump, nipple discharge or breast pain, respectively. The average tumor size was 22.0 mm (range 2.0-86.9) and 12.2 mm (range 3-25) for patients who presented with symptoms and non-symptomatic group, respectively. Cases presenting with symptoms were statistically associated with higher grade (p = 0.0090). On median follow-up of 85 months, there were 3 (7.3%) recurrences, which were not statistically associated with presentation mode.Conclusion: Young women with DCIS tend to present with symptoms, with breast lump as the commonest symptom. Symptomatic patients tend to be associated with grade III tumours, compared to non-symptomatic patients. On long-term follow-up, mode of presentation was not statistically associated with recurrence.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"42 1","pages":"299-303"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41092631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast amyloidosis associated with Sjögren syndrome: A diagnostic pitfall in breast pathology. 与斯约格伦综合征相关的乳腺淀粉样变性：乳腺病理诊断中的一个陷阱。

Breast disease Pub Date : 2023-01-01 DOI: 10.3233/BD-230006

Oumeima Khaldi, Montassar Ghalleb, Amani Jallali, Insaf Fenniche, Mehdi Somai, Fatma Daoud, Fatma Boussema, Salma Kammoun, Khadija Hamza, Med Ali Ayadi, Tarek Dhieb

引用次数: 0

Comparison of tumor size, histopathological grade, and molecular subtype of breast cancer at a single center study. 单中心研究中乳腺癌肿瘤大小、组织病理分级和分子亚型的比较

Breast disease Pub Date : 2023-01-01 DOI: 10.3233/BD-239000

Awaluddin Awaluddin, John Pieter, Elridho Sampepajung, Salman Ardi Syamsu, Nilam Smaradhania, Firdaus Hamid, Prihantono Prihantono, Sachraswaty R Laidding, Muhammad Ihwan Kusuma, Muhammad Faruk

{"title":"Comparison of tumor size, histopathological grade, and molecular subtype of breast cancer at a single center study.","authors":"Awaluddin Awaluddin, John Pieter, Elridho Sampepajung, Salman Ardi Syamsu, Nilam Smaradhania, Firdaus Hamid, Prihantono Prihantono, Sachraswaty R Laidding, Muhammad Ihwan Kusuma, Muhammad Faruk","doi":"10.3233/BD-239000","DOIUrl":"https://doi.org/10.3233/BD-239000","url":null,"abstract":"Background: Breast cancer (BC) is the second most frequent cancer-related death among women worldwide. Factors influencing BC patients' survival include histopathological grade, histopathological type, stage, hormonal receptors, and number of mitotic images.Objective: To compare the tumor size, histopathological grade, and molecular type of BC patients.Methods: This was an observational analytic retrospective study. The population was BC patients at Dr. Wahidin Sudirohusodo Hospital from 2017 to 2021. The Kruskal-Wallis test was used to compare statistically between tumor size, histopathological grade, and molecular subtype. Significance was set at p < 0.05.Results: The study included 784 patients. Most were aged 50-59 years (34.8%), with tumor size 4c (37.0%) and moderate grade (66.1%), and the most common molecular subtype was luminal A (34.2%). Bivariate analysis using the Kruskal-Wallis test found no significant difference in molecular subtypes based on tumor size (p = 0.079), but significant differences existed in molecular subtype by histopathological grade (p = 0.005) and tumor size by histopathological grade (p < 0.001).Conclusions: Significant differences existed between histopathological grade by tumor size and molecular subtype. Early diagnosis and prompt treatment of BC patients are important to prevent morbidity and mortality.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"42 1","pages":"191-195"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10167184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone modifying agents in postmenopausal breast cancer patients treated with aromatase inhibitors: beyond bone protection? 芳香酶抑制剂治疗绝经后乳腺癌患者的骨修饰剂:超越骨保护?

Breast disease Pub Date : 2023-01-01 DOI: 10.3233/BD-220014

Andrea Villasco, Carola Minella, Valentina Elisabetta Bounous, Roberta Rosso, Nicoletta Biglia

引用次数: 0

A rapidly growing fibroadenoma in a pregnant woman: A case report. 孕妇快速生长的纤维腺瘤：一例报告。

Breast disease Pub Date : 2023-01-01 DOI: 10.3233/BD-230030

I M Brouwer de Koning, H C van Heusden, S J J Mol, M L Rots, W A Draaisma, K Bosscha

{"title":"A rapidly growing fibroadenoma in a pregnant woman: A case report.","authors":"I M Brouwer de Koning, H C van Heusden, S J J Mol, M L Rots, W A Draaisma, K Bosscha","doi":"10.3233/BD-230030","DOIUrl":"https://doi.org/10.3233/BD-230030","url":null,"abstract":"Background: Fibroadenomas are the most common benign breast lesions in women. They present as a unilateral mass and can rapidly enlarge in size through hormonal changes. Fibroadenomas could be classified as small or giant, and as simple or complex. They are classified as 'giant' when the size exceeds 5 cm and/or weight 500 gram; and as 'complex' if one of the following characteristics is present: cysts with a size >3 mm, epithelial calcifications, sclerosing adenosis and papillary apocrine metaplasia. Giant fibroadenomas can cause compression of surrounding breast tissue or breast asymmetry, requiring surgical excision in order to preserve a normal breast shape.Case: A 26-year-old pregnant woman was referred with a palpable mass of her right breast. The mass rapidly increased in size to a diameter of 13 cm during the second trimester of her pregnancy. A tru-cut biopsy confirmed a fibroadenoma. The rapid growth and compression of normal breast tissues indicated a lumpectomy during her pregnancy. The mass was easily excised without any consequences for the pregnancy. Pathological examination showed a complex giant fibroadenoma.Conclusion: A unique case of a pregnant woman with rapid progression of a fibroadenoma that met the criteria of a complex and giant fibroadenoma, was presented. This case emphasizes the importance of timely surgical intervention, even during pregnancy, to prevent permanent breast tissue damage.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"42 1","pages":"325-330"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A controversial ER negative PR positive molecular subtype of breast carcinoma-Report of two cases. 一种有争议的乳腺癌ER阴性PR阳性分子亚型——附两例报告。

Breast disease Pub Date : 2023-01-01 DOI: 10.3233/BD-230039

Smita Chandra, Sanya Bhasin, Sunil Saini

引用次数: 0

Breast lymphoma: General review. 乳腺淋巴瘤：综述。

Breast disease Pub Date : 2023-01-01 DOI: 10.3233/BD-220051

Emad M N Rezkallah, Andrew Elsaify, Su M M Tin, Debdeep Dey, Wael M Elsaify

{"title":"Breast lymphoma: General review.","authors":"Emad M N Rezkallah, Andrew Elsaify, Su M M Tin, Debdeep Dey, Wael M Elsaify","doi":"10.3233/BD-220051","DOIUrl":"10.3233/BD-220051","url":null,"abstract":"Background: Lymphoma of the breast can be classified as either primary breast lymphoma (PBL) or secondary to systemic lymphoma (SBL). PBL is a rare disease with Diffuse Large B cell Lymphomas (DLBCL) being the most common subtype.Objectives: In the current study, we represented eleven cases diagnosed with breast lymphoma in our trust; two of them had PBL and nine had SBL. We focused mainly on the clinical presentation, diagnosis, management and outcomes.Methods: We did this retrospective review for all breast lymphoma patients who were diagnosed in our trust during the periods from 2011-2022. Patients' data were obtained from the hospital recording system. We followed up these patients thus far to identify the outcome of treatment in each patient.Results: Eleven patients were included in our review. All patients were females. Average age of diagnosis was 66.1 ± 13 years of age. Eight patients were diagnosed with DLBCL, two patients were diagnosed with follicular lymphomas, and the last one had lymphoplasmacytic lymphoma. Chemotherapy +∕- radiotherapy was the standard treatment regimen in all patients. Four patients passed away within one year of chemotherapy, five patients achieved complete remission, one patient had two relapses and is still under treatment, while the last patient was diagnosed recently and still awaiting treatment.Conclusion: Primary breast lymphoma is an aggressive disease. The treatment for PBL is mainly systemic with chemoradiotherapy. The role of surgery is now limited to the diagnosis of the disease. Early diagnosis and proper treatment are crucial for the management of such cases.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"42 1","pages":"197-205"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9737150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0