单中心研究中乳腺癌肿瘤大小、组织病理分级和分子亚型的比较

Breast disease Pub Date : 2023-01-01 DOI:10.3233/BD-239000

Awaluddin Awaluddin, John Pieter, Elridho Sampepajung, Salman Ardi Syamsu, Nilam Smaradhania, Firdaus Hamid, Prihantono Prihantono, Sachraswaty R Laidding, Muhammad Ihwan Kusuma, Muhammad Faruk

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引用次数: 0

摘要

背景:乳腺癌(BC)是全世界女性中第二常见的癌症相关死亡。影响BC患者生存的因素包括组织病理分级、组织病理类型、分期、激素受体和有丝分裂成像次数。目的:比较BC患者的肿瘤大小、组织病理分级和分子分型。方法:观察性分析回顾性研究。人群为2017年至2021年在Dr. Wahidin Sudirohusodo医院就诊的BC患者。采用Kruskal-Wallis检验对肿瘤大小、组织病理分级和分子亚型进行统计学比较。结果:研究纳入784例患者。大多数患者年龄在50-59岁(34.8%)，肿瘤大小为4c(37.0%)，中度(66.1%)，最常见的分子亚型为腔内A(34.2%)。采用Kruskal-Wallis检验进行双变量分析发现，基于肿瘤大小的分子亚型差异无统计学意义(p = 0.079)，而基于组织病理分级的分子亚型差异有统计学意义(p = 0.005)，基于组织病理分级的肿瘤大小差异有统计学意义(p)。结论:基于肿瘤大小和分子亚型的组织病理分级存在统计学意义。早期诊断和及时治疗BC患者是重要的，以防止发病率和死亡率。

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Comparison of tumor size, histopathological grade, and molecular subtype of breast cancer at a single center study.

Background: Breast cancer (BC) is the second most frequent cancer-related death among women worldwide. Factors influencing BC patients' survival include histopathological grade, histopathological type, stage, hormonal receptors, and number of mitotic images.

Objective: To compare the tumor size, histopathological grade, and molecular type of BC patients.

Methods: This was an observational analytic retrospective study. The population was BC patients at Dr. Wahidin Sudirohusodo Hospital from 2017 to 2021. The Kruskal-Wallis test was used to compare statistically between tumor size, histopathological grade, and molecular subtype. Significance was set at p < 0.05.

Results: The study included 784 patients. Most were aged 50-59 years (34.8%), with tumor size 4c (37.0%) and moderate grade (66.1%), and the most common molecular subtype was luminal A (34.2%). Bivariate analysis using the Kruskal-Wallis test found no significant difference in molecular subtypes based on tumor size (p = 0.079), but significant differences existed in molecular subtype by histopathological grade (p = 0.005) and tumor size by histopathological grade (p < 0.001).

Conclusions: Significant differences existed between histopathological grade by tumor size and molecular subtype. Early diagnosis and prompt treatment of BC patients are important to prevent morbidity and mortality.

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来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.