Study of risk factors and marker status in women with breast cancer in Brunei Darussalam.

Breast disease Pub Date : 2023-01-01 DOI:10.3233/BD-239001

Chieng Bing Wong, Aklimah Mustapa, Siti Nur Idayu Matusin, Muhammad Syafiq Abdullah, Andi Nilawati Usman, Mas Rina Wati Haji Abdul Hamid

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引用次数: 0

Abstract

Objective: To investigate the associations between breast cancer staging and body mass index (BMI), menopausal status, and family history of breast cancer, as well as to assess the expression of tumor markers in women with breast cancer in Brunei Darussalam.

Methods: A retrospective cross-sectional study was carried out at The Brunei Cancer Centre. Cases of women with breast cancer between 2000 and 2013 were retrieved from the medical records section and entered into a clinical proforma. These were reviewed and analyzed using appropriate statistical methods.

Results: Overall, the mean age at diagnosis was 53.6 years ± 9.83. The postmenopausal women had a significantly higher risk of being diagnosed with late-onset breast cancer than premenopausal women (P = 0.022). The expressions of PR (P = 0.034), Her2 (P = 0.046), and CatD (P = 0.004) were significantly different in breast cancer staging. Other factors did not have a statistically-significant association with breast cancer staging.

Conclusion: While most of the factors studied were not significantly different in breast cancer staging, our findings showed that it is recommended that high-risk women perform regular breast screening after the age of 40 years old. A future study highly appreciates comparing breast cancer risk factors among the Bruneian and Western populations.

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文莱达鲁萨兰国妇女乳腺癌危险因素及标志物状况的研究。

目的:探讨文莱达鲁萨兰国乳腺癌分期与体重指数(BMI)、绝经状况、乳腺癌家族史的关系，并评估肿瘤标志物在乳腺癌妇女中的表达。方法:在文莱癌症中心进行回顾性横断面研究。从医疗记录部分检索2000年至2013年期间患乳腺癌的妇女病例，并输入临床形式表。使用适当的统计方法对这些进行了审查和分析。结果:总体而言，平均诊断年龄为53.6岁±9.83岁。绝经后妇女被诊断为晚发型乳腺癌的风险明显高于绝经前妇女(P = 0.022)。PR (P = 0.034)、Her2 (P = 0.046)、CatD (P = 0.004)在乳腺癌分期中的表达差异有统计学意义。其他因素与乳腺癌分期没有统计学上的显著关联。结论:虽然所研究的大多数因素在乳腺癌分期方面没有显著差异，但我们的研究结果表明，建议高危女性在40岁以后定期进行乳房筛查。一项未来的研究高度赞赏在文莱和西方人群中比较乳腺癌的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.