Breast disease最新文献_第3页

Nipple-sparing mastectomy and immediate breast reconstruction by prepectoral implant for the management of giant phyllodes tumors: A case series. 巨型植物瘤的保乳乳房切除术和胸前假体即刻乳房重建术：病例系列。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-240011

Khaled M Abdelwahab, Sara Elsaeed, Omar Hamdy, Mahmoud M Saleh, Amr Hosam

{"title":"Nipple-sparing mastectomy and immediate breast reconstruction by prepectoral implant for the management of giant phyllodes tumors: A case series.","authors":"Khaled M Abdelwahab, Sara Elsaeed, Omar Hamdy, Mahmoud M Saleh, Amr Hosam","doi":"10.3233/BD-240011","DOIUrl":"10.3233/BD-240011","url":null,"abstract":"Phyllodes tumor is an uncommon breast neoplasm that is present in variable sizes. Giant phyllodes are those larger than 10 cm in diameter. Clinically, giant phyllodes tumors present as a visible, rapidly growing mass distorting the breast contour. Such tumors with large size and rapid growth rate suggest a phyllode diagnosis of fibroadenoma. Planning a standard treatment strategy for these tumors is quite challenging. While adequate surgical excision with tumor-free resection margins is the standard of care for most giant phyllodes cases, borderline and malignant giant phyllodes tumors might require wider resections given their high recurrence rates. Some authors described total mastectomy as the treatment option for giant borderline and malignant phyllodes to obtain wide, clear margins. Between March 2022 and September 2023, our surgical oncology department presented and operated on three cases of giant phyllodes. They underwent a nipple-sparing mastectomy and immediate breast reconstruction using pre-pectoral silicone implants. We think that with such a procedure, we can benefit from the wide, safe margins of mastectomy that have been proven to decrease local recurrence rates while considering the aesthetic outcome.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of variables on breast self-examination: Potential barrier or enhancement of breast cancer prevention. 各种变量对乳房自我检查的影响：预防乳腺癌的潜在障碍或促进因素。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-249001

Hijrah Hijrah, Andi Nilawati Usman, Yusring Sanusi Baso, Syafruddin Syarif, Mardiana Ahmad, Zafitri Nulandari

{"title":"Influence of variables on breast self-examination: Potential barrier or enhancement of breast cancer prevention.","authors":"Hijrah Hijrah, Andi Nilawati Usman, Yusring Sanusi Baso, Syafruddin Syarif, Mardiana Ahmad, Zafitri Nulandari","doi":"10.3233/BD-249001","DOIUrl":"10.3233/BD-249001","url":null,"abstract":"Introduction: Breast self-examination (BSE) is an important tool for early detection of breast cancer and can contribute to increased awareness and familiarity with breast tissue. This study aimed to review factors that influenced BSE in preventing breast cancer.Methods: In the initial stage of searching for journal articles, 186 journals were obtained, then screening was carried out within a time span of 2019-2024 and using Indonesian and English 54 journals. Of the 12 journals reviewed, the results showed that 4 journals reviewed had conducted pre and post-BSE practices, and 8 journal reviews conducted BSE practices conducted by students and health workers.Results: Several factors play an important role in implementing BSE, namely age, knowledge, history of exposure to information, family history, ethnicity, and attitude. Overall, the study shows that the need to create awareness and educate women, especially rural women, on the importance of BSE as a preventive measure for breast cancer is paramount.Conclusions: Factors influencing the implementation of BSE can be a barrier or an enhancement in breast cancer prevention.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: Anti-IL-8 monoclonal antibodies inhibits the autophagic activity and cancer stem cells maintenance within breast cancer tumor microenvironment. 勘误：抗IL-8单克隆抗体抑制乳腺癌肿瘤微环境中的自噬活性和癌症干细胞的维持。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-241111

Seham Abou Shousha, Eman M Osman, Suzan Baheeg, Yasmine Shahine

引用次数: 0

Contraceptive use with breast cancer incidence in Indonesia. 印度尼西亚的避孕药具使用与乳腺癌发病率。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-249007

Sulfiana Sulfiana, Prihantono Prihantono, Andi Nilawati Usman, Mardiana Ahmad, M Aryadi Arsyad, Andi Agus Mumang

{"title":"Contraceptive use with breast cancer incidence in Indonesia.","authors":"Sulfiana Sulfiana, Prihantono Prihantono, Andi Nilawati Usman, Mardiana Ahmad, M Aryadi Arsyad, Andi Agus Mumang","doi":"10.3233/BD-249007","DOIUrl":"10.3233/BD-249007","url":null,"abstract":"Introduction: Breast cancer is the most common cancer in women worldwide and is a significant threat to public health. This study aims to conduct a systematic review of the relationship between hormonal contraceptive use and breast cancer incidence.Methods: The search was conducted using Google Scholar, Proquest, Pubmed and one Indonesian database, Garuda, using English and Indonesian keywords. The inclusion criteria in this study were the publication year of the last five years, namely 2019-2023, English and Indonesian language, case-control observational research, using the Indonesian population, and full-text access.Results: A total of 165 studies were obtained from the Google Scholar database, including 104 studies. The overall multivariate analysis revealed that there was a statistically significant association of hormonal contraception with the incidence of breast cancer with OR values in the range of 2-6.Conclusions: The findings of this systematic study suggest that the use of hormones can contribute to hormonal imbalances that further increase breast cell proliferation and disrupt gene expression, resulting in uncontrolled cell development/cancer. In addition, the findings recommend increasing the number of studies on this topic to obtain more adequate and possibly more diverse information.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early detection of self-breast examination using smartphone breast application. 使用智能手机乳房应用程序进行自我乳房检查的早期检测。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-249004

Nur Indah, Andi Nilawati Usman, Yusring Sanusi Baso, Syafruddin Syarif, Mardiana Ahmad, Andi Agus Mumang

{"title":"Early detection of self-breast examination using smartphone breast application.","authors":"Nur Indah, Andi Nilawati Usman, Yusring Sanusi Baso, Syafruddin Syarif, Mardiana Ahmad, Andi Agus Mumang","doi":"10.3233/BD-249004","DOIUrl":"10.3233/BD-249004","url":null,"abstract":"Introduction: Breast self-examination (BSE) is a screening method that can help empower, raise awareness, and detect breast abnormalities in women. The use of smartphone applications for breast cancer early detection is able to overcome some of these barriers. This study aimed to conduct a systematic review to assess the effectiveness of the effect of using smartphone application-based technology on breast cancer.Methods: Google Scholar, PubMed, Proquest, and ScienceDirect were searched for \"breast self-examination\" and \"smartphone application\" literature. This literature's study designs were quasi-experimental, prospective cohort, qualitative, and systematic review. The study contained five unique research projects with 828 varied participants.Results: The use of smartphones was seen to have advantages in terms of increased knowledge, perceived vulnerability, barriers to breast self-examination (BSE), self-efficacy, health motivation, and BSE practices.Conclusions: The utilization of smartphone apps related to BSE is shown through the availability, accessibility, and focus of information and is in line with the Health Belief Model (HBM).","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lectins as a promising therapeutic agent for breast cancer: A review. 作为乳腺癌治疗剂前景看好的凝集素：综述。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-230047

Keerti Singh, Lokita Agrawal, Rhea Gupta, Divyam Singh, Meghavi Kathpalia, Navkiran Kaur

{"title":"Lectins as a promising therapeutic agent for breast cancer: A review.","authors":"Keerti Singh, Lokita Agrawal, Rhea Gupta, Divyam Singh, Meghavi Kathpalia, Navkiran Kaur","doi":"10.3233/BD-230047","DOIUrl":"10.3233/BD-230047","url":null,"abstract":"Efficient treatment of cancer has been a subject of research by scientists for many years. Current treatments for cancer, such as radiotherapy, chemotherapy and surgery have been used in traditional combination therapy, but they have major setbacks like non-specificity, non-responsiveness in certain cancer types towards treatment, tumor recurrence, etc. Epidemiological data has shown that breast cancer accounts for 14% of cancer cases occurring in Indian women. In recent years, scientists have started to focus on the use of natural compounds like lectins obtained from various sources to counter the side effects of traditional therapy. Lectins like Sambucus nigra Agglutinin, Maackia amurensis lectin, Okra lectins, Haliclona caerulea lectin, Sclerotium rolfsii lectin, etc., have been discovered to have both diagnostic and therapeutic potential for breast cancer patients. Lectins have been found to have inhibitory effects on various cancer cell activities such as neo-angiogenesis, causing cell cycle arrest at the G1 phase, and inducing apoptosis. The major idea behind the use of lectins in cancer diagnostics and therapeutics is their capability to bind to glycosylated proteins that are expressed on the cell surface. This review focuses on an exploration of the roles of post-translational modification in cancer cells, especially glycosylation, and the potential of lectins in cancer diagnosis and therapeutics.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of neuro-Behcet's disease in a patient with operable HER2-positive breast cancer during neoadjuvant chemotherapy: A case report. 一名可手术的 HER2 阳性乳腺癌患者在新辅助化疗期间出现神经性贝赫切特病：病例报告。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-230026

Taketo Nakai, Hirohito Seki, Akitsugu Makino, Yoshie Kadota, Takuji Kaburagi, Takehiro Okumura, Tsuyoshi Karahashi

{"title":"Development of neuro-Behcet's disease in a patient with operable HER2-positive breast cancer during neoadjuvant chemotherapy: A case report.","authors":"Taketo Nakai, Hirohito Seki, Akitsugu Makino, Yoshie Kadota, Takuji Kaburagi, Takehiro Okumura, Tsuyoshi Karahashi","doi":"10.3233/BD-230026","DOIUrl":"10.3233/BD-230026","url":null,"abstract":"Background: Neuro-Behcet's disease (NBD) is a variant of Behcet's disease (BD). To our knowledge, there have been no previous reports on concurrent NBD in breast cancer patients undergoing chemotherapy.Case presentation: Our patient had a history of BD and was asymptomatic. She was diagnosed with human epidermal growth factor receptor 2-positive breast cancer by core needle biopsy and was administered neoadjuvant chemotherapy. After four courses, in addition to the aggravation of the existing adverse events, headache, fever, dysarthria, and muscle weakness in the upper left and lower extremities appeared. On admission, she was diagnosed with acute NBD, and steroid therapy was initiated. After her symptoms improved gradually, she was discharged. Then, she underwent mastectomy and axillary lymph node dissection for breast cancer. Trastuzumab and pertuzumab plus tamoxifen were administered postoperatively. Two years postoperatively, no recurrence of breast cancer and NBD was noted.Conclusion: When chemotherapy is administered to breast cancer patients with a history of BD, it is necessary to select chemotherapy with as few adverse events as possible and to continue with treatment while paying attention to the risk of NBD.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic signatures in breast cancer in a real-world setting: Experience in a Brazilian Northeastern Center. 现实世界中乳腺癌的基因组特征：巴西东北部中心的经验。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-230044

Sabas Carlos Vieira, Cristiane Amaral Dos Reis, Mariana Elvas Feitosa Holanda, Danilo Rafael da Silva Fontinele, Alessandro Igor Cavalcanti Leal, Fernanda Teresa de Lima

{"title":"Genomic signatures in breast cancer in a real-world setting: Experience in a Brazilian Northeastern Center.","authors":"Sabas Carlos Vieira, Cristiane Amaral Dos Reis, Mariana Elvas Feitosa Holanda, Danilo Rafael da Silva Fontinele, Alessandro Igor Cavalcanti Leal, Fernanda Teresa de Lima","doi":"10.3233/BD-230044","DOIUrl":"10.3233/BD-230044","url":null,"abstract":"Objective: We aim to evaluate the indication and use of genomic signatures in breast cancer patients and outcomes who in patients undergoing adjuvant chemotherapy or not.Methods: This is a retrospective study of breast cancer patients managed in a private oncology clinic in Teresina, from November 2014 to February 2021. All patients with an indication of genomic signature were included. Clinical and pathological variables, use of genomic signatures, treatment and follow-up were obtained. The nomogram to predict Oncotype DX results (University of Tennessee Medical Center) was also calculated. Clinical risk calculation was based on MINDACT, using the modified version of Adjuvant Online. The genetic signatures performed were: the Oncotype, MammaPrint and EndoPredict.Results: Fifty (50) female patients were included in the study. The mean age of the participants was 57.1 years. Among the patients receiving a genomic signature (26-52.0%), there was a change in treatment in 8 (30.7%) cases. Chemotherapy was indicated in four patients, It was contraindicated in another four patients. Treatment changed in 30.7% of the tested patients. Chemotherapy was indicated for those who would not receive it before. It was contraindicated in patients who would previously undergo chemotherapy.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141598439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast gel based on Boswellia serrata, Betaine and myo-Inositol improves cyclic mastodynia in fertile women: A retrospective clinical study. 基于乳香、甜菜碱和肌醇的乳房凝胶可改善育龄妇女的周期性乳房疼痛：回顾性临床研究

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-240012

Moira Burratti, Giuseppina Morano, Chiara Pasquale, Grazia Di Fonso, Loredana Costabile

{"title":"Breast gel based on Boswellia serrata, Betaine and myo-Inositol improves cyclic mastodynia in fertile women: A retrospective clinical study.","authors":"Moira Burratti, Giuseppina Morano, Chiara Pasquale, Grazia Di Fonso, Loredana Costabile","doi":"10.3233/BD-240012","DOIUrl":"10.3233/BD-240012","url":null,"abstract":"Background: The management of mastodynia plays a central role in improving women quality of life. Despite its high occurrence, specific therapeutic guidelines for mastalgia are still lacking. Available therapies include unspecific anti-inflammatories, even though they may often expose to undesirable effects and low compliance.Objective: The aim of this study was to highlight the efficacy of the topical application of combined natural molecules including Boswellia serrata, Betaine and myo-Inositol in improving cyclic mastalgia.Methods: In this retrospective pilot clinical study, patients with cyclic mastalgia applied a specific breast gel for three months. The severity of the pain was measured through the Visual Analogue Score (VAS) in the treated group compared to untreated one. Treated patients also filled in a questionnaire evaluating acceptance and safety of the breast gel.Results: This pilot clinical study demonstrated for the first time the efficacy of the topical application of a breast gel based on Betaine, Boswellia serrata, and myo-Inositol in improving cyclic mastodynia. The completed questionnaires also revealed high levels of acceptance, as both safety and compliance.Conclusions: Besides confirming the positive effects of these natural molecules in the management of conditions affecting breast physiology - so far evaluated as oral supplementation - the obtained results pave the way for further studies supporting the use of such molecules as a tailored medical device in the management of breast pain, thus also opening toward a combined oral and topical approach.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression and promoter methylation of mitogen-activated protein kinase 1 in tumor and marginal cells of breast cancer 乳腺癌肿瘤细胞和边缘细胞中丝裂原活化蛋白激酶 1 的表达和启动子甲基化情况

Breast disease Pub Date : 2023-12-22 DOI: 10.3233/bd-230001

Solmaz Goldoost, H. Zarredar, M. Asadi, Milad Shirvaliloo, M. Raeisi

{"title":"Expression and promoter methylation of mitogen-activated protein kinase 1 in tumor and marginal cells of breast cancer","authors":"Solmaz Goldoost, H. Zarredar, M. Asadi, Milad Shirvaliloo, M. Raeisi","doi":"10.3233/bd-230001","DOIUrl":"https://doi.org/10.3233/bd-230001","url":null,"abstract":"AIM: In the present study, we sought to explore potential differences in the expression and promoter methylation of mitogen-activated protein kinase 1 (MAPK1) between tumor and marginal cells of breast cancer lesions. METHODS: A total of 50 randomly selected patients with breast cancer (BCa) undergoing needle biopsy were enrolled. Clinical specimens containing both tumor and marginal cells were collected and preserved. After DNA extraction using specific primers, MAPK1 mRNA and promoter methylation were measured with spectrophotometry at 260/280 nm absorption wavelengths. To deliver a comparative analysis, data from The Cancer Genome Atlas (TCGA) program regarding breast cancer (BRCA), were downloaded from Xena Functional Genomics Explorer and separately analyzed. The suitability of MAPK1 expression and promoter methylation as biomarkers for BCa was analyzed with receiver operating characteristic (ROC) curves. RESULTS: We found a positive correlation between tumor stage and MAPK1 expression (P-value: 0.029) in BCa. Likewise, MAPK1 expression was significantly associated with lymph node metastasis (P-value: 0.018). There was a significant difference in the expression of MAPK1 mRNA between tumor and marginal cells of BCa and BRCA (P-value < 0.001). However, we did not find any statistically significant difference in MAPK1 promoter methylation between tumor and marginal cells of both BCa and BRCA. With an area under the curve (AUC) of 0.71, the diagnostic accuracy of MAPK1 expression in BCa and BRCA was validated. However, MAPK1 promoter methylation was not found to be a suitable biomarker. CONCLUSION: Our findings suggest that while MAPK1 expression, might be a promising biomarker for evaluating oncogenic activity in patients suspected of BCa. We were not able to detect a prognostic/diagnostic role for MAPK1 promoter methylation.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138944204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0