Breast disease最新文献_第3页

Nipple-sparing mastectomy and immediate breast reconstruction by prepectoral implant for the management of giant phyllodes tumors: A case series. 巨型植物瘤的保乳乳房切除术和胸前假体即刻乳房重建术：病例系列。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-240011

Khaled M Abdelwahab, Sara Elsaeed, Omar Hamdy, Mahmoud M Saleh, Amr Hosam

{"title":"Nipple-sparing mastectomy and immediate breast reconstruction by prepectoral implant for the management of giant phyllodes tumors: A case series.","authors":"Khaled M Abdelwahab, Sara Elsaeed, Omar Hamdy, Mahmoud M Saleh, Amr Hosam","doi":"10.3233/BD-240011","DOIUrl":"10.3233/BD-240011","url":null,"abstract":"Phyllodes tumor is an uncommon breast neoplasm that is present in variable sizes. Giant phyllodes are those larger than 10 cm in diameter. Clinically, giant phyllodes tumors present as a visible, rapidly growing mass distorting the breast contour. Such tumors with large size and rapid growth rate suggest a phyllode diagnosis of fibroadenoma. Planning a standard treatment strategy for these tumors is quite challenging. While adequate surgical excision with tumor-free resection margins is the standard of care for most giant phyllodes cases, borderline and malignant giant phyllodes tumors might require wider resections given their high recurrence rates. Some authors described total mastectomy as the treatment option for giant borderline and malignant phyllodes to obtain wide, clear margins. Between March 2022 and September 2023, our surgical oncology department presented and operated on three cases of giant phyllodes. They underwent a nipple-sparing mastectomy and immediate breast reconstruction using pre-pectoral silicone implants. We think that with such a procedure, we can benefit from the wide, safe margins of mastectomy that have been proven to decrease local recurrence rates while considering the aesthetic outcome.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"43 1","pages":"231-236"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship of changes in molecular subtypes with metastases and progression-free survival in breast cancer. 乳腺癌分子亚型的变化与转移和无进展生存期的关系。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-249000

Fitran Amansyah, Prihantono Prihantono, Firdaus Hamid, Salman Ardi Syamsu, John Pieter, Muhammad Faruk

{"title":"The relationship of changes in molecular subtypes with metastases and progression-free survival in breast cancer.","authors":"Fitran Amansyah, Prihantono Prihantono, Firdaus Hamid, Salman Ardi Syamsu, John Pieter, Muhammad Faruk","doi":"10.3233/BD-249000","DOIUrl":"10.3233/BD-249000","url":null,"abstract":"Background: Molecular subtyping of breast cancer cells is increasingly being developed as an initial step in selecting therapy and predicting the prognosis of breast cancer patients. During breast cancer, the molecular subtype of cancer cells can change. This study aimed to analyze the relationship between changes in the intrinsic subtype of breast cancer with metastasis and progression-free survival in breast cancer patients.Methods: This was a retrospective cohort study of patients diagnosed with breast cancer from 2016 to 2021. The molecular subtypes from the immunohistochemical examination results were recorded twice, and metastasis and progression-free survival (PFS) were recorded. The data were analyzed using the chi-square test and SPSS 26.Results: Of the 44 patients, 19 (43.2%) experienced a change in molecular subtype, and 25 (56.8%) did not. No significant relationship existed between changes in molecular subtype and metastasis (p = 0.405). No significant relationship existed between changes in molecular subtype and PFS (p = 0.900). A significant relationship was found between changes in the molecular subtype and PFS in the patients with changes in the molecular subtype (p = 0.022).Conclusions: Changes in the intrinsic subtype were associated with PFS in breast cancer patients. Patients with an intrinsic subtype that changed to triple-negative showed worse PFS.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"43 1","pages":"71-78"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The quality of life assessment of breast cancer patients. 乳腺癌患者的生活质量评估。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-249008

Uswatun Hasanah, Mardiana Ahmad, Prihantono Prihantono, Andi Nilawati Usman, Aryadi Arsyad, Dinah Inrawati Agustin

{"title":"The quality of life assessment of breast cancer patients.","authors":"Uswatun Hasanah, Mardiana Ahmad, Prihantono Prihantono, Andi Nilawati Usman, Aryadi Arsyad, Dinah Inrawati Agustin","doi":"10.3233/BD-249008","DOIUrl":"10.3233/BD-249008","url":null,"abstract":"Objectives: Research investigating the quality of life (QOL) of breast cancer patients undergoing chemotherapy has yielded useful knowledge regarding the effects of cancer treatment on the quality of life of patients. This study reviews the assessment of the quality of life for those diagnosed with breast cancer.Design: A systematic review was conducted.Data sources: This systematic review utilized online databases, including PubMed, Web of Science, Scopus, and Google Scholar. A search ranging from 2018 to 2024 was carried out.Review method: Medical Subject Headings (MESH) were used for keyword selection along with other target keywords, such as \"Quality of life\", \"Breast cancer\", \"Chemotherapy\", \"Treatment side effects\", \"Patient experience\", \"Psychosocial well-being\", \"Physical functioning\", \"Emotional distress\", and \"Supportive care\". We reviewed and included all English-language publications. A narrative synthesis was conducted to present the results of the studies.Results: A total of 300 studies were obtained from the search using the specified keywords. Each result underwent another filtering round after applying the inclusion and exclusion criteria. This process led to a final selection of 20 papers that met the requirements and were included in the systematic review.Conclusion: The use of instruments to measure the quality of life (QoL) of breast cancer patients is crucial in understanding the impact of breast cancer on patients' lives, from physical and mental health to social aspects.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"43 1","pages":"173-185"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141320561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-silico prediction of anti-breast cancer activity of ginger (Zingiber officinale) using machine learning techniques. 利用机器学习技术对生姜（Zingiber officinale）的抗乳腺癌活性进行室内预测。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-249002

Marisca Evalina Gondokesumo, Muhammad Rezki Rasyak

{"title":"In-silico prediction of anti-breast cancer activity of ginger (Zingiber officinale) using machine learning techniques.","authors":"Marisca Evalina Gondokesumo, Muhammad Rezki Rasyak","doi":"10.3233/BD-249002","DOIUrl":"10.3233/BD-249002","url":null,"abstract":"Introduction: Indonesian civilization extensively uses traditional medicine to cure illnesses and preserve health. The lack of knowledge on the security and efficacy of medicinal plants is still a significant concern. Although the precise chemicals responsible for this impact are unknown, ginger is a common medicinal plant in Southeast Asia that may have anticancer qualities.Method: Using data from Dudedocking, a machine-learning model was created to predict possible breast anticancer chemicals from ginger. The model was used to forecast substances that block KIT and MAPK2 proteins, essential elements in breast cancer.Result: Beta-carotene, 5-Hydroxy-74'-dimethoxyflavone, [12]-Shogaol, Isogingerenone B, curcumin, Trans-[10]-Shogaol, Gingerenone A, Dihydrocurcumin, and demethoxycurcumin were all superior to the reference ligand for MAPK2, according to molecular docking studies. Lycopene, [8]-Shogaol, [6]-Shogaol, and [1]-Paradol exhibited low toxicity and no Lipinski violations, but beta carotene had toxic predictions and Lipinski violations. It was anticipated that all three substances would have anticarcinogenic qualities.Conclusion: Overall, this study shows the value of machine learning in drug development and offers insightful information on possible anticancer chemicals from ginger.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"43 1","pages":"99-110"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: Anti-IL-8 monoclonal antibodies inhibits the autophagic activity and cancer stem cells maintenance within breast cancer tumor microenvironment. 勘误：抗IL-8单克隆抗体抑制乳腺癌肿瘤微环境中的自噬活性和癌症干细胞的维持。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-241111

Seham Abou Shousha, Eman M Osman, Suzan Baheeg, Yasmine Shahine

引用次数: 0

Influence of variables on breast self-examination: Potential barrier or enhancement of breast cancer prevention. 各种变量对乳房自我检查的影响：预防乳腺癌的潜在障碍或促进因素。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-249001

Hijrah Hijrah, Andi Nilawati Usman, Yusring Sanusi Baso, Syafruddin Syarif, Mardiana Ahmad, Zafitri Nulandari

{"title":"Influence of variables on breast self-examination: Potential barrier or enhancement of breast cancer prevention.","authors":"Hijrah Hijrah, Andi Nilawati Usman, Yusring Sanusi Baso, Syafruddin Syarif, Mardiana Ahmad, Zafitri Nulandari","doi":"10.3233/BD-249001","DOIUrl":"10.3233/BD-249001","url":null,"abstract":"Introduction: Breast self-examination (BSE) is an important tool for early detection of breast cancer and can contribute to increased awareness and familiarity with breast tissue. This study aimed to review factors that influenced BSE in preventing breast cancer.Methods: In the initial stage of searching for journal articles, 186 journals were obtained, then screening was carried out within a time span of 2019-2024 and using Indonesian and English 54 journals. Of the 12 journals reviewed, the results showed that 4 journals reviewed had conducted pre and post-BSE practices, and 8 journal reviews conducted BSE practices conducted by students and health workers.Results: Several factors play an important role in implementing BSE, namely age, knowledge, history of exposure to information, family history, ethnicity, and attitude. Overall, the study shows that the need to create awareness and educate women, especially rural women, on the importance of BSE as a preventive measure for breast cancer is paramount.Conclusions: Factors influencing the implementation of BSE can be a barrier or an enhancement in breast cancer prevention.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"43 1","pages":"145-155"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast gel based on Boswellia serrata, Betaine and myo-Inositol improves cyclic mastodynia in fertile women: A retrospective clinical study. 基于乳香、甜菜碱和肌醇的乳房凝胶可改善育龄妇女的周期性乳房疼痛：回顾性临床研究

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-240012

Moira Burratti, Giuseppina Morano, Chiara Pasquale, Grazia Di Fonso, Loredana Costabile

{"title":"Breast gel based on Boswellia serrata, Betaine and myo-Inositol improves cyclic mastodynia in fertile women: A retrospective clinical study.","authors":"Moira Burratti, Giuseppina Morano, Chiara Pasquale, Grazia Di Fonso, Loredana Costabile","doi":"10.3233/BD-240012","DOIUrl":"10.3233/BD-240012","url":null,"abstract":"Background: The management of mastodynia plays a central role in improving women quality of life. Despite its high occurrence, specific therapeutic guidelines for mastalgia are still lacking. Available therapies include unspecific anti-inflammatories, even though they may often expose to undesirable effects and low compliance.Objective: The aim of this study was to highlight the efficacy of the topical application of combined natural molecules including Boswellia serrata, Betaine and myo-Inositol in improving cyclic mastalgia.Methods: In this retrospective pilot clinical study, patients with cyclic mastalgia applied a specific breast gel for three months. The severity of the pain was measured through the Visual Analogue Score (VAS) in the treated group compared to untreated one. Treated patients also filled in a questionnaire evaluating acceptance and safety of the breast gel.Results: This pilot clinical study demonstrated for the first time the efficacy of the topical application of a breast gel based on Betaine, Boswellia serrata, and myo-Inositol in improving cyclic mastodynia. The completed questionnaires also revealed high levels of acceptance, as both safety and compliance.Conclusions: Besides confirming the positive effects of these natural molecules in the management of conditions affecting breast physiology - so far evaluated as oral supplementation - the obtained results pave the way for further studies supporting the use of such molecules as a tailored medical device in the management of breast pain, thus also opening toward a combined oral and topical approach.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"43 1","pages":"243-249"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synchronous primary breast angiosarcoma with invasive ductal carcinoma. 原发性乳腺血管肉瘤与浸润性导管癌同步。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-240003

Wala Ben Kridis, Mayssa Lajnef, Afef Khanfir

引用次数: 0

Contraceptive use with breast cancer incidence in Indonesia. 印度尼西亚的避孕药具使用与乳腺癌发病率。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-249007

Sulfiana Sulfiana, Prihantono Prihantono, Andi Nilawati Usman, Mardiana Ahmad, M Aryadi Arsyad, Andi Agus Mumang

{"title":"Contraceptive use with breast cancer incidence in Indonesia.","authors":"Sulfiana Sulfiana, Prihantono Prihantono, Andi Nilawati Usman, Mardiana Ahmad, M Aryadi Arsyad, Andi Agus Mumang","doi":"10.3233/BD-249007","DOIUrl":"10.3233/BD-249007","url":null,"abstract":"Introduction: Breast cancer is the most common cancer in women worldwide and is a significant threat to public health. This study aims to conduct a systematic review of the relationship between hormonal contraceptive use and breast cancer incidence.Methods: The search was conducted using Google Scholar, Proquest, Pubmed and one Indonesian database, Garuda, using English and Indonesian keywords. The inclusion criteria in this study were the publication year of the last five years, namely 2019-2023, English and Indonesian language, case-control observational research, using the Indonesian population, and full-text access.Results: A total of 165 studies were obtained from the Google Scholar database, including 104 studies. The overall multivariate analysis revealed that there was a statistically significant association of hormonal contraception with the incidence of breast cancer with OR values in the range of 2-6.Conclusions: The findings of this systematic study suggest that the use of hormones can contribute to hormonal imbalances that further increase breast cell proliferation and disrupt gene expression, resulting in uncontrolled cell development/cancer. In addition, the findings recommend increasing the number of studies on this topic to obtain more adequate and possibly more diverse information.","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"43 1","pages":"127-134"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early detection of self-breast examination using smartphone breast application. 使用智能手机乳房应用程序进行自我乳房检查的早期检测。

Breast disease Pub Date : 2024-01-01 DOI: 10.3233/BD-249004

Nur Indah, Andi Nilawati Usman, Yusring Sanusi Baso, Syafruddin Syarif, Mardiana Ahmad, Andi Agus Mumang

{"title":"Early detection of self-breast examination using smartphone breast application.","authors":"Nur Indah, Andi Nilawati Usman, Yusring Sanusi Baso, Syafruddin Syarif, Mardiana Ahmad, Andi Agus Mumang","doi":"10.3233/BD-249004","DOIUrl":"10.3233/BD-249004","url":null,"abstract":"Introduction: Breast self-examination (BSE) is a screening method that can help empower, raise awareness, and detect breast abnormalities in women. The use of smartphone applications for breast cancer early detection is able to overcome some of these barriers. This study aimed to conduct a systematic review to assess the effectiveness of the effect of using smartphone application-based technology on breast cancer.Methods: Google Scholar, PubMed, Proquest, and ScienceDirect were searched for \"breast self-examination\" and \"smartphone application\" literature. This literature's study designs were quasi-experimental, prospective cohort, qualitative, and systematic review. The study contained five unique research projects with 828 varied participants.Results: The use of smartphones was seen to have advantages in terms of increased knowledge, perceived vulnerability, barriers to breast self-examination (BSE), self-efficacy, health motivation, and BSE practices.Conclusions: The utilization of smartphone apps related to BSE is shown through the availability, accessibility, and focus of information and is in line with the Health Belief Model (HBM).","PeriodicalId":9224,"journal":{"name":"Breast disease","volume":"43 1","pages":"135-144"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0