Contraceptive use with breast cancer incidence in Indonesia.

Breast disease Pub Date : 2024-01-01 DOI:10.3233/BD-249007

Sulfiana Sulfiana, Prihantono Prihantono, Andi Nilawati Usman, Mardiana Ahmad, M Aryadi Arsyad, Andi Agus Mumang

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引用次数: 0

Abstract

Introduction: Breast cancer is the most common cancer in women worldwide and is a significant threat to public health. This study aims to conduct a systematic review of the relationship between hormonal contraceptive use and breast cancer incidence.

Methods: The search was conducted using Google Scholar, Proquest, Pubmed and one Indonesian database, Garuda, using English and Indonesian keywords. The inclusion criteria in this study were the publication year of the last five years, namely 2019-2023, English and Indonesian language, case-control observational research, using the Indonesian population, and full-text access.

Results: A total of 165 studies were obtained from the Google Scholar database, including 104 studies. The overall multivariate analysis revealed that there was a statistically significant association of hormonal contraception with the incidence of breast cancer with OR values in the range of 2-6.

Conclusions: The findings of this systematic study suggest that the use of hormones can contribute to hormonal imbalances that further increase breast cell proliferation and disrupt gene expression, resulting in uncontrolled cell development/cancer. In addition, the findings recommend increasing the number of studies on this topic to obtain more adequate and possibly more diverse information.

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印度尼西亚的避孕药具使用与乳腺癌发病率。

导言：乳腺癌是全球妇女最常见的癌症，对公众健康构成重大威胁。本研究旨在对激素避孕药的使用与乳腺癌发病率之间的关系进行系统回顾：方法：使用 Google Scholar、Proquest、Pubmed 和一个印尼数据库 Garuda，使用英语和印尼语关键词进行检索。本研究的纳入标准为：最近五年（即 2019-2023 年）的发表年份、英语和印尼语、病例对照观察研究、使用印尼人口、全文获取：从谷歌学术数据库中共获得165项研究，其中包括104项研究。总体多变量分析显示，激素避孕与乳腺癌的发病率有显著的统计学关联，OR 值在 2-6 之间：这项系统性研究的结果表明，激素的使用会导致荷尔蒙失衡，从而进一步增加乳腺细胞的增殖并扰乱基因表达，导致细胞不受控制地发展/癌变。此外，研究结果还建议增加有关这一主题的研究数量，以获得更充分、可能更多样的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.