Journal of diabetes, metabolic disorders & control最新文献

{"title":"Does percutaneous transluminal coronary angioplasty (PTCA) have comparable long-term outcomes compared to coronary artery bypass grafting (CABG) in diabetic patients?","authors":"Ahmad Farouk Musa, Cheang Jia Min, A. A. Abdul Rahim, J. Dillon, Rusli Bin Nordi","doi":"10.15406/jdmdc.2020.07.00207","DOIUrl":"https://doi.org/10.15406/jdmdc.2020.07.00207","url":null,"abstract":"Abbreviations: SYNTAX, synergy between percutaneous coronary intervention with taxus and cardiac surgery; CAD, coronary artery disease; CABG, coronary artery bypass grafting; PTCA, percutaneous transluminal coronary angioplasty; ACS, acute coronary syndrome; MODY, maturity-onset diabetes of the young; LADA, latent autoimmune diabetes of adulthood; MI, myocardial infarction; LMSD, left main stem disease; MVD, multivessel disease; DES, drug eluting stent; RCS, randomised controlled trials; OS, observational studies; BARI, bypass angioplasty revascularization investigation; MACCE, major adverse cardiac and cerebrovascular events; EES, everolimus-eluting stent; ACR, hybrid coronary revascularization","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90907564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empagliflozin role in the treatment of type 2 diabetes with cardiovascular disease and subclinical cardiovascular disease in outpatient setting: case reports","authors":"R. Jain, Mohammadreza Shoghli, Muhammad Iqbal, Amit P. Chauhan, Rachna Jain","doi":"10.15406/jdmdc.2020.07.00205","DOIUrl":"https://doi.org/10.15406/jdmdc.2020.07.00205","url":null,"abstract":"SGLT2 inhibitors based on recent evidence have shown promising Cardio vascular benefits apart from Glycemic Control in T2DM management. ESC-EASD 2019 clearly suggest that All SGLT2i reduces CV risk (3P MACE), HHF, worsening of Nephropathy .Only Empagliflozin has been recommended for reducing the Risk of CV death in T2DM with ASCVD & the CV death remains independent of baseline HbA1c or control of HbA1c. Empagliflozin CV death is very unique because the consistency of Mortality benefit remains very significant in patients of T2DM with various CVD (like Single Vessel disease CAD, Multiple Vessel Disease CAD, Prior CABG, Prior MI, Prior Stroke, Prior HHF, PAD).","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"7 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82646032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Failure of heparin associated to insulin in treatment of a hypertriglyceridemia-induced acute pancreatitis","authors":"Mounir Khalil, Chouikh Chaki, E. Zakarya, Mattous Mohamed","doi":"10.15406/jdmdc.2020.07.00204","DOIUrl":"https://doi.org/10.15406/jdmdc.2020.07.00204","url":null,"abstract":"was significant for sensibility in the epigastric region without palpable spleen or any mass. Capillary dextrose was 4.47g/l and urines ketones were positives. Intensive management was started immediately. Physiologic saline serum 0.9% was administered by two peripheral venous catheters (16G). A tracheal tube after a crush induction by Etomidat and succinylcholine allowed invasive ventilation under 60% of oxygen to reach 98% of saturation. Sedation was realized with fentanyl only at first. Then, femoral venous catheter allows adrenalin administration at progressively dose to 0.5μg/kg/min for obtaining stabilized hemodynamic status. Her first labs were significant for blood lipase of 609 UI/L. White blood cells count was 17100/mm3 and serum triglyceride level was elevated at 11g/l. Serum anion gap was normal. Chest X-ray was normal. Abdominal CT scan showed a necrosis of the pancreatic parenchyma and peri pancreatic tissues without fluid collection.","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"216 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91396735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel effect of medicinal plants on diabetes mellitus","authors":"M. Win","doi":"10.15406/jdmdc.2020.07.00203","DOIUrl":"https://doi.org/10.15406/jdmdc.2020.07.00203","url":null,"abstract":"glycogenesis but also increase glucose utilization in periphery. 8 It can inhibit α-amylase and α-glucosidase in vitro and reduce blood glucose level in Streptozotocin-induced diabetic rats when they were given orally. These two enzymes may play a role in carbohydrates metabolism and cause postprandial increase glucose level in diabetic patients. 9 One of the medicinal plants which have beneficial effect on DM is resveratrol. It has many different mechanisms like prevention of abnormal glucose uptake and storage, apoptosis and dysfunction pancreatic β cells and improved insulin resistance. 10 Similarly, traditional plants used in Persian medicine","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88160129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes and musculoskeletal disorders-a review","authors":"S. Ghosal, A. Ghosal","doi":"10.15406/JDMDC.2020.07.00202","DOIUrl":"https://doi.org/10.15406/JDMDC.2020.07.00202","url":null,"abstract":"Diabetes mellitus comprises of metabolic diseases that are characterized by elevated levels of blood glucose or hyperglycaemia, which is a result of insulin deficiency, insulin resistance or both. Marked hyperglycaemia causes an increase in morbidity and mortality that are related to macrovascular and microvascular complications. Musculoskeletal disorders seem to occur often in patients who have diabetes. Musculoskeletal pain is a usual occurrence in patients who have diabetes compared to the general population. The aim of this review was to explore and musculoskeletal disorders in diabetes. Diabetes causes significant morbidity and mortality and has been found to have an association with musculoskeletal disorders. A number of studies have found that diabetes has an association with musculoskeletal disorders such as osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia and carpal tunnel syndrome however the reasons underlying them are unclear. This review looks at the effects of diabetes on musculoskeletal disorders and the mechanisms through which diabetes contributes to them, so as to have a better understanding of the impact they may have in patients with diabetes. Further studies are necessary to understand how diabetes correlates with connective tissue metabolism, cytokines obesity, for better patient care,","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85119879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between oxidative stress and diabetes: a mini-review","authors":"Royana Singh, A. Ashish, Arunim Shah, S. Pandey","doi":"10.15406/JDMDC.2020.07.00201","DOIUrl":"https://doi.org/10.15406/JDMDC.2020.07.00201","url":null,"abstract":"The Diabetes Mellitus (DM) is increasing in incidence and prevalence worldwide, taking the shape of the pandemic proportions, which is expected to increase further over a couple of decades. In 2019, an estimated 9.3% of the population (463 million people), globally had DM. Projection of future DM burden may increase to 10.2% (578 million people) by 2030 and 10.9% (700 million people) by next 25 years (2045). The decrease in immunity in diabetic patients has been a significant concern for physicians and patients alike. The role of mitochondria and it is cellular signaling can elaborate on this problem in depth. Mitochondria is a rich source of reactive oxygen species (ROS) and plays a crucial role in cellular metabolism for energy. They are targets of ROS and many different cellular signals like mitochondrial membrane apoptosis due to hyperglycemia and ROS. The interplay between oxidative stress and diabetes further activated, leading to increased permeability of mitochondrial membrane & apoptosis; this leads to a decrease in immunity in diabetic patients leading to increased mortality and morbidity. Hyperglycemia and ROS major pathways of apoptosis through mitochondrial activation in diabetic patients leading to decreased immunity. They can become drug targets for further intervention of this problem in Diabetic patients. Access","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82303025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helicobacter pylori infection among patients with type II diabetes mellitus","authors":"Saad Al-Arnoot, E. Al-Awadhi, S. Bahaj, Basher Al-Oferi, A. Esmail","doi":"10.15406/jdmdc.2020.07.00200","DOIUrl":"https://doi.org/10.15406/jdmdc.2020.07.00200","url":null,"abstract":"T2DM formerly known as non-insulin-dependent diabetes mellitus or adult-onset diabetes is a metabolic disorder that is characterized by high levels of blood glucose resulting from insulin resistance and relative insulin deficiency. It is an emerging pandemic and is rapidly becoming a serious threat to public health.1 H. pylori is a gram-negative, spiral shaped pathogenic bacterium that specifically colonizes on the gastric epithelium, it is one of the most common human bacterial pathogens and infection causes a wide array of gastric disorders, including simple gastritis, peptic ulcers and gastric malignancies. Gastrointestinal inflammation caused by H. pylori can influence the absorption of glucose and lipids, which are also abnormal in DM patients.2,3 It is a common infection in diabetic patients who have inadequate metabolic control, individuals are colonized by H. pylori infection in the gastric antrum, probably because of chemotactic factors such as tumor necrotic factor (TNF), interleukins-IL-1, IL-2, and IL-8, which are present in gastric epithelium.4,5 Beside DM the H. pylori is also a well be established cause of dyspepsia, the incidence of H. pylori is increased in DM may be due to delay gastric emptying and antraldy smotility, which are important causes of dyspepsia in diabetes, the role of H. pylori infection in diabetic dyspepsia is mainly related to blood glucose concentration, reduce of acid secretion and secrete higher of pro-inflammatory cytokines.5,6 Recent evidence has shown that qat chewing does indeed delay gastric emptying of a semisolid meal, probably as a result of the sympathomimetic action of cathinone in qat. Inflammation and activated innate immunity have been implicated in pathogenesis of diabetes through insulin resistance, for example, elevated levels of inflammatory cytokines may lead to phosphorylation of serine residues on the insulin receptor substrate, which prevents its interaction with insulin receptors, inhibiting insulin action or altered glucose metabolism may produce chemical changes in the gastric mucosa that promote H. pylori colonization So, individuals with diabetes are more frequently exposed to pathogens than their healthy counterparts.7–10 This study was conducted to reveal the prevalence of H. pylori among T2DM and non-DM patients with the association between Qat chewing and potential risk factors.","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74417752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurse-Led diabetes clinics in Southeast Asia: scope,feasibility, challenges and facilitators","authors":"Suresh K. Sharma, Kalpana Thakur, R. Kant, S. Kalra","doi":"10.15406/JDMDC.2020.07.00199","DOIUrl":"https://doi.org/10.15406/JDMDC.2020.07.00199","url":null,"abstract":"Burden of diabetes has escalated worldwide and global death rate has doubled in last two decades. About 88 million people are living with diabetes in Southeast Asian countries and it is expected to shoot up rapidly because of changing life style and longevity of life. Unfortunately, diabetes is not well managed in these countries because of several factors but mainly due to poor doctor-to-population ratio. Recently, World Health Organization has also advised accessible, affordable and quality diabetes care in Southeast Asian countries through extended role of nurses in diabetes care. The model of independent nurse-led diabetes clinic and advanced diabetes nurse practitioner for management of diabetes has been successful in the western world. This article highlights the scope, feasibility, challenges, barriers and facilitators in implementation of nurse-led diabetes clinics (NLDC) in Southeast Asian countries.","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80433750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of vitamin D deficiency among health care professionals in a medical college of India","authors":"A. Mitra, S. Ray, Kingshuk Bhattacharjee","doi":"10.15406/JDMDC.2020.07.00198","DOIUrl":"https://doi.org/10.15406/JDMDC.2020.07.00198","url":null,"abstract":"Background: Vitamin D is unique among vitamins as it can be synthesized from the action of ultra violet radiation upon the skin. This study was done to investigate prevalence of Vitamin D deficiency among health care professionals. Method: This was an institution based cross sectional prevalence study conducted over period of one year at Medical College, Kolkata, India. The study was conducted among 50 doctors, 25 nurses and 25 laboratory technicians. After getting demographic data, serum Vitamin D level was measured in each subject and statistical analysis done. Result: Mean age of study subject was 51.69±7.61 years. Result showed that 63% were male and 37% were female. In this study 73% of the subjects were deficient in Vitamin D level. 25% of subjects had insufficient Vitamin D level and only 2% subject has sufficient D level. Conclusion: Vitamin D deficiency is highly prevalent among health care professionals. Lack of sunlight exposure, changes in lifestyle and food habits contribute to low Vitamin D levels in this population.","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87728967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-diabetic, haematinic and anti-cholesterolmic effects of carrot (Daucus carota Linn.) juice metabolites to cure alloxan monohydrate induced type-1 diabetes in albino rats","authors":"K. Shachi, N. Dubey, Sanjeev Kumar, N. K. Prasad, U. Dubey","doi":"10.15406/JDMDC.2020.07.00197","DOIUrl":"https://doi.org/10.15406/JDMDC.2020.07.00197","url":null,"abstract":"Introduction In present study an effort has been made to assess the hypoglycemic Anticholestrolemic and haematinic activity of carrot juice in alloxan monohydrate induced experimental animal model nbsp Materials and methods Rats were acclimatized for days in lab temperature All animals were given standard water and pellet diet Diabetes was induced in rats with the help of alloxan monohydrate mg kg body weight After alloxan monohydrate injection rats were separated and treatment started with carrot juice and insulin nbsp Results and discussion A marked rise in fasting blood glucose as well as serum cholesterol level was observed in diabetic control rats when compared to normal control rats Antihyperglycemic Anti cholesterolmic and haematinic activity observed in carrot juice administered rats on th th st and th days post treatment Anti hyperglycemic and anti cholesterol mic activity was found less effective than that of insulin treatment group nbsp Conclusion It is hope that present investigation will be helpful in establishing a scientific basis for antidiabetic haematinic and Anti cholesterolmic effects in experimental animal model The results are lt statistically significant","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85216465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}