BMJ : British Medical Journal最新文献

{"title":"Health equity in Scotland.","authors":"Michael Marmot, Jessica Allen","doi":"10.1136/bmj-2026-101128","DOIUrl":"https://doi.org/10.1136/bmj-2026-101128","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"395 ","pages":"e101128"},"PeriodicalIF":55.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reporting completeness of clinical trials evaluating large language model interventions in medicine: systematic review.","authors":"David Chen, Ayden Blayne, Tony Ning, Inaam Chattha, Majid Afshar, Jasmine Chiat Ling Ong, Julian C Hong, Nan Liu, Leo Anthony Celi, Karel G M Moons, Gary S Collins, Danielle S Bitterman","doi":"10.1136/bmj-2026-100855","DOIUrl":"https://doi.org/10.1136/bmj-2026-100855","url":null,"abstract":"<p><strong>Objective: </strong>To characterise the reporting completeness of clinical trials involving large language model (LLM) interventions using established reporting guidelines.</p><p><strong>Design: </strong>Systematic review and meta-research analysis.</p><p><strong>Data sources: </strong>Bibliographic databases (Embase, Medline, and CENTRAL) were searched for trial reports and protocols, and trial registries (ClinicalTrials.gov and World Health Organization International Clinical Trials Registry Platform) were searched for trial registrations published from 1 January 2017 to 6 December 2025.</p><p><strong>Eligibility criteria: </strong>Trial reports, trial protocols, and trial registrations describing clinical trials of LLM interventions in medicine. LLM interventions used for a healthcare function in a clinical trial setting included patient education, clinical documentation, communication support, triage, care navigation, management recommendations, or clinical decision support. Eligible studies prospectively assigned human participants to the intervention and evaluated a health related biomedical or behavioural outcome.</p><p><strong>Main outcome measures: </strong>Overall study level and item level reporting completeness assessed using reporting guidelines matched to study design and purpose, including TRIPOD-LLM (Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis-LLM), CONSORT (Consolidated Standards of Reporting Trials) 2025 and CONSORT-AI, SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2025 and SPIRIT-AI, CHART (Chatbot Assessment Reporting Tool), and the WHO Trial Registration Dataset (version 1.3.1). Two reviewers independently screened and extracted trial and intervention characteristics, and three calibrated raters assessed item level reporting completeness.</p><p><strong>Results: </strong>The systematic search yielded 461 records, including 68 trial reports, 15 protocols, and 378 registrations. Trial reports were predominantly small sample, single site randomised studies published between 2024 and 2025, spanning diverse clinical specialties and primarily targeting patient facing education and management recommendations. Mean reporting completeness was modest across eligible trial reports (TRIPOD-LLM 40%, CONSORT 2025 44%, CONSORT-AI 59%, CHART 52%), trial protocols (SPIRIT 2025 51%, SPIRIT-AI 57%), and trial registrations (WHO Trial Registration Dataset 61%). Clinical trial reports of LLM interventions prioritise narrative framing and commentary over the methodological detail needed for replication, risk-of-bias assessment, and governance of model performance over time. Critical methodological elements for reproducibility, including data and intervention provenance, input preprocessing, model versioning and access modality, inference parameters, output postprocessing, as well as protocol, data, and code access, were inconsistently reported. Harms planni","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"395 ","pages":"e100855"},"PeriodicalIF":55.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical punishment of children: the remaining barrier to equal protection in England and Northern Ireland.","authors":"Andrew Rowland","doi":"10.1136/bmj-2026-101058","DOIUrl":"https://doi.org/10.1136/bmj-2026-101058","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"395 ","pages":"e101058"},"PeriodicalIF":55.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"England's \"Babies Bill\" explained: what it promises and what it needs to succeed.","authors":"Gareth Iacobucci","doi":"10.1136/bmj-2026-101126","DOIUrl":"https://doi.org/10.1136/bmj-2026-101126","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"395 ","pages":"e101126"},"PeriodicalIF":55.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RFK Jr opens NIH clinic to investigate vaccine injuries, announces reporting reforms.","authors":"Janice Hopkins Tanne, Mun-Keat Looi","doi":"10.1136/bmj-2026-101129","DOIUrl":"https://doi.org/10.1136/bmj-2026-101129","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"395 ","pages":"e101129"},"PeriodicalIF":55.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measles death toll exceeds 1100 as Bangladesh struggles with outbreak.","authors":"Elisabeth Mahase","doi":"10.1136/bmj-2026-101120","DOIUrl":"https://doi.org/10.1136/bmj-2026-101120","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"395 ","pages":"e101120"},"PeriodicalIF":55.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doctors must be more open about antimicrobial resistant infections in cancer deaths, says Sally Davies.","authors":"Rebecca Coombes","doi":"10.1136/bmj-2026-101125","DOIUrl":"https://doi.org/10.1136/bmj-2026-101125","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"395 ","pages":"e101125"},"PeriodicalIF":55.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reel or perish: the \"social media impact factor\".","authors":"Francesco Ferrara, Danilo Buonsenso","doi":"10.1136/bmj-2026-101053","DOIUrl":"https://doi.org/10.1136/bmj-2026-101053","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"395 ","pages":"e101053"},"PeriodicalIF":55.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Governments selling patient data are \"betraying\" their people, says AI expert.","authors":"Elisabeth Mahase","doi":"10.1136/bmj-2026-101119","DOIUrl":"https://doi.org/10.1136/bmj-2026-101119","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"395 ","pages":"e101119"},"PeriodicalIF":55.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attacks on healthcare: World Medical Association issues new declaration on \"medical neutrality\".","authors":"Rosa Furneaux","doi":"10.1136/bmj-2026-101124","DOIUrl":"https://doi.org/10.1136/bmj-2026-101124","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"395 ","pages":"e101124"},"PeriodicalIF":55.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}