BMJ : British Medical Journal最新文献

{"title":"Measles is resurging in Bangladesh-but this outbreak was entirely preventable.","authors":"Rubhana Raqib, Mahmudur Rahman","doi":"10.1136/bmj.s819","DOIUrl":"https://doi.org/10.1136/bmj.s819","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"393 ","pages":"s819"},"PeriodicalIF":42.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated non-invasive brain stimulation in childhood autism.","authors":"Benjamin Becker","doi":"10.1136/bmj.s783","DOIUrl":"https://doi.org/10.1136/bmj.s783","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"393 ","pages":"s783"},"PeriodicalIF":42.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRISMA-Children and Adolescents (PRISMA-C) 2026 extension statement and explanation: enhancing the reporting and utility of systematic reviews of interventions in paediatrics.","authors":"Ami Baba, Mufiza Farid-Kapadia, Maureen Smith, Lisa Hartling, David Moher, Lotty Hooft, Martin Offringa","doi":"10.1136/bmj-2025-088561","DOIUrl":"https://doi.org/10.1136/bmj-2025-088561","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"393 ","pages":"e088561"},"PeriodicalIF":42.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaesthetist restored to GMC register in 2020 struck off again.","authors":"Clare Dyer","doi":"10.1136/bmj.s832","DOIUrl":"https://doi.org/10.1136/bmj.s832","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"393 ","pages":"s832"},"PeriodicalIF":42.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated continuous theta burst stimulation targeting left primary motor cortex for children with autism spectrum disorder: multicentre randomised sham controlled trial.","authors":"Hangyu Tan, Tai Ren, Aihua Cao, Shuanfeng Fang, Lin Deng, Bo Hu, Mei Wang, Ye Cheng, Xi Zhang, Yawen Li, Yixia Zhang, Lingli Zhang, Luan Chen, Wei Zhou, Qianlong Zhang, Jiong Li, Xin Zhou, Christelle Langley, Qiang Luo, Jun Zhang, Barbara J Sahakian, Ti-Fei Yuan, Fei Li","doi":"10.1136/bmj-2025-086295","DOIUrl":"10.1136/bmj-2025-086295","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the efficacy and safety of a five day accelerated continuous theta burst stimulation (a-cTBS) protocol in improving social communication impairment in children with autism spectrum disorder.</p><p><strong>Design: </strong>Multicentre randomised sham controlled trial.</p><p><strong>Setting: </strong>Three academic hospitals across three provinces in China, conducted from July 2023 to October 2024.</p><p><strong>Participants: </strong>200 children aged 4-10 years with autism spectrum disorder (167 boys and 33 girls) all with a full scale intelligence quotient ≥50.</p><p><strong>Interventions: </strong>Participants were randomised 1:1 to receive active a-cTBS (n=100) or sham (n=100) treatment stratified by full scale intelligence quotient (≥70 or <70) and study site. Participants received 10 sessions each day for five consecutive days, targeting the left primary motor cortex. Participants and evaluators were masked to interventions.</p><p><strong>Main outcome measures: </strong>Two primary outcomes were assessed using the Social Responsiveness Scale, second edition (SRS-2): changes in social communication impairment from baseline to post-intervention and from baseline to one month follow-up. Primary analyses were conducted on a modified intention-to-treat population, including participants who received at least one stimulation session. Secondary outcomes included language improvements assessed from baseline to one month follow-up and changes in SRS-2 subscales.</p><p><strong>Results: </strong>Of the 200 participants, 198 were included in the modified intention-to-treat analysis (99 in each group) and 193 completed the full intervention. Compared with the sham group, the a-cTBS group showed significantly greater reductions in SRS-2 scores post-intervention (-6.25, 95% confidence interval -8.69 to -3.81; Cohen's d -0.92; P<0.001) and at one month follow-up (-6.17, -8.65 to -3.70; -0.90; P<0.001). Secondary outcomes also favoured a-cTBS, with significant improvements observed in language abilities (Cohen's d 0.12-0.47; all P<0.02; measured by Multilingual Assessment Instrument for Narratives). Reported adverse events were all mild to moderate and resolved without intervention.</p><p><strong>Conclusions: </strong>A five day a-cTBS protocol targeting the left primary motor cortex significantly improved social communication in children with autism spectrum disorder and showed a favourable safety profile. These findings support a-cTBS as a viable and scalable therapeutic option for children with autism spectrum disorder.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT05927792.</p>","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"393 ","pages":"e086295"},"PeriodicalIF":42.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV transmission cannot be stopped without equity.","authors":"Erica Pool, Marc Thompson, Jo Gibbs, Maryam Shahmanesh, Binta Sultan","doi":"10.1136/bmj.s775","DOIUrl":"https://doi.org/10.1136/bmj.s775","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"393 ","pages":"s775"},"PeriodicalIF":42.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excess weight drives cancer rise in under 50s but is not full story, say researchers.","authors":"Jacqui Wise","doi":"10.1136/bmj.s817","DOIUrl":"https://doi.org/10.1136/bmj.s817","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"393 ","pages":"s817"},"PeriodicalIF":42.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedatives in pregnancy and psychiatric outcomes in offspring.","authors":"Hyesung Lee, Eun-Young Choi, Björn Pasternak, Carolyn E Cesta","doi":"10.1136/bmj.s705","DOIUrl":"https://doi.org/10.1136/bmj.s705","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"393 ","pages":"s705"},"PeriodicalIF":42.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NHS workers join cast of musical about AMR.","authors":"Alison Shepherd","doi":"10.1136/bmj.s800","DOIUrl":"https://doi.org/10.1136/bmj.s800","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"393 ","pages":"s800"},"PeriodicalIF":42.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why some patients may feel safer with AI than with clinicians.","authors":"Marta Isibor","doi":"10.1136/bmj.s797","DOIUrl":"https://doi.org/10.1136/bmj.s797","url":null,"abstract":"","PeriodicalId":9201,"journal":{"name":"BMJ : British Medical Journal","volume":"393 ","pages":"s797"},"PeriodicalIF":42.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}