Archives of medicine最新文献_第3页

The Value of Different Electrocardiographic Patterns at Hospital Admission in Predicting Clinical Outcome in Pulmonary Embolism 住院时不同心电图对预测肺栓塞临床预后的价值

Archives of medicine Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.31

Darko Angjushev, Marija Kotevska Angjushev, M. Srceva, A. Kartalov

{"title":"The Value of Different Electrocardiographic Patterns at Hospital Admission in Predicting Clinical Outcome in Pulmonary Embolism","authors":"Darko Angjushev, Marija Kotevska Angjushev, M. Srceva, A. Kartalov","doi":"10.36648/1989-5216.21.13.31","DOIUrl":"https://doi.org/10.36648/1989-5216.21.13.31","url":null,"abstract":"Background: Literature reports the presence of several Electrocardiographic (ECG) patterns of Right Ventricular (RV) strain in acute Pulmonary Embolism (PE). These reports are inconsistent considering the prognostic value of these patterns. Aim: to evaluate the significance of ECG RV strain patterns, as well as the total number of these ECG patterns in predicting short-term (in-hospital) clinical outcome. Methods: This retrospective study was consisted of 183 patients (107 male, age: 61±14 years) with acute PE. The 12-lead ECG done at hospital admission was analysed. ECG RV strain was diagnosed in presence of one or more of following 12 patterns: tachycardia, atrial fibrillation, low QRS voltage, S1Q3T3, Q in III, aVF, right axis deviation, right bundle branch block, Qr in V1, negative T wave in inferior, precordial leads, ST elevation in inferior leads, aVR, V1 and ST depression. The outcome was defined as experience of an adverse event (in-hospital complications and death all-cause). The association of ECG patterns with outcome was evaluated by multivariable Cox hazards regression analysis. Results: During a median hospitalization time of 15 days, 41 (22.4%) adverse events occurred. Event rate was higher in patients with ≥5 ECG patterns than in <5 (63.4% vs. 0.7%; p<0.0001). Number of ECG RV strain patterns (Hazard Ratio (HR):1.7 per pattern; 95% Confidence Interval (CI): 1.1-2.6; p=0.009), ST elevation in inferior leads (HR: 8.4; 95% CI: 6.0-68.3; p=0.001) and ST depression (HR: 0.1; 95% CI: 0.03-0.6; p=0.01) were independently associated with adverse outcome. Conclusion: Number of ECG RV strain patterns, ST elevation in inferior leads, ST depression has independent value in predicting in-hospital adverse outcome in acute PE.","PeriodicalId":92003,"journal":{"name":"Archives of medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84774837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brief Note on Pulmonary Hypertension 简述肺动脉高压

Archives of medicine Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.39

Dogan Zeytun

引用次数: 0

The Systematic Review and Implications of Organoid Technology 类器官技术的系统综述及其意义

Archives of medicine Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.29

Giovana Macêdo Egídio Cavalcante, Taysa Leite de Aquino, Jaiany Rodrigues Libório, Dara Fern, A. Duarte, Juliana Oliveira Duarte Rebouças, Eugenia Machado Couto, Pablo de Oliveira Saraiva Bezerra, Gabriela Macedo Egidio Cavalcante, Maria Águeda Brito Leite Duarte, M. L. Neto

{"title":"The Systematic Review and Implications of Organoid Technology","authors":"Giovana Macêdo Egídio Cavalcante, Taysa Leite de Aquino, Jaiany Rodrigues Libório, Dara Fern, A. Duarte, Juliana Oliveira Duarte Rebouças, Eugenia Machado Couto, Pablo de Oliveira Saraiva Bezerra, Gabriela Macedo Egidio Cavalcante, Maria Águeda Brito Leite Duarte, M. L. Neto","doi":"10.36648/1989-5216.21.13.29","DOIUrl":"https://doi.org/10.36648/1989-5216.21.13.29","url":null,"abstract":"Background: The induction of the formation of organoids derived from induced pluripotent stem cells (iPSC) is a new technology that is being well studied and aims to improve the clinical condition of patients with various diseases and even patients undergoing certain types of procedures. Methods: A systematic review, using the PRISMA protocol. The study period was from 2010 to 2020 and the keywords included “Organoids”, “iPSC”, “Ethic” and “Evidence-Based Medicine”, one at a time and then combined with the Boolean operator “AND”. Results: A total of 44 registrations were found. Of this total, 15 articles were excluded because they have not approached organoids and stem cells objectively, often attending to other phenomena or details that are not of interest to the review. Limitations: Discoveries about organoids and new methods to promote their generation and growth are constantly being tested and developed around the world, this implies a constant renewal of sources of information. The article was based on current and highly respected sources in the scientific community. Conclusion: Organoids are unquestionably a technology capable of changing many concepts and guidelines in the medical environment. Faced with this enormous capacity, it is necessary that studies are constantly made and that the use of this new technology is widely discussed, since it addresses not only the scientific sphere, but also the ethical sphere, the social sphere. Improving this already existing technology so that it will increasingly mimic the human body is the challenge that exists and needs to be addressed by many professionals in different areas in harmony.","PeriodicalId":92003,"journal":{"name":"Archives of medicine","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88293139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Burden of Diabetic Kidney Disease in Nigeria - A Systematic Review and Meta-Analysis 尼日利亚糖尿病肾病的负担——系统回顾和荟萃分析

Archives of medicine Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.35

Adegoke Azeez Taoreed

{"title":"The Burden of Diabetic Kidney Disease in Nigeria - A Systematic Review and Meta-Analysis","authors":"Adegoke Azeez Taoreed","doi":"10.36648/1989-5216.21.13.35","DOIUrl":"https://doi.org/10.36648/1989-5216.21.13.35","url":null,"abstract":"Background: Diabetic Kidney Disease (DKD) is a micro vascular complication of diabetes mellitus. Considering that the burden of diabetes mellitus is rising in Nigeria, there is a need to ascertain the burden of one of its most common complications. The objective of the meta-analysis was to determine the pooled prevalence of DKD in Nigeria and identify its risk factors. Methods: The study is a meta-analysis and it followed the PRISMA guidelines. Google scholar, PubMed, AJOL, SCOPUS, medRxiv and the grey literature were systematically searched using appropriate key terms. Statistical analysis was done with MetaXL. The inverse variance heterogeneity model was used for the metaanalysis and heterogeneity was determined using the I2 statistic and the Cochran’s Q test. Publication bias was checked with the Doi plot and LFK index. Results: Nineteen studies met the eligibility criteria. The total sample size was 56 571. The pooled prevalence of diabetic kidney disease in Nigeria was 28% (95% CI 3-58). The Cochran’s Q was 747 (p<0.001) while the I2 statistic was 97.6%. The Doi plot was drawn and the LFK index was 6.22. The most common risk factors for DKD were suboptimal glycaemic control, hypertension and obesity, duration of diabetes, male gender and advancing age. Conclusion: The prevalence of DKD in Nigeria is high and greater attention should be focused on managing the risk factors so as to alleviate the burden of the disease.","PeriodicalId":92003,"journal":{"name":"Archives of medicine","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87844335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibody Response in COVID-19 among Healthcare Workers 医护人员COVID-19抗体反应

Archives of medicine Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.10

M. Younas, K. Afzal, H. Iqbal, Asma Khan, Kainat Younas, Asma N. Cheema, Muskan Younas

{"title":"Antibody Response in COVID-19 among Healthcare Workers","authors":"M. Younas, K. Afzal, H. Iqbal, Asma Khan, Kainat Younas, Asma N. Cheema, Muskan Younas","doi":"10.36648/1989-5216.21.13.10","DOIUrl":"https://doi.org/10.36648/1989-5216.21.13.10","url":null,"abstract":"Objectives: To determine association between Polymerase Chain Reaction (PCR) and antibody positivity by assessing the antibody response in PCR positive Versus PCR negative COVID-19 exposed symptomatic/ asymptomatic healthcare workers. Methods: A Total of 102 healthcare workers (HCW) were included in this crosssectional study after written informed consent including doctors, nurses, laboratory and janitorial staff who were working in isolation ward admitted with symptomatic COVID-19 patients and their samples. Specimen swabs from posterior oropharyngeal wall and nasopharynx were taken and kept in viral transport medium to perform Polymerase Chain Reaction (PCR) testing of SARS-CoV-2 either at onset of symptoms or at 6 weeks (42 days) after first day of duty with COVID-19 patient and blood samples were drawn to measure the serum antibody response after recovery or at completion of 6 weeks (42 days) of their first duty in COVID-19 wards. Serum C- reactive protein (CRP) in mg/L was measured by immuno-turbidimetry in both groups at the time of PCR. Results: Mean age of our study participants was 31 ± 8.9 years. Of 102 HCW, 60(58.8%) were males and 42(41.2%) were males; 42 (36.23%) were PCR positive and 60(63.76%) were PCR negative, 57(50.72%) had reactive antibodies and 45(49.28%) had non-reactive antibodies. Of 35 PCR positive subjects, 11 remained asymptomatic. There were 76% subjects who had positive PCR & reactive antibodies, 63.6% subjects with negative PCR and Non-reactive antibodies. Interestingly, (22)36.4% subjects had negative PCR but reactive antibodies. Likewise, 16.7% subjects had positive PCR but non-reactive antibodies. However, statistically moderate significant association (x2(1) =10.02; P=0.00) was found between PCR positivity and antibody positivity. Serum CRP in PCR positive and negative HCWs was 1.5 mg/L and 1 mg/L correspondingly. Conclusion: Antibody response may be used as a screening tool for COVID-19 infection particularly in asymptomatic exposed subjects.","PeriodicalId":92003,"journal":{"name":"Archives of medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89182386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological Treatments for Coronavirus Disease (COVID-19) 冠状病毒病(COVID-19)的药物治疗

Archives of medicine Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.20

Dogan Zeytun

引用次数: 1

Gastric Outlet Obstruction Due to Primary Duodenal Tuberculosis - A Case Report on Rare Presentation of an Uncommon Condition 原发性十二指肠结核致胃出口梗阻1例

Archives of medicine Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.24

P. AjayKumar, Ey

引用次数: 0

The Urology Checklist towards a Structured Consultant-Led Ward Round 面向结构化会诊医生主导的病房查房的泌尿外科检查表

Archives of medicine Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.13.1.5

Jennie Han, J. Gibbard, C. Cutting, Elsawi Osman

{"title":"The Urology Checklist towards a Structured Consultant-Led Ward Round","authors":"Jennie Han, J. Gibbard, C. Cutting, Elsawi Osman","doi":"10.36648/1989-5216.13.1.5","DOIUrl":"https://doi.org/10.36648/1989-5216.13.1.5","url":null,"abstract":"Objective: Formulating a comprehensive, practical, and urology-focused ward round checklist to enhance safety, efficiency and clear documentation for the Urology ward team when reviewing in-patients. Design: Identification of important parameters which should be addressed in every patient interaction. FIASCO – VH was coined for ease: • Fluid balance • Investigations • Intravenous access • Antibiotics • Analgesia • Stool • Catheter status • Observations • Venous thromboembolism (VTE) risk assessment • Home and follow up. Baseline measurement followed by implementation of the checklist and completion of three plan-do-study-act (PDSA) cycles. Setting: Single-centre district general hospital within the United Kingdom Participants: 279 ward round interactions with Urology inpatients Intervention: Implementation of the ward round checklist Main outcome measures: Adherence to parameters identified in the urology checklist Results: Stool (23.5%) and pain (30.6%) were worst assessed at baseline, with median 39.3% parameters assessed over all interactions. Significant improvement in assessed parameters after first (median 74.3%), second (median 84.0%), and third cycles (median 100%). These were associated with positive patient outcomes. There was discrepancy between factors verbally addressed and clinically documented (median 84.0% to 57.7% after second cycle). A dedicated third cycle reduced this gap (median 100% to 97%). 100% junior doctors surveyed believed the checklist has enabled addressing of factors which might have otherwise been missed. Conclusion: The use of a comprehensive, urology-focused, easy-to-memorise ward round checklist is feasible and led to sustained, well-documented improvements in all measured aspects of patients’ care, and perceived level of care by the team.","PeriodicalId":92003,"journal":{"name":"Archives of medicine","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81363292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microcephaly in the Maternal-Child Life Cycle 母婴生命周期中的小头畸形

Archives of medicine Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.42

Sarah Ellen Ribeiro Grangeiro, Lucas de Alencar Viana Melo, Wantuil Matias Neto, Luis Luciano Neto, A. Moreira, M. L. Neto

{"title":"Microcephaly in the Maternal-Child Life Cycle","authors":"Sarah Ellen Ribeiro Grangeiro, Lucas de Alencar Viana Melo, Wantuil Matias Neto, Luis Luciano Neto, A. Moreira, M. L. Neto","doi":"10.36648/1989-5216.21.13.42","DOIUrl":"https://doi.org/10.36648/1989-5216.21.13.42","url":null,"abstract":"Microcephaly is characterized by a complex etiology, in addition to being associated with congenital Zika virus infection, being caused by environmental, genetic factors, metabolism diseases, as well as by the use of drugs and maternal diseases during the gestational period. This study aimed to know the microcephaly in the maternal-child life cycle in the Cariri region and its repercussion on maternal mental health. This is a cross-sectional, descriptive research with a quantitative-qualitative approach, delineated through a descriptive study in the formal statistical analysis for quantitative results. Schutze’s narrative was used for qualitative analysis. The study was carried out in inland Ceara in a reference unit for children with microcephaly. Thirteen mothers were interviewed, who have children with microcephaly due to ZIKAV, who had contact with the virus during the fertile period during pregnancy. The profile of the study subject showed that maternal education corresponds to secondary education, 23.1%, with Pardo selfreported colour 92.3%, married marital status 61.5%, with 46.2% as housekeeper occupation, and the mean age of 29.38% (range: 15 to 41 years). The results showed that there is a difference between living conditions of families, knowledge about Zika virus and mothers’ feelings about this pathology. Therefore, public policies and health education should be implemented in relation to ZIKAV, in an attempt to reduce cases of microcephaly in the NE of Brazil.","PeriodicalId":92003,"journal":{"name":"Archives of medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87612921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Developing Diabetes Mellitus Type 2: San Matías, Francsico Morazan, Honduras 患2型糖尿病的风险:San Matías，弗朗西斯科·莫拉赞，洪都拉斯

Archives of medicine Pub Date : 2021-01-01 DOI: 10.36648/1989-5216.21.13.43

Jhiamluka Solano, Alcides Alvarez, Ada Valenzuela, Italia Laitano

{"title":"Risk of Developing Diabetes Mellitus Type 2: San Matías, Francsico Morazan, Honduras","authors":"Jhiamluka Solano, Alcides Alvarez, Ada Valenzuela, Italia Laitano","doi":"10.36648/1989-5216.21.13.43","DOIUrl":"https://doi.org/10.36648/1989-5216.21.13.43","url":null,"abstract":"Background: Diabetes mellitus represents a public health problem worldwide; in 2014, 422 million people were reported with this disease. Objective: Assess the risk to develop type 2 diabetes mellitus through the Finnish Diabetes Risk Score (FINDRISK) in people from ages from 20 to 35 years old. Methods: We conducted a quantitative, descriptive, and transversal study with a sample of 59 patients, randomly selected with a non-probabilistic sampling by convenience. We provided a consent form, followed by the FINDRISK, assessing age, body max index, abdominal perimeter, daily exercise, fruit and vegetable ingestion, hypertension treatment, the background of hyperglycaemia and family history of T2DM. We categorized them as low risk, slightly elevated risk, moderate risk, high risk and extremely high risk according to the test score. Results: The prevalent risk factors were sedentarism 64% (38), unhealthy diet 51% (30) and obesity according to their BMI of 20% (12). 40% (24) of the patients were classified as low risk, 46% (27) slightly elevated risk, 12% (7) moderate risk, 2% (1) high risk and 0% (0) extremely high risk. Conclusion: The use of the FINDRISK test in Primary Health Care is a useful tool for the early detection of patients with high risk to develop diabetes mellitus type 2 and intervene promoting healthy lifestyles.","PeriodicalId":92003,"journal":{"name":"Archives of medicine","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84054570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0