Brain, Behavior, and Immunity最新文献

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Depletion of the paternal gut microbiome alters sperm small RNAs and impacts offspring physiology and behavior in mice 消耗父代肠道微生物群会改变精子的小核糖核酸,并影响小鼠后代的生理和行为。
IF 8.8 2区 医学
Brain, Behavior, and Immunity Pub Date : 2024-09-16 DOI: 10.1016/j.bbi.2024.09.020
Bethany A. Masson , Pamudika Kiridena , Da Lu , Elizabeth A. Kleeman , Sonali N. Reisinger , Wendy Qin , William J. Davies , Rikeish R. Muralitharan , Hamdi A. Jama , Simona Antonacci , Francine Z. Marques , Carolina Gubert , Anthony J. Hannan
{"title":"Depletion of the paternal gut microbiome alters sperm small RNAs and impacts offspring physiology and behavior in mice","authors":"Bethany A. Masson ,&nbsp;Pamudika Kiridena ,&nbsp;Da Lu ,&nbsp;Elizabeth A. Kleeman ,&nbsp;Sonali N. Reisinger ,&nbsp;Wendy Qin ,&nbsp;William J. Davies ,&nbsp;Rikeish R. Muralitharan ,&nbsp;Hamdi A. Jama ,&nbsp;Simona Antonacci ,&nbsp;Francine Z. Marques ,&nbsp;Carolina Gubert ,&nbsp;Anthony J. Hannan","doi":"10.1016/j.bbi.2024.09.020","DOIUrl":"10.1016/j.bbi.2024.09.020","url":null,"abstract":"<div><div>The paternal environment prior to conception has been demonstrated to influence offspring physiology and behavior, with the sperm epigenome (including noncoding RNAs) proposed as a potential facilitator of non-genetic inheritance. Whilst the maternal gut microbiome has been established as an important influence on offspring development, the impact of the paternal gut microbiome on offspring development, health and behavior is largely unknown. Gut microbiota have major influences on immunity, and thus we hypothesized that they may be relevant to paternal immune activation (PIA) modulating epigenetic inheritance in mice. Therefore, male C57BL/6J mice (F0) were orally administered non-absorbable antibiotics via drinking water in order to substantially deplete their gut microbiome. Four weeks after administration of the antibiotics (gut microbiome depletion), F0 male mice were then mated with naïve female mice. The F1 offspring of the microbiome-depleted males had reduced body weight as well as altered gut morphology (shortened colon length). F1 females showed significant alterations in affective behaviors, including measures of anxiety and depressive-like behaviors, indicating altered development. Analysis of small noncoding RNAs in the sperm of F0 mice revealed that gut microbiome depletion is associated with differential expression of 8 different PIWI-interacting RNAs (piRNAs), each of which has the potential to modulate the expression of multiple downstream gene targets, and thus influence epigenetic inheritance and offspring development. This study demonstrates that the gut-germline axis influences sperm small RNA profiles and offspring physiology, with specific impacts on offspring affective and/or coping behaviors. These findings may have broader implications for other animal species with comparable gut microbiota, intergenerational epigenetics and developmental biology, including humans.</div></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":null,"pages":null},"PeriodicalIF":8.8,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential effects of social versus monetary incentives on inhibitory control under acute inflammation. 在急性炎症情况下,社会激励与金钱激励对抑制控制的不同影响。
IF 15.1 2区 医学
Brain, Behavior, and Immunity Pub Date : 2024-09-16 DOI: 10.1016/j.bbi.2024.09.010
Gabriella M Alvarez,Tatum A Jolink,Taylor N West,Megan N Cardenas,Mallory J Feldman,Jessica R Cohen,Keely A Muscatell
{"title":"Differential effects of social versus monetary incentives on inhibitory control under acute inflammation.","authors":"Gabriella M Alvarez,Tatum A Jolink,Taylor N West,Megan N Cardenas,Mallory J Feldman,Jessica R Cohen,Keely A Muscatell","doi":"10.1016/j.bbi.2024.09.010","DOIUrl":"https://doi.org/10.1016/j.bbi.2024.09.010","url":null,"abstract":"While the impact of chronic, low-grade inflammation on cognitive functioning is documented in the context of neurodegenerative disease, less is known about the association between acute increases in inflammation and cognitive functioning in daily life. This study investigated how changes in interleukin-6 (IL-6) levels were associated with performance on an inhibitory control task, the go/no-go task. We further examined whether the opportunity to earn different incentive types (social or monetary) and magnitudes (high or low) was associated with differential performance on the task, depending on IL-6 levels. Using a within-participant design, individuals completed an incentivized go/no-go task before and after receiving the annual influenza vaccine. Multilevel logistic regressions were performed on the trial-level data (Nobs = 30,528). For no-go trials, we did not find significant associations between IL and 6 reactivity between the sessions and changes in trial accuracy. For go trials, we found significant differences in the associations between IL and 6 reactivity and changes in accuracy from session 1 to session 2 as a function of the incentive condition. Notably, greater IL-6 reactivity was consistently associated with fewer omission errors (i.e., greater accuracy on go trials) on high-magnitude social incentives (i.e., viewing a picture of a close-other picture) when compared to both low-magnitude social and high-magnitude monetary incentives. Together, these results suggest that mild fluctuations in inflammation might alter the valuation of an incentive, and possibly a shift toward devoting greater attentional resources when a large social incentive is on the line. Overall, this study sheds light on how everyday, low-grade fluctuations in inflammation may influence cognitive abilities essential for daily life and effective inhibitory control.","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":null,"pages":null},"PeriodicalIF":15.1,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skull bone marrow-derived immune cells infiltrate the injured cerebral cortex and exhibit anti-inflammatory properties 颅骨骨髓免疫细胞渗入受伤的大脑皮层并表现出抗炎特性
IF 8.8 2区 医学
Brain, Behavior, and Immunity Pub Date : 2024-09-16 DOI: 10.1016/j.bbi.2024.09.023
Eman Soliman , Erwin Kristobal Gudenschwager Basso , Jing Ju , Andrew Willison , Michelle H. Theus
{"title":"Skull bone marrow-derived immune cells infiltrate the injured cerebral cortex and exhibit anti-inflammatory properties","authors":"Eman Soliman ,&nbsp;Erwin Kristobal Gudenschwager Basso ,&nbsp;Jing Ju ,&nbsp;Andrew Willison ,&nbsp;Michelle H. Theus","doi":"10.1016/j.bbi.2024.09.023","DOIUrl":"10.1016/j.bbi.2024.09.023","url":null,"abstract":"<div><p>Identifying the origins and contributions of peripheral-derived immune cell populations following brain injury is crucial for understanding their roles in neuroinflammation and tissue repair. This study investigated the infiltration and phenotypic characteristics of skull bone marrow-derived immune cells in the murine brain after traumatic brain injury (TBI). We performed calvarium transplantation from GFP donor mice and subjected the recipients to controlled cortical impact (CCI) injury 14 days post-transplant. Confocal imaging at 3 days post-CCI revealed GFP+ calvarium-derived cells were present in the ipsilateral injured cortex, expressing CD45 and CD11b immune markers. These cells included Ly6G-positive neutrophil or Ccr2-positive monocyte identities. Calvarium-derived GFP+/Iba1+ monocyte/macrophages expressed the efferocytosis receptor MERTK and displayed engulfment of NeuN+ and cleaved caspase 3+ apoptotic cells. Phenotypic analysis showed that greater calvarium-derived monocytes/macrophages disproportionately express the anti-inflammatory arginase-1 marker than pro-inflammatory CD86. To differentiate the responses of blood- and calvarium-derived macrophages, we transplanted GFP calvarium skull bone into tdTomato bone marrow chimeric mice, then performed CCI injury 14 days post-transplant. Calvarium-derived GFP+cells predominantly infiltrated the lesion boundary, while blood-derived tdTomato+ cells dispersed throughout the lesion and <em>peri</em>-lesion. Compared to calvarium-derived cells, more blood-derived cells expressed pro-inflammatory CD86 and displayed altered 3D morphologic traits. These findings uniquely demonstrate that skull bone marrow-derived immune cells infiltrate the brain after injury and contribute to the neuroinflammatory milieu, representing a novel immune cell source that may be further investigated for their causal role in functional outcomes.</p></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":null,"pages":null},"PeriodicalIF":8.8,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocyte-neuron communication through the complement C3-C3aR pathway in Parkinson’s disease 帕金森病中通过补体 C3-C3aR 通路进行的星形胶质细胞-神经元交流。
IF 8.8 2区 医学
Brain, Behavior, and Immunity Pub Date : 2024-09-15 DOI: 10.1016/j.bbi.2024.09.022
Xiaosa Chi , Sijia Yin , Yadi Sun, Liang Kou, Wenkai Zou, Yiming Wang, Zongjie Jin, Tao Wang, Yun Xia
{"title":"Astrocyte-neuron communication through the complement C3-C3aR pathway in Parkinson’s disease","authors":"Xiaosa Chi ,&nbsp;Sijia Yin ,&nbsp;Yadi Sun,&nbsp;Liang Kou,&nbsp;Wenkai Zou,&nbsp;Yiming Wang,&nbsp;Zongjie Jin,&nbsp;Tao Wang,&nbsp;Yun Xia","doi":"10.1016/j.bbi.2024.09.022","DOIUrl":"10.1016/j.bbi.2024.09.022","url":null,"abstract":"<div><p>Neuroinflammation and autoimmunity are pivotal in the pathogenesis of neurodegenerative diseases. Complement activation and involvement of astrocyte-neuron C3/C3aR pathway have been observed, yet the mechanisms influencing α-synuclein (α-syn) pathology and neurodegeneration remain unclear. In this study, elevated levels of complement C3 were detected in the plasma of α-syn PFF-induced mice and the substantia nigra of A53T transgenic mice. Colocalization of complement C3 with astrocytes was also observed. Overexpression of complement C3 exacerbated motor dysfunction, dopaminergic neuron loss, and phosphorylated α-syn expression in mice injected with α-syn preformed fibrils (α-syn PFFs). Conversely, downregulation of complement C3 protected α-syn PFF-induced mice. Molecular investigations revealed that inhibition of Toll-like receptor 2 (TLR2) or NF-κB reduced complement C3 expression in primary astrocytes following α-syn PFF treatment. Astrocyte-neuron communication via the C3/C3aR pathway influenced α-syn PFF-induced neuronal apoptosis and α-syn pathology, potentially through modulation of GSK3β. These findings underscore the critical role of astrocyte-neuron communication via the C3/C3aR pathway in PD pathogenesis, highlighting its potential as a therapeutic target.</p></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":null,"pages":null},"PeriodicalIF":8.8,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0889159124006251/pdfft?md5=ba7f790fb8c7650251187fba02347b9c&pid=1-s2.0-S0889159124006251-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biobehavioral mechanisms underlying symptoms in cancer patients with chronic graft-versus-host disease 慢性移植物抗宿主疾病癌症患者症状的生物行为机制
IF 8.8 2区 医学
Brain, Behavior, and Immunity Pub Date : 2024-09-15 DOI: 10.1016/j.bbi.2024.09.017
Jenna L. Hansen , Meredith E. Rumble , Christopher L. Coe , Mark B. Juckett , Mikayla A. Foster , Daniel Dickson , Keayra E. Morris , Peiman Hematti , Erin S. Costanzo
{"title":"Biobehavioral mechanisms underlying symptoms in cancer patients with chronic graft-versus-host disease","authors":"Jenna L. Hansen ,&nbsp;Meredith E. Rumble ,&nbsp;Christopher L. Coe ,&nbsp;Mark B. Juckett ,&nbsp;Mikayla A. Foster ,&nbsp;Daniel Dickson ,&nbsp;Keayra E. Morris ,&nbsp;Peiman Hematti ,&nbsp;Erin S. Costanzo","doi":"10.1016/j.bbi.2024.09.017","DOIUrl":"10.1016/j.bbi.2024.09.017","url":null,"abstract":"<div><p>Chronic graft-versus-host disease (cGVHD) is a complication of allogeneic hematopoietic cell transplant (HCT) and is associated with morbidity and high symptom burden. This study evaluated two biobehavioral mechanisms, inflammation and circadian rest-activity rhythms, that may underly commonly reported psychological and physical symptoms in cGVHD patients. Adults with cGVHD (<em>N</em>=57) wore a wrist actigraph for 7 days, provided a blood sample, and completed patient-reported outcome (PRO) measures. 24-hour rest-activity indices were derived from actigraphy. Cytokines and chemokines relevant to cGVHD were measured in peripheral blood plasma using multi-analyte immunoassays. Multiple regression evaluated the extent to which rest-activity indices and inflammatory biomarkers predicted PROs. Higher levels of circulating IL-8 and MIP-1α were associated with worse depression (<em>β</em> = 0.35, <em>p</em> = 0.01; <em>β</em> = 0.33, <em>p</em> = 0.02) and sexual function (<em>β</em> = -0.41, <em>p</em> = 0.01; <em>β</em> = -0.32, <em>p</em> = 0.03). MIP-1α was associated with more severe insomnia (<em>β</em> = 0.36, <em>p</em> = 0.01). Higher circulating MIF was associated with more severe anxiety (<em>β</em> = 0.28, <em>p</em> = 0.048) and fatigue (<em>β</em> = 0.35, <em>p</em> = 0.02). Il-6, TNFα, and MCP-1 showed few associations with PROs. There were few associations between actigraphy indices and PROs; however, participants with a later daily activity peak (acrophase) reported poorer sexual function (<em>β</em> = -0.31, <em>p</em> = 0.04). Models covarying for age, cGVHD severity, and time since HCT yielded a similar pattern of results. Results suggest that pro-inflammatory cytokines and chemokines associated with cGVHD may contribute to PROs, identifying a biobehavioral mechanism that may be a useful target for future interventions.</p></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":null,"pages":null},"PeriodicalIF":8.8,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depression-like behavior is associated with deficits in cognition and hippocampal neurogenesis in a subset of spinally contused male, but not female, rats 在一部分脊髓挫伤的雄性大鼠(而非雌性大鼠)中,抑郁样行为与认知缺陷和海马神经发生有关。
IF 8.8 2区 医学
Brain, Behavior, and Immunity Pub Date : 2024-09-15 DOI: 10.1016/j.bbi.2024.09.015
Alex Stefanov , Kiralyn Brakel , Josephina Rau , Rose M. Joseph , Corey Guice , Kendall Araguz , Annebel Hemphill , Jessica Madry , Andrew Irion , Swapnil Dash , Karienn A. Souza , Michelle A. Hook
{"title":"Depression-like behavior is associated with deficits in cognition and hippocampal neurogenesis in a subset of spinally contused male, but not female, rats","authors":"Alex Stefanov ,&nbsp;Kiralyn Brakel ,&nbsp;Josephina Rau ,&nbsp;Rose M. Joseph ,&nbsp;Corey Guice ,&nbsp;Kendall Araguz ,&nbsp;Annebel Hemphill ,&nbsp;Jessica Madry ,&nbsp;Andrew Irion ,&nbsp;Swapnil Dash ,&nbsp;Karienn A. Souza ,&nbsp;Michelle A. Hook","doi":"10.1016/j.bbi.2024.09.015","DOIUrl":"10.1016/j.bbi.2024.09.015","url":null,"abstract":"<div><div>Depression and cognitive deficits present at higher rates among people with spinal cord injury (SCI) compared to the general population, yet these SCI comorbidities are poorly addressed. Sex and age appear to play roles in depression incidence, but consensus on the direction of their effects is limited. Systemic and cortical inflammation and disruptions in hippocampal neurogenesis have been identified as potential treatment targets, but a comprehensive understanding of these mechanisms remains elusive.</div><div>We used a rodent SCI model to interrogate these gaps in knowledge. We examined post-injury depression-like behavior and cognitive deficits, as well as the association between affect, cognition, chronic hippocampal inflammation and hippocampal neurogenesis, in young and middle-aged male and female Sprague-Dawley rats. Depression-like behavior manifested in male and female subsets of SCI rats irrespective of age, at rates commensurate with the incidence of clinical depression. Changes in components of behavior were driven by sex and age, and affective outcomes were independent of common post-injury pathophysiological outcomes including locomotor functional deficits and spinal lesion severity. Interestingly, however, only male depression-like SCI rats exhibited deficits in hippocampal-associated spatial cognition. Neurogenesis was also disrupted in only SCI males in regions of the hippocampus responsible for affective outcomes. Decreased neurogenesis among middle-aged male subjects coincided with increases in numbers of the pro-inflammatory markers CD86 and iNOS, while middle-aged females had increased numbers of cells expressing Iba-1 and anti-inflammatory marker CD206.</div><div>Overall, the present data suggest that post-SCI depression and cognition may be affected, in part, by sex- and age-dependent changes in hippocampal neurogenesis and inflammation. Hippocampal neurogenesis is a potential target to address psychological wellbeing after SCI, but therapeutic strategies must carefully consider sex and age as biological variables.</div></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":null,"pages":null},"PeriodicalIF":8.8,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microglial and neuronal fates following inhibition of CSF-1R in synucleinopathy mouse model 在突触核蛋白病小鼠模型中抑制 CSF-1R 后的小胶质细胞和神经元命运
IF 8.8 2区 医学
Brain, Behavior, and Immunity Pub Date : 2024-09-14 DOI: 10.1016/j.bbi.2024.09.016
Michiyo Iba , Yeon-Joo Lee , Liam Horan-Portelance , Katherine Chang , Marcell Szabo , Robert A. Rissman , Sungyong You , Eliezer Masliah , Changyoun Kim
{"title":"Microglial and neuronal fates following inhibition of CSF-1R in synucleinopathy mouse model","authors":"Michiyo Iba ,&nbsp;Yeon-Joo Lee ,&nbsp;Liam Horan-Portelance ,&nbsp;Katherine Chang ,&nbsp;Marcell Szabo ,&nbsp;Robert A. Rissman ,&nbsp;Sungyong You ,&nbsp;Eliezer Masliah ,&nbsp;Changyoun Kim","doi":"10.1016/j.bbi.2024.09.016","DOIUrl":"10.1016/j.bbi.2024.09.016","url":null,"abstract":"<div><p>Synucleinopathies are age-related neurological disorders characterized by the abnormal accumulation of α-synuclein (α-syn) in neuronal and non-neuronal cells. It has been proposed that microglial cells play an important role in synucleinopathy neuroinflammation, as well as homeostatically, such as in the clearance of α-syn aggregates in the brain. Here, we examined the effects of microglia on the pathogenesis of synucleinopathies by cell depletion in a mouse model of synucleinopathies. For this purpose, we treated non-transgenic (Non-tg) and α-synuclein transgenic (α-<em>syn</em>-tg) mice with pexidartinib (PLX3397), a tyrosine kinase inhibitor of colony-stimulating factor 1 receptor (CSF-1R). Neuropathological and immunoblot analysis confirmed that Iba-1 immunoreactive microglial cells were decreased by 95% following PLX3397 treatment in Non-tg and α-<em>syn</em>-tg mice. The level of total α-syn in the Triton X-insoluble fraction of brain homogenate was significantly decreased by microglial depletion in the α-<em>syn</em>-tg mice, while the level of Triton X-soluble human α-syn was not affected. Furthermore, the number of p-α-syn immunoreactive inclusions was reduced in α-<em>syn</em>-tg mice treated with PLX3397. Microglial depletion also ameliorated neuronal and synaptic degeneration in α-<em>syn</em>-tg mice, thereby resulted partially improving the motor behavioral deficit in α-<em>syn</em>-tg mice. Moreover, we demonstrated that microglia that survived post-PLX3397 treatment (PLX-resistant microglia) have lower expressions of CSF-1R, and microglial transcriptome analysis further elucidated that PLX-resistant microglia have unique morphology and transcriptomic signatures relative to vehicle-treated microglia of both genotypes; these include differences in definitive microglial functions such as their immune response, cell mobility, cell–cell communications, and regulation of neural homeostasis. Therefore, we suggest that microglia play a critical role in the pathogenesis of synucleinopathies, and that modulation of microglial status might be an effective therapeutic strategy for synucleinopathies.</p></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":null,"pages":null},"PeriodicalIF":8.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0889159124006196/pdfft?md5=ee6c5397b4f764db8279bbf3606b3730&pid=1-s2.0-S0889159124006196-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PNIRS Society Announcements PNIRS 协会公告
IF 8.8 2区 医学
Brain, Behavior, and Immunity Pub Date : 2024-09-13 DOI: 10.1016/S0889-1591(24)00611-1
{"title":"PNIRS Society Announcements","authors":"","doi":"10.1016/S0889-1591(24)00611-1","DOIUrl":"10.1016/S0889-1591(24)00611-1","url":null,"abstract":"","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":null,"pages":null},"PeriodicalIF":8.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice 通过微生物群-肠-脑轴改善高脂和高果糖饮食诱导的肥胖雄性小鼠的认知和行为损伤
IF 8.8 2区 医学
Brain, Behavior, and Immunity Pub Date : 2024-09-12 DOI: 10.1016/j.bbi.2024.09.008
Shuqing Zhang , Xiaoyu Wang , Shenlin Liu , Chingyuan Hu , Yonghong Meng
{"title":"Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice","authors":"Shuqing Zhang ,&nbsp;Xiaoyu Wang ,&nbsp;Shenlin Liu ,&nbsp;Chingyuan Hu ,&nbsp;Yonghong Meng","doi":"10.1016/j.bbi.2024.09.008","DOIUrl":"10.1016/j.bbi.2024.09.008","url":null,"abstract":"<div><p>The long-term high-fat, high-sugar diet exacerbates type 2 diabetes mellitus (T2DM)-related cognitive impairments. Phlorizin, a well-studied natural compound found in apples and other plants, is recognized for its bioactive properties, including modulation of glucose and lipid metabolism. Despite its established role in mitigating metabolic disorders, the neuroprotective effects of phlorizin, particularly against diabetes-related cognitive dysfunction, have not been fully elucidated. Therefore, the present study aimed to investigate the effect of dietary supplementation of phlorizin on high-fat and high-fructose diet (HFFD)-induced cognitive dysfunction and evaluate the crucial role of the microbiota-gut-brain axis. We found that dietary supplementation of phlorizin for 14 weeks effectively prevented glucolipid metabolism disorder, spatial learning impairment, and memory impairment in HFFD mice. In addition, phlorizin improved the HFFD-induced decrease in synaptic plasticity, neuroinflammation, and excessive activation of microglia in the hippocampus. Transcriptomics analysis shows that the protective effect of phlorizin on cognitive impairment was associated with increased expression of neurotransmitters and synapse-related genes in the hippocampus. Phlorizin treatment alleviated colon microbiota disturbance, mainly manifested by an increase in gut microbiota diversity and the abundance of short-chain fatty acid (SCFA)-producing bacteria. The level of microbial metabolites, including SCFA, inosine 5′-monophosphate (IMP), and D (−)-beta-hydroxybutyric acid (BHB) were also significantly increased after phlorizin treatment. Integrating multiomics analysis observed tight connections between phlorizin-regulated genes, microbiota, and metabolites. Furthermore, removal of the gut microbiota via antibiotics treatment diminished the protective effect of phlorizin against HFFD-induced cognitive impairment, underscoring the critical role of the gut microbiota in mediating cognitive behavior. Importantly, supplementation with SCFA and BHB alone mimicked the regulatory effects of phlorizin on cognitive function. Therefore, phlorizin shows promise as a potential nutritional therapy for addressing cognitive impairment associated with metabolic disorders. Further research is needed to explore its effectiveness in preventing and alleviating neurodegenerative diseases.</p></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":null,"pages":null},"PeriodicalIF":8.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High level of immunoglobulin G targeting mycoplasma or cytomegalovirus in the newborn increases risk of ADHD 新生儿体内针对支原体或巨细胞病毒的免疫球蛋白 G 含量高会增加患多动症的风险
IF 8.8 2区 医学
Brain, Behavior, and Immunity Pub Date : 2024-09-12 DOI: 10.1016/j.bbi.2024.09.009
Nis Borbye-Lorenzen , Solveig Holmgaard , Filip Ottosson , Ron Nudel , Vivek Appadurai , Thomas Munk Laursen , Marie Bækvad-Hansen , Jonas Bybjerg-Grauholm , Merete Nordentoft , Anders D Børglum , Preben Bo Mortensen , Thomas Werge , Michael E Benros , David Michael Hougaard , Kristin Skogstrand
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