Brain, Behavior, and Immunity最新文献

{"title":"Corrigendum to “Omega-3 fatty acids for inflamed depression – A match/mismatch study” [Brain Behav. Immun. 118 (2024) 192–201]","authors":"Klara Suneson , Gustav Söderberg Veibäck , Jesper Lindahl , Johanna Tjernberg , Darya Ståhl , Simon Ventorp , Filip Ängeby , Karl Lundblad , Owen M. Wolkowitz , Daniel Lindqvist","doi":"10.1016/j.bbi.2025.02.021","DOIUrl":"10.1016/j.bbi.2025.02.021","url":null,"abstract":"","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":"125 ","pages":"Page 473"},"PeriodicalIF":8.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Neurofilament light and glial fibrillary acidic protein in mood and anxiety disorders: A systematic review and meta-analysis” [Brain, Behavior, and Immunity 123 (2025) 1091–1102]","authors":"Matthew J.Y. Kang , Jasleen Grewal , Dhamidhu Eratne , Charles Malpas , Wei-Hsuan Chiu , Kasper Katisko , Eino Solje , Alexander F. Santillo , Philip B. Mitchell , Malcolm Hopwood , Dennis Velakoulis","doi":"10.1016/j.bbi.2025.01.004","DOIUrl":"10.1016/j.bbi.2025.01.004","url":null,"abstract":"","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":"125 ","pages":"Pages 466-470"},"PeriodicalIF":8.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of vagus nerve stimulation on microglia inhibit heroin-induced conditional place preference","authors":"Jianhua Bai ,&nbsp;Yingbiao Yue ,&nbsp;Zunyue Zhang ,&nbsp;Kunhua Wang ,&nbsp;Yun Jin ,&nbsp;Junfeng Wang ,&nbsp;Lei Zou","doi":"10.1016/j.bbi.2025.02.031","DOIUrl":"10.1016/j.bbi.2025.02.031","url":null,"abstract":"<div><h3>Background</h3><div>Heroin addiction remains a significant global health challenge with limited effective treatments. Vagus nerve stimulation (VNS) has shown promise in treating various neurological disorders, but its potential in addiction treatment is unexplored.</div></div><div><h3>Objective</h3><div>To investigate the effects of VNS on heroin-induced conditioned place preference (CPP) and elucidate the underlying neurobiological mechanisms.</div></div><div><h3>Methods</h3><div>We employed bilateral subphrenic vagotomy and VNS models in mice. Heroin-induced CPP was assessed following transcervical (nVNS) or transcutaneous auricular (taVNS) stimulation. Microglial activation in the nucleus accumbens (NAc) was evaluated using immunofluorescence and ELISA. The role of α7 nicotinic acetylcholine receptors (α7nAChRs) was investigated using the antagonist methyllycaconitine.</div></div><div><h3>Results</h3><div>Both nVNS and taVNS significantly attenuated heroin-induced CPP. VNS reversed heroin-induced microglial activation in the NAc, reducing pro-inflammatory markers and cytokines while increasing anti-inflammatory markers. These effects were mediated by α7nAChRs, as antagonist administration abolished VNS efficacy. Notably, subphrenic vagotomy did not affect VNS efficacy, suggesting a primarily central mechanism of action.</div></div><div><h3>Conclusion</h3><div>VNS inhibits heroin-induced CPP, likely through modulation of NAc microglia via α7nAChRs. taVNS, while less effective than nVNS, offers a promising non-invasive approach to addiction treatment. These findings provide a rationale for further clinical investigation of VNS, particularly taVNS, as an adjunct therapy for heroin addiction.</div></div><div><h3>Brief abstract</h3><div>Vagus nerve stimulation (VNS) attenuates heroin-induced conditioned place preference in mice by modulating microglial activation in the nucleus accumbens via α7 nicotinic acetylcholine receptors. Both invasive and non-invasive VNS show efficacy, with the latter offering potential as a novel addiction treatment approach. These findings warrant further investigation of VNS in clinical settings for heroin addiction management.</div></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":"127 ","pages":"Pages 45-56"},"PeriodicalIF":8.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “House dust mite-induced asthma exacerbates Alzheimer’s disease changes in the brain of the AppNL-G-F mouse model of disease” [Brain Behav. Immunity 121 (2024) 365–383]","authors":"Bijayani Sahu ,&nbsp;Suba Nookala ,&nbsp;Angela M. Floden ,&nbsp;Nilesh S. Ambhore ,&nbsp;Venkatachalem Sathish ,&nbsp;Marilyn G. Klug ,&nbsp;Colin K. Combs","doi":"10.1016/j.bbi.2025.01.018","DOIUrl":"10.1016/j.bbi.2025.01.018","url":null,"abstract":"","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":"125 ","pages":"Page 472"},"PeriodicalIF":8.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of childhood maltreatment on adult mental health trajectories during the COVID-19 pandemic","authors":"Johannes Julius Mohn ,&nbsp;Malvika Godara ,&nbsp;Sarita Silveira ,&nbsp;Hannah Matthaeus ,&nbsp;Tania Singer ,&nbsp;Christine Heim","doi":"10.1016/j.bbi.2025.02.022","DOIUrl":"10.1016/j.bbi.2025.02.022","url":null,"abstract":"<div><div>The relationship between changes in mental health during the severe and sustained stresses of the COVID-19 pandemic and exposure to childhood maltreatment is not well-characterized despite the recognition of early life adversity as a pervasive risk factor for adverse mental health outcomes throughout the lifespan. To determine whether a history of childhood maltreatment was associated with vulnerable mental health trajectories during the pandemic, we analyzed data from the CovSocial study, a longitudinal online study that assessed 3,522 adult respondents from Berlin, Germany at seven time points during the pandemic, including two lockdowns. Exposure to childhood maltreatment was assessed with the Childhood Trauma Questionnaire. The main outcome was membership in one of four latent mental health profile classes identified in a previous study from dynamic changes of resilience-vulnerability factor scores that captured variance in longitudinal measures of vulnerability (depression, anxiety, stress, burdens) and resilience (coping, optimism, social support). Exposure to childhood maltreatment significantly increased the odds of belonging to the most vulnerable compared to the most resilient latent class (OR, 4.66 [95 % CI, 3.57, 5.98]). On average, individuals with exposure had a greater mental health burden at baseline compared to non-exposed individuals (<em>p</em> &lt; 0.001, Cohen’s <em>d</em> = 0.24) and increasing mental health problems during the second sustained lockdown (<em>p</em> = 0.003, Cohen’s <em>d</em> = 0.18). Our results suggest that individuals who experienced childhood maltreatment are at increased risk for mental health problems during the pandemic, emphasizing the need for detection of cases and targeted interventions during future crises.</div></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":"125 ","pages":"Pages 444-451"},"PeriodicalIF":8.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PNIRS Society Announcements","authors":"","doi":"10.1016/S0889-1591(25)00080-7","DOIUrl":"10.1016/S0889-1591(25)00080-7","url":null,"abstract":"","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":"125 ","pages":"Pages iv-v"},"PeriodicalIF":8.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of the kynurenine pathway is related to persistent cognitive impairment in tick-borne encephalitis","authors":"Jacob Ahlberg Weidenfors ,&nbsp;Vytautas Griška ,&nbsp;Xueqi Li ,&nbsp;Aistė Pranckevičienė ,&nbsp;Jolita Pakalnienė ,&nbsp;Ann Atlas ,&nbsp;Elisabeth Franzén-Röhl ,&nbsp;Fredrik Piehl ,&nbsp;Lars Lindquist ,&nbsp;Auksė Mickienė ,&nbsp;Göran Engberg ,&nbsp;Lilly Schwieler ,&nbsp;Sophie Erhardt","doi":"10.1016/j.bbi.2025.02.005","DOIUrl":"10.1016/j.bbi.2025.02.005","url":null,"abstract":"<div><h3>Background</h3><div>Tick-borne encephalitis (TBE) patients frequently suffer cognitive and neuropsychiatric sequelae, which may be severe and long-lasting. The underlying mechanisms remain poorly understood, but likely involve dysregulation of immunological and neuroinflammatory processes. Here, we investigated the activity of the kynurenine pathway (KP), an immunologically induced set of enzymes generating neuroactive metabolites <em>via</em> degradation of the amino acid tryptophan and their correlation with the cognitive performance in TBE patients.</div></div><div><h3>Methods</h3><div>KP metabolite concentrations were measured in serum and cerebrospinal fluid (CSF) samples from patients taken during hospitalization for acute TBE (n = 87) and a control group (n = 12) by UPLC/MS-MS. At two follow-up occasions, 6 and 18 months after hospital discharge, additional serum samples were obtained from TBE patients and their cognitive performance was evaluated by the Matrics Consensus Cognitive Battery.</div></div><div><h3>Results</h3><div>Relative to controls, TBE patients exhibited a robust induction of the KP in both the central nervous system and peripheral blood during the acute phase of the disease, with drastic elevations of the neuroactive QUIN and KYNA in CSF. KP activity remained significantly elevated in serum of TBE patients at the 6- and 18-month follow-ups. Several inverse associations between cognitive performance and measurements of KP activity recorded in both CSF and serum were found by rank correlation analysis. Further, <em>via</em> ROC analysis, serum rKT was found to be an accurate predictor of impaired overall cognition (&lt;35 T-score) 6 months after acute TBE (AUC 0.79, CI 0.64–0.93, p &lt; 0.01 for rKT measured during acute TBE; AUC 0.68, CI 0.50–0.86, p &lt; 0.05 for rKT measured at 6 months).</div></div><div><h3>Interpretation</h3><div>We have found evidence of both acute and chronic dysregulation of KP activity in TBE patients, which correlated with degree of cognitive impairment at long-term follow-up. Our findings suggest that KP metabolites may serve as biomarkers for TBE-related cognitive sequelae, and more broadly, that the KP may offer avenues for development of novel treatments.</div></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":"125 ","pages":"Pages 452-465"},"PeriodicalIF":8.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay between oxidative stress and inflammation supports autistic-related behaviors in Cntnap2 knockout mice","authors":"Luca Pangrazzi ,&nbsp;Enrica Cerilli ,&nbsp;Luigi Balasco ,&nbsp;Chrow Khurshid ,&nbsp;Caterina Tobia ,&nbsp;Ginevra Matilde Dall’O’ ,&nbsp;Gabriele Chelini ,&nbsp;Samuel Perini ,&nbsp;Michele Filosi ,&nbsp;Anna Barbieri ,&nbsp;Teresa Ravizza ,&nbsp;Annamaria Vezzani ,&nbsp;Giovanni Provenzano ,&nbsp;Anna Pastore ,&nbsp;Birgit Weinberger ,&nbsp;Josep Rubert ,&nbsp;Enrico Domenici ,&nbsp;Yuri Bozzi","doi":"10.1016/j.bbi.2025.02.030","DOIUrl":"10.1016/j.bbi.2025.02.030","url":null,"abstract":"<div><div>Autism Spectrum Disorder (ASD) is a highly prevalent neurodevelopmental condition characterized by social communication deficits and repetitive/restricted behaviors. Several studies showed that oxidative stress and inflammation may contribute to ASD. Indeed, increased levels of oxygen radicals and pro-inflammatory molecules were described in the brain and peripheral blood of persons with ASD and mouse models. Despite this, a potential direct connection between oxidative stress and inflammation within specific brain areas and ASD-related behaviors has not been investigated in detail yet. Here, we used RT-qPCR, RNA sequencing, metabolomics, immunohistochemistry, and flow cytometry to show that pro-inflammatory molecules were increased in the cerebellum and periphery of mice lacking <em>Cntnap2</em>, a robust model of ASD. In parallel, oxidative stress was present in the cerebellum of mutant animals. Systemic treatment with N-acetyl-cysteine (NAC) rescued cerebellar oxidative stress, inflammation, as well as motor and social impairments in <em>Cntnap2^-/-</em> mice, concomitant with enhanced function of microglia cells in NAC-treated mutants. Intriguingly, social deficits, cerebellar inflammation, and microglia dysfunction were induced by NAC in <em>Cntnap2^+/+</em> animals. Our findings suggest that the interplay between oxidative stress and inflammation accompanied by genetic vulnerability may underlie ASD-related behaviors in <em>Cntnap2</em> mutant mice.</div></div>","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":"127 ","pages":"Pages 57-71"},"PeriodicalIF":8.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on the article “Hippocampal GPR35 is involved in the depression-like behaviors induced by inflammation and mediates the antidepressant effects of fluoxetine in mice”","authors":"Peng Ren ,&nbsp;Jing-Ya Wang ,&nbsp;Yun-Feng Li","doi":"10.1016/j.bbi.2025.02.027","DOIUrl":"10.1016/j.bbi.2025.02.027","url":null,"abstract":"","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":"126 ","pages":"Pages 311-312"},"PeriodicalIF":8.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions between sex hormones and the gut microbiome","authors":"Linnea R. Freeman","doi":"10.1016/j.bbi.2025.02.025","DOIUrl":"10.1016/j.bbi.2025.02.025","url":null,"abstract":"","PeriodicalId":9199,"journal":{"name":"Brain, Behavior, and Immunity","volume":"126 ","pages":"Pages 313-314"},"PeriodicalIF":8.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}