Integrative clinical medicine最新文献_第4页

Effectivity of a joint didactic intervention by school for patients on inappropriate control prothrombin time anticoagulated patients 学校联合教学干预对不适当控制凝血酶原时间抗凝患者的效果

Integrative clinical medicine Pub Date : 2019-01-01 DOI: 10.15761/icm.1000162

Ginel Mendoza L, Hidalgo Natera A

引用次数: 0

Changing treatment landscape of Marginal zone lymphoma 改变边缘地带淋巴瘤的治疗前景

Integrative clinical medicine Pub Date : 2019-01-01 DOI: 10.15761/icm.1000159

P. Barde

引用次数: 0

Treatment with mesenchymal stem cells for xerostomia: A new paradigm in cell therapy 间充质干细胞治疗口干症:细胞治疗的新范例

Integrative clinical medicine Pub Date : 2019-01-01 DOI: 10.15761/icm.1000152

Soler Rich Robert, C. Jordi, Rius Tarruella Joan, Zamora Bustamante Jeanneth, Orozco Delclós Lluís

引用次数: 3

Renal colic pain and the TENS as an alternative analgesia 肾绞痛与TENS作为替代镇痛

Integrative clinical medicine Pub Date : 2019-01-01 DOI: 10.15761/ICM.1000151

Umadevan Rajasagaram

引用次数: 0

Immunological modulation of mesenchymal stem cells in repairing of acute kidney injury 间充质干细胞在急性肾损伤修复中的免疫调节作用

Integrative clinical medicine Pub Date : 2019-01-01 DOI: 10.15761/icm.1000149

Qin Tan, Yichuan Li

引用次数: 0

NC-6004, a novel cisplatin nanoparticle, in combination with pembrolizumab for head and neck cancer NC-6004，一种新型顺铂纳米颗粒，联合派姆单抗治疗头颈癌

Integrative clinical medicine Pub Date : 2019-01-01 DOI: 10.15761/icm.1000147

A. Osada

引用次数: 5

Melatonin supplementation to improve quality of life for elderly cancer patients 补充褪黑素改善老年癌症患者的生活质量

Integrative clinical medicine Pub Date : 2019-01-01 DOI: 10.15761/icm.1000148

A. Ginzac, E. Thivat, X. Durando

{"title":"Melatonin supplementation to improve quality of life for elderly cancer patients","authors":"A. Ginzac, E. Thivat, X. Durando","doi":"10.15761/icm.1000148","DOIUrl":"https://doi.org/10.15761/icm.1000148","url":null,"abstract":"The incidence of elderly population living with cancer increases. Maintaining or improving the quality of life (QoL) has become an important goal in the treatment of cancer disease and is even an endpoint in clinical trials. The elderly are underrepresented within these clinical trials and often undertreated. The aged population with cancer is very heterogeneous and has certain characteristics (comorbidities, vulnerability) making the management and assessment of QoL more complex in this population. Melatonin, a hormone secreted by the pineal gland, regulates various physiological functions and is involved in the initiation of sleep. With age, the secretion of melatonin decreases and thus disrupts circadian rhythm. Circadin® (a prolonged-release form of melatonin) is used in France in the treatment of primary insomnia in person over 55 years old and contributes to improvement of QoL. Melatonin also presents a potential interest in addition to chemotherapy in the treatment of cancer by reducing or preventing certain symptoms (e.g., fatigue, depression) that constitute essential components of QoL. In this context, it seems appropriate to study the impact of supplementation with melatonin during chemotherapy on QoL of elderly patients with metastatic cancer. *Correspondence to: Angeline GINZAC, 58, rue Montalembert, 63011 Clermont-Ferrand, France, Tel: +33 473278005; Fax: +33 473278029; E-mail: Angeline.ginzac@clermont.unicancer.fr","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67469459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of fat grafting technique using autologous micro-fragmented adipose tissue (Lipogems®) in female patients suffering from stress urinary incontinence 自体微碎片脂肪组织(Lipogems®)脂肪移植技术在女性压力性尿失禁患者中的应用价值

Integrative clinical medicine Pub Date : 2019-01-01 DOI: 10.15761/icm.1000158

J. Cortes, Daniel Vélez

{"title":"Evaluation of fat grafting technique using autologous micro-fragmented adipose tissue (Lipogems®) in female patients suffering from stress urinary incontinence","authors":"J. Cortes, Daniel Vélez","doi":"10.15761/icm.1000158","DOIUrl":"https://doi.org/10.15761/icm.1000158","url":null,"abstract":"Stress urinary incontinence (SUI) is a common occurrence in women. Although causes may be multi-factorial, the ultimate consequence of urethral sphincter weakness is urinary leakage with increase in intra-abdominal pressure. The gold standard treatment for SUI is urethral sling, for which the patient may not be a candidate, versus injection of synthetic bulking agents, which requires repeat injections over the patient’s lifetime. Autologous mesenchymal stem cells are an area of great interest within regenerative medicine to offer longer lasting effects over synthetic bulking agents. Microfragmentation of the harvested fat, to isolate the mesenchymal stem cells, is a novel technique that has shown great promise in other fields. Here, we present our preliminary data for 11 women with primary stress urinary incontinence after mid-urethral injection of autologous mesenchymal stem cells. Eight women were at least one-year post-Lipogems® injection and had an average improvement in VAS score from 9 to 4.7, and a decrease in pad count from 5.3 to 4.2. Two women had complete resolution of their SUI (VAS 0, pad count 0) at 18 and 24 months post-Lipogems® injection. Only one patient had a harvest site hematoma, and three patients had post-op urinary retention which resolved. These preliminary results are supportive of the regenerative potential of autologous mesenchymal stem cells for the treatment of stress urinary incontinence. *Correspondence to: Janice Santos Cortes, Department of Surgery, Urology, The Warren Alpert School of Medicine of Brown University, 2 Dudley Street Suite 185, Providence, RI 02906, USA, E-mail: jasmd25@gmail.com","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67469765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Beneficial effects of Monascus purpureus NTU 568-fermented products on cholesterol in vivo and clinical trial: A review 红曲霉NTU 568发酵产物对体内胆固醇的有益作用及临床研究综述

Integrative clinical medicine Pub Date : 2019-01-01 DOI: 10.15761/icm.1000161

Chien-Li Chen, T. Pan

{"title":"Beneficial effects of Monascus purpureus NTU 568-fermented products on cholesterol in vivo and clinical trial: A review","authors":"Chien-Li Chen, T. Pan","doi":"10.15761/icm.1000161","DOIUrl":"https://doi.org/10.15761/icm.1000161","url":null,"abstract":"Red yeast rice (RYR) is prepared by fermenting rice with Monascus. RYR contains the compound monacolin K-the same active ingredient found in prescription cholesterol-lowering medications like lovastatin. Hypercholesterolemia is a dangerous form of cardiovascular disease, for which statins are generally prescribed as the main therapeutic drug. One of the most common complaints of people taking statins is muscle pain as a soreness, tiredness, weakness or induced rhabdomyolysis. The U.S. Food and Drug Administration has issued warnings that memory loss, mental confusion, neuropathy, high blood sugar, and type 2 diabetes are possible side effects. Monascus purpureus NTU 568-fermented product (Ankascin 568-R) contains monascin and ankaflavin as major active compounds, which was different from Monascus species fermented major compound monacolin K. Due to the high levels of Monascus metabolites and other ingredients, minimal amounts of Ankascin 568R can be completely assimilated into the digestive system. Clinical results have showed statistically significant decreases of 11.9% and 19.0% were observed in total cholesterol and low-density lipoprotein cholesterol levels, respectively. This systematic review describes the applications, side effects, and health benefits of monacolin K, monascin, and ankaflavin in Monascus-fermented products based on animal studies and clinical trial. Empirical studies suggest that a potentially useful agent for the regulation of blood lipids and the treatment of coronary artery diseases. *Correspondence to: Tzu-Ming Pan, Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan, Tel: +886-2-33664519 (Extn. 10); Fax: +886-2-33663838; E-mail: tmpan@ntu.edu.tw","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67469899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The effects of blood flow restriction exercise on vascular function in the elderly: A systematic review 限制血流运动对老年人血管功能的影响:系统综述

Integrative clinical medicine Pub Date : 2019-01-01 DOI: 10.15761/ICM.1000140

S. Amorim, Alexandra PGaspar, H. Degens, L. Matos

{"title":"The effects of blood flow restriction exercise on vascular function in the elderly: A systematic review","authors":"S. Amorim, Alexandra PGaspar, H. Degens, L. Matos","doi":"10.15761/ICM.1000140","DOIUrl":"https://doi.org/10.15761/ICM.1000140","url":null,"abstract":"Background: Blood flow restriction (BFR) exercise has been used to induce skeletal muscle and aerobic adaptations that are similar to those induced by high intensity training, but with less time and lower intensities. The lower time demand and exercise intensity appear advantageous, especially for older people but there may be risks associated with a potential impairment of vascular function after BFR trainings. Therefore, the purpose of this systematic review was to evaluate the effects of aerobic and resistance exercise with BFR on vascular function in the elderly. Methods: PubMed, Embase, Scopus, Lilacs, Web of science, Pedro, Google Scholar and the Cochrane library were searched for articles published until January 2019. This review included randomized and non-randomized controlled trials of BFR exercise for ≥ 4 weeks in older humans. Results: In the first step, 133 articles were identified, of which 22 articles met the inclusion criteria. Sixteen studies were excluded because of the short training period (< 4 weeks) or the average age of participants (< 60 years). Six articles were included in this review (n = 146 individuals, mean age = 69 years old, 71,46% women and 28,54% men). BFR combined with aerobic exercise (n = 2) enhanced arterial and venous compliance in healthy elders and resistance exercises (n = 4) demonstrated no significant effects on vascular function in healthy elders compared to exercise without BFR. Conclusion: These results suggest that the addition of BFR to exercise does even improve vascular function in healthy elderly people. This is a first indication that superimposing BFR is safe also in sedentary elders. However, future research, especially in sedentary elders, is necessary to assess the safety of this method. *Correspondence to: Luciana Diniz Nagem Janot de Matos, Hospital Israelita Albert Einstein, Avenida Albert Einstein 627/701, Jardim Leonor CEP: 05652-900 São Paulo, SP – Brazil, Tel. +55 11 2151-1444, E-mail: lucianajanot@einstein.br","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67469545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4