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Integrative clinical medicine最新文献

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Discussion on traditional Chinese medical ideas and the etiology of some common chronic diseases from the perspective of comparative anatomy 从比较解剖学角度谈中医思想及常见慢性病的病因
Integrative clinical medicine Pub Date : 2021-01-01 DOI: 10.15761/icm.1000194
Xiaoqing Wang, Ling Wang, Junhua Yang
{"title":"Discussion on traditional Chinese medical ideas and the etiology of some common chronic diseases from the perspective of comparative anatomy","authors":"Xiaoqing Wang, Ling Wang, Junhua Yang","doi":"10.15761/icm.1000194","DOIUrl":"https://doi.org/10.15761/icm.1000194","url":null,"abstract":"","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67470616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and efficacy data of a randomized, double-blind, placebo-controlled phase II study with the biological response modifier “bRESCAP” in patients undergoing cardiac surgery (APPIRED II) 一项随机、双盲、安慰剂对照的心脏手术患者使用生物反应调节剂“bRESCAP”的II期研究(APPIRED II)的安全性和有效性数据
Integrative clinical medicine Pub Date : 2021-01-01 DOI: 10.15761/icm.1000193
H. Keizer, S. Kats, Ines Christis, R. Heylen, Ronald Oosting, W. Seinen, R. Brands
{"title":"Safety and efficacy data of a randomized, double-blind, placebo-controlled phase II study with the biological response modifier “bRESCAP” in patients undergoing cardiac surgery (APPIRED II)","authors":"H. Keizer, S. Kats, Ines Christis, R. Heylen, Ronald Oosting, W. Seinen, R. Brands","doi":"10.15761/icm.1000193","DOIUrl":"https://doi.org/10.15761/icm.1000193","url":null,"abstract":"","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67471062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Safety and efficacy of CIMAvax-EGF vaccine for the treatment of real-world non-small cell lung cancer patients CIMAvax-EGF疫苗治疗现实世界非小细胞肺癌患者的安全性和有效性
Integrative clinical medicine Pub Date : 2021-01-01 DOI: 10.15761/icm.1000195
M. Hernández, Ramon A. Ortiz, E. Salomon, S. Acosta, E. Santiesteban, Rosa M. Amador, Ivis C. Mendoza, Pedro P. Guerra, Maité Robaina, Carlos Sanchez, C. Viada, O. Torres, T. Crombet, A. Lage
{"title":"Safety and efficacy of CIMAvax-EGF vaccine for the treatment of real-world non-small cell lung cancer patients","authors":"M. Hernández, Ramon A. Ortiz, E. Salomon, S. Acosta, E. Santiesteban, Rosa M. Amador, Ivis C. Mendoza, Pedro P. Guerra, Maité Robaina, Carlos Sanchez, C. Viada, O. Torres, T. Crombet, A. Lage","doi":"10.15761/icm.1000195","DOIUrl":"https://doi.org/10.15761/icm.1000195","url":null,"abstract":"","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67471540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms. 作为快速抗抑郁药的 NMDAR 调节剂：信号机制的趋同性与差异性
Integrative clinical medicine Pub Date : 2020-06-01 Epub Date: 2020-02-04 DOI: 10.15761/icm.1000173
Boyoung Lee, Santosh Pothula, Ronald S Duman
{"title":"NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms.","authors":"Boyoung Lee, Santosh Pothula, Ronald S Duman","doi":"10.15761/icm.1000173","DOIUrl":"10.15761/icm.1000173","url":null,"abstract":"<p><p>Dysregulation of the glutamatergic system underlies the pathophysiology of depression. Both negative and positive modulation of NMDARs exert rapid and sustained antidepressant effects by reversing the dysregulated glutamatergic system. Research in the past decades has identified key signaling pathways activated by these rapid acting antidepressants. Here, we review the converging signaling mechanisms shared by rapid acting antidepressants and discuss the recent progress on distinct actions of NMDAR antagonists and NMDAR positive modulators to trigger rapid antidepressant actions.</p>","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39302847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A treatment strategy for sex offenders in Japan 日本性犯罪者的治疗策略
Integrative clinical medicine Pub Date : 2020-01-01 DOI: 10.15761/ICM.1000178
Kumiko Ando
{"title":"A treatment strategy for sex offenders in Japan","authors":"Kumiko Ando","doi":"10.15761/ICM.1000178","DOIUrl":"https://doi.org/10.15761/ICM.1000178","url":null,"abstract":"Examining the crime statistics for Japan [1], we see that while the number of criminal arrests has been declining since 2003, sex offenses are on the rise. Recidivism rates are also high for sex offenders (27.7% for rape and 32.3% for sexual battery) [2,3], so there are efforts to prevent repeat offenses in Japan. Although sex offenses are often committed by people with intellectual disabilities, nearly all rehabilitation programs are designed for individuals with no such disabilities [4], and there is insufficient treatment and support for offenders as they reenter society. We therefore developed a rehabilitation program that can also be used with sex offenders that have intellectual and mental disabilities.","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67470117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Factors affecting digestibility of South Indian white rice 影响南印度白米消化率的因素
Integrative clinical medicine Pub Date : 2020-01-01 DOI: 10.15761/ICM.1000172
Fatima Humaira, R. Yashwanth, Chandrasekharan C Lakshmanan
{"title":"Factors affecting digestibility of South Indian white rice","authors":"Fatima Humaira, R. Yashwanth, Chandrasekharan C Lakshmanan","doi":"10.15761/ICM.1000172","DOIUrl":"https://doi.org/10.15761/ICM.1000172","url":null,"abstract":"Rice is a staple food of most Asian diets and a major contributor to high carbohydrate load. The objective of our study was to evaluate factors that affect digestibility of rice and corroborate in vitro estimated Glycaemic Index (GI) with clinically evaluated GI. We hypothesised that in vitro digestibility and thus estimation of GI may be impacted by multiple parameters including amylose content, particle size and method of cooking. In this study, a commonly consumed South Indian white rice variety, was evaluated for various factors that affect in vitro digestibility. Our results suggest amylose content and particle size of rice to be inversely related to digestibility and estimated Glycaemic Index (GI). Of the five different commonly followed consumer cooking methods tested, electric cooking method increased in vitro digestibility. GI was evaluated in fifty healthy volunteers with the selected variety cooked by an optimized method, showed a high GI of 70 ± 3 (SEM). This study thus extends the current knowledge on factors affecting in vitro digestibility of selected variety of rice and suggests an important role of consumer processing methods.","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67470370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inter-individuality and plant hormones. Commentary on systems, variation, individuality and plant hormones 个体间与植物激素。系统、变异、个体性和植物激素评论
Integrative clinical medicine Pub Date : 2020-01-01 DOI: 10.15761/ICM.1000174
T. Trewavas
{"title":"Inter-individuality and plant hormones. Commentary on systems, variation, individuality and plant hormones","authors":"T. Trewavas","doi":"10.15761/ICM.1000174","DOIUrl":"https://doi.org/10.15761/ICM.1000174","url":null,"abstract":"Received: January 20, 2020; Accepted: February 04, 2020; Published: February 10, 2020 It is not common for papers on plant hormones to find their way into any endocrinological journals. Plants and mammals seem as far apart biologically as one could get. But in a number of respects animal and plant hormones do share some common issues in which knowledge in one can help better understanding of the other.","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67470433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the study of CAR-T in digestive system malignancies CAR-T在消化系统恶性肿瘤中的研究进展
Integrative clinical medicine Pub Date : 2020-01-01 DOI: 10.15761/ICM.1000190
Zhengchao Zhang, Yumin Li
{"title":"Advances in the study of CAR-T in digestive system malignancies","authors":"Zhengchao Zhang, Yumin Li","doi":"10.15761/ICM.1000190","DOIUrl":"https://doi.org/10.15761/ICM.1000190","url":null,"abstract":"In recent years, tumor immunotherapy has obtained remarkable outcomes in the treatment of hematologic malignancies, tumor immunotherapy has been gradually applied to digestive system malignancies (DSMs) and has achieved some results. Chimeric antigen receptor T cells (CAR-T) is a gene-engineered receptor technology that integrates the antibody fragment of malignancy antigen and T cell activation domain to target and kill malignancy cells. CAR-T has been proved to be a strong killer of malignancies in B-cell leukemia and lymphoma. Therefore, a large number of research centers around the world have begun to focus on the application of CAR-T technology in DSMs, and their research has confirmed that CAR-T technology has a clear effect on the treatment of DSMs. Through reading a large number of literatures, we summarized the progress of CAR-T technology and its application in DSMs.","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67470781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Success rate of epicardial left atrial ablation during coronary artery bypass grafting and aortic valve replacement: A pilot single centre study 冠状动脉旁路移植术和主动脉瓣置换术中心外膜左房消融的成功率:一项试点单中心研究
Integrative clinical medicine Pub Date : 2020-01-01 DOI: 10.15761/ICM.1000183
M. Salem, A. Thiem, Jan Dreyer, C. Grothusen, T. Puehler, M. Ernst, C. Friedrich, A. Haneya, J. Cremer, J. Schöttler
{"title":"Success rate of epicardial left atrial ablation during coronary artery bypass grafting and aortic valve replacement: A pilot single centre study","authors":"M. Salem, A. Thiem, Jan Dreyer, C. Grothusen, T. Puehler, M. Ernst, C. Friedrich, A. Haneya, J. Cremer, J. Schöttler","doi":"10.15761/ICM.1000183","DOIUrl":"https://doi.org/10.15761/ICM.1000183","url":null,"abstract":"Objective: The incidence of atrial fibrillation is increasing continuously. The impact of the underlying cardiac disease on success rate of epicardial left atrial ablation after cardiac surgery is not consistently investigated. Success rate of epicardial left atrial ablation after cardiac surgery were analysed in 30 patients, who intraoperatively received an event recorder. Therapeutic success was evaluated one year postoperatively. Furthermore, long-term survival after five years was investigated. Patients with isolated coronary artery bypass graft (n=17) were compared to patients with aortic valve replacement with or without combination with coronary artery bypass graft (n=13). Results: There was no significant difference between both groups in demographic, intraoperative and postoperative variables. One year after aortic valve replacement, the proportion of patients with a stable sinus rhythm was significantly lower than after coronary artery bypass grafting only (23.1% vs. 64.7%, p=0.033). If preoperatively paroxysmal atrial fibrillation was diagnosed, the success rate after coronary artery bypass grafting (77.8%) as well as aortic valve replacement (25.0%) were higher. Five-year survival rate after isolated coronary artery bypass grafting was 82.4% and after aortic valve replacement was 100%. Conclusions: Epicardial left atrial ablation is a good treatment option for patients with atrial fibrillation undergoing an isolated CABG. Due to the low chance of success in patients undergoing isolated aortic valve replacement or combined intervention with CABG, the epicardial ablation rather not to be performed. Fortunately, a satisfying overall five-year survival rate could be seen.","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67471038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The reference interval of blood pressure is essential for preemptive medicine in the prediction and prevention of hypertension 血压的参考区间对高血压的预测和预防具有重要意义
Integrative clinical medicine Pub Date : 2020-01-01 DOI: 10.15761/ICM.1000176
M. Yamakado
{"title":"The reference interval of blood pressure is essential for preemptive medicine in the prediction and prevention of hypertension","authors":"M. Yamakado","doi":"10.15761/ICM.1000176","DOIUrl":"https://doi.org/10.15761/ICM.1000176","url":null,"abstract":"unique medical checkup conducted electronically in a Ningen facility for the early detection and prevention of cancer and lifestyle-related diseases as obesity, hypertension, lipid disorders and glucose metabolism by risk management The detection of early stage lifestyle-related diseases requires a number of relevant clinical tests, a frame of reference to access these test results. this frame of reference consists of the reference intervals (RIs), these RIs are often set for each medical checkup facility, even if the test results at different facilities are similar. in order to provide high-quality medical examinations uniformly throughout the country, is to set standardized RIs that could be adopted by all Ningen facilities on this of new RIs for basic laboratory tests in where cerebrovascular disease is a prevalent cause of death and reduces healthy life expectancy, we also described the RIs for blood pressure (BP) that indicate cerebrovascular disease, and their use in preventive medicine. In in the of hypertension, the of","PeriodicalId":91880,"journal":{"name":"Integrative clinical medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67470449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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